[HN Gopher] Efficient mRNA delivery to resting T cells to revers...
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       Efficient mRNA delivery to resting T cells to reverse HIV latency
        
       Author : matthewmacleod
       Score  : 65 points
       Date   : 2025-06-05 09:37 UTC (3 days ago)
        
 (HTM) web link (www.nature.com)
 (TXT) w3m dump (www.nature.com)
        
       | Jalad wrote:
       | Also discussed here https://news.ycombinator.com/item?id=44202664
        
       | Zigurd wrote:
       | MRNA therapies have such high potential, there really ought to be
       | much more public education and outreach to prevent people falling
       | down the quackery rabbit hole. I don't just say that to pile on
       | to the quacks. It's so detrimental and costs so many lives that
       | it's probably a target for influence by adversary nation actors.
        
         | the_real_cher wrote:
         | Lobotomy's were viewed to have so much high potential back in
         | the day that they won the Nobel prize.
         | 
         | In true scientific fashion both sides would ideally just stick
         | with the facts.
        
         | dpe82 wrote:
         | If we hadn't had a pandemic in which lots of people lost their
         | collective minds and an irresponsible political machine that
         | took advantage of that, mRNA would be pretty universally hailed
         | as the miracle it is.
         | 
         | That aside, yes. Education is important. Sadly at least in the
         | US some of the people who lost their minds are now in charge of
         | such education.
        
           | chasil wrote:
           | This article asserts that white blood cells are the target,
           | but we also know that (within the brain) astrocytes and
           | [iirc] microglia can bear latent infection.
           | 
           | Is such a carrier capable of addressing latent reservoirs
           | inside the blood-brain barrier? Can it cross the barrier,
           | pervade the cerebrospinal fluid, then penetrate all infected
           | cells?
           | 
           | White blood cells are a fantastic achievement, but far from
           | the whole story.
        
       | sroussey wrote:
       | I wonder if this can be used for other latent viruses that embed
       | in cells like herpes and chickenpox/shingles.
        
         | XorNot wrote:
         | That would be interesting because both of those have links to
         | various late-life neurological conditions aa well.
        
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