[HN Gopher] Psilocybin treatment extends cellular lifespan, impr...
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Psilocybin treatment extends cellular lifespan, improves survival
of aged mice
Author : atombender
Score : 90 points
Date : 2025-07-24 20:29 UTC (2 hours ago)
(HTM) web link (news.emory.edu)
(TXT) w3m dump (news.emory.edu)
| lawlessone wrote:
| So it's Spice?
| manmal wrote:
| It's definitely geriatric.
| SketchySeaBeast wrote:
| Geriatric spice was the worst spice girl.
| tombakt wrote:
| Melange.
| kubb wrote:
| Time to get some shrooms. I could really do with isolated
| psilocybin capsules though, the taste is terrible.
| e40 wrote:
| I wonder if the taste is mainly responsible for people throwing
| up? Done capsules and never had a problem that particular
| symptom.
| metadaemon wrote:
| I think it's person to person, I've never had any stomach
| issues at all.
| andoando wrote:
| No I dont think so. Mushroom outer layer is chitin-glucan
| complex which is really hard for our digestive system to
| process.
|
| Lemon-trek is supposed to help by 1. griding it to a powder,
| and 2. Putting it in a lemon solution to help do some of that
| breaking down process
| titanomachy wrote:
| I've heard this a lot, but I think a good part of the
| nausea is caused by the same compounds as the psychedelia.
| LSD seems to cause just as much nausea, and it's a tiny
| droplet of liquid absorbed through the mucous membranes.
| andoando wrote:
| I haven't experienced stomach issues from LSD, though I
| haven't always experienced them on shrooms either, so I
| don't know
| zoklet-enjoyer wrote:
| I get motion sick when I hallucinate. I think LSD is the only
| one that never made my tummy rumble
| basisword wrote:
| As someone who gets motion sick very easily you have put me
| off mushrooms. Hours of motion sickness while high sounds
| atrocious.
| basisword wrote:
| I feel like even normal mushrooms can make you queasy if you
| eat too many, they are undercooked, or you're already feeling
| a little ill.
| dpc050505 wrote:
| Grind them into powder, mix them to melted semi-sweet chocolate
| at low heat, pour into ice cube trays and let it harden.
| throwaway743 wrote:
| If you grow them yourself they taste pretty fine. Unsure if not
| using manure improved the taste though.
| dpc050505 wrote:
| I find it's not the taste but the texture when they get stuck
| in my teeth.
| dkenyser wrote:
| Look up lemontek. Drastically shortens the experience, makes it
| much more consistent and the lemon juice overwhelms the flavor
| of the mushrooms.
| hombre_fatal wrote:
| Man, trying to look up "lemon tek shrooms" was worse than
| navigating the worst food recipe websites.
|
| Alllll that text just to say "grind/soak the shrooms in lemon
| juice first and it will hit harder and last shorter".
| gooodvibes wrote:
| It's so unnecessary though. You can just eat them as they
| are, no need to fuss around with grinding and soaking.
| zoklet-enjoyer wrote:
| 4-aco-dmt is what you want
| andoando wrote:
| You can buy gelatin capsules on amazon and powder it yourself.
| foobarian wrote:
| Wonder if the extra lifespan time is larger than the extra time
| spent mentally incapacitated due to the effects of the drug.
| itake wrote:
| that is how I feel about exercise... spending 10 hours per week
| in my youth at a gym for 40 years to buy me an extra 10-20
| years at the end of my life.
| henry2023 wrote:
| 10-20 extra years + another 15 high quality years in your 60s
|
| Finally, exercise is not only gym, hiking, climbing, running,
| the list is endless
| make3 wrote:
| you can do 3 hours and have huge benefits already
| SketchySeaBeast wrote:
| Yeah, 10 hours a week is totally unneeded.
| dtauzell wrote:
| The main advantage is to make the last 10-20 years better by
| avoiding injury. Maybe you do t even need 10 hours a week for
| that, more like 5
| maplant wrote:
| Exercising makes you feel better. It's a necessary component
| of living a good life. Extending your life is irrelevant.
| However, strength training is necessary to ensure the later
| parts of your life are worth living
| cherryteastain wrote:
| > Exercising makes you feel better
|
| Speak for yourself...
| zoklet-enjoyer wrote:
| Go running, hiking, cycling, kayaking, rock climbing,
| snowshoeing, skiing, etc
|
| There are plenty of fun ways to exercise where you won't be
| stuck in a gym using a machine or just repeatedly lifting
| heavy things.
| andoando wrote:
| It's not just about the extra life span, it's the quality of
| life until then.
|
| I wish the same focus was given to weight loss, smoking, etc.
| No one really cares about living an extra 10 years from 70 to
| 80 if it means giving up 40+ yesrs of enjoying bad habits.
|
| Exercise is especially neat because there are enjoyable ways
| to do it
| SketchySeaBeast wrote:
| And it pays off today. You feel better, both physically and
| emotionally. It's a win win all around.
| jader201 wrote:
| > _I wish the same focus was given to weight loss, smoking,
| etc. No one really cares about living an extra 10 years
| from 70 to 80 if it means giving up 40+ yesrs of enjoying
| bad habits._
|
| It's the same thing, right?
|
| That is, exercise may not necessarily make your life
| longer, but has a good chance of making your life higher
| quality.
|
| Similarly, bad habits _can_ shorten your life, and even if
| it doesn't, will most definitely make your life lower
| quality (eventually).
|
| Or maybe that's the point you were making?
| andoando wrote:
| I mean most of the anti-smoking, weight-loss, campaigns
| are focused on trying to convince people thats its bad
| for you because it increases the chance of lung cancer,
| or heart morbidity. Ergo, you shouldn't do them because
| you won't live as long.
|
| Instead, I think we need to focus on "you'll feel better,
| like right now".
| Noumenon72 wrote:
| Exercise starts paying off in midlife by fixing your back
| pain, letting you go trampolining, steadying your balance,
| not getting winded or having to breathe through your mouth on
| stairs, and just generally making your body spend its repair
| cycles on things that make you feel healthy instead of
| inflamed. I develop so many aches and pains that exercise
| helps fix. Without the exercise you might not even want the
| extra 10-20 years.
| Etheryte wrote:
| This is misguided. A healthy lifestyle doesn't simply mean
| extra decades at the end of your life and everything else
| remains the same. It means many health issues also start
| later and you have more healthy years available to in your
| younger years as well. Many turn 30 and already find some
| things ache or don't work quite the right way. Take care of
| your body and those risks drastically go down, it doesn't
| take ten hours a week.
| droopyEyelids wrote:
| DALY - disability adjusted life years.
|
| https://en.m.wikipedia.org/wiki/Disability-
| adjusted_life_yea...
|
| Thanks for helping people understand this concept!
| itake wrote:
| > Many turn 30 and already find some things ache or don't
| work quite the right way
|
| it also goes the other direction: Men in their 20s and 30s
| get hurt doing the same risky activities they did in high
| school (rock climbing, basketball, soccer, etc) resulting
| in lower back pain, damaged hands, etc.
| ravenstine wrote:
| Who says you have to spend that much time in the gym? Unless
| you're really going for pro, nutrition and maintaining
| healthy blood pressure will get you most if not all the way
| to a longer lifespan while saving you countless hours. Even
| just an hour of high intensity exercise a week can maintain
| muscle and provide cardiovascular benefits.
| apwell23 wrote:
| ppl who feel that way won't be able do it for that long, so
| kind of moot point anyways.
|
| i have worked out for atleast 3 times /week for last 30yrs.
| It has always been my fav part of my day.
| fsloth wrote:
| It's not about buying extra years but making your life a hole
| lotta better as well.
|
| Am not kidding. I hated exercise, I still hate it, but it
| objectively makes everything else so much better I keep at
| it.
|
| There are simple and effective protocols. You don't need to
| be "in to it". You don't need to buy extra equipment
| (necessarily) nor do you need purchase anything from anyone
| (unless you want to).
|
| Running, pushups and kettle bell swings are enough (with a
| good strategy). Having a daily stretching/mobility routine is
| advisable the older you get.
|
| Just do it! If you think it will totally suck, it probably
| will! If the question "what are you training for" irritates
| you it sure as hell will keep irritating. There are _zero_
| lifestyle things you need to buy into. But it's medicine.
| Pure medicine.
| louison11 wrote:
| 30 min a day or 3hrs a week in a gym is all you need. I've
| been working out for 10 years, and if I can pull 3 hours in 1
| week, it's a great week! And it'll keep me real strong. Plus,
| makes you sleep better, which means you probably need to
| sleep less. Working out is almost always a "you get more than
| what you gave" kinda deal.
| MathMonkeyMan wrote:
| I thought that the trip was the point.
| jimbo808 wrote:
| There are a lot of ways I could describe the experience, but
| mentally incapacitated definitely wouldn't be among them.
| TechDebtDevin wrote:
| people literally shoot themselves in the head because of this
| drug, this whole popularization of these drugs is the dumbest
| shit I've ver seen.
| jakupovic wrote:
| "People do this, people do that ..." Unless you're speaking
| from personal experience or have some hard data, you're
| spewing utter BS, you're doing this now. Teach yourself!
| hagbard_c wrote:
| > people literally shoot themselves in the head
|
| How does that work? I would have understood this if it said
| _people shoot themselves in the head_ or - if you insist -
| _people_ physically /actually/sometimes/even _shoot
| themselves in the head_ , it would be people taking up
| ballistic weapons which they point at their heads and fire
| away. _Literal_ shooting on the other hand sounds like
| something Chekov would write about, something about the
| rifle above the fireplace in chapter 1 which needs to have
| been used by the next chapter [1].
|
| Maybe I'm taking all the superfluous use of the word
| _literally_ too literal?
|
| [1] https://en.wikipedia.org/wiki/Chekhov%27s_gun
| titanomachy wrote:
| Probably, I think they just did it once per month.
| andoando wrote:
| 5mg/kg? 1g of shrooms has something like 5-20mg of psilocybin. An
| equivalent human dose would seem to be 1.3-2.6g a day
|
| Edit: Did the math wrong.
| tombakt wrote:
| Ah yes, a proper morning routine. A bit of coffee, exercise,
| becoming one with the void...
| samtp wrote:
| Well your perception of time would certainly be longer at that
| dose. Probably feel like you've lived for centuries.
| shawabawa3 wrote:
| Your two statements contradict
|
| If 1g of shrooms has 5mg psilocybin, to get a dose of 5mg/kg
| would be like 75g for an average man (still feels very high but
| nowhere near 1kg)
| andoando wrote:
| Sorry did the math completely wrong. And this was a monthly
| dose, for 75g thats ~2.5g a day
| neom wrote:
| "First, we sought to model high-dose used in a clinical study
| for chronic pain, where patients were administered a
| psychedelic dose (25 mg) of psilocybin. Using the standard
| allometric scaling method, a human dose of 25 mg of psilocybin
| translates to a mouse dose of approximately 5.14 mg/kg."
| andoando wrote:
| Interesting. I thought linear would obviously be incorrect,
| but didn't think it scaled so strongly.
|
| At 25mg, thats 2.5g first month and 7.5g monthly afterwards.
| I wonder if the effects are the same with monthly injections
| vs daily though.
| titanomachy wrote:
| I don't think you multiplied quite right. An 80-kg person would
| need 400mg, which would take 40g of shrooms if potency is 10mg
| per dried gram.
|
| That would still be 10 times larger than a regular dose. I
| think that would make most people seriously ill, not to mention
| the mental effects. One must assume that mice respond
| differently than humans.
| andoando wrote:
| Yeah someone also brought up that its not a linear scaling.
| https://pmc.ncbi.nlm.nih.gov/articles/PMC4804402/
|
| And the study calculates it a 5mg for rats as 25mg for
| humans.
| leoh wrote:
| After a few days, such a dose would likely become imperceptible
| in "healthy normals."
| EGreg wrote:
| By how much does it actually extend it?
|
| Vegetarians live 10 years longer than meat-eaters.
|
| Some studies indicate that vegetarians may live an average of 6
| to 10 years longer than meat-eaters, with some studies showing
| even larger differences for those who switch to a plant-based
| diet early in life.
| isatty wrote:
| Citation?
| bena wrote:
| It sounds familiar, but it's one of those things that's
| secretly checking something else.
|
| Vegetarians are generally more conscious of their health than
| omnivores. Because you have to realize that omnivores
| includes the vast majority of people.
| amanaplanacanal wrote:
| People following _any_ kind of intentional diet live longer
| than average. Because they are people that care any their
| health, not because of whichever diet they choose.
| puppycodes wrote:
| the only catch is you eventually become a stage 3 guild navigator
| mosferatu wrote:
| This comment made me laugh harder than it should have.
| nntwozz wrote:
| The spice must flow!
| EvanAnderson wrote:
| Press release titles really need to say "in vitro" and/or "in
| mice" when the study was done only in vitro and/or in mice.
| tomhow wrote:
| We've inmiced the title.
| EvanAnderson wrote:
| Thank you! I wish PR offices would do that themselves. So
| many health study press releases need the words "in mice"
| appended to the title.
| gooodvibes wrote:
| Nice. Although even if it shortened it, it would still be worth
| taking.
| evanjrowley wrote:
| They feed us poison
|
| so we take their 'cures'
|
| while they suppress our medicine.
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(page generated 2025-07-24 23:01 UTC)