add pubmed feed - sfeed_tests - sfeed tests and RSS and Atom files
(HTM) git clone git://git.codemadness.org/sfeed_tests
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(DIR) Files
(DIR) Refs
(DIR) README
(DIR) LICENSE
---
(DIR) commit 138441d6fb5e94afe733f4717c1ecb53d8f37f80
(DIR) parent 4bfab6ad4b84cdcd4e95358373f98dfac12a8ee9
(HTM) Author: Hiltjo Posthuma <hiltjo@codemadness.org>
Date: Sun, 18 Jun 2023 17:56:01 +0200
add pubmed feed
https://pubmed.ncbi.nlm.nih.gov/rss/search/1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN/?limit=15&utm_campaign=pubmed-2&fc=20230611160724
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1 file changed, 305 insertions(+), 0 deletions(-)
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(DIR) diff --git a/input/sfeed/realworld/pubmed.ncbi.nlm.nih.gov.rss.xml b/input/sfeed/realworld/pubmed.ncbi.nlm.nih.gov.rss.xml
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+<?xml version='1.0' encoding='UTF-8'?>
+<rss xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:atom="http://www.w3.org/2005/Atom" xmlns:content="http://purl.org/rss/1.0/modules/content/" version="2.0">
+ <channel>
+ <title>kampo</title>
+ <link>https://pubmed.ncbi.nlm.nih.gov/rss-feed/?feed_id=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&utm_source=no_user_agent&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&utm_campaign=pubmed-2&v=2.17.9.post6+86293ac&utm_medium=rss</link>
+ <description>kampo: Latest results from PubMed</description>
+ <atom:link href="https://pubmed.ncbi.nlm.nih.gov/rss-feed/?feed_id=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&utm_source=no_user_agent&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&utm_campaign=pubmed-2&v=2.17.9.post6+86293ac&utm_medium=rss" rel="self"/>
+ <docs>http://www.rssboard.org/rss-specification</docs>
+ <generator>PubMed RSS feeds (2.17.9.post6+86293ac)</generator>
+ <language>en</language>
+ <lastBuildDate>Sun, 18 Jun 2023 15:50:41 +0000</lastBuildDate>
+ <pubDate>Fri, 16 Jun 2023 06:00:00 -0400</pubDate>
+ <ttl>120</ttl>
+ <item>
+ <title>Comparative study of the effects of the three kinds of Kampo-hozai: Ninjinyoeito, Hochuekkito, and Juzentaihoto on anxious and low sociability behavior using NPY-knockout zebrafish</title>
+ <link>https://pubmed.ncbi.nlm.nih.gov/37324500/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac</link>
+ <description>Ninjinyoeito, Hochuekkito, and Juzentaihoto are the three types of Kampo-hozai used to support the treatment of various diseases by energizing patients through improved mental health. While Kampo-hozais are clinically used to improve mental energy decline, a comparison between their effects on neuropsychiatric symptoms like anxiety and sociability and the strength of their effects has not been conducted. Therefore, this study compared the effects of Ninjinyoeito, Hochuekkito, and Juzentaihoto on...</description>
+ <content:encoded><![CDATA[<div><p style="color: #4aa564;">Front Pharmacol. 2023 May 30;14:1168229. doi: 10.3389/fphar.2023.1168229. eCollection 2023.</p><p><b>ABSTRACT</b></p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">Ninjinyoeito, Hochuekkito, and Juzentaihoto are the three types of Kampo-hozai used to support the treatment of various diseases by energizing patients through improved mental health. While Kampo-hozais are clinically used to improve mental energy decline, a comparison between their effects on neuropsychiatric symptoms like anxiety and sociability and the strength of their effects has not been conducted. Therefore, this study compared the effects of Ninjinyoeito, Hochuekkito, and Juzentaihoto on psychiatric symptoms using neuropeptide Y knockout (NPY-KO) zebrafish, a suitable animal model for anxiety and low sociability. Neuropeptide Y knockout zebrafish were fed a Ninjinyoeito, Hochuekkito, or Juzentaihoto-supplemented diet for 4 days. Then, sociability was analyzed using a three-Chambers test and anxiety-like behavior was evaluated using the cold stress and novel tank tests. The results showed that Ninjinyoeito treatment improved the low sociability of neuropeptide Y knockout, while Hochuekkito and Juzentaihoto did not. Neuropeptide Y knockout exhibited anxiety-like behaviors, such as freezing and swimming in the wall area under cold stress, but Ninjinyoeito treatment improved these behaviors. However, these anxiety-like behaviors were not improved by Hochuekkito and Juzentaihoto. Ninjinyoeito treatment also improved anxiety-like behaviors of neuropeptide Y knockout in the novel tank test. However, no improvement was shown in the Hochuekkito and Juzentaihoto groups. This trend was also confirmed in the low water stress test using wild-type zebrafish. This study exhibits that among the three types of Kampo-hozai, Ninjinyoeito is the most effective in psychiatric disorders associated with anxiety and low sociability.</p><p style="color: lightgray">PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/37324500/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">37324500</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC10267730/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">PMC10267730</a> | DOI:<a href=https://doi.org/10.3389/fphar.2023.1168229>10.3389/fphar.2023.1168229</a></p></div>]]></content:encoded>
+ <guid isPermaLink="false">pubmed:37324500</guid>
+ <pubDate>Fri, 16 Jun 2023 06:00:00 -0400</pubDate>
+ <dc:creator>Momoko Kawabe</dc:creator>
+ <dc:creator>Takumi Nishida</dc:creator>
+ <dc:creator>Ryuji Takahashi</dc:creator>
+ <dc:creator>Akio Inui</dc:creator>
+ <dc:creator>Kazuhiro Shiozaki</dc:creator>
+ <dc:date>2023-06-16</dc:date>
+ <dc:source>Frontiers in pharmacology</dc:source>
+ <dc:title>Comparative study of the effects of the three kinds of Kampo-hozai: Ninjinyoeito, Hochuekkito, and Juzentaihoto on anxious and low sociability behavior using NPY-knockout zebrafish</dc:title>
+ <dc:identifier>pmid:37324500</dc:identifier>
+ <dc:identifier>pmc:PMC10267730</dc:identifier>
+ <dc:identifier>doi:10.3389/fphar.2023.1168229</dc:identifier>
+ </item>
+ <item>
+ <title>DRUG-INDUCED LUNG INJURY DUE TO OTSU-JI-TO FOLLOWED BY DRUG-INDUCED LIVER INJURY: A CASE REPORT</title>
+ <link>https://pubmed.ncbi.nlm.nih.gov/37316243/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac</link>
+ <description>A 69-year-old woman who had been treated with Otsu-ji-to for fourteen days developed liver dysfunction. She continued to take Otsu-ji-to and was admitted to our hospital due to respiratory failure with extensive ground-glass opacities on chest computed tomography 22 days after starting to take Otsuji-to. Although she developed severe respiratory failure, her condition was improved by discontinuation of Otsu-ji-to and high-dose corticosteroid pulse therapy. The lymphocyte stimulation test was...</description>
+ <content:encoded><![CDATA[<div><p style="color: #4aa564;">Arerugi. 2023;72(4):388-392. doi: 10.15036/arerugi.72.388.</p><p><b>ABSTRACT</b></p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">A 69-year-old woman who had been treated with Otsu-ji-to for fourteen days developed liver dysfunction. She continued to take Otsu-ji-to and was admitted to our hospital due to respiratory failure with extensive ground-glass opacities on chest computed tomography 22 days after starting to take Otsuji-to. Although she developed severe respiratory failure, her condition was improved by discontinuation of Otsu-ji-to and high-dose corticosteroid pulse therapy. The lymphocyte stimulation test was positive for Otsu-ji-to. Finally, we diagnosed drug-induced lung injury due to Otsu-ji-to. As in this case, severe herbal medicine-induced lung injury may be developed secondary to preceding liver injury. When a patient prescribed ou-gon-containing herbal medicines such as Otsu-ji-to develops liver dysfunction, due to herbal medicines containing ou-gon such as Otsu-ji-to, it is important to evaluate lung injury and discontinue the Kampo drug.</p><p style="color: lightgray">PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/37316243/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">37316243</a> | DOI:<a href=https://doi.org/10.15036/arerugi.72.388>10.15036/arerugi.72.388</a></p></div>]]></content:encoded>
+ <guid isPermaLink="false">pubmed:37316243</guid>
+ <pubDate>Wed, 14 Jun 2023 06:00:00 -0400</pubDate>
+ <dc:creator>Takuma Katano</dc:creator>
+ <dc:creator>Hitomi Amano</dc:creator>
+ <dc:creator>Tomoyuki Ogisu</dc:creator>
+ <dc:creator>Hiroyuki Tanaka</dc:creator>
+ <dc:creator>Shigehisa Kajikawa</dc:creator>
+ <dc:creator>Satoru Ito</dc:creator>
+ <dc:date>2023-06-14</dc:date>
+ <dc:source>Arerugi = [Allergy]</dc:source>
+ <dc:title>DRUG-INDUCED LUNG INJURY DUE TO OTSU-JI-TO FOLLOWED BY DRUG-INDUCED LIVER INJURY: A CASE REPORT</dc:title>
+ <dc:identifier>pmid:37316243</dc:identifier>
+ <dc:identifier>doi:10.15036/arerugi.72.388</dc:identifier>
+ </item>
+ <item>
+ <title>Heating or ginger extract reduces the content of Pinellia ternata lectin in the raphides of Pinellia tuber</title>
+ <link>https://pubmed.ncbi.nlm.nih.gov/37311896/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac</link>
+ <description>Pinellia tuber, the dried tuber of Pinellia ternata, causes a very strong acridity sensation in the oral and laryngopharynx mucosa when taken orally in its unprocessed form. In traditional Chinese medicine (TCM), this sensation has been called "toxicity", and Pinellia tuber must be processed using ginger extract, licorice, or alum. In Japanese traditional Kampo medicine, since "toxicity" can be eliminated by decocting, it should not be processed. However, little is known about the mechanism...</description>
+ <content:encoded><![CDATA[<div><p style="color: #4aa564;">J Nat Med. 2023 Jun 13. doi: 10.1007/s11418-023-01717-7. Online ahead of print.</p><p><b>ABSTRACT</b></p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">Pinellia tuber, the dried tuber of Pinellia ternata, causes a very strong acridity sensation in the oral and laryngopharynx mucosa when taken orally in its unprocessed form. In traditional Chinese medicine (TCM), this sensation has been called "toxicity", and Pinellia tuber must be processed using ginger extract, licorice, or alum. In Japanese traditional Kampo medicine, since "toxicity" can be eliminated by decocting, it should not be processed. However, little is known about the mechanism underlying the "detoxification" of Pinellia tubers. In this study, we produced murine antiserum using recombinant P. ternata lectin (PTL), developed an immuno-fluorescence staining method for PTL in the needle-shaped crystals (raphides) that were prepared by petroleum ether extraction (PEX) from Pinellia tuber, and elucidated the mechanism of the processing of Pinellia tuber using heat or ginger extract. After heating the raphides in water, the amount of PTL contained in the raphides was significantly reduced by the immunostaining, although the shape of the raphides was not changed. Incubating raphides with dried ginger extract also significantly reduced the amount of PTL in the raphides in a concentration-dependent manner. By the activity-guided fractionation of ginger extract, the active ingredients in the ginger extract were oxalic acid, tartaric acid, malic acid, and citric acid. Among these four organic acids, oxalic acid mainly contributed to the effect of dried ginger extract by its content in ginger extract and its activity. These results exhibit scientific evidences for the traditional theories of processing to "detoxify" Pinellia tuber in TCM and Kampo medicine.</p><p style="color: lightgray">PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/37311896/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">37311896</a> | DOI:<a href=https://doi.org/10.1007/s11418-023-01717-7>10.1007/s11418-023-01717-7</a></p></div>]]></content:encoded>
+ <guid isPermaLink="false">pubmed:37311896</guid>
+ <pubDate>Tue, 13 Jun 2023 06:00:00 -0400</pubDate>
+ <dc:creator>Yan Liu</dc:creator>
+ <dc:creator>Itsuki Nose</dc:creator>
+ <dc:creator>Kazuyoshi Terasaka</dc:creator>
+ <dc:creator>Tsukasa Fueki</dc:creator>
+ <dc:creator>Toshiaki Makino</dc:creator>
+ <dc:date>2023-06-13</dc:date>
+ <dc:source>Journal of natural medicines</dc:source>
+ <dc:title>Heating or ginger extract reduces the content of Pinellia ternata lectin in the raphides of Pinellia tuber</dc:title>
+ <dc:identifier>pmid:37311896</dc:identifier>
+ <dc:identifier>doi:10.1007/s11418-023-01717-7</dc:identifier>
+ </item>
+ <item>
+ <title>Inhibitory effect of Ephedra herba on human norovirus infection in human intestinal organoids</title>
+ <link>https://pubmed.ncbi.nlm.nih.gov/37302295/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac</link>
+ <description>Human norovirus (HuNoV) is a major cause of acute gastroenteritis and foodborne diseases worldwide with public health concern, yet no antiviral therapies have been developed. In this study, we aimed to screen crude drugs, which are components of Japanese traditional medicine, ''Kampo'' to see their effects on HuNoV infection using a reproducible HuNoV cultivation system, stem-cell derived human intestinal organoids/enteroids (HIOs). Among the 22 crude drugs tested, Ephedra herba significantly...</description>
+ <content:encoded><![CDATA[<div><p style="color: #4aa564;">Biochem Biophys Res Commun. 2023 Jun 2;671:200-204. doi: 10.1016/j.bbrc.2023.05.127. Online ahead of print.</p><p><b>ABSTRACT</b></p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">Human norovirus (HuNoV) is a major cause of acute gastroenteritis and foodborne diseases worldwide with public health concern, yet no antiviral therapies have been developed. In this study, we aimed to screen crude drugs, which are components of Japanese traditional medicine, ''Kampo'' to see their effects on HuNoV infection using a reproducible HuNoV cultivation system, stem-cell derived human intestinal organoids/enteroids (HIOs). Among the 22 crude drugs tested, Ephedra herba significantly inhibited HuNoV infection in HIOs. A time-of-drug addition experiment suggested that this crude drug more preferentially targets post-entry step than entry step for the inhibition. To our knowledge, this is the first anti-HuNoV inhibitor screen targeting crude drugs, and Ephedra herba was identified as a novel inhibitor candidate that merits further study.</p><p style="color: lightgray">PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/37302295/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">37302295</a> | DOI:<a href=https://doi.org/10.1016/j.bbrc.2023.05.127>10.1016/j.bbrc.2023.05.127</a></p></div>]]></content:encoded>
+ <guid isPermaLink="false">pubmed:37302295</guid>
+ <pubDate>Sun, 11 Jun 2023 06:00:00 -0400</pubDate>
+ <dc:creator>Tsuyoshi Hayashi</dc:creator>
+ <dc:creator>Kosuke Murakami</dc:creator>
+ <dc:creator>Hirokazu Ando</dc:creator>
+ <dc:creator>Sayuri Ueno</dc:creator>
+ <dc:creator>Sakura Kobayashi</dc:creator>
+ <dc:creator>Masamichi Muramatsu</dc:creator>
+ <dc:creator>Takashi Tanikawa</dc:creator>
+ <dc:creator>Masashi Kitamura</dc:creator>
+ <dc:date>2023-06-11</dc:date>
+ <dc:source>Biochemical and biophysical research communications</dc:source>
+ <dc:title>Inhibitory effect of Ephedra herba on human norovirus infection in human intestinal organoids</dc:title>
+ <dc:identifier>pmid:37302295</dc:identifier>
+ <dc:identifier>doi:10.1016/j.bbrc.2023.05.127</dc:identifier>
+ </item>
+ <item>
+ <title>LC-MS Profiling of Kakkonto and Identification of Ephedrine as a Key Component for Its Anti-Glycation Activity</title>
+ <link>https://pubmed.ncbi.nlm.nih.gov/37298887/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac</link>
+ <description>A total of 147 oral Kampo prescriptions, which are used clinically in Japan, were evaluated for their anti-glycation activity. Kakkonto demonstrated significant anti-glycation activity, prompting further analysis of its chemical constituents using LC-MS, which revealed the presence of two alkaloids, fourteen flavonoids, two but-2-enolides, five monoterpenoids, and four triterpenoid glycosides. To identify the components responsible for its anti-glycation activity, the Kakkonto extract was...</description>
+ <content:encoded><![CDATA[<div><p style="color: #4aa564;">Molecules. 2023 May 29;28(11):4409. doi: 10.3390/molecules28114409.</p><p><b>ABSTRACT</b></p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">A total of 147 oral Kampo prescriptions, which are used clinically in Japan, were evaluated for their anti-glycation activity. Kakkonto demonstrated significant anti-glycation activity, prompting further analysis of its chemical constituents using LC-MS, which revealed the presence of two alkaloids, fourteen flavonoids, two but-2-enolides, five monoterpenoids, and four triterpenoid glycosides. To identify the components responsible for its anti-glycation activity, the Kakkonto extract was reacted with glyceraldehyde (GA) or methylglyoxal (MGO) and analyzed using LC-MS. In LC-MS analysis of Kakkonto reacted with GA, the peak intensity of ephedrine was attenuated, and three products from ephedrine-scavenging GA were detected. Similarly, LC-MS analysis of Kakkonto reacted with MGO revealed two products from ephedrine reacting with MGO. These results indicated that ephedrine was responsible for the observed anti-glycation activity of Kakkonto. Ephedrae herba extract, which contains ephedrine, also showed strong anti-glycation activity, further supporting ephedrine's contribution to Kakkonto's reactive carbonyl species' scavenging ability and anti-glycation activity.</p><p style="color: lightgray">PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/37298887/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">37298887</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC10254259/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">PMC10254259</a> | DOI:<a href=https://doi.org/10.3390/molecules28114409>10.3390/molecules28114409</a></p></div>]]></content:encoded>
+ <guid isPermaLink="false">pubmed:37298887</guid>
+ <pubDate>Sat, 10 Jun 2023 06:00:00 -0400</pubDate>
+ <dc:creator>Kaori Ito</dc:creator>
+ <dc:creator>Takashi Kikuchi</dc:creator>
+ <dc:creator>Kanako Ikube</dc:creator>
+ <dc:creator>Kouharu Otsuki</dc:creator>
+ <dc:creator>Kazuo Koike</dc:creator>
+ <dc:creator>Wei Li</dc:creator>
+ <dc:date>2023-06-10</dc:date>
+ <dc:source>Molecules (Basel, Switzerland)</dc:source>
+ <dc:title>LC-MS Profiling of Kakkonto and Identification of Ephedrine as a Key Component for Its Anti-Glycation Activity</dc:title>
+ <dc:identifier>pmid:37298887</dc:identifier>
+ <dc:identifier>pmc:PMC10254259</dc:identifier>
+ <dc:identifier>doi:10.3390/molecules28114409</dc:identifier>
+ </item>
+ <item>
+ <title>Role of p53 in Cisplatin-Induced Myotube Atrophy</title>
+ <link>https://pubmed.ncbi.nlm.nih.gov/37298128/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac</link>
+ <description>Chemotherapy-induced sarcopenia is an unfavorable prognostic factor implicated in the development of postoperative complications and reduces the quality of life of patients with cancer. Skeletal muscle loss due to cisplatin use is caused by mitochondrial dysfunction and activation of muscle-specific ubiquitin ligases Atrogin-1 and muscle RING finger 1 (MuRF1). Although animal studies suggest the involvement of p53 in age-, immobility-, and denervation-related muscle atrophy, the association...</description>
+ <content:encoded><![CDATA[<div><p style="color: #4aa564;">Int J Mol Sci. 2023 May 24;24(11):9176. doi: 10.3390/ijms24119176.</p><p><b>ABSTRACT</b></p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">Chemotherapy-induced sarcopenia is an unfavorable prognostic factor implicated in the development of postoperative complications and reduces the quality of life of patients with cancer. Skeletal muscle loss due to cisplatin use is caused by mitochondrial dysfunction and activation of muscle-specific ubiquitin ligases Atrogin-1 and muscle RING finger 1 (MuRF1). Although animal studies suggest the involvement of p53 in age-, immobility-, and denervation-related muscle atrophy, the association between cisplatin-induced atrophy and p53 remains unknown. Herein, we investigated the effect of a p53-specific inhibitor, pifithrin-alpha (PFT-α), on cisplatin-induced atrophy in C2C12 myotubes. Cisplatin increased the protein levels of p53, phosphorylated p53, and upregulated the mRNA expression of p53 target genes <i>PUMA</i> and <i>p21</i> in C2C12 myotubes. PFT-α ameliorated the increase in intracellular reactive oxygen species production and mitochondrial dysfunction, and also reduced the cisplatin-induced increase in the <i>Bax/Bcl-2</i> ratio. Although PFT-α also reduced the cisplatin-induced increase in <i>MuRF1</i> and <i>Atrogin-1</i> gene expression, it did not ameliorate the decrease in myosin heavy chain mRNA and protein levels and muscle-specific actin and myoglobin protein levels. We conclude that cisplatin increases muscle degradation in C2C12 myotubes in a p53-dependent manner, but p53 has minimal involvement in the reduction of muscle protein synthesis.</p><p style="color: lightgray">PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/37298128/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">37298128</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC10253206/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">PMC10253206</a> | DOI:<a href=https://doi.org/10.3390/ijms24119176>10.3390/ijms24119176</a></p></div>]]></content:encoded>
+ <guid isPermaLink="false">pubmed:37298128</guid>
+ <pubDate>Sat, 10 Jun 2023 06:00:00 -0400</pubDate>
+ <dc:creator>Chinami Matsumoto</dc:creator>
+ <dc:creator>Hitomi Sekine</dc:creator>
+ <dc:creator>Nana Zhang</dc:creator>
+ <dc:creator>Sachiko Mogami</dc:creator>
+ <dc:creator>Naoki Fujitsuka</dc:creator>
+ <dc:creator>Hiroshi Takeda</dc:creator>
+ <dc:date>2023-06-10</dc:date>
+ <dc:source>International journal of molecular sciences</dc:source>
+ <dc:title>Role of p53 in Cisplatin-Induced Myotube Atrophy</dc:title>
+ <dc:identifier>pmid:37298128</dc:identifier>
+ <dc:identifier>pmc:PMC10253206</dc:identifier>
+ <dc:identifier>doi:10.3390/ijms24119176</dc:identifier>
+ </item>
+ <item>
+ <title>A Case of Pseudohyperaldosteronism Induced by Yokukansan and Shakuyakukanzoto That Resulted in Severe Hypokalemia</title>
+ <link>https://pubmed.ncbi.nlm.nih.gov/37261160/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac</link>
+ <description>Pseudohyperaldosteronism can be induced by the excessive use of Chinese herbal medicines (Kampo medicines), resulting in serious disorders. We report a case of pseudohyperaldosteronism induced by two Kampo medicines which resulted in severe hypokalemia. A 70-year-old woman was hospitalized for a left calcaneal fracture. She had no subjective symptoms other than trauma. On her admission, blood test results revealed a low serum potassium level of 2.4 mmol/L by chance, as well as low levels of both...</description>
+ <content:encoded><![CDATA[<div><p style="color: #4aa564;">Cureus. 2023 Apr 28;15(4):e38267. doi: 10.7759/cureus.38267. eCollection 2023 Apr.</p><p><b>ABSTRACT</b></p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">Pseudohyperaldosteronism can be induced by the excessive use of Chinese herbal medicines (Kampo medicines), resulting in serious disorders. We report a case of pseudohyperaldosteronism induced by two Kampo medicines which resulted in severe hypokalemia. A 70-year-old woman was hospitalized for a left calcaneal fracture. She had no subjective symptoms other than trauma. On her admission, blood test results revealed a low serum potassium level of 2.4 mmol/L by chance, as well as low levels of both renin and aldosterone. The patient had been taking 5 g of Yokukansan per day for the past three months. In addition, she was on 5 g Shakuyakukanzoto per day for three months until a month prior to hospitalization. The daily licorice content from the aforementioned herbs was 1.0 g and 4.0 g, respectively. After hospitalization, the administration of the Kampo medicines was discontinued, and 610 mmol of potassium was administered over a period of 13 days, which resulted in the normalization of serum potassium levels. Pre-existing hypertension slowly improved as well. Patients consuming licorice at doses of 2.5 g per day or more, as in our case, are at a high risk of developing pseudohyperaldosteronism. Furthermore, the risk is particularly high with long-term licorice consumption as well as for women and elderly patients. To this end, high-dose potassium supplementation may be necessary for normalizing serum potassium levels. Therefore, awareness regarding the adverse effects of licorice is crucial, even in cases of low dosages of licorice.</p><p style="color: lightgray">PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/37261160/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">37261160</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC10228552/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">PMC10228552</a> | DOI:<a href=https://doi.org/10.7759/cureus.38267>10.7759/cureus.38267</a></p></div>]]></content:encoded>
+ <guid isPermaLink="false">pubmed:37261160</guid>
+ <pubDate>Thu, 01 Jun 2023 06:00:00 -0400</pubDate>
+ <dc:creator>Mika Arai</dc:creator>
+ <dc:creator>Hiroki Isono</dc:creator>
+ <dc:creator>Momoko Isono</dc:creator>
+ <dc:creator>Kousuke Ihara</dc:creator>
+ <dc:creator>Keisuke Kondo</dc:creator>
+ <dc:date>2023-06-01</dc:date>
+ <dc:source>Cureus</dc:source>
+ <dc:title>A Case of Pseudohyperaldosteronism Induced by Yokukansan and Shakuyakukanzoto That Resulted in Severe Hypokalemia</dc:title>
+ <dc:identifier>pmid:37261160</dc:identifier>
+ <dc:identifier>pmc:PMC10228552</dc:identifier>
+ <dc:identifier>doi:10.7759/cureus.38267</dc:identifier>
+ </item>
+ <item>
+ <title>Immunoaffinity separation of miroestrol and deoxymiroestrol from Pueraria candollei var. mirifica (Airy Shaw &amp; Suvat.) Niyomdham using fragment antigen-binding antibody produced via Escherichia coli</title>
+ <link>https://pubmed.ncbi.nlm.nih.gov/37254639/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac</link>
+ <description>CONCLUSION: The proposed methods can simplify the miroestrol and deoxymiroestrol extraction process and provide a basis for applications utilising recombinant antibodies to separate target compounds.</description>
+ <content:encoded><![CDATA[<div><p style="color: #4aa564;">Phytochem Anal. 2023 May 30. doi: 10.1002/pca.3251. Online ahead of print.</p><p><b>ABSTRACT</b></p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">INTRODUCTION: Miroestrol and deoxymiroestrol are potent phytoestrogens and are oestrogen markers of Pueraria candollei var. mirifica. However, purifying these compounds is difficult because they only exist in trace amounts.</p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">OBJECTIVES: Active fragment antigen-binding (Fab) antibodies were produced via Escherichia coli SHuffle® T7 and used to selectively separate these compounds.</p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">MATERIALS AND METHODS: Two immunoaffinity separation approaches were developed, namely the immunoaffinity column (IAC) and a cell-based method. Group-specific Fab antibodies against miroestrol and deoxymiroestrol (anti-MD Fab) were used as biological binding reagents for selective separation.</p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">RESULTS: The Fab-based IAC effectively separated miroestrol and deoxymiroestrol (0.65 and 2.24 μg per 2 mL of resin, respectively) from P. mirifica root extract. When P. mirifica extract was added to E. coli cultures during Fab expression via a cell-based method, the target compound accumulated in intracellular compartments and, thus, were separated from E. coli cells after the removal of other compounds. A yield of 1.07 μg of miroestrol per gram of cell pellet weight was obtained. Miroestrol and deoxymiroestrol were successfully purified from P. mirifica extract using anti-MD Fab via the IAC and an intracellular cell-based method.</p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">CONCLUSION: The proposed methods can simplify the miroestrol and deoxymiroestrol extraction process and provide a basis for applications utilising recombinant antibodies to separate target compounds.</p><p style="color: lightgray">PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/37254639/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">37254639</a> | DOI:<a href=https://doi.org/10.1002/pca.3251>10.1002/pca.3251</a></p></div>]]></content:encoded>
+ <guid isPermaLink="false">pubmed:37254639</guid>
+ <pubDate>Wed, 31 May 2023 06:00:00 -0400</pubDate>
+ <dc:creator>Wipawee Juengsanguanpornsuk</dc:creator>
+ <dc:creator>Nut Poopanee</dc:creator>
+ <dc:creator>Supaluk Krittanai</dc:creator>
+ <dc:creator>Seiichi Sakamoto</dc:creator>
+ <dc:creator>Hiroyuki Tanaka</dc:creator>
+ <dc:creator>Waraporn Putalun</dc:creator>
+ <dc:creator>Gorawit Yusakul</dc:creator>
+ <dc:date>2023-05-31</dc:date>
+ <dc:source>Phytochemical analysis : PCA</dc:source>
+ <dc:title>Immunoaffinity separation of miroestrol and deoxymiroestrol from Pueraria candollei var. mirifica (Airy Shaw &amp; Suvat.) Niyomdham using fragment antigen-binding antibody produced via Escherichia coli</dc:title>
+ <dc:identifier>pmid:37254639</dc:identifier>
+ <dc:identifier>doi:10.1002/pca.3251</dc:identifier>
+ </item>
+ <item>
+ <title>Identifying Crude Drugs in Kampo Medicines Associated with Drug-Induced Liver Injury Using the Japanese Adverse Drug Event Report Database: A Comprehensive Survey</title>
+ <link>https://pubmed.ncbi.nlm.nih.gov/37242461/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac</link>
+ <description>The current study aimed to identify the crude drugs associated with drug-induced liver injury (DILI) in 148 Kampo medicines prescribed throughout Japan using the Japanese Adverse Drug Event Report (JADER) database, a large-scale spontaneous reporting system in Japan. First, we tabulated the number of DILI reports from the report-based dataset and the background information from the patient-based dataset. Thereafter, we combined the 126 crude drugs into 104 crude drug groups to examine...</description>
+ <content:encoded><![CDATA[<div><p style="color: #4aa564;">Pharmaceuticals (Basel). 2023 May 1;16(5):678. doi: 10.3390/ph16050678.</p><p><b>ABSTRACT</b></p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">The current study aimed to identify the crude drugs associated with drug-induced liver injury (DILI) in 148 Kampo medicines prescribed throughout Japan using the Japanese Adverse Drug Event Report (JADER) database, a large-scale spontaneous reporting system in Japan. First, we tabulated the number of DILI reports from the report-based dataset and the background information from the patient-based dataset. Thereafter, we combined the 126 crude drugs into 104 crude drug groups to examine multicollinearity. Finally, the reporting odds ratios (RORs), 95% confidence intervals, <i>p</i> values for Fisher's exact test, and number of reports were calculated for each crude group to identify those associated with DILI. Notably, the number of adverse event reports for DILI (63,955) exceeded that for interstitial lung disease (51,347), the most common adverse event. In total, 78 crude drug groups (90 crude drugs) were reported to have an ROR > 1, a <i>p</i> < 0.05, and ≥10 reported cases. Our results highlight DILI as an essential issue, given that it was among the most frequently reported adverse drug reactions. We were able to clearly identify the crude drugs associated with DILI, which could help manage adverse drug reactions attributed to Kampo medicines and crude drugs.</p><p style="color: lightgray">PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/37242461/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">37242461</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC10222220/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">PMC10222220</a> | DOI:<a href=https://doi.org/10.3390/ph16050678>10.3390/ph16050678</a></p></div>]]></content:encoded>
+ <guid isPermaLink="false">pubmed:37242461</guid>
+ <pubDate>Sat, 27 May 2023 06:00:00 -0400</pubDate>
+ <dc:creator>Kyosuke Kimura</dc:creator>
+ <dc:creator>Mami Kikegawa</dc:creator>
+ <dc:creator>Yusuke Kan</dc:creator>
+ <dc:creator>Yoshihiro Uesawa</dc:creator>
+ <dc:date>2023-05-27</dc:date>
+ <dc:source>Pharmaceuticals (Basel, Switzerland)</dc:source>
+ <dc:title>Identifying Crude Drugs in Kampo Medicines Associated with Drug-Induced Liver Injury Using the Japanese Adverse Drug Event Report Database: A Comprehensive Survey</dc:title>
+ <dc:identifier>pmid:37242461</dc:identifier>
+ <dc:identifier>pmc:PMC10222220</dc:identifier>
+ <dc:identifier>doi:10.3390/ph16050678</dc:identifier>
+ </item>
+ <item>
+ <title>Kampo Medicines Used in Psychiatry</title>
+ <link>https://pubmed.ncbi.nlm.nih.gov/37194544/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac</link>
+ <description>Compared to psychotropic drugs, the clinical use of Kampo medicines (Japanese herbal medicines) is unclear because of the difficulty in accumulating scientific evidence for various reasons. This study reviews Kampo medicines frequently prescribed in psychiatry and the principles of disorders of qi, blood, and fluid for their use, which are considered particularly important in this field. Kampo medicines are one of the preferred treatment modalities for patients with mental disorders in Japan,...</description>
+ <content:encoded><![CDATA[<div><p style="color: #4aa564;">Brain Nerve. 2023 May;75(5):641-644. doi: 10.11477/mf.1416202391.</p><p><b>ABSTRACT</b></p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">Compared to psychotropic drugs, the clinical use of Kampo medicines (Japanese herbal medicines) is unclear because of the difficulty in accumulating scientific evidence for various reasons. This study reviews Kampo medicines frequently prescribed in psychiatry and the principles of disorders of qi, blood, and fluid for their use, which are considered particularly important in this field. Kampo medicines are one of the preferred treatment modalities for patients with mental disorders in Japan, and we hope that these will become a treatment option for patients refractory to psychotropic drugs.</p><p style="color: lightgray">PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/37194544/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">37194544</a> | DOI:<a href=https://doi.org/10.11477/mf.1416202391>10.11477/mf.1416202391</a></p></div>]]></content:encoded>
+ <guid isPermaLink="false">pubmed:37194544</guid>
+ <pubDate>Wed, 17 May 2023 06:00:00 -0400</pubDate>
+ <dc:creator>Takashi Tsuboi</dc:creator>
+ <dc:date>2023-05-17</dc:date>
+ <dc:source>Brain and nerve = Shinkei kenkyu no shinpo</dc:source>
+ <dc:title>Kampo Medicines Used in Psychiatry</dc:title>
+ <dc:identifier>pmid:37194544</dc:identifier>
+ <dc:identifier>doi:10.11477/mf.1416202391</dc:identifier>
+ </item>
+ <item>
+ <title>Kampo Medicine for Neurological Diseases</title>
+ <link>https://pubmed.ncbi.nlm.nih.gov/37194543/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac</link>
+ <description>Goreisan, Goshuyuto, Tokishakuyakusan, and Keishibukuryogan are frequently used to treat migraines. Goreisan is also used to treat chronic subdural hematoma. Yokukansan and Keishikaryukotsuboreito are useful for alleviating the behavioral and psychological symptoms of dementia. Keishikajyutsubuto and Shinbuto are used to treat numbness and pain associated with peripheral neuropathy. Hangeshashinto has been successfully attempted to treat intractable hiccoughs. It is advisable to use an extract...</description>
+ <content:encoded><![CDATA[<div><p style="color: #4aa564;">Brain Nerve. 2023 May;75(5):637-640. doi: 10.11477/mf.1416202390.</p><p><b>ABSTRACT</b></p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">Goreisan, Goshuyuto, Tokishakuyakusan, and Keishibukuryogan are frequently used to treat migraines. Goreisan is also used to treat chronic subdural hematoma. Yokukansan and Keishikaryukotsuboreito are useful for alleviating the behavioral and psychological symptoms of dementia. Keishikajyutsubuto and Shinbuto are used to treat numbness and pain associated with peripheral neuropathy. Hangeshashinto has been successfully attempted to treat intractable hiccoughs. It is advisable to use an extract of stable quality in accordance with the rule of thumb described in the classics. However, awareness of side effects, such as pseudoaldosteronism caused by licorice, is important.</p><p style="color: lightgray">PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/37194543/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">37194543</a> | DOI:<a href=https://doi.org/10.11477/mf.1416202390>10.11477/mf.1416202390</a></p></div>]]></content:encoded>
+ <guid isPermaLink="false">pubmed:37194543</guid>
+ <pubDate>Wed, 17 May 2023 06:00:00 -0400</pubDate>
+ <dc:creator>Shin-Ichi Muramatsu</dc:creator>
+ <dc:date>2023-05-17</dc:date>
+ <dc:source>Brain and nerve = Shinkei kenkyu no shinpo</dc:source>
+ <dc:title>Kampo Medicine for Neurological Diseases</dc:title>
+ <dc:identifier>pmid:37194543</dc:identifier>
+ <dc:identifier>doi:10.11477/mf.1416202390</dc:identifier>
+ </item>
+ <item>
+ <title>Seroprevalence and Risk Factors of Sexually Transmitted Blood-Borne Infections among Pregnant Women Attending Antenatal Care in Jirapa, Upper West Region of Ghana</title>
+ <link>https://pubmed.ncbi.nlm.nih.gov/37168817/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac</link>
+ <description>CONCLUSION: The occurrence of STBBIs among pregnant women was strongly associated with FGM and gravidity. Public health education should be directed at stopping the practice of FGM and improving reproductive health in the study area.</description>
+ <content:encoded><![CDATA[<div><p style="color: #4aa564;">Can J Infect Dis Med Microbiol. 2023 Apr 30;2023:3157202. doi: 10.1155/2023/3157202. eCollection 2023.</p><p><b>ABSTRACT</b></p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">BACKGROUND: Sexually transmitted blood-borne infections (STBBIs) contribute to negative outcomes of pregnancy. Hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and syphilis infections in pregnancy contribute significantly to maternal and child morbidities and mortalities. This study assessed the prevalence, knowledge, and risk factors of STBBIs (HBV, HCV, HIV, and syphilis) among pregnant women attending antenatal clinics in Jirapa.</p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">METHODS: A cross-sectional study design involving 246 pregnant women was employed for the study. A structured questionnaire was used to solicit information about the knowledge, prevalence, and risk factors of STBBIs.</p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">RESULTS: The overall prevalence of STBBIs was 11.4%; HBV prevalence was 9.8% and 0.8% each for HCV, HIV, and syphilis. About 66% of mothers were aware of mother-to-child transmission of infections during pregnancy. Knowledge of transmission of HIV (93.9%), hepatitis (67.1%), and syphilis (53.7%) in pregnancy was relatively high. Knowledge of risk factors for HIV, hepatitis, and syphilis was 97.6%, 74.4%, and 76.0%, respectively. More than 98% of respondents knew about the prevention of HIV, hepatitis, and syphilis. Significant risk factors associated with and predictive of STBBIs were female genital mutilation (FGM) and gravidity.</p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">CONCLUSION: The occurrence of STBBIs among pregnant women was strongly associated with FGM and gravidity. Public health education should be directed at stopping the practice of FGM and improving reproductive health in the study area.</p><p style="color: lightgray">PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/37168817/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">37168817</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC10164872/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">PMC10164872</a> | DOI:<a href=https://doi.org/10.1155/2023/3157202>10.1155/2023/3157202</a></p></div>]]></content:encoded>
+ <guid isPermaLink="false">pubmed:37168817</guid>
+ <pubDate>Thu, 11 May 2023 06:00:00 -0400</pubDate>
+ <dc:creator>Eugene D Kuugbee</dc:creator>
+ <dc:creator>Gloria Maaldu</dc:creator>
+ <dc:creator>Aseta Adamu</dc:creator>
+ <dc:creator>Nafisa Salia</dc:creator>
+ <dc:creator>Williams Walana</dc:creator>
+ <dc:creator>Sylvanus Kampo</dc:creator>
+ <dc:creator>Ezekiel K Vicar</dc:creator>
+ <dc:creator>Juventus B Ziem</dc:creator>
+ <dc:date>2023-05-11</dc:date>
+ <dc:source>The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale</dc:source>
+ <dc:title>Seroprevalence and Risk Factors of Sexually Transmitted Blood-Borne Infections among Pregnant Women Attending Antenatal Care in Jirapa, Upper West Region of Ghana</dc:title>
+ <dc:identifier>pmid:37168817</dc:identifier>
+ <dc:identifier>pmc:PMC10164872</dc:identifier>
+ <dc:identifier>doi:10.1155/2023/3157202</dc:identifier>
+ </item>
+ <item>
+ <title>Intestinal hypomotility due to longitudinal enterotomy can be alleviated by transverse closure</title>
+ <link>https://pubmed.ncbi.nlm.nih.gov/37164718/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac</link>
+ <description>CONCLUSIONS: The HM configuration, which widens the incision site and distal diameter and shortens the cut surface of the circular muscle in the longitudinal direction, may help maintain basal and HAS-induced intestinal peristalsis and motility. J. Med. Invest. 70 : 180-188, February, 2023.</description>
+ <content:encoded><![CDATA[<div><p style="color: #4aa564;">J Med Invest. 2023;70(1.2):180-188. doi: 10.2152/jmi.70.180.</p><p><b>ABSTRACT</b></p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">BACKGROUND: Heineke-Mikulicz (HM) strictureplasty is commonly used to treat short stenoses in Crohn's disease. However, the degree to which intestinal motility is maintained remains unclear. We compared the peristalsis and transport capacity of the sutured intestines with HM configuration and transverse (TS) and longitudinal (LS) incisions.</p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">METHODS: The intestinal diameter, intraluminal pressure, and bead transit time of each sutured group were compared with that of the non-treatment (NT) group in the isolated proximal colon of rats. Propulsive contractions were induced using hydroxy-?-sanshool (HAS), a constituent of Japanese pepper.</p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">RESULTS: There was no change in the intestinal diameter between HM, TS, and NT groups ; however, it was significantly narrowed at the suture site and its distal side in the LS group. After HAS administration, the intestinal diameter at the suture site in the HM group was higher than that in the LS group. The intraluminal pressure was higher and the transit time was shorter in the HM group compared to those in the LS group.</p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">CONCLUSIONS: The HM configuration, which widens the incision site and distal diameter and shortens the cut surface of the circular muscle in the longitudinal direction, may help maintain basal and HAS-induced intestinal peristalsis and motility. J. Med. Invest. 70 : 180-188, February, 2023.</p><p style="color: lightgray">PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/37164718/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">37164718</a> | DOI:<a href=https://doi.org/10.2152/jmi.70.180>10.2152/jmi.70.180</a></p></div>]]></content:encoded>
+ <guid isPermaLink="false">pubmed:37164718</guid>
+ <pubDate>Wed, 10 May 2023 06:00:00 -0400</pubDate>
+ <dc:creator>Kunitsugu Kubota</dc:creator>
+ <dc:creator>Toru Kono</dc:creator>
+ <dc:creator>Mitsuo Shimada</dc:creator>
+ <dc:creator>Atsushi Takata</dc:creator>
+ <dc:creator>Jun Higashijima</dc:creator>
+ <dc:creator>Kozo Yoshikawa</dc:creator>
+ <dc:creator>Takuya Tokunaga</dc:creator>
+ <dc:creator>Naoki Fujitsuka</dc:creator>
+ <dc:creator>Alessandro Fichera</dc:creator>
+ <dc:date>2023-05-10</dc:date>
+ <dc:source>The journal of medical investigation : JMI</dc:source>
+ <dc:title>Intestinal hypomotility due to longitudinal enterotomy can be alleviated by transverse closure</dc:title>
+ <dc:identifier>pmid:37164718</dc:identifier>
+ <dc:identifier>doi:10.2152/jmi.70.180</dc:identifier>
+ </item>
+ <item>
+ <title>Predictors for the Development of Hypoxia or Prolonged Acute Symptoms Among Non-Hospitalized Mild-To-Moderate Patients with Coronavirus Disease 2019</title>
+ <link>https://pubmed.ncbi.nlm.nih.gov/37164697/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac</link>
+ <description>No abstract</description>
+ <content:encoded><![CDATA[<div><p style="color: #4aa564;">Tohoku J Exp Med. 2023 May 11. doi: 10.1620/tjem.2023.J038. Online ahead of print.</p><p><b>NO ABSTRACT</b></p><p style="color: lightgray">PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/37164697/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">37164697</a> | DOI:<a href=https://doi.org/10.1620/tjem.2023.J038>10.1620/tjem.2023.J038</a></p></div>]]></content:encoded>
+ <guid isPermaLink="false">pubmed:37164697</guid>
+ <pubDate>Wed, 10 May 2023 06:00:00 -0400</pubDate>
+ <dc:creator>Yasunori Tadano</dc:creator>
+ <dc:creator>Tetsuya Akaishi</dc:creator>
+ <dc:creator>Satoko Suzuki</dc:creator>
+ <dc:creator>Rie Ono</dc:creator>
+ <dc:creator>Natsumi Saito</dc:creator>
+ <dc:creator>Ryutaro Arita</dc:creator>
+ <dc:creator>Takeshi Kanno</dc:creator>
+ <dc:creator>Junichi Tanaka</dc:creator>
+ <dc:creator>Akiko Kikuchi</dc:creator>
+ <dc:creator>Minoru Ohsawa</dc:creator>
+ <dc:creator>Shin Takayama</dc:creator>
+ <dc:creator>Michiaki Abe</dc:creator>
+ <dc:creator>Ko Onodera</dc:creator>
+ <dc:creator>Tadashi Ishii</dc:creator>
+ <dc:date>2023-05-10</dc:date>
+ <dc:source>The Tohoku journal of experimental medicine</dc:source>
+ <dc:title>Predictors for the Development of Hypoxia or Prolonged Acute Symptoms Among Non-Hospitalized Mild-To-Moderate Patients with Coronavirus Disease 2019</dc:title>
+ <dc:identifier>pmid:37164697</dc:identifier>
+ <dc:identifier>doi:10.1620/tjem.2023.J038</dc:identifier>
+ </item>
+ <item>
+ <title>CD8<sup>+</sup> T Cell-Mediated Therapeutic Antitumor Effect of an Herbal Mixture Containing <em>Ganoderma lucidum</em></title>
+ <link>https://pubmed.ncbi.nlm.nih.gov/37152373/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac</link>
+ <description>Although Kampo-a traditional Japanese herbal medicine-contributes in the control of tumor growth in vivo in experimental animals, most of the antitumor effects are prophylactic and not therapeutic. In this study, we determined whether oral administration of an herbal mixture containing Ganoderma lucidum (WTMCGEP; Wisteria floribunda, Trapae fructus, Myristica fragrans, Coicis semen, Ganoderma lucidum, Elfvingia applanata, and Punica granatum), anecdotally used in Japan for the palliative care of...</description>
+ <content:encoded><![CDATA[<div><p style="color: #4aa564;">Evid Based Complement Alternat Med. 2023 Apr 28;2023:9630816. doi: 10.1155/2023/9630816. eCollection 2023.</p><p><b>ABSTRACT</b></p><p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">Although Kampo-a traditional Japanese herbal medicine-contributes in the control of tumor growth <i>in vivo</i> in experimental animals, most of the antitumor effects are prophylactic and not therapeutic. In this study, we determined whether oral administration of an herbal mixture containing <i>Ganoderma lucidum</i> (WTMCGEP; <i>Wisteria floribunda</i>, <i>Trapae fructus</i>, <i>Myristica fragrans</i>, <i>Coicis semen</i>, <i>Ganoderma lucidum</i>, <i>Elfvingia applanata</i>, and <i>Punica granatum</i>), anecdotally used in Japan for the palliative care of patients with cancer, exhibits a therapeutic effect on tumor growth <i>in vivo</i> in a hypodermic murine CT26 colorectal tumor model. An <i>in vitro</i> tumor assay revealed that WTMCGEP extract has some direct influence over suppression of tumor growth. In wild-type BALB/c mice, WTMCGEP did not show any antitumor effect <i>in vivo</i>. However, in BALB-CD1d<sup>-/-</sup> mice with partly mitigated immunosuppression by reason of them being devoid of both antitumoral type I and immunosuppressive type II natural killer T (NKT) cells, WTMCGEP therapeutically suppressed tumor growth. CD8<sup>+</sup> T cell depletion significantly accelerated tumor growth in WTMCGEP mice; therefore, its antitumor activity was primarily in a CD8<sup>+</sup> T cell-dependent manner. Regarding immunosuppressive cells in tumor-bearing CD1d<sup>-/-</sup> mice, WTMCGEP did not influence the abundance of tumor-infiltrating CD4<sup>+</sup> and Forkhead box protein 3<sup>+</sup> regulatory T cells. However, it reduced both intratumoral and splenic Ly6G<sup>+</sup> Ly6C<sup>lo</sup> polymorphonuclear myeloid-derived suppressor cells, which were most likely involved in tumor growth inhibition related to higher frequency of intratumoral CD107a<sup>+</sup> CD8<sup>+</sup> T cells in these mice. Overall, these data illustrate that the deficiency of NKT cells urges WTMCGEP to exert a therapeutic antitumor effect mainly through CD8<sup>+</sup> T cells. Our efforts are the first to scientifically demonstrate the WTMCGEP's contribution to tumor immunity.</p><p style="color: lightgray">PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/37152373/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">37152373</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC10162866/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Rkszs2HVZ24HN3sWg8aH-KwBpe-f4PJqn84a1SLRQDBF17cKN&fc=20230611160724&ff=20230618115039&v=2.17.9.post6+86293ac">PMC10162866</a> | DOI:<a href=https://doi.org/10.1155/2023/9630816>10.1155/2023/9630816</a></p></div>]]></content:encoded>
+ <guid isPermaLink="false">pubmed:37152373</guid>
+ <pubDate>Mon, 08 May 2023 06:00:00 -0400</pubDate>
+ <dc:creator>Shun Takaku</dc:creator>
+ <dc:creator>Masumi Shimizu</dc:creator>
+ <dc:creator>Rimpei Morita</dc:creator>
+ <dc:date>2023-05-08</dc:date>
+ <dc:source>Evidence-based complementary and alternative medicine : eCAM</dc:source>
+ <dc:title>CD8<sup>+</sup> T Cell-Mediated Therapeutic Antitumor Effect of an Herbal Mixture Containing <em>Ganoderma lucidum</em></dc:title>
+ <dc:identifier>pmid:37152373</dc:identifier>
+ <dc:identifier>pmc:PMC10162866</dc:identifier>
+ <dc:identifier>doi:10.1155/2023/9630816</dc:identifier>
+ </item>
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+</rss>