[HN Gopher] Cleaning up the aging brain: Scientists restore brai...
___________________________________________________________________
Cleaning up the aging brain: Scientists restore brain's trash
disposal system
Author : jdmark
Score : 52 points
Date : 2024-08-15 20:31 UTC (2 hours ago)
(HTM) web link (www.sciencedaily.com)
(TXT) w3m dump (www.sciencedaily.com)
| hyrix wrote:
| _In mice_
| alephnerd wrote:
| Mice are in the same clade as primates, and share around 95-99%
| of the same genome as primates.
|
| We're all part of the Euarchontoglires clade
| cyberax wrote:
| The problem is that primates are pretty far removed from
| mice. And our sheer weight difference often makes is a
| decisive factor.
|
| This is especially true for cancer, brain, and inflammation
| research. Mice just don't make good models for that.
| alephnerd wrote:
| > that primates are pretty far removed from mice
|
| They are a good initial test for viability because of the
| overwhelming genetic similarity.
|
| This is why mice and rodents are used to test initial
| viability before then moving on to theraputics development.
|
| You can read some sources if you want [0][1][2]
|
| [0] - https://www.jax.org/why-the-mouse/excellent-models
|
| [1] - https://www.cam.ac.uk/research/research-at-
| cambridge/animal-...
|
| [2] - https://www.genome.gov/10001345/importance-of-mouse-
| genome
| cyberax wrote:
| > This is why mice and rodents are used to test initial
| viability before then moving on to theraputics
| development.
|
| They are used because they're the _only_ way to test
| drugs early in development. Animal cruelty laws make it
| nearly impossible to use non-murine species for initial
| drug tests.
|
| Additionally, mice are easy to breed and to keep, and
| there's a great variety of specialized genetic lines.
| hombre_fatal wrote:
| Yet none of that matters because only a tiny fraction of
| interventions make it from rat models to humans.
| manmal wrote:
| This mechanism sounds like it could have a strong nootropic
| effect for everyone not having totally ideal sleep. Whenever I
| sleep badly, or not long enough for some days in a row, my
| cognitive performance deteriorates rather quickly. Supposedly,
| the glymphatic system's work has a major role to play in this.
|
| Melatonin also has been found to have a stimulating effect on the
| glymphatic system, though we need better trials on that.
| ggm wrote:
| Are there non drug methods which could restore or assist lymph
| pumping functions in the head-neck region? Should we all be doing
| some kind of rotation/lift/squeeze cycle on our cervical spine
| region?
| OutOfHere wrote:
| Nafaik, but anything that gives you two extra hours of sleep
| should help. Also, intense exercise should over time help heal
| it in part. And as far as drug methods go, a 2-3 month course
| of memantine could be worth exploring for anyone who doesn't
| have to drive or operate machinery.
| thordenmark wrote:
| Exercise, good food, and good sleep. Pretty much the universal
| panacea.
| thordenmark wrote:
| Sounds easy, but difficult in practice. Especially for those
| of us chained to a desk all day.
| hi-v-rocknroll wrote:
| For disabled and elderly people, these aren't always
| possible.
| DoreenMichele wrote:
| _" Unlike the cardiovascular system which has one big pump, the
| heart, fluid in the lymphatic system is instead transported by a
| network of tiny pumps,"_
|
| Not entirely accurate.
|
| https://news.ycombinator.com/item?id=25427090
| pedalpete wrote:
| This study in aging adults measured amyloid in blood with phase-
| targeted auditory stimulation, the technology we've been
| developing at affectablesleep.com - it's not exactly the same as
| measuring the glymphatic process, but might be related.
___________________________________________________________________
(page generated 2024-08-15 23:00 UTC)