[HN Gopher] How far neuroscience is from understanding brains (2...
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       How far neuroscience is from understanding brains (2023)
        
       Author : Gooblebrai
       Score  : 84 points
       Date   : 2025-03-12 12:13 UTC (10 hours ago)
        
 (HTM) web link (pmc.ncbi.nlm.nih.gov)
 (TXT) w3m dump (pmc.ncbi.nlm.nih.gov)
        
       | bena wrote:
       | I would think a large part of the problem is the difficulty in
       | observing a working brain.
       | 
       | There are very few non-destructive ways we can get a look into a
       | brain while it is living. And even research into ways we can look
       | into a living brain is hindered by the fact we don't want to harm
       | the person being observed.
       | 
       | I could see that making progress a lot slower
        
         | jampekka wrote:
         | > And even research into ways we can look into a living brain
         | is hindered by the fact we don't want to harm the person being
         | observed.
         | 
         | Animal brains are harmed for research all the time. Some
         | species, like Zebrafish can be even imaged real-time at
         | neuronal level.
         | 
         | As the article says, the problem is really that there are no
         | good foundational ideas of what are the basic operating
         | principles of the brain.
        
           | bena wrote:
           | I did mention people specifically. Mammalian brains are
           | fairly more complex than piscine brains.
           | 
           | People are important because we can't tell a fish to perform
           | an action or to think of an elephant, etc. So while we can
           | image, we can't know what correlates with a high degree of
           | certainty.
           | 
           | But even in other cases, a working brain is an entirely
           | different object than a non-working one. Finding those
           | foundational ideas and basic operating principles because we
           | can't test a living brain. It's almost chicken/egg. Being
           | able to experiment on a living human brain would probably
           | give us much better ideas of the basic operating principles.
           | And once we know those principles, we could probably move
           | from experimenting on living human brains.
           | 
           | Like, we can dick around with muscle. We can force it to
           | perform as it were living and receiving signals. And that's
           | partly because you can cut open a living person and watch
           | those muscles operate. You can manipulate those muscles in a
           | living person. You can measure things, etc. It's much harder
           | to do that with a brain. Because it's incredibly easy to make
           | irredeemable mistakes.
        
             | glenstein wrote:
             | >So while we can image, we can't know what correlates with
             | a high degree of certainty.
             | 
             | I don't think I agree just on this piece, though you are
             | making important points here. We can know, for instance, of
             | visual or spacial awareness, reactions to certain stimuli
             | or objects introduced in their environment, and so on.
             | 
             | You're not wrong on the importance of learning from active
             | brain functions but I think we can at least make meaningful
             | inroads with animals.
             | 
             | > Finding those foundational ideas and basic operating
             | principles
             | 
             | I know a lot of people talk this way about brains and
             | consciousness, that we need to first have our definitional
             | elements before we proceed with research. But I think we
             | often have, as the object of research, closing in on those
             | elements, while gathering all kinds of functional and
             | theoretical data from the mass of complicated noise that is
             | brain structure and activity. We can build out
             | correlations, mechanisms, and so on and close in on
             | foundational elements.
             | 
             | It may even be the case that foundational organizing
             | principles turn our understanding inside out in important
             | ways, but I have never understood the idea that we are
             | stuck if we can't _start_ with such things in hand.
        
               | bena wrote:
               | I'm sorry, I see where I wasn't clear.
               | 
               | I'm talking about very specific correlation. Like when I
               | type these words, exactly how and what fires to achieve
               | that. Which neurons and pathways are the thought "hit
               | these keys", what's the signal to the fingers etc. We
               | know "When this area is active, this group of actions can
               | happen".
               | 
               | It's hard to get good resolution.
               | 
               | And I believe it would be _easier_ to replicate
               | consciousness if we knew how it worked, I also believe it
               | 's possible we eventually figure it out. It will just be
               | much harder. And we may not know when we do it either. I
               | believe _that_ is where we will need common, agreed upon
               | definitions.
               | 
               | But defining intelligence and consciousness is difficult
               | because you have to define it in a way that includes
               | everything we agree is conscious and excludes everything
               | we agree is not. And we'll also have to agree what is and
               | is not conscious. It's a way more involved problem than a
               | lot of people give credit.
        
               | glenstein wrote:
               | >But defining intelligence and consciousness is difficult
               | because you have to define it in a way that includes
               | everything we agree is conscious and excludes everything
               | we agree is not.
               | 
               | I think this is extremely important, but I would say that
               | methodologically, messy definitions can nevertheless be
               | stepping stones that bring us closer to full
               | comprehension of definitions. I suppose I just have a
               | specific hobby horse in this context and I don't know
               | that I'm responding to you so much as a general idea I've
               | seen elsewhere, that you're rhyming with, which is this
               | idea that research has to start from agreed upon
               | definitions.
               | 
               | I would say instead that there are such things as
               | characteristic instances that embody lots of the stuff we
               | are interested in, such that we can say "whatever
               | consciousness is, it involves _that_ " and we can just
               | point to something that's a wild, underdefined
               | phenomenon, and make it subject of study. Without a
               | definition, I can still understand that states of mind
               | that involve, say, wakeful awareness and intention are
               | going to be about consciousness. We can know necessary
               | conditions even if we don't know "sufficient" conditions,
               | and the former are a stepping stone to comprehending the
               | latter.
        
             | jampekka wrote:
             | Animals are quite easy to get to do all sorts of
             | experiments, and per very similar anatomy it seems very
             | likely that the basic fundamental operating principles are
             | same across species. If we can't figure out how a fruit
             | fly's nervous system works, we have no hope at figuring out
             | the human brain.
        
         | mbauman wrote:
         | The even bigger challenge is determining _what_ you need to
         | observe in the first place.
         | 
         | As a simplistic analogy, evolutionary designs of FPGA boards
         | can end up relying upon idiosyncratic properties of the
         | board(s) and create circuits that "shouldn't work" based on an
         | idealized electrical circuit model. And they may not be
         | transferable to other boards. In other words, to "understand"
         | some evolutionary FPGA circuits, you need to "observe" more
         | than just the gate configurations and idealized schematic.
         | 
         | Brains are not FPGAs or even circuits, but I think the analogy
         | holds. They're not _just_ idealized representations of spiking
         | neural networks.
        
           | NoxiousPluK wrote:
           | I remember reading an article about this years ago - a non-
           | transferable FPGA configuration which had some logic that
           | should be unreachable but didn't work without it. Very
           | faschinating but I've not been able to find it since.
        
             | nick__m wrote:
             | I think you want that paper "An Evolved Circuit, Intrinsic
             | in Silicon, Entwined with Physics" available there https://
             | cgi.cse.unsw.edu.au/~cs4601/refs/papers/es97thompson...
        
         | tim333 wrote:
         | I agree and think the way forward is computer simulation.
         | Figure out a simulation equivalent of a neuron and put a lot
         | together and see how well the simulated brain portion matches
         | the real thing. That hasn't really been possible due to lack
         | capability of computer power but we are getting to where it
         | could be. They have of course done stuff with "artificial
         | neural networks" of the ChatGPT type but those are very far
         | from biology.
         | 
         | DeepMind has been doing work along those lines with 'AI BRAIN'
         | https://medium.com/@daneallist/unlocks-secrets-of-real-brain...
        
           | renewedrebecca wrote:
           | How do you simulate something you don't understand?
           | 
           | The basic problem here is that we don't understand what a
           | neuron does, so how would we model it?
        
             | KineticLensman wrote:
             | > The basic problem here is that we don't understand what a
             | neuron does, so how would we model it?
             | 
             | We understand lots of aspects of neurons and can model
             | those. See the wikipedia page for some examples of well-
             | understood principles.
        
               | tim333 wrote:
               | Yeah and you can do a simulation using a rough
               | approximation and then it is interesting to see in what
               | ways it matches real brains and in what it does not.
               | 
               | It seems the DeepMind rat brain didn't really try to get
               | close to biological neurons but still produced outputs
               | close to a real brain. (vid from here for about 2 mins
               | https://youtu.be/hIuXXvWY6-4?t=125)
        
         | seejayjordan wrote:
         | Look up Wada Test, where we shut down each hemisphere (one at a
         | time) of the brain, while the patient is awake, to see how
         | their personality changes without 1/2 their brain. Also stereo
         | EEG. 200+ sensors placed in/on/around the brain, patient stays
         | in bed for a week measuring brain activity. Here's the
         | kicker... neurologists can plug into the brain and send teeny
         | bits of electricity to each of the 200+ sensors individually to
         | see what happens (typically this is for identifying seizure
         | spots). Wish I didn't have to know this, but my partner is very
         | epileptic, and has an RNS device implanted in her head. We
         | upload her brain activity daily!
        
           | Gooblebrai wrote:
           | According to Wikipedia the personality barely changes and the
           | tests is mainly done to detect which side is on charge of
           | language and memory
        
       | imchillyb wrote:
       | We are just now uncovering an underlying principle of science:
       | 'everything is a wave.'
       | 
       | Neurological connective tissues and their corresponding signals
       | may be more of a symptom of electrical wave action rather than a
       | signaling nexus.
       | 
       | Everything is a wave. Everything is a probabilistic wave form
       | with probabilistic outcomes.
       | 
       | Once science understands these waves and their myriad forms, we
       | may have a greater understanding of our own wires and grey matter
       | signaling.
        
         | guappa wrote:
         | We understand gravity and the 3 body problem still exists...
        
           | 0x1ceb00da wrote:
           | We just don't have a general solution of the 3 body problem
           | in the form of equations. Practically speaking it's a solved
           | problem because we can simulate the motion. We could do the
           | same with brain. That's basically what neural networks are.
        
             | willy_k wrote:
             | We can simulate the three body problem because all of the
             | significant parts of the problem can be known. This is FAR
             | from the case when it comes to the brain.
        
             | goatlover wrote:
             | Neural networks are not simulations of neurons.
        
             | Gooblebrai wrote:
             | Can we simulate it indefinitely? I thought chaotic
             | behaviour entered the game at some point.
        
       | prismatix wrote:
       | If you find this interesting, the Theories of Everything podcast
       | with Curt Jaimungal does a good job exploring this topic. The
       | neuroscience-centered conversations focus mostly on
       | consciousness, but they still discuss similar problems with
       | measuring and explaining how consciousness comes about from a
       | collection of matter.
        
       | intrasight wrote:
       | I took a break from artificial networks to study neuroscience for
       | a couple years. We hardly understand how a single synapse works -
       | and we have trillions of them.
        
         | minihat wrote:
         | This is exactly right.
         | 
         | I started a PhD in 2017 studying neuroscience + ML. I thought
         | studying the brain would help me understand ANNs better. I was
         | wrong. Ended up applying ML to analyzing EEG, MRI and similar.
        
           | bumby wrote:
           | Is this because we're misapplying the analogy to ML? I.e., in
           | an effort to communicate and understand ANNs, we "pretend"
           | it's like a brain. Just like before, we used "file retrieval
           | systems" to understand the brain, or electricity is like
           | "water in a pipe", which are also wrong. Analogies often only
           | go so far, beyond which they do more harm than good.
        
             | beezlebroxxxxxx wrote:
             | What you're describing is endemic across HN (and tech,
             | tbh). Lots of people on here "know"
             | computers/programming/CS very well. They, naturally, tend
             | to use analogies to computers/programming/CS when trying to
             | explain or "think out loud" in their comments. That's fine.
             | It's what they know. The common problem arises when people
             | forget they're analogizing and begin to see their analogy
             | as ontologically and conceptually identical to the thing
             | they were making an analogy for. This requires a certain
             | amount of ego, echo chambers, and self-valorization, so
             | that they never have to face the actual issues with these
             | analogies.
             | 
             | But as many comments here have pointed out, studying
             | neuroscience, for example, usually makes those analogies
             | seem painfully inadequate. The same is true in philosophy
             | of mind, for example.
        
             | SkyBelow wrote:
             | Have we hit the limit of the analogy, or have we hit a
             | limit in our understanding? Both neural networks and actual
             | brains have behaviors that emerge from the interactions of
             | smaller components. Neural networks have trivial
             | connections compared to brains, but our understanding of
             | the emergent behaviors seems very limited. To me, this is a
             | sign not that the analogy has reached a point of breaking
             | down, but that our tools aren't sufficient to work on even
             | then trivial connections. I do expect the analogy will
             | break at some point, but I'm not sure we have reached that
             | point yet.
        
             | erikerikson wrote:
             | I'm sure that there exist people who get lost in the
             | analogies. Practitioners are generally not confused that
             | ANNs are simplifications of the brain. The questions are
             | which simplifications are most relevant and whether
             | complexities can be added that yield better results. My own
             | research was about reintroducing absolute location. I'm
             | standard ANNs location is relative within a graph model of
             | the network. I'm the real brain blood vessels and other
             | macrostructures deliver materials used to grow and modify
             | the neurons and these affect the network based on physical
             | location. I'm fact, by adding these back in we bypassed the
             | XOR limitation (i.e. Minsky's result leading to back
             | propagation). Concretely, we observed learning XOR over the
             | inputs within a Hopfield network using Hebbian learning
             | modulated by spatially modulated trophic factor).
        
             | desdenova wrote:
             | Good thing there's not a lot of ML being done in Haskell...
             | imagine a Brain Monad tutorial.
        
             | hnuser123456 wrote:
             | Turns out "water in a pipe" is actually surprisingly
             | accurate, just that the "waves" are sloshing around at half
             | the speed of light.
             | 
             | https://youtu.be/2AXv49dDQJw?si=ZxRyiu8WwynUXwf_&t=655
        
               | bumby wrote:
               | I believe, at its best, it's an incomplete model (which
               | may be enough for most people). But it leaves out
               | important aspects like magnetic field work and probably a
               | host of aspects from quantum theory.
               | 
               | https://www.slideshare.net/slideshow/georgia-state-
               | universit...
        
               | hnuser123456 wrote:
               | Ok, yeah, I'll agree with incomplete. Only useful for
               | considering the bulk flow of electrons assuming no bulk
               | EM field.
               | 
               | Thanks for the read.
        
         | morkalork wrote:
         | Plus the overall network architecture was evolved over millions
         | of years, is compressed in DNA and grows from cells multiplying
         | and self-organizing.
        
         | JJMcJ wrote:
         | As an example, a not very good partial modeling of a three cell
         | neuron cluster in C. Elegans is a significant research result.
         | 
         | C. Elegans because every adult has the same number of cells in
         | the same configuration.
        
       | teqsun wrote:
       | This is the main reason why I have skepticism towards any claims
       | of imminent AGI.
        
         | mellosouls wrote:
         | I'm also sceptical but to be fair, we don't need to understand
         | how the brain works for AGI, that's just one (obvious) path.
        
           | JackFr wrote:
           | Who knows? Maybe it'll turn out like flying and birds.
           | 
           | Studying birds gave us some data, but mimicking them wasn't
           | what got us jumbo jets.
        
             | southernplaces7 wrote:
             | Sort of a shame... I always wanted to fly in an
             | ornithopter.
        
           | southernplaces7 wrote:
           | Since we don't yet have anything remotely like AGI and at the
           | same time, don't even really know how the brain works or what
           | consciousness is aside from being aware that we feel it, you
           | and nobody else really know if our path to consciousness is
           | just one of many. For all we know it might be the only one.
           | There could be some very big unknown unknowns in those
           | waters.
        
             | glenstein wrote:
             | I would say I think those are all pretty good observations,
             | all perfectly true _and_ I think AGI is more plausible than
             | it 's ever been in light of what we've demonstrated via
             | LLMs. Our understanding really is that limited but I don't
             | take it to be a counterpoint to the prospect of AGI.
        
             | Traubenfuchs wrote:
             | > what consciousness is
             | 
             | Probably an unavoidable property that emerges from the
             | sheer and perverse complexity of the human brain, its 100
             | billion connections and the unimaginable amount of
             | interactions between them, modulated by neurotransmitters +
             | their reuptake, length, amount, location, quality and
             | condition of pre/post-synaptic receptors, axons and other
             | nano structures in the brain...
             | 
             | Comparing this disgusting moist, fleshy and electric
             | masterpiece of nature with something primitive like a
             | """neuronal""" network or LLM was always ridiculous.
        
               | Windchaser wrote:
               | > Probably an unavoidable property that emerges from the
               | sheer and perverse complexity of the human brain
               | 
               | I don't think complexity alone leads to consciousness.
               | Rather, consciousness is the mechanism by which
               | information is integrated in a relatively resource-cheap
               | fashion: dump all this info into a shared mental
               | workspace, add some reflective awareness of that
               | info/workspace, and _bam_ , you can both process the
               | information in an integrated way, and you're also now
               | aware of it all. The higher-level information processing
               | and the awareness go hand-in-hand.
               | 
               | There're good reasons why most of the leading theories of
               | consciousness focus on information integration. (Baars'
               | Global Workspace Theory, Graziano's Attention Schema
               | Theory, Tononi's Integrated Information Theory, etc.)
        
               | goatlover wrote:
               | I don't see how the sensations of color, sound, etc come
               | out of information integration. Sensory experience along
               | with internal sensations form the hard problem of
               | consciousness.
        
               | LinuxAmbulance wrote:
               | > Probably an unavoidable property that emerges from the
               | sheer and perverse complexity of the human brain
               | 
               | Complexity alone causing consciousness, much like an
               | infinite amount of monkeys coming up with Shakespeare's
               | complete works, is a far flung pipe dream.
               | 
               | The hardware doesn't guarantee the software, but the
               | software can't exist without the appropriate hardware is
               | probably a better way to look at it.
               | 
               | There's so much life out there that survives just fine
               | without consciousness that it seems like a very narrow
               | stroke of luck that it occurred at all.
        
         | srveale wrote:
         | Not trying to be sassy but what definition of AGI are you
         | using? I've never seen a concrete goal, just vague stuff like
         | "better than humans at a wide range of tasks." Depending on
         | which tasks you include and what percentage of humans you need
         | to beat, we could be already there or maybe never will be.
         | Several of these tests [1] have been passed, some appear
         | reasonably tractable. Like if Boston Dynamics cared about the
         | Coffee Test I bet they could do it this year.
         | 
         | [1]
         | https://en.wikipedia.org/wiki/Artificial_general_intelligenc...
        
           | calepayson wrote:
           | > I've never seen a concrete goal, just vague stuff like
           | "better than humans at a wide range of tasks."
           | 
           | I think you're pointing out a bit of a chicken vs. the egg
           | situation here.
           | 
           | We have no idea how intelligence works and I expect this will
           | be the case until we create it artificially. Because we have
           | no idea how it works, we put out a variety of metrics that
           | don't measure intelligence but approximate something that
           | only an intelligent thing could do (we think). Then engineers
           | optimize their ML systems for that task, we blow by the
           | metric, and everyone is left feeling a bit disappointed by
           | the fact that it still doesn't _feel_ intelligent.
           | 
           | Neuroscience has plenty of theories for how the brain works
           | but lacks the ability to validate them. It's incredibly
           | difficult to look into a working brain (not to mention deeply
           | unethical) with the necessary spatial _and_ temporal
           | resolution.
           | 
           | I suspect we'll solve the chicken vs. egg situation when
           | someone builds an architecture around a neuroscience theory
           | and it _feels_ right or neuroscientists are able to find
           | evidence for some specific ML architecture within the brain.
        
             | srveale wrote:
             | I get what you're saying, but I think "boiling frog" is
             | more applicable than "chicken v egg."
             | 
             | You mention that people feel disappointed by ML systems
             | because they don't feel intelligent. But I think that's
             | just because they emerged one step at a time, and each
             | marginal improvement doesn't blow your socks off.
             | Personally, I'm amazed by a system that can answer PhD
             | level questions across all disciplines, pass the Turing
             | Test, walk me through DIY plumbing, etc etc, all at
             | superhuman speed. Do we need neuroscience to progress
             | before we call these things intelligent? People are polite
             | to ChatGPT because it triggers social cues like a human.
             | Some, for better or worse, get in full-blown relationships
             | with an AI. Doesn't this mean that it "feels" right, at
             | least for some?
             | 
             | We already know that among humans there are different kinds
             | of intelligence. I'm reminded of the problem with
             | standardized testing - kids can be monkeys or fish or
             | iguanas and we evaluate tree climbing ability. We're making
             | the same mistake by evaluating computer intelligence using
             | human benchmarks. Put another way: it's extremely vain to
             | say a system needs to be human-like in order to be called
             | intelligent. Like if aliens visited us with
             | incomprehensibly advanced technology we'd be forced to
             | conclude they were intelligent, despite knowing absolutely
             | nothing about how their intelligence works. To me that's
             | proof by (hypothetical) example that we can call something
             | intelligent based on capability, not at all conditional on
             | internal mechanism.
             | 
             | Of course that's just my two cents. Without a strict
             | definition of AGI there's no way to achieve it, and right
             | now everyone is free to define it how they want. I can see
             | the argument that to define AGI you have to first
             | understand I (heh), but I think that's putting an unfair
             | boundary around the conversation.
        
       | calepayson wrote:
       | To anyone interested in this article I highly recommend "The
       | Cerebral Code" by William Calvin.
       | (https://williamcalvin.com/bk9/index.htm)
       | 
       | It's the only theory of how the brain works that I've come across
       | that seems like it could be valid. Unfortunately, like other
       | posters have already mentioned, neuroscience is incredibly
       | complex and we just don't have the tools to test it.
       | 
       | Even if it ends up being completely wrong, it's a beautiful
       | theory and well worth checking out!
        
         | dleeftink wrote:
         | The cerebral code as an ensemble of signals, music. Or rather,
         | music as metaphor of neuronal patterning. Gives another
         | dimension to being 'in tune' with someone.
         | 
         | I think the clinical shift to focus on 'the individual' instead
         | of the ensemble has overlooked the importance of inter-brain
         | synchronisation, the process of which we are only start to
         | grapple [0]. A feeling all to familiar to fellow musicians, and
         | no doubt anyone involved in activities in which timing
         | coordination is key.
         | 
         | [0]:
         | https://www.sciencedirect.com/science/article/abs/pii/S01497...
        
           | calepayson wrote:
           | > Gives another dimension to being 'in tune' with someone.
           | 
           | Love this.
           | 
           | > I think the clinical shift to focus on 'the individual'
           | instead of the ensemble has overlooked the importance of
           | inter-brain synchronisation
           | 
           | My sense is this is also the case for our cultural story of
           | neuroscience. We can run massive analysis of the brain and
           | what brain regions or neurons or transmitters are being
           | used/activated and it all boils down to something we can't
           | conceptualize. Even the principal components seem to be too
           | complex for us to grock.
           | 
           | With this barrage of complexity I feel like we have a (bad
           | but understandable) habit of reducing to the individual. We
           | talk about the grandmother neuron or what region x is
           | responsible for. We harp on the cog sci of individuals and we
           | run experiments where we try to isolate them for "confounding
           | factors" (other people).
           | 
           | I keep coming back to evolutionary theory as the middle
           | ground between this over and under simplification of
           | cognition.
        
             | dleeftink wrote:
             | I cannot find the source right now, but the past 20 years
             | has seen a marked shift from individual to ensemble brain
             | imaging, as individual brain responses (and by extension
             | our imaging data) do not fully reflect or capture our
             | natural state that is often far less compartmentalised. It
             | took some advocacy for the field to move towards multi-
             | brain imaging, not the least due to its technical
             | challenges.
             | 
             | On a deeper level, I also think the prior discrepency stems
             | from how we perceive the world as individuals rather than a
             | collective, our research methods implicitly reflecting this
             | bias. In regards to synchronisation, you might find the
             | following interesting:
             | 
             | "Brain Waves Synchronize when People Interact" [0]:
             | https://www.scientificamerican.com/article/brain-waves-
             | synch...
        
         | n4r9 wrote:
         | Thanks for the link. Have you come across Dennett's multiple
         | drafts model of consciousness, and if so how would you say this
         | compares with that? Scanning the intro section of your link
         | suggests that perhaps Calvin is modelling at a lower-level, but
         | I don't pretend to understand either very deeply.
         | 
         | > Even if it ends up being completely wrong, it's a beautiful
         | theory
         | 
         | Not just that, but I think it's vitally important to be able to
         | demonstrate how much we can _potentially_ explain. There are
         | some people that will never accept a physicalist model, but I
         | suspect there are many who will happily accept it once they
         | conceive of the possibilities. At least, that 's the process I
         | went through when originally learning about evolution by
         | natural selection.
        
           | calepayson wrote:
           | I love Dennett. I think he's a n incredible philosopher, at
           | least when it comes to biology, but philosophy always leaves
           | me wanting for the actual mechanisms.
           | 
           | On a high level, I think Calvin's theory is in the exact same
           | vein as Dennett's. Seems like we could sum them both up by
           | saying the brain is paralleled and there is competition
           | between thoughts?
           | 
           | What grabs me about Calvin's work is he gets much closer to
           | how this might work than anything else I've seen. Even
           | cooler, I think he provides enough depth that we could
           | potentially design a new architecture around his theory.
        
         | alok-g wrote:
         | Am curious, how deep or detailed is this? Is there enough
         | material there that someone could understand and write a
         | program out of it to simulate or make something useful? (My
         | sense looking at the book contents is that it isn't.) Thanks.
        
           | calepayson wrote:
           | It provides a clearer direction than any other theory of how
           | the brain works that I have come across. But no, it's not
           | going to be simple project to implement. Maybe if you've got
           | a strong background in ML you could hack something together?
           | 
           | Still I can't recommend it highly enough. Act I is enough to
           | grock the concept and you can crush it in an evening.
        
       | damnitbuilds wrote:
       | Think this is bad?
       | 
       | Psychology is worse, much worse, and yet is used around the world
       | to make many, many life-changing or life-ending decisions.
        
         | jajko wrote:
         | Which part of psychology?
         | 
         | To me as a layman, getting interested in what makes people
         | tick, how different issues manifest, how bad childhood and
         | especially missing good father figure affects people proved
         | invaluable.
         | 
         | But I dont mean clinical psychology, university textbooks etc
         | but rather easy to digest popular stuff from ie Jordan Peterson
         | (before he got addicted and crazy).
         | 
         | Understanding (ex)girlfriends, colleagues, parents,
         | politicians, everybody and especially myself. People cant shock
         | or surprise me these days.
        
         | mvieira38 wrote:
         | Maybe off topic: I can't for the life of me figure out how
         | therapy isn't a scam. CBT as proposed and studied in lab
         | settings can't really be applied in the wild like most evidence
         | based therapists try to, and the results of therapy I come
         | across always seem extremely underwhelming. Maybe for some
         | cases like severe phobias there is something to be solved, but
         | do we really need to be paying thousands of dollars a year for
         | a therapist to say "hey, maybe if you'd invest more in hobbies,
         | social relationships and a healthy lifestyle you would feel
         | better"?
        
           | bildung wrote:
           | _> CBT as proposed and studied in lab settings can 't really
           | be applied in the wild like most evidence based therapists
           | try to,_
           | 
           | Because that part is wrong, apart from the underlying inner
           | working being dissected in labs (the cognitive science part),
           | the therapy part it is well studied in the wild - and it
           | works.
           | 
           |  _> and the results of therapy I come across always seem
           | extremely underwhelming._
           | 
           | So you mean anecdotes? Of course you recognize the
           | underwhelming results - the people where it worked well are
           | less noticable, by definition.
           | 
           |  _> Maybe for some cases like severe phobias there is
           | something to be solved, but do we really need to be paying
           | thousands of dollars a year_
           | 
           | That you have to pay money has been a decision of the society
           | you reside in. It doesn't have to be this way, and in fact it
           | isn't in most industrialized countries.
           | 
           |  _> for a therapist to say  "hey, maybe if you'd invest more
           | in hobbies, social relationships and a healthy lifestyle you
           | would feel better"?_
           | 
           | That is a strawman, not CBT.
        
           | mtlmtlmtlmtl wrote:
           | >"hey, maybe if you'd invest more in hobbies, social
           | relationships and a healthy lifestyle you would feel better"
           | 
           | "Just saying" the above is not what CBT is, though. I've had
           | a lot of CBT and other kinds of therapy, and I've never had a
           | therapist just tell me "so don't do that", or "do more x".
           | 
           | It's about analysing your own thinking(cognitive) and
           | actions/habits(behavioral) in cases where those are keeping
           | you stuck in a miserable situation, and identifying what you
           | can do to change them.
           | 
           | Sure, if you put the most inanely over-abstracted
           | construction on it like "just live healthier and you'll feel
           | better", it sounds meaningless, but the implicit assumption
           | there is that's something you can just decide to do, and
           | succeed in. That's not the case for many people, and those
           | people can benefit from CBT.
        
           | pixl97 wrote:
           | Eh, therapy can vary widely in quality.
           | 
           | And peoples lives can also vary in quality. If you're raised
           | in a nest of narcissists it is likely you'll have a very
           | skewed view on relationships and your idea of normal could be
           | considerably different from the average and have negative
           | effects on your social relationships. Sometimes you just need
           | a 3rd party to tell you that's not normal.
           | 
           | Coming from a family of narcissists myself they quite
           | adamantly stuck to the idea that therapy was a total scam.
           | Though my observing their behaviors it is my believe they are
           | really saying "Therapy is a total scam because they didn't
           | tell me what I wanted to hear".
        
           | moi2388 wrote:
           | It generally is. People like being heard. But usually they
           | sort themselves out during the first therapy. If that fails
           | usually more therapy doesn't solve anything either.
           | 
           | As somebody who studies psychology.. If a psychological study
           | says A, it's more likely to be actually B. The quality of
           | research is much, much worse than people think.
        
           | fragmede wrote:
           | You can only get out of therapy what you put into it, so if
           | there only problems you are bringing to your therapist are a
           | need for investment in hobbies, social relationships, and a
           | healthy lifestyle, then that's all you're gonna get. Now,
           | it's entirely possible that really is all you need, but for
           | those stuck in traumatic response loops due to eg PTSD from
           | respressed memories of childhood, leading to, say, a string
           | of failed relationships with toxic people who don't respect
           | your boundaries because you didn't have a good model for them
           | growing up, therapy can be quite useful for helping people
           | heal from generational trauma and break the cycle. It sounds
           | cliche to blame it all on bad reaction to things that
           | happened in childhood, but, well, we did all have one (unless
           | you didn't; early parentification is an acknowledged failure
           | mode), and even if the worst was emotional stunted parents
           | (as documented by the book Adult Children of Emotionally
           | Immature Parents), childhood that was totally fine on the
           | surface may not have been.
           | 
           | Again, of course, if you are a well adjusted adult, and no
           | one in you life is clamoring for you to get therapy, then
           | chances are, either you've pushed anyone and everyone away
           | that cares for you that deeply, or you don't need it, both of
           | which are totally possible.
           | 
           | As for if it's a scam? That word gets thrown around too
           | easily these days. Do they cost a lot? Yes. Are you worth it?
           | Also yes. That's not to say all therapist are equal, and
           | someone that's great for you might be terrible for the next
           | person, and some of them are just bad. (There are also those
           | that are quite good!) As there are with all things. Going
           | into therapy with specific goals on things you want to work
           | on (eg irrational anger at some specific thing that's ruining
           | your life) tends to help it not be just an ongoing extra
           | expense like a gym membership, if that's not what you want.
           | At the end of the day, they're stuck in the system as much as
           | you are, and paying them also makes it feel more balanced in
           | that they're being paid listen to you go on and on and help
           | you with your ish. You wouldn't/shouldn't treat your friends
           | so one-sidedly. That said, it's entirely possible to pay to
           | see a therapist and not get anything out of it. I will admit
           | to that as a possible failure mode, but it's a failure mode
           | and there are certainly success stories out there of people
           | turning their life around and becoming happy well-adjusted
           | adults.
        
           | keybored wrote:
           | What's the practical difference wrt. psychology (whether it
           | can solve it) between the problem of not being able to get
           | over a phobia and the problem of not being able to apply
           | rationally simple life advice? Why is the former "something
           | to be solved" but the latter one is not?
        
           | pocket_cheese wrote:
           | I think therapy can be used very strategically. Maybe you
           | want to end a friendship and don't know how to break it to
           | them. Or maybe you don't like the way you are being treated
           | by someone and you want to know effective ways of setting
           | boundaries. Therapy can be super useful in giving you the
           | tools to confront difficult emotional/psychological
           | situations.
        
       | dvh wrote:
       | "Human brain is too big to be understood with current technology,
       | that's why scientists use simpler organisms to study brain.
       | Flatworm's brain has 52 neurons. We have no idea how it works."
       | 
       | I've read this few years ago, how far we've come?
        
         | xkcd-sucks wrote:
         | Just for cultural reasons, a roundworm's brain with 302 neurons
         | (each one always in the same place spatially and topologically
         | I might add) is likely better understood. And we don't have a
         | great idea of how it works. But the OpenWorm simulation project
         | seems to have current development
         | https://github.com/orgs/openworm/repositories
        
       | leptoniscool wrote:
       | it looks like we can now actually use brains as computers:
       | https://corticallabs.com/
        
         | perching_aix wrote:
         | i'm simultainously unsurprised and blown away. i should rewatch
         | the anime _Psycho Pass_ sometime.
        
           | Gooblebrai wrote:
           | How is the anime related?
        
             | perching_aix wrote:
             | The show is oriented around a fictitious law enforcement
             | technology called the Sibyl System. This system is capable
             | of determining the intent of people, and based on that, it
             | can predict crimes and criminal intent, allowing law
             | enforcement to preventively take action. The kicker is, as
             | the MC learns, that there are people who the system doesn't
             | seem to work on.
             | 
             | Minor(?) plot point spoiler ahead for season one:
             | 
             |  _Later on the story the main character further learns that
             | the system is actually a mainframe made up of living human
             | brains connected together. Hence the relation._
        
         | Gooblebrai wrote:
         | I'm really fascinated by the idea of biological computers.
         | Doesn't get enough recognition.
        
       | pedalpete wrote:
       | We keep plugging biology into our understanding of physics, which
       | I believe, is the greatest limitation to our understanding. We
       | don't know what we don't know.
       | 
       | What I mean by this is that we thought we understood the body
       | when we understood thermodynamics. The blood pumps through the
       | heart, goes to the brain, nutrients feed the muscles, etc etc.
       | Then we discovered how electricity works and we thought "oh! of
       | course, it's all electric!" The heart pumps because of
       | electricity, and the nerves are all electric synapses, etc etc.
       | 
       | I fully expect in the future we will look at quantum mechanics
       | and apply that to our understanding of biology (if we aren't
       | doing that yet), and down the rabbit hole we will continue.
       | 
       | That doesn't mean we can't do some incredible things with our
       | current understanding of the brain, I work in neurotech at
       | https://affectablesleep.com, where we are increasing the
       | effectiveness of deep sleep. We know the mechanism we can use to
       | trick the brain to increasing the synchronous firing of neurons
       | which define deep sleep, but we don't know WHY it works.
        
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