Post AVO52Ddcs0ILIVTO6a by jgordon@appdot.net
(DIR) More posts by jgordon@appdot.net
(DIR) Post #AVMfTPJalul5MhRj1s by jgordon@appdot.net
2023-05-05T20:06:49Z
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The international consensus seems to be that we have selected for a much less harmful strain of COVID.Has anyone seen an academic pub on how it evolved this way? To dodge immune response did it need to start slower?A year ago the consensus was that it could evolve as readily to more aggressive as less aggressive. PS. Many have wondered if SARS 1 did this.
(DIR) Post #AVMfTQ7vkl1ZsozvUW by jeffcliff@shitposter.club
2023-05-06T02:46:13.763913Z
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> The international consensus seems to be that we have selected for a much less harmful strain of COVID. No. What's happened is 12 billion vaccine doses have been administered, attenuating its virulence.
(DIR) Post #AVMfjlIanuSaBEmFFY by jeffcliff@shitposter.club
2023-05-06T02:49:13.278521Z
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but there was also https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577707/
(DIR) Post #AVO4H6ocQ2TsWj9QCe by jgordon@appdot.net
2023-05-06T18:57:58Z
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@jeffcliff How is that related? (I read the abstract).
(DIR) Post #AVO4H7MeNVheEH4bFQ by jeffcliff@shitposter.club
2023-05-06T18:58:51.876743Z
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> Has anyone seen an academic pub on how it evolved this way? it evolved away ORF8> To dodge immune response did it need to start slower?ORF8 was involved in immune response dodging
(DIR) Post #AVO4jwWhkgY90wWMW8 by jgordon@appdot.net
2023-05-06T18:57:17Z
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@jeffcliff The vaccines have worked very well and, surprisingly, continue to be effective with minor tweaks.But my question was about natural selection. There really is a CDC/WHO consensus that the dominant viral strains cause less damage that the original even among immune naive. The question is about why that happened.
(DIR) Post #AVO4jx9LR1SSwmbDkG by jeffcliff@shitposter.club
2023-05-06T19:04:03.688191Z
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>. There really is a CDC/WHO consensus that the dominant viral strains cause less damage that the original even among immune naiveThere was also a CDC/WHO consensus that it isn't airborn. There is no consensus on this, generally, ORF8 notwithstanding - this was mostly wishful thinking from day 1
(DIR) Post #AVO52Ddcs0ILIVTO6a by jgordon@appdot.net
2023-05-06T19:00:19Z
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@jeffcliff Did they say what the adaptive advantage of losing ORF8 was? How did it benefit the virus?
(DIR) Post #AVO52EDQisw15YDyue by jeffcliff@shitposter.club
2023-05-06T19:07:22.657992Z
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558349/ suggests that it was involved in the initial zoonotic transmission, allowing both human and whatever species we got it from to both get it
(DIR) Post #AVOA3ZOVxwJ2pkrtcO by jgordon@appdot.net
2023-05-06T20:01:55Z
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@jeffcliff That's an interesting example, that the virus would do better to replicate faster than to "invest" more in immune evasion.
(DIR) Post #AVOAFHusm3Ze6Nazrc by jeffcliff@shitposter.club
2023-05-06T20:05:45.970949Z
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well it depends : there's a tradeoff between a high replication rate and immune response (both individual and at the human-species level)but now that it's so omnipresent maybe the nash equilibrium is different
(DIR) Post #AVOByJQs5IYxmyajOS by jgordon@appdot.net
2023-05-06T20:24:51Z
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@jeffcliff It’s the kind of example I was wondering about. If immune evasion isn’t working (vaccine, past exposure) then try to replicate fast to spread fast … but that can be a dead end too. I hope we will see some good academic pubs on the viral evolution.