[HN Gopher] Oral microbiome sequencing after taking probiotics
___________________________________________________________________
Oral microbiome sequencing after taking probiotics
Author : sethbannon
Score : 176 points
Date : 2026-01-06 21:10 UTC (1 days ago)
(HTM) web link (blog.booleanbiotech.com)
(TXT) w3m dump (blog.booleanbiotech.com)
| ravedave5 wrote:
| A surprising amount of variation from day to day even.
| temp0826 wrote:
| I have been wondering about these oral probiotics for a while. I
| have used BLIS K12 lozenges before and had a strange experience-
| it seemed like they changed my baseline for what I could detect
| as fresh/clean breath and I began noticing everyone else's breath
| (which isn't exactly pleasant, even if it's not bad per se). I
| never asked anyone or received feedback about my own breath
| personally but it made me very curious what anyone who's breath I
| noticed would have sensed.
| net01 wrote:
| i remember reading about "lumina probiotic" Has anyone done
| research on it since, reviewing thier claims ?
|
| their claims on their website:
|
| replaces S. mutans, alters oral microbiome, reduces acid via
| ethanol metabolism, produces antibiotic, freshens breath,
| brightens teeth, lasts decades. etc
|
| i am very skeptical of it
| TheJoeMan wrote:
| I recall they were offering a few people mail-in swabs to test
| if the colonization had taken hold, but haven't read any
| follow-up.
| SirensOfTitan wrote:
| Only tangentially relevant, but I've dealt with mouth and gut
| microbiome issues my whole life, the latter exacerbated by a
| strong antibiotic I had to go on in mid 2017 for a super
| resistant staph infection. L Reuteri supplementation and "L
| Reuteri yogurt" was one of those alternative methods I read about
| (though I'm skeptical that reuteri is the dominant strain in this
| "yogurt")
|
| Doctors don't really care to look at these kinds of issues. It
| took years of suffering and autoimmune issues (particularly
| muscle spasms and joint pain) alongside gut problems before I
| demanded a gastroenterologist test me for H pylori and SIBO: I
| was positive for both.
|
| H pylori was a painful treatment process, but I cleared it after
| one round of quad therapy. SIBO on the other hand, a condition I
| think we hardly understand, has been hard to deal with. Many
| rounds of rifaximin with very minimal relief and no real answer
| as to how to deal with it.
|
| Doctors are hesitant to help, so I've resulted to a lot of
| personal experimentation to deal with it. The only thing that
| ever worked (and it's just anecdata so unsure) was sulbultiamine
| supplementation, but I can't actually get that anymore and normal
| thiamine doesn't help.
|
| This is all to say: I think microbiome is supremely important to
| health, very few things seem to really impact it, and doctors are
| hesitant to deal with these systems at all. I'm sure FMTs will
| become much more popular for a variety of conditions, but it
| seems like it's a real risk where not only might someone else's
| microbiome not be a fit for your physiology, but you could be
| inheriting a variety of risks the donor is susceptible to but you
| are not.
|
| I am not a doctor and much of what I'm saying may be wrong. Don't
| quote me please.
| robocat wrote:
| > Doctors don't really care to look at these kinds of issues
|
| Perhaps for good reasons?
|
| The science is messy, there are few proven interventions and
| every woowoo worrywart will be pestering their doctor. Your
| doctor is in an unenviable position.
|
| With doctors in New Zealand, my one trick is to find good
| specialists and pay them privately.
|
| I believe that a GP only helps point you in the right
| direction. Our public health system is mostly too overloaded to
| help (unless you have a critical problem and your GP helps you
| get in a queue).
|
| Not sure what helps in other countries.
|
| But I 100% agree that you need to take responsibility for
| healing yourself. Only you have the motivation, and the context
| and experience to judge your own problems -- however one needs
| to take care not to get caught in irrelevant or misleading
| deadends (especially when mislead by corporations or
| alternative woowoo freaks).
| majormajor wrote:
| > Doctors don't really care to look at these kinds of issues.
| It took years of suffering and autoimmune issues (particularly
| muscle spasms and joint pain) alongside gut problems before I
| demanded a gastroenterologist test me for H pylori and SIBO: I
| was positive for both.
|
| I went through a similar post-antibiotics gut nightmare. There
| are good doctors and there are bad doctors and like everything,
| there are fewer good ones than bad+average ones.
|
| Seems like you got testing and treatment eventually, I'm sorry
| it didn't work better; I'm replying less for you and more for
| anyone who encounters similar. Shop around for your docs!
|
| I got tested very quickly for both H Pylori and SIBO in 2019 on
| doctor suggestions, I'd never heard of either. Sounds like this
| was probably around the same time as you went through this
| based no the antibiotic course that messed up your gut being in
| 2017).
|
| I went to three doctors in six months, the one that did the
| testing was the second one. The one who was confident in their
| knowledge but didn't do anything, including the testing ->
| immediate no-return-visit from me. The one who said "we don't
| really know how this works" but also didn't do anything -> no
| return visit, but appreciate the candor. The one I went back to
| is the one who said "we don't really know how this works, but
| let's test for these other things we've learned more about
| recently, and let's also try some experimental/off-label
| things." I was actually negative for both of those things, so
| there was even more random stuff beyond that, but the only one
| the doctor I liked was really resistant to was a poop
| transplant, though personally... seems like the only known way
| to repopulate some of the shit, pun intended.
| a_conservative wrote:
| Not a doctor either.
|
| Japan seems to love creating fat soluble forms of thiamine.
| I've been experimenting with a form of thiamine called TTFD.
| TTFD is synthetic, there's a natural form called allithiamine,
| derived from garlic. There's also another form called
| benfotiamine. All of these are fat soluble and highly highly
| available forms of thiamine. TTFD in particular is associated
| with paradoxical effects where a person can have a temporary
| worsening of thiamine deficiency symptoms when first consuming
| TTFD. Thiamine is generally considered very safe, but these
| supplements are pretty hefty doses, so I would suggest treading
| lightly.
|
| There's also some thinking amongst some doctors that sub-
| clinical thiamine deficiencies being more common than most
| doctors realize [0] [1]
|
| [0] Thiamine Deficiency Disease, Dysautonomia, and High Calorie
| Malnutrition
|
| [1]
| https://www.sciencedirect.com/science/chapter/monograph/pii/...
| biotinker wrote:
| I love that this is something that is feasible for someone to
| just do right now as a hobbyist or blogger. The prices involved
| here are very reasonable and well within reach of someone wanting
| to do some project, though not yet at "sequence your microbiome
| every day" levels.
|
| I hope we see a lot more posts like this in the future.
| the__alchemist wrote:
| Yea; Plasmidsaurus slaps. Especially if you live near one of
| the drop boxes. (e.g. a research university) $15/sample, and
| they email the results the next morning. This sort of service
| is enabled in part by nanopore sequencing.
|
| I have just used them to dork around with my home lab to
| validate cloning results. Now I want to try something like
| this!
| samuell wrote:
| Nice experiment and writeup!
|
| On a tangent, nice to see Plasmidsaurus using Emu [1], which has
| been shown to work great for 16S ribosomal RNA analysis on ONT by
| basically everyone I've heard who tried it. It has a nice
| algorithm for predicting if variants are due to ONT sequencing
| errors or are true variants, based on an expectation maximization
| algorithm, and thus working around the somewhat limited accuracy
| in ONT reads. Pretty clever stuff.
|
| And if you want to run your own analysis on the raw data using
| Emu, you might want to try out our Trana pipeline built around
| Emu in Nextflow [2]. Apart from running Emu, it does some of the
| preprocessing like filtering, as well as exporting as Krona
| diagrams etc.
|
| We're just putting it through validation at the clinical
| microbiology lab at Karolinska here in Stockholm right now.
|
| The main caveat worth mentioning is that the choice of database
| seems to be able to affect results quite a lot in some cases.
|
| [1] https://github.com/treangenlab/emu
|
| [2] https://github.com/genomic-medicine-sweden/TRANA
| compass_copium wrote:
| >However, there is some light evidence that the variation I see
| is not just intra-day variation. Specifically, there are several
| species that stay consistent in frequency across all samples:
| e.g., Neisseria subflava, Streptococcus viridans, Streptococcus
| oralis.
|
| Disagree. You can not make that claim without sequencing your
| mouth's microbiome in the absence of probiotics for a month as
| well (and, really, many more than one persom's). Was your diet
| controlled all month? Oral hygiene habits? Any of a million other
| variables?
|
| Also, it's worth pointing out that the study was designed to test
| one hypothesis, and you need to be very careful about looking at
| further claims. This test only really provided evidence that
| these probiotics don't introduce L. reuterii.
| rossdavidh wrote:
| Well, they did say "light evidence" rather than "proof".
| Aurornis wrote:
| Unfortunately self-testing something like this isn't trivially
| cheap, so the self experimenters tend to skip the very
| important control step.
|
| This happens a lot when people discover that you can order your
| own bloodwork. Reddit supplement and biohacking forums gets a
| lot of posts from people sharing bloodwork from two different
| dates and concluding that the changes are entirely due to their
| supplement regimen. When you're only getting a couple tests
| it's not easy to see that even day to day variations in these
| tests can be very large. Even timing of tests during the day,
| how you slept, or what you ate can have a lot of impact on many
| tests.
|
| Doing some basic controlling without taking the supplement is
| important. Doing double-blind tests on yourself also isn't that
| hard if you put some effort in. There have been some surprising
| results from people doing controlled tests on themselves and
| discovering that the supplements that looked promising on paper
| were either doing nothing or were trending toward being
| negative. Gwern's experiments with magnesium supplementation
| which were generally flat with hints of trending toward being
| negative are a good example. That experiment was a good reality
| check during the era when the popular narrative that we were
| all severely magnesium deficient and the solution was high
| doses of magnesium for everyone.
| throwoutway wrote:
| I would love to see this same analysis with a gut probiotic! I am
| never convinced if I'm wasting my money, which strains are best,
| should I do refrigerated or shelf-stable, etc.
| staticassertion wrote:
| As far as I am aware, fiber has infinitely superior research
| behind it with far more drastic effects. Just take fiber if
| you're worried about gut health imo.
| monkpit wrote:
| Yes, feeding good bacteria is the best bet. Probiotics are
| transient, they don't colonize.
| ungreased0675 wrote:
| How do they get there initially?
| ac29 wrote:
| The environment we live in and the foods we eat are
| hardly sterile.
|
| There is also a significant microbiome on your skin.
| throwoutway wrote:
| I agree, but if one has ever taken an antibiotic then they
| should replace the bacteria that they lost? Strong
| antibiotics completely destroy the gut biome
| staticassertion wrote:
| The research doesn't strongly support probiotics even in
| that case one way or the other.
| thom wrote:
| Anecdata/placebo/whatever: I use BioGaia's Gastrus tablets and
| they increase my quality of life noticeably, and I can tell
| when I've been off them for a while. I got refrigerated
| deliveries of probiotic yoghurt drinks for a while previously
| and in addition to the faff, didn't notice as good results.
| tonyarkles wrote:
| Additional Anecdata: I head about BioGaia's Gastrus tablets
| here on HN a couple of years ago and they have dramatically
| improved my wife's quality of life as well. She suffered from
| significant GI problems. We bought a pack of the BioGaia
| tablets based on an anecdote here. Within about 3 weeks her
| year-long GI problems were gone. She discontinued the tablets
| and the GI issues stayed away. About 18 months later, after a
| period of heavy stress and travel, her GI issues returned and
| then disappeared again after another round of BioGaia
| tablets.
| throwoutway wrote:
| Thank you both for the anecdata!
| CGMthrowaway wrote:
| PSA: If a probiotic is on the shelf, not in a cooler, it's
| probably not worth buying. The best companies certify the count
| of organisms _at time of manufacture_ , but no counts are
| guaranteed at the shelf. Probiotics are living organisms and
| ought to be refrigerated for max lifespan.
|
| You can get refrigerated probiotic supps at a place like Whole
| Foods.
|
| Source: I used to work in the industry.
| Aeglaecia wrote:
| does this apply universally to bacterial strains ?
| CGMthrowaway wrote:
| Yes
| zdragnar wrote:
| The Internet almost universally disagrees, based on a quick
| search:
|
| https://seed.com/cultured/probiotics-refrigeration-
| storage-g...
| CGMthrowaway wrote:
| Lyophilization is a fancy word for freeze-drying. "If a
| probiotic is refrigerated, it doesn't mean it's a better
| quality" is of course true. But nothing that I said is
| false. If I am getting probiotics from a quality source,
| I am going to prefer the refrigerated product over the
| "shelf-stable" one every time.
| zdragnar wrote:
| There's a difference between "choosing one over the
| other" and the original claim of shelf stabilized
| probiotics being not worth buying.
|
| On a few occasions when my dog has gotten sick, or needed
| antibiotics, shelf stabilized probiotics cleaned their
| digestion right up.
|
| Are strains that only survive when refrigerated probably
| a higher count? Maybe. Are there stains that are better
| but can't be freeze dried? Probably. Are there shelf
| stable probiotics that are worth buying, especially if
| you don't have access to refrigerated stuff? Absolutely!
| CGMthrowaway wrote:
| I never denied any of that. Read my comment again, more
| carefully.
| zdragnar wrote:
| The very first line of your comment:
|
| > PSA: If a probiotic is on the shelf, not in a cooler,
| it's probably not worth buying.
|
| is exactly what I was responding to, along with your one
| word response "Yes" to that applying equally to all
| bacterial strains, which is also untrue.
| CGMthrowaway wrote:
| The statements below can all be taken as true, together.
| Probably doesn't not mean always.
| https://i.imgur.com/BRNn0rJ.png If a
| probiotic is on the shelf, not in a cooler, it's probably
| not worth buying Strains that only survive when
| refrigerated are maybe probably a higher count
| There are probably strains that are better but can't be
| freeze dried There are absolutely shelf stable
| probiotics that are worth buying, especially if you don't
| have access to refrigerated stuff
| DANmode wrote:
| Why do you think they're here, sharing the info with you?
|
| If you could just Google it up, not nearly as interesting
| to HN.
| CGMthrowaway wrote:
| Thank you
| temp0826 wrote:
| There are some newer types of probiotics (called "spore-based")
| which claim better shelf stability (don't require
| refrigeration) and resistance (to populate further down the
| digestive system). But you're absolutely right, they tend to
| die off pretty quickly (be extra weary of ordering them online,
| especially during the summer if they're going to sit around in
| a hot delivery truck or mailbox!).
| CGMthrowaway wrote:
| That is more around solving a different problem than shelf-
| stability, which is the fact that most probiotics targeting
| the intestines don't survive in great measure beyond the
| stomach.
| zamadatix wrote:
| When I asked my doctor about which kinds of probiotics are most
| effective she specifically mentioned refrigerated vs non-
| refrigerated is not a way to identify quality or effectiveness
| unless you know the specific strain(s) needed cannot be made
| shelf-stable. This lined up with asking my endodontist after
| they prescribed some antibiotics for a tooth infection. They
| did warn that the use by dates are a bit bull, not to stock up
| on them as they do deteriorate in quality with time, and not to
| try to keep even the shelf-stable ones above room temperature.
|
| Maybe I misunderstood what my doctor said, maybe my doctor was
| just wrong, maybe it's actually extremely nuanced, maybe it's
| something I hadn't even considered. I guess all I'm saying is
| it's probably better to talk to your doctor(s) about it than
| follow self-sourced (in both the above and this comment)
| medical advice from HN.
| Enginerrrd wrote:
| Also frankly, doctor =/= expert on probiotics.
|
| None of their training really addresses that and while they
| might be more qualified to read research than random layman I
| would not in general ascribe authority to what a random
| practitioner has to say about probiotics. Frankly, the
| research on probiotics is still very much in its infancy and
| a LOT remains to be figured out.
| xattt wrote:
| > doctor =/= expert on probiotics
|
| Medical microbiologists would love to have a word with you.
| Medicine and medicine-adjacent disciplines each develop
| institutional knowledge that percolates from each
| specialized discipline.
|
| > ...the research on probiotics is still very much in its
| infancy and a LOT remains to be figured out.
|
| I'm curious who you think does the research. It's certainly
| not Bubba from down the creek.
| cwnyth wrote:
| PhDs do the research. Not your typical overworked family
| practitioner.
| xattt wrote:
| They don't develop treatment protocols or testing
| modalities either. Knowledge gets disseminated as best
| practices and gets applied as needed to different
| specialties.
|
| If probiotics is what you're after, why not eat or drink
| something fermented?
| zamadatix wrote:
| Absolutely, if you have access to domain specific experts
| or researchers than that should trump whatever your more
| generalized expert will say.
|
| Also right to highlight that just because there exist
| specialist in something does not mean we have the full or
| correct understanding yet, it's just your best place to
| find information regarding it unless you want to go join
| the field.
|
| Great points!
| refulgentis wrote:
| " and not to try to keep even the shelf-stable ones above
| room temperature." - hate to ask, but night brain kicked in -
| could I trouble you to give me an alternative way of phrasing
| this? I keep parsing it as "don't even bother trying to keep
| probiotics warm"
| stavros wrote:
| "Even the ones that can be kept outside a fridge shouldn't
| be kept above room temperature".
| zamadatix wrote:
| No night brain, just a good splice on my part after editing
| that sentence down :). stavros has a great rewrite already,
| but an even more succinct one for just the particular
| snippet could be:
|
| "even shelf-stable probiotics should not be kept above room
| temperature".
| justinclift wrote:
| "room temperature" has a whole lot of variation without
| even thinking about the extremes of population location.
| :(
| zamadatix wrote:
| They gave it as a defined term with a pdf copy of
| https://www.goodrx.com/drugs/medication-basics/which-is-
| the-... describing the ranges - I just neglected to
| include all of that detail in my comment :). Another
| example of why it's great to discuss with your doctor
| instead of advice from forum comments! Googling around,
| apparently these values are standardized for pharmacology
| in the US by the USP, other areas may have other
| standards.
|
| Hope that helps!
| DANmode wrote:
| > maybe my doctor was just wrong
|
| Yes, doctors are similar to mechanics or any other trade, in
| that some simply suck.
|
| Some got Ds.
| CGMthrowaway wrote:
| >self-sourced
|
| It's not "self-sourced" whatever that means (like that's a
| bad thing per se?). I saw the sausage being made and I spoke
| to the sausage makers. The source is the sausage makers, not
| me. Sorry I don't have a link. These facts may or may not be
| trade secrets.
| zamadatix wrote:
| "Self-sourced" as in both of our comments are hearsay: we
| say we heard this information from someone and our source
| for that is only us saying so. That's pretty bad in terms
| of what others can actually do with that information (from
| either of our comments). Not just because hearsay can be
| faked, but more because it's unquestionable, untestable,
| and the quality of the information has almost always
| greatly degraded compared to the source.
|
| This doesn't mean the comments should be assumed to be
| false any more than they should be assumed to be true. It
| also doesn't imply we necessarily have some way to provide
| an actual source either. Just that folks will have to go
| elsewhere if they want any certainty about this
| information, since we didn't provide any as random
| usernames on a message board saying we heard something
| before.
| agumonkey wrote:
| what kind of cooler, near zero or just yogurt level
| temperatures ?
| CGMthrowaway wrote:
| Freezing has potential to cause damage to the organisms,
| safer to refrigerate (and consume asap)
| anjel wrote:
| They sell a yogurt starter that is purportedly Salivarius and
| ruteirii culture over at Beazos' Clubhouse. I haven't had it
| tested but it's way easier than the usual Bulgarian microbes.
| Assuming the cultures are as labeled, I have to imagine eating
| live culture yogurt is more likely to propogate than loszenges
| made in a factory though.
| davio wrote:
| I've made the L. reuteri "yogurt" from the BioGaia Gastrus
| tablets from amazon and it works well. First batch is a
| little watery but after that it pretty much looks like greek
| yogurt when I use half and half.
| ac29 wrote:
| > The best companies certify the count of organisms at time of
| manufacture
|
| The best companies certify the viable count at expiration, I've
| seen many that do.
|
| There is a difference between probiotics in live culture and
| shelf stable products but both can be viable methods of
| delivery.
| dsego wrote:
| So I shouldn't spend money lactibiane buccodental oral
| probiotics in pills?
| curl-up wrote:
| A very naive question: why are "dry and on the shelf" not worth
| buying, when so many of the food-related microorganisms
| obviously work fine through such distribution (baking yeasts,
| various yogurt starters, cheese molds, etc.)?
| michael1999 wrote:
| Yeasts and fungi produce durable spores. But most gut
| bacteria do not form spores. When they dry out, they die.
| mlmonkey wrote:
| Why not run an experiment like this post: take a probiotic
| capsule, put its contents in a growing medium; after a day or
| two, sample from the medium and send it in for testing, and see
| which strains actually grew?
| knowitnone3 wrote:
| interesting and well written article. I would imagine what you
| eat, amount of saliva, dental hygiene, and a lot of other
| variables would affect your oral microbiome. what would be a
| better test is for people with "red complex" bacteria to take
| this and see the results. the fact that it didn't colonize tells
| me this is pretty much useless like most probiotics
| https://medicine.tufts.edu/news-events/news/are-probiotics-a...
| the author concluded that they will use it again only because of
| the taste, not because it works.
| OutOfHere wrote:
| Wasn't there recently a discussion of a risk of methanol
| formation from an ethanol producing strain? I sure hope that none
| of your strains produce ethanol.
| cluckindan wrote:
| Why not? Ethanol kills competing bacteria and is only produced
| in microscopic quantities.
|
| Methanol is produced by a lot of bacteria, almost every human
| produces it within their body.
| OutOfHere wrote:
| Isn't methanol a strong poison? I do not believe that any
| probiotic or native strains produce it.
|
| Chemically the problem with ethanol is that it's too close to
| methanol.
| cluckindan wrote:
| From Wikipedia:
|
| "Small amounts of methanol are present in normal, healthy
| human individuals. One study found a mean of 4.5 ppm in the
| exhaled breath of test subjects.[19] The mean endogenous
| methanol in humans of 0.45 g/d may be metabolized from
| pectin found in fruit; one kilogram of apple produces up to
| 1.4 g of pectin (0.6 g of methanol.)[20]"
|
| "Ingestion of as little as 3.16 grams of methanol can cause
| irreversible optic nerve damage, and the oral LD50 for
| humans is estimated to be 56.2 grams.[66]"
|
| 19: https://iopscience.iop.org/article/10.1088/0967-3334/27
| /7/00...
|
| 20: https://onlinelibrary.wiley.com/doi/10.1111/j.1530-0277
| .1997...
|
| 66: https://aoemj.org/journal/view.php?doi=10.1186/s40557-0
| 17-01...
| OutOfHere wrote:
| It doesn't mean it's safe to risk adding to the burden.
| The danger is that low-grade non-acute toxicity over the
| natural level could still be harmful over time. All it
| could take is one mutation.
| vibrio wrote:
| Slightly different point but many bacteria in us right now also
| make lipopolysaccharide (LPS). If it were purified and injected
| iv, the LPS in me could probably kill me 1000 x over.
| OutOfHere wrote:
| Nothing about this discussion was about injecting anything.
| echelon wrote:
| LPS is a critical component of gram negative bacteria, like
| E. coli.
|
| We evolved LPS detection so long ago that it's in our innate
| immune system instead of adaptive immunity. It's so ancient
| we share this immune function with fruit flies.
|
| LPS detection is so good and immediate because it's tuned to
| pick up single instances of LPS molecules. Not a few nmol.
| Single molecules. Detection will trigger inflammation and
| immune scale up to deal with the problem.
|
| If you go injecting LPS or E coli into your blood stream, of
| course your own body is going to kill you. It'll freak out
| and think WW III has started and begin firing the nukes in
| every direction to stop it.
|
| This is septic shock.
| dekhn wrote:
| This article is basically cargo cult biotech.
| ch4s3 wrote:
| Tech bro woo at its finest. Can't wait until they discover
| crystals.
| bzmrgonz wrote:
| I want this for nasal microbiome. I think modern living is
| wreaking havoc on our upper respiratory track. We need to find a
| way to regenerate or improve nasal cavity microbiome.
| cluckindan wrote:
| Just don't get caught insufflating your probiotics during lunch
| hour :)
| ahstilde wrote:
| I think your best bet is first curing your allergies. That's
| what I've been working on for 5 years: www.wyndly.com
| chasebank wrote:
| how do you test for allergens? i did 5 years of immunotherapy
| shots, twice weekly at a doctors office and i had to stay 30
| minutes after each shot for the anaphylaxis risk. it worked
| quite well but it was really inconvenient.
| inglor_cz wrote:
| Nasal rinsing may help. In my case, it reduced my number of
| colds per year from 6 to approx. 1, and they also tend to be
| milder. This was likely accompanied by some change in nasal
| microbiome as well.
| tboyd47 wrote:
| Fresh air
| ck2 wrote:
| the supplement industry is ridiculously sketchy and virtually
| unregulated wild-west
|
| and probiotics are the absolute worst of the industry with
| endless lies in claims and products that often test with nothing
| of the claim in them
|
| if you want to try probiotics
|
| 1. start with a single strain probiotic, multi-strain are often
| lies
|
| 2. try an extremely well known/proven probiotic
|
| want to know something is happening? try lp299v Lactobacillus
| Plantarum
|
| it's cheap, it's been studied for 30+ years so lots of trials and
| proven claims
|
| it won't colonize, no oral probiotic will colonize, so you have
| to keep taking it or it's gone in a few days from your GI
| bhouston wrote:
| Hmmm makes me want to sequence by own oral biome just for kicks
| or my gut flora - two sides of the same system. That would be
| neat and I would definitely pay $100 for either if it included an
| analysis.
| mcc1ane wrote:
| https://arstechnica.com/science/2018/09/probiotics-if-you-do...
| dsego wrote:
| Any opinions on using pure xylitol to stamp out streptococcus
| mutans and improve the oral microbiome.
| port3000 wrote:
| Eat 30 different types of fruits and vegetables every week. There
| is no 'hacking' your way to a good microbiome via these pills.
| daveguy wrote:
| Fun fact: kombucha is an excellent source of probiotics and is
| refrigerated.
|
| I used to turn my nose up at it, but I got some branching out at
| a beer bar that tasted pretty good (0.5% ABV so you'd puke from
| too much liquid before getting drunk). It seemed more of a
| breakfast drink so I had a few ounces every morning. Most regular
| I've been in my life. That said, the "evidence" presented in the
| article should not be considered due to the lack of controls
| (just look at the variance between day -4 and day -1). Both this
| comment and the article are anecdotal.
|
| But kombucha is a lot cheaper than manufactured probiotics,
| refrigerated, and the drink is acidic so the bacteria in the
| drink should already be well suited to the stomach pH (1-3 vs
| 2.5-3.5 kombucha).
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