[HN Gopher] Sleep pressure accumulates in a voltage-gated lipid ...
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       Sleep pressure accumulates in a voltage-gated lipid peroxidation
       memory
        
       Author : gnabgib
       Score  : 16 points
       Date   : 2025-03-19 19:17 UTC (3 hours ago)
        
 (HTM) web link (www.nature.com)
 (TXT) w3m dump (www.nature.com)
        
       | xeonmc wrote:
       | hightlights:
       | 
       | (From Abstract)
       | 
       | > The presence of a lipid peroxidation sensor at the core of
       | homeostatic sleep control suggests that sleep protects neuronal
       | membranes against oxidative damage. Indeed, brain phospholipids
       | are depleted of vulnerable polyunsaturated fatty acyl chains
       | after enforced waking, and slowing the removal of their
       | carbonylic breakdown products increases the demand for sleep.
       | 
       | (From Discussion)
       | 
       | > Our experiments also suggest, but do not prove beyond doubt,
       | that sleep loss causes widespread lipid peroxidation in the
       | brain. Definitive proof would require a demonstration that
       | peroxidation products accumulate, rather than that
       | polyunsaturated phospholipids are depleted, as we have shown.
        
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