[HN Gopher] MRI Contrast Agent Causes Harmful Metal Buildup in S...
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       MRI Contrast Agent Causes Harmful Metal Buildup in Some Patients
       [study]
        
       Author : nikolay
       Score  : 39 points
       Date   : 2025-10-24 20:48 UTC (2 hours ago)
        
 (HTM) web link (www.ormanager.com)
 (TXT) w3m dump (www.ormanager.com)
        
       | hereme888 wrote:
       | You know what other metal stays in the body, permanently bound to
       | bone and other organs? Bismuth, as in bismuth salycilate, aka
       | Peptobismol. A tiny % actually stays in your body.
        
         | ToDougie wrote:
         | Can you please share more?
        
         | DennisP wrote:
         | Does that cause any symptoms? Because apparently this can, and
         | they tell you how to avoid it.
         | 
         | > Lead author Dr Brent Wagner told Newsweek he personally
         | avoids vitamin C when undergoing MRI with contrast, citing its
         | potential to increase gadolinium reactivity. "Metabolic
         | milieu," including high oxalic acid levels, could explain why
         | some individuals experience severe symptoms while others do
         | not, he said.
         | 
         | Avoiding high-oxalic foods for a few days before the MRI also
         | seems like a good idea. Just check the diet for calcium oxalate
         | kidney stones.
        
       | gclawes wrote:
       | Every time I've gotten an MRI the doctors and techs have sworn up
       | and down it's impossible for this stuff to stick around. Getting
       | tired of not being able to believe what doctors say...
        
         | bamboozled wrote:
         | The other day I had to get a CT scan, I was kind of annoyed I
         | wasn't offered and MRI, and here we are.
         | 
         | I hold a different opinion to you though, I'm glad doctors are
         | always learning more while generally operating with good
         | /extremely good intentions.
        
           | byryan wrote:
           | Really wish more people had that mind set. Practicing
           | medicine isn't easy, especially in the US when you have to
           | battle the insane insurance industry.
        
           | margalabargala wrote:
           | > I hold a different opinion to you though, I'm glad doctors
           | are always learning more while generally operating with good
           | /extremely good intentions.
           | 
           | I agree. Expecting perfection from humans, even experts, is
           | not reasonable and is frankly counterproductive.
           | 
           | Willful ignorance is one thing, but people who genuinely
           | attempt to do the right thing at worst just need to be
           | steered slightly differently.
        
           | torstenvl wrote:
           | Except that a disturbing number of doctors insist that they
           | are always right and you are always wrong.
           | 
           | A year ago, one insisted vehemently--to the point of yelling
           | --that I shouldn't be supplementing Vitamin K because my
           | _potassium_ levels were fine.
        
         | drum55 wrote:
         | That's surprising, it's at least casually known that they're
         | bio accumulative to some extent. I've joked to the techs before
         | about gadolinium eventually accumulating enough to not be
         | necessary if you do it with enough frequency. Realistically
         | though any situation that you're doing the contrast you're
         | probably at a lot more risk of whatever they've found than from
         | the contrast agent.
        
           | smeej wrote:
           | I had to have contrast to diagnose a simple cyst, which is
           | entirely asymptomatic and was discovered by accident in the
           | background of a cardiac MRI (family history of SCD, but my
           | own heart is fine).
           | 
           | You're making me feel lucky about what was otherwise a very
           | unpleasant experience!
        
         | hammock wrote:
         | They said the same thing about mRNA vaccines staying at the
         | injection site and degrading quickly.
         | https://x.com/Inversionism/status/1690043574644092940
         | 
         | I know my doctors are good people. I just can't understand how
         | this happens.
        
           | javascriptfan69 wrote:
           | Is this a study in rats? Is there any data beyond 48 hours?
           | 
           | The concentrations outside of the injection site are
           | vanishingly small. And I would consider 48 hours to be pretty
           | quick. If it was still around after a week I would be
           | concerned. Not really sure what I'm supposed to take away
           | from this.
        
         | zoeysmithe wrote:
         | The data until recently suggested that, so thats the risk you
         | take. Would you rather be living in ancient greece and shoved
         | full of hemlock leaves for arthritis? Or have a 19th century
         | surgeon remove your appendix?
         | 
         | There's risk in life and odds-wise if you're in the developed
         | West, you're going to get care and medicine that will greatly
         | prolong your life.
         | 
         | Also this paper is super vague. What percent of people even get
         | this? How long does it last? They havent even done a study to
         | see how long it lasts yet. I have a feeling this isnt going to
         | be our generation's asbestos or thalidomide.
         | 
         | That being said, you should decide your own risk profile. If
         | MRI gives you concerns there are alternatives that dont involve
         | contrast.
        
           | appreciatorBus wrote:
           | No one is asking to go back to Ancient Greece.
           | 
           | But given our track record, a little humility would go along
           | way.
           | 
           | When a highly educated doctor tells you that something is
           | safe, a person is going to assume that means that someone
           | somewhere has proven that the substance is safe. If what they
           | really mean is that no one really knows, but so far, no
           | experiments have been able to prove danger, then we should
           | say that instead.
        
             | bawolff wrote:
             | By that definition, nobody knows anything is safe.
        
       | shakna wrote:
       | Or to not click through multiple layers of clickbait:
       | https://doi.org/10.1016/j.mri.2025.110383
       | 
       | Unfortunately, the article isn't much better. It has as an
       | underpinning, a corrected paper:
       | https://doi.org/10.1093/ndt/gfl294
        
       | anon291 wrote:
       | The link between NSF and gadolinium-based agents has been known
       | for almost two decades and is common knowledge in the industry.
        
         | Neywiny wrote:
         | Yes. The problem is that it's common in the industry. But it's
         | ultimately up to the patient. Maybe alone. Pretty much
         | guaranteed scared. Undereducated, worrying about their likely
         | life threatening potential illness or injury. That's basically
         | under duress.
        
           | bawolff wrote:
           | What are you proposing instead? Should patients just die of
           | their illness instead?
           | 
           | Medical procedures have risk, some are small risk some are
           | higher risk. There are none that are 100% safe. Doctors are
           | supposed to evaluate if the risk is worth the value the
           | procedure would supply.
           | 
           | What is the alternative to the status quo that you would
           | propose?
        
             | Neywiny wrote:
             | There's a big difference between not getting the MRI and
             | getting the MRI without gadolinium. My suggestion is to
             | ensure that people know the risks _outside_ of just the
             | people who work in it. I 'm not sure how that didn't get
             | across in my original comment. With your comprehension
             | skills, you are at an increased risk of falling victim to
             | this exact scenario
        
       | Neywiny wrote:
       | This is very interesting to see on here. My mother was the
       | dissenting vote on an FDA panel on this. There are articles about
       | it. I'll copy her words (as reported by something but seems
       | legit)
       | 
       | > She said that the FDA's plan doesn't go far enough.
       | 
       | > "It's hard to dismiss an anecdotal report when you are the
       | anecdote. When a patient is finally tested and found to have
       | gadolinium retention, there's no FDA-approved antidote. So what
       | does the patient do?"
       | 
       | And I want to reiterate that she was "the" no not "a" no. I don't
       | know if her vote alone is what's caused more research into this.
       | But it's probably the thing I brag about her the most. Even
       | though everybody else said it was fine or abstained, she stood
       | strong. If you look up the articles from the time of the panel
       | (2017) you'll see a lot of articles about this panel and how she
       | was the sole no vote. Included in that was a public post from
       | Chuck Norris praising her. He was going to come out to meet us
       | but I think it was a bad Texas hurricane season so that fell
       | through
        
       | unsupp0rted wrote:
       | Nobody told me gadolinium can be retained before I had it the
       | first couple times.
       | 
       | Like somebody else mentioned, they swore up and down it's
       | perfectly safe.
        
       | bonsai_spool wrote:
       | This is a poor explanation of an older publication, when the
       | actual new work has a good description:
       | 
       | https://www.frontiersin.org/journals/toxicology/articles/10....
        
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       (page generated 2025-10-24 23:00 UTC)