Post Ar59vsHPLWhSSyhTbk by mittimithai@neenster.org
 (DIR) More posts by mittimithai@neenster.org
 (DIR) Post #Ar4rOvH1Ocnh1Jeobo by polarisera@spinster.xyz
       2025-02-13T13:41:20.182887Z
       
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       The infinite life cycle of drugs is hilarious....  A drug that formerly made you lose weight, then...
       
 (DIR) Post #Ar4wyj3smDYzLEP3kO by Erin@gigaohm.bio
       2025-02-13T14:25:01.493472Z
       
       1 likes, 0 repeats
       
       Front Pharmacol. 2023 May 12;14:1192022. doi: 10.3389/fphar.2023.1192022According to the current hypothetical model, FFA enhances GABAergic signaling via activity at serotonin (5-hydroxytryptophan, 5-HT) receptors and inhibits excitatory signaling through sigma-1 (σ1)-mediated mechanisms, thereby restoring the balance between inhibition and excitation (Sourbron et al., 2017; Martin et al., 2020; Sourbron and Lagae, 2022). Nonetheless, other mechanisms are likely to be involved. Recent data suggest that FFA confers clinical benefit beyond seizure reduction alone (Jensen et al., 2022; Jensen et al., 2023),According to the current hypothetical model AND other mechanisms are likely to be involved? What could possibly go wrong?
       
 (DIR) Post #Ar4wyjrrmNXtqFmyem by polarisera@spinster.xyz
       2025-02-13T14:43:48.609345Z
       
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       @Erin Yes, and the American retard has no idea that the FDA went from requiring a "mechanism of action" to just saying "fuck it" drug 'em up and let's see what happens.
       
 (DIR) Post #Ar58bZFsGoMNiTjhFA by mittimithai@neenster.org
       2025-02-13T15:23:31.098058Z
       
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       When did the FDA require a mechanism of action?
       
 (DIR) Post #Ar58baUnentRZ3j89A by Erin@gigaohm.bio
       2025-02-13T15:43:42.881781Z
       
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       Good question.. but I would think the agency resposible for anointing something "safe and effective" would at least want to know how something works in order to proclaim it so? But perhaps that's a flawed assumption on my part..
       
 (DIR) Post #Ar58bbOoIYhEMlvrRw by mittimithai@neenster.org
       2025-02-13T16:49:53.255066Z
       
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       Mechanisms are hard to understand. The FDA likes to know them but doesn't require them. The two sides of the coin:https://pmc.ncbi.nlm.nih.gov/articles/PMC7479624/The real question: how much should you invest in them? The answer depends on what you are getting out of the drug.
       
 (DIR) Post #Ar58bbyGAl3K8iWAhk by polarisera@spinster.xyz
       2025-02-13T16:54:03.374201Z
       
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       @mittimithai @Erin The worship of ignorance is the founding principle of biology. Every study designed to destroy and ignore information.
       
 (DIR) Post #Ar59vsHPLWhSSyhTbk by mittimithai@neenster.org
       2025-02-13T17:02:05.554942Z
       
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       Sure but we don't really know how tylenol/paracetamol work...Gotzche will suggest taking on in many circumstances involving pain instead of many other drugs.
       
 (DIR) Post #Ar59vswAtxJGVPm29Q by polarisera@spinster.xyz
       2025-02-13T17:08:58.647319Z
       
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       @mittimithai @Erin Instead of surveillance we spread ignorance over it. The HMOs have life histories and all the drugs ever taken. They ran a few statistical independence tests, and were horrified at what they found and the implications of the entire racket of lies. The entire statistical foundation of medicine is a fraud, end to end, and they know it. They never do independence tests, they never try to do background rate (they know the answer will be bad). They never do spot checks or randomized testing outside the mystical framework. They do nothing like an industrial engineer would.