Post AZHEC7as3vPhaEfI9o by calsnoboarder@universeodon.com
 (DIR) More posts by calsnoboarder@universeodon.com
 (DIR) Post #AZHDJn0wMPSw7Tx2Ya by clive@saturation.social
       2023-08-31T03:04:44Z
       
       0 likes, 1 repeats
       
       Okay, so when it comes to adjudicating the validity of this supposed pre-hangover drug -- to prevent hangovers -- I'm going to defer to @jetjocko, who *literally wrote the book* on this science: https://boingboing.net/2023/08/30/zbiotics-is-a-new-pre-alcohol-drink-that-claims-to-prevent-hangovers.htmlAdam, could this drug actually work?
       
 (DIR) Post #AZHEC7as3vPhaEfI9o by calsnoboarder@universeodon.com
       2023-08-31T03:14:26Z
       
       0 likes, 0 repeats
       
       @clive @jetjocko Is it milk? Drinking 8 ounces of milk has always been my pre party ritual after one of the worst hangovers I ever had and haven’t had as much as a head ache since.
       
 (DIR) Post #AZHEmsXoyg7FcjlXJA by amy@jawns.club
       2023-08-31T03:21:10Z
       
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       @clive i’m not the scientist but i can report that a lot of the hangover feeling is from dehydration, potentially even causing low pressure on the brain. dehydration -> lowered CSF production. csf leaks feel a LOT like hangovers. like disturbingly.i take extra electrolyte pills and drink a lot of water when i drink. i’ve had 2 real hangovers ever bc 1. i sweated a lot & forgot to account for that, 2. drank casually with russians and ukrainians and just… really lost track
       
 (DIR) Post #AZHQXmQcdMeXlFxuJE by jetjocko@mastodon.social
       2023-08-31T05:32:27Z
       
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       @clive it’s *possible* that acetaldehyde is a cause of hangover symptoms—nobody really knows. Acetaldehyde is so fleeting that it’s hard to get blood levels, so as far as I know no one has ever associated it cleanly with hangover….
       
 (DIR) Post #AZIaayDETGIDsRp1xQ by clive@saturation.social
       2023-08-31T18:59:44Z
       
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       @amy yeah I bet electrolytes are a great idea! I take them all the time when I’m doing long-distance cycling, they really help with dehydration
       
 (DIR) Post #AZIahdR07ZhhSkRMG0 by jetjocko@mastodon.social
       2023-08-31T05:36:13Z
       
       0 likes, 0 repeats
       
       …and it’s *possible* that these folks have made a bacteria that makes an enzyme that breaks down acetaldehyde. But whether they have it packaged in such a way that it survives the trip through your GI tract and delivers that enzyme in quantities large enough to break down the acetaldehyde we make after drinking? Well…
       
 (DIR) Post #AZIaheHoxBxG6Z9XaS by jetjocko@mastodon.social
       2023-08-31T05:38:34Z
       
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       …absent evidence of a strong link to hangover, and absent a good study showing the enzyme produced in a human gut, and absent a good study showing a reduction in perceived symptoms *and* objective markers like inflammatory response? I’m skeptical.
       
 (DIR) Post #AZIahf08IROsJzsvei by clive@saturation.social
       2023-08-31T18:59:14Z
       
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       @jetjocko This sounds right!
       
 (DIR) Post #AZIeK3nQrB6O5Zwjy4 by ProgressiveRaymond@mastodon.sdf.org
       2023-08-31T19:41:38Z
       
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       @clive @jetjocko We've had great success with hangover pretreatment. It involves determinative outcomes and predictive forecast models. Basically, we drink almost whatever and as much as we possibly can. And since none of the drinks contain alcohol, hangovers are almost 100% eliminated.
       
 (DIR) Post #AZKL7Smf8HN30cmnL6 by clive@saturation.social
       2023-09-01T15:11:01Z
       
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       @ProgressiveRaymond @jetjocko lol perfect