[HN Gopher] Microplastics in the human brain
       ___________________________________________________________________
        
       Microplastics in the human brain
        
       Author : headclone
       Score  : 223 points
       Date   : 2025-02-06 01:13 UTC (21 hours ago)
        
 (HTM) web link (www.smithsonianmag.com)
 (TXT) w3m dump (www.smithsonianmag.com)
        
       | bhaney wrote:
       | > not a spoonful, but the same weight as a plastic spoon
       | 
       |  _oh_
        
         | SecretDreams wrote:
         | That's not great
        
         | silisili wrote:
         | That's both a misleading headline and a really odd unit of
         | measurement. So odd that I wouldn't be surprised if the US
         | adopted it as the official unit of measurement of microplastics
         | (I kid, as an American).
        
           | ryandrake wrote:
           | How many Bald Eagle Per Football Fields would that amount to?
        
         | smnrchrds wrote:
         | - There is a horrifying 512-ounce version that they call Child
         | size. How is this a Child-sized soda?
         | 
         | - Well, it's roughly the size of a two-year old child, if the
         | child were liquefied.
        
         | mindwok wrote:
         | I find this hilarious. Why would they choose such a misleading
         | unit
        
           | card_zero wrote:
           | Isn't it about the same?
           | 
           | How big is a spoon, anyway?
        
         | upghost wrote:
         | do we need a unit conversion for how many spoonfuls of plastic
         | are in a plastic spoon?? seems like it might be important for
         | this article.
         | 
         | Well article says a teaspoon has 7g mass, and just spitballin
         | here but I'd say a plastic spoon has about 1g/cm^3 density. And
         | there are 4.83cm^3 in a teaspoon. So I guess in fact there are
         | 1.44 teaspoons of teaspoon in the brain. Or would that be 1.44
         | tsp^2...?
         | 
         | But I'm an American and I have at least 3 imperial teaspoons of
         | microplastic in my brain or gosh darnit I'm 2 bald eagles short
         | of a touch down. If you know what I'm sayin.[1]
         | 
         | [1]: https://news.ycombinator.com/item?id=42958104
        
         | TZubiri wrote:
         | So more
        
       | chiefalchemist wrote:
       | As I understand it, they took a small sample of brain tissue,
       | extracted the plastic, and then extrapolated that (based on the
       | tissue sample size) over the whole of the brain.
       | 
       | This assumes the presence of plastic is evenly distributed
       | throughout the brain, which isn't necessarily the case.
        
         | robocat wrote:
         | I am hoping that they discover that polyethylene is a natural
         | component of brain chemistry.
        
           | jondwillis wrote:
           | What about polystyrene, polyvinyl chloride, et. al?
        
         | medellin wrote:
         | I would think that we would be seeing a lit more issues if we
         | had that much plastic just in our brain. But maybe our body
         | doesn't mind all that much. I guess we will see how things play
         | out in another 30 years though.
        
           | chiefalchemist wrote:
           | Huberman Labs has been mentioning plastics in the body
           | frequently.
           | 
           | Don't laugh, but I'm getting a new toothbrush to be safe.
        
         | mythrwy wrote:
         | This is one of those headlines that smells like nonsense before
         | even reading the article (doesn't mean it is nonsense, but the
         | quantity advertised seems implausible).
        
       | megamike wrote:
       | just a spoon full of plastic helps the medicine go down the
       | medicine go down the......
        
       | koolala wrote:
       | I thought it was our gonads that had the most?
        
         | jdiff wrote:
         | This statement isn't necessarily at odds with that one.
        
       | shironandonon_ wrote:
       | I like the analogy where other articles have said we have
       | microplastics in our brain about the size of a credit card (which
       | generally weigh between 4g and 10g) better.
       | 
       | Saying a "spoon's worth" seems to be downplaying the unmitigated
       | potential risk. We have no idea what will happen as we (and all
       | the other creatures on earth) keep storing more and more
       | microplastics in our organs.
       | 
       | Nobody is going to stop driving. Car tires are the largest source
       | of microplastics.
       | 
       | (actually I don't drive though so who am I to judge)
        
         | roenxi wrote:
         | > unmitigated potential risk
         | 
         | The risk does seem fairly mitigated, most of us will make it
         | through today fine. The only part of my brain I can account for
         | now is the 1x credit card worth of plastic, all the other bits
         | are a mystery. Death was inevitable before the microplastics,
         | remains inevitable after the microplastics and things seem fine
         | so far.
         | 
         | We don't know much about the risks of anything. People
         | regularly douse themselves with mind-altering substances and
         | ingest the weirdest variety of stuff.
        
           | rTX5CMRXIfFG wrote:
           | Shortening your period of observation so that the effects
           | have not occurred yet does not mean it's "mitigated".
           | 
           | And your philosophy of your own mortality is just as
           | reductive, because humans have been trying to survive since
           | time immemorial and do not actively work on their deaths
           | unless in an unhealthy mental state.
        
             | card_zero wrote:
             | Seems like a more important problem, then, the part where
             | people inevitably die. I mean compared to having some
             | plastic in their heads.
        
             | johnnyanmac wrote:
             | I mean, what are we really going to do about it? So much
             | chaos in the world, I don't think many are focusing on
             | keeping plastics out of our body. No one's championing it.
        
           | SmirkingRevenge wrote:
           | Would be nice if just once these sorts of things could have
           | beneficial effects.
        
             | card_zero wrote:
             | Like the ship-produced aerosols that seeded clouds,
             | increased albedo, and cooled the planet, in what James
             | Hansen has called a "Faustian bargain". We successfully
             | stopped that with regulations.
        
           | itishappy wrote:
           | > The risk does seem fairly mitigated, most of us will make
           | it through today fine.
           | 
           | This is an incorrect usage of the word "mitigate." To
           | mitigate means to lessen the risk. Mitigation requires
           | action.
           | 
           | I suspect you mean that the risks are "overstated."
        
             | roenxi wrote:
             | I barely think the risks have been stated at all. They
             | found a correlation between high levels of microplastics in
             | the brain and dementia. There is a correlation between a
             | bunch of things and dementia. I expect there is a
             | correlation between good health and dementia, unhealthy
             | people would tend to die off young without the time to fall
             | apart mentally.
        
         | tcfhgj wrote:
         | > Nobody is going to stop driving. Car tires are the largest
         | source of microplastics.
         | 
         | many already have, bicycles and public transport ftw
        
           | lenerdenator wrote:
           | There's realistically fewer than twenty metro areas in the US
           | where the majority of commuters could rely solely on biking
           | and public transit for everything. Twenty might be generous,
           | even.
        
             | sien wrote:
             | Since the pandemic passenger car miles, airline miles are
             | back at pre-pandemic levels.
             | 
             | Transit use is at 80% of pre-pandemic levels.
             | 
             | https://ti.org/antiplanner/?p=22722
             | 
             | Farebox recovery ratios have consequently become even
             | worse.
             | 
             | The new US government is also presumably not going to fund
             | much transit expansion.
             | 
             | It'd be interesting to see if more people work from home on
             | a given day than use mass transit to get to work.
             | 
             | It's also pretty similar in Australia at least and probably
             | in more places around the world.
        
             | idle_zealot wrote:
             | There is a positive spin on this: the majority of Americans
             | already live in or near dense urban centers. If we had
             | solid public transportation only within these centers and
             | to adjacent suburbs we would eliminate most car trips.
             | That's bot much physical area to cover.
        
               | lenerdenator wrote:
               | Depends on what you consider "in or near".
               | 
               | I live "in" a major American city. Well, a reasonably
               | major Midwestern city. It's roughly a third the size of
               | Rhode Island. It has half a million people in it.
        
             | raddan wrote:
             | That may be true, but you don't have to rely on biking for
             | "everything." Some biking is better than no biking.
             | 
             | I live in a small college town a couple of miles from the
             | college. I walk, run, or bike to work nearly every day. But
             | I am not a purist about it. We have a snowstorm forecast
             | for tomorrow so I am going to drive (my EV). Would it be
             | better for the environment if I walked? Probably? Does one
             | trip really make that much of a difference though? Probably
             | not.
             | 
             | I think there are likely many many places where people can
             | walk or bike to some of the things if not all of the
             | things. People really should do that more (not the least
             | reason because biking is wonderful). Biking to the grocery
             | store is mostly impractical for me as it is many miles
             | away. But that's ok! I am doing other things.
        
           | knowitnone wrote:
           | still rubber so still microplastics?
        
             | tcfhgj wrote:
             | Less!
        
           | pants2 wrote:
           | Unfortunately a bicyclist on the road will be exposed to far
           | more tire microplastics than drivers in their enclosed cabins
           | with filtered and recirculated air.
        
         | card_zero wrote:
         | To me, the spoon sounds scarier. But I don't think there's a
         | right answer to how scary a new phenomenon should be made to
         | sound. You want it to sound scarier, this thing we don't know
         | much about? Won't that happen naturally since everybody's ready
         | to be scared of news anyway? Is it being downplayed? Relative
         | to what, hunches? The information should be presented
         | dispassionately, but engagingly, and that is an impossible
         | combination, so it what we'll actually get is always something
         | with the wrong overtones.
        
         | wruza wrote:
         | Not to mention that all spoons are different. I always get
         | confused about "half a spoon". Is it half of a "pile" or there
         | must be half of its surface visible from above, while the
         | subject matter is flat in the spoon (i.e. the lateral
         | projection shows only the spoon). And should you account for
         | the pile slope in case of bulk materials? And then when you
         | figure that out, your spoon may be anywhere 0.5-1.5x in
         | size/depth than someone else's. It may be literally 3x times
         | more or less. But even that is still less inexact than
         | measurement extrapolation methods that the article uses,
         | according to the top commenter.
        
           | plagiarist wrote:
           | I was trying to figure out from the headline if they meant
           | enough microplastics to fill the bowl of a spoon or
           | microplastics equivalent to a plastic spoon. I don't know why
           | everyone is allergic to weights and measures.
           | 
           | If they're going for shock value they should use something
           | more sinister than a spoon. Like enough plastic to make a
           | little decorative Halloween spider. People would be more
           | frightened by a spider than a spoonful of plastic.
        
       | adriand wrote:
       | The only good news here is that it's possible that the body can
       | clear the plastics. This is from the linked study:
       | 
       | > While we suspected that MNPs might accumulate in the body over
       | a lifespan, the lack of correlation between total plastics and
       | decedent age (P = 0.87 for brain data) does not support this
       | (Supplementary Fig. 1). However, total mass concentration of
       | plastics in the brains analyzed in this study increased by
       | approximately 50% in the past 8 years. Thus, we postulate that
       | the exponentially increasing environmental concentrations of
       | MNPs2,14 may analogously increase internal maximal
       | concentrations. Although there are few studies to draw on yet
       | performed in mammals, in zebrafish exposed to constant
       | concentrations, nanoplastic uptake increased to a stable plateau
       | and cleared after exposure15; however, the maximal internal
       | concentrations were increased proportionately with higher
       | nanoplastic exposure concentrations. While clearance rates and
       | elimination routes of MNPs from the brain remain uncharacterized,
       | it is possible that an equilibrium--albeit variable between
       | people--might occur between exposure, uptake and clearance, with
       | environmental exposure concentrations ultimately determining the
       | internal body burden.
       | 
       | Which means that if we were to take action on this, we might
       | actually be able to reduce our exposure. Unfortunately, things
       | are going in the wrong direction.
       | 
       | I keep thinking it would be nice if microplastic exposure were to
       | start generating the kind of focus and controversy that is
       | currently taking place with vaccines and autism spectrum
       | disorder.
        
         | russdill wrote:
         | My understanding is the best thing you can be doing along with
         | reducing exposure is regular blood donation
        
           | ericd wrote:
           | So what you're saying is that leeches as medicine are coming
           | back.
        
           | lemonberry wrote:
           | Interesting. My father has received a ton of donor blood over
           | the past few years. Once he's gone I'll be donating
           | regularly. My father's alive because dozens of people
           | donated.
           | 
           | To anyone here that has made a deposit to the blood bank: we
           | thank you.
        
             | knowitnone wrote:
             | blood bank CEO thanks you too because the make millions
             | selling your blood
        
               | Loughla wrote:
               | Go away. Just go away. Sometimes too much cynicism is
               | toxic.
               | 
               | Donating blood is good for other people regardless of the
               | profit motive from the company.
               | 
               | And if you're talking about the Red Cross, their CEO is
               | reported to make less than 700k/year.
               | 
               | That's not bad for running one of the largest medical
               | non-profits in the world.
        
               | johnnyanmac wrote:
               | Cool, what was I gonna do with it? Unless we're selling
               | to Dracula, owning external blood is highly regulated. So
               | anyone buying has some credentials to use it.
        
           | throwaway657656 wrote:
           | dilution is the solution to the pollution
        
           | card_zero wrote:
           | Pass the microplastics along to some other sucker, a cunning
           | plan.
        
           | TZubiri wrote:
           | So bloodletting?
        
         | throwaway657656 wrote:
         | >>environmental exposure concentrations ultimately determining
         | the internal body burden.
         | 
         | As another commenter asked "How did the amount of brain
         | microplastic manage to double between 2016 and 2025?" It is
         | doubtful that the environmental concentration level doubled
         | during this time.
        
       | mreid wrote:
       | I must have some of that microplastic in my brain since I misread
       | the start of the title as "Human, Brian May, ..." and then
       | couldn't parse the rest properly.
        
       | scotty79 wrote:
       | Cool. Now how much sand is in your brain? Equivalent of two glass
       | spoons? Sand dust is way more abundant than plastic and similarly
       | inert.
        
         | kijin wrote:
         | Depends on where the sand is. I don't want that stuff in my
         | lungs.
        
           | pulvinar wrote:
           | Lungs have been dealing with sand dust since there were
           | lungs, have they not?
           | 
           | Honest science on a foreign material in the brain or body
           | should be able to present a baseline amount of total foreign
           | material for comparison.
           | 
           | If our environment is now 10% microplastics, then 10% of the
           | foreign material found in the brain being microplastics would
           | be normal.
        
             | drawkward wrote:
             | Such an easy point, and yet the parent posters dont get
             | it...
        
         | pfdietz wrote:
         | Or plant fiber. You eat enormous amounts of this stuff that you
         | can't break down.
        
         | crazygringo wrote:
         | You're being downvoted, but I think it's a really good
         | question.
         | 
         | We eat and breathe all sorts of stuff that comes in nano-sized
         | particles. We've been inhaling smoke from cooking fire, eating
         | plant matter crushed between rocks rubbing against each other,
         | drinking water with dissolved bits of all sorts of things, and
         | so forth for many millenia now.
         | 
         | The body seems to have mechanisms to clear most of this stuff
         | out of us over time, no? Isn't our body chock-full of waste
         | products from our cells that are constantly getting flushed
         | out? Is there any reason to think that nanoplastics would be
         | different?
        
       | Kapura wrote:
       | Remember that car tire degredation is a significant portion of
       | microplastics in the environment. Investing in mass transit is as
       | imperative as it was to move away from leaded gasoline.
        
         | mythrwy wrote:
         | Move away from big cities and high traffic areas in the
         | meantime is my solution.
        
           | dymk wrote:
           | Hope you never have to drive to the grocery store
        
             | forgetfreeman wrote:
             | Hope you never have to haul a family of 4 worth of
             | groceries on a bus.
        
               | dashundchen wrote:
               | I do on a bike or walking weekly, it's not that crazy.
               | 
               | In a prewar US mid sized city, the density supports
               | multiple grocery stores I can reach in about the same
               | time as driving and finding parking.
        
               | forgetfreeman wrote:
               | Groceries. For a family of four (4). On a bicycle. Sure.
               | How many times a day do you make the trip?
        
               | andrewshadura wrote:
               | What's so crazy about that? Never seen a bicycle with
               | panniers and a basket? Or a cargo bicycle?
        
               | forgetfreeman wrote:
               | I've seen what a week's worth of groceries looks like for
               | four people and short of a rickshaw you ain't getting all
               | of that on a bicycle with or without panniers. I'm fairly
               | certain the respondent is coyly ignoring the headcount
               | requirement in my original sneer.
        
               | dashundchen wrote:
               | I make at least trip one trip a week. Why would I need to
               | go every day?
               | 
               | I may stop by a store again during the week for a smaller
               | trip if there's something I really need, or pop to a
               | corner store if I need to grab something like drinks for
               | guests, but it's not out of my way.
               | 
               | It's really not a big deal. Bike panniers can hold a ton.
        
               | hombre_fatal wrote:
               | Trivial if you leave near a grocery store. If you live in
               | most US cities, much more the suburbs, then being
               | dependent on your vehicle to do literally anything is
               | part of the problem. In very few places in the US can you
               | choose to do otherwise.
        
             | mc3301 wrote:
             | 15 minute cities is the answer.
        
             | bilbo0s wrote:
             | Not only that, but if you're close to a road at all, you'll
             | intake the micro-plastics and nano-plastics.
             | 
             | So you really need to move away from roads. That's
             | possible, but it's really hard to do in most developed
             | nations. Just moving away from a city won't get you to
             | where you need to be. Even when you get there, you have
             | other issues. Like, food, energy, water/sewage treatment,
             | etc.
             | 
             | I don't think people realize how difficult it would be to
             | get away from this particular pollutant in our environment.
             | I mean most of us don't own 500 acres in the Brazilian,
             | Namibian, or Ghanaian countryside that we can retreat to.
             | Even Brazil may be too far gone at this point to be honest.
             | And Brazil is enormous. A lot of space. The number of
             | tolerable nations that would have unaffected areas is
             | decreasing fast. This really is a global problem.
             | 
             | ETA: Some remote parts of Canada and Alaska might fit the
             | bill? Assuming you're not big on quality of life.
        
               | idiotsecant wrote:
               | You can have really very good quality of life in remote
               | areas. You just might die before you get help if you have
               | a heart attack or something. But the rest of the time
               | it's great!
        
             | mythrwy wrote:
             | I don't think you understand where I'm living.
             | 
             | "Microplastic Free", no, there is no such thing right now.
             | But I'm very far from any major roads/interstates and
             | hundreds of miles to any big city. I didn't move out here
             | to avoid microplastics though, it just (maybe) turned out
             | that way.
             | 
             | I'm actually not terribly afraid of microplastics at all, I
             | just don't like urban environments.
        
             | epistasis wrote:
             | Imagine a grocery store that is within a short walking
             | distance, such that you don't need to haul a weeks worth of
             | groceries but can get fresh food every single day.
             | 
             | US supermarkets are massive, take forever to buy small
             | amounts of groceries, and even the walk to and from the car
             | is long.
             | 
             | A better world is possible! (If better grocery stores
             | constitute a "better world")
        
               | bluefirebrand wrote:
               | > you don't need to haul a weeks worth of groceries but
               | can get fresh food every single day
               | 
               | I lived that life in my 20s
               | 
               | Turns out I don't actually want to go to the grocery
               | store every day. I want to go once a week and stock up,
               | which I can do thanks to inventions like the refrigerator
               | and the automobile
        
               | lurking_swe wrote:
               | no judgment on you in particular, but i'm not a fan of
               | this thought process. I believe it's a major cause for
               | why americans (statistically) are so obese. and i say
               | this as an american that lives in a city but has family
               | in the suburbs.
               | 
               | running errands with your own two feet every day by
               | walking, cycling, etc keeps people healthy and lean. this
               | country has a major car problem. it's sad.
               | 
               | of course one can go to the gym to stay lean and healthy,
               | but that's even more time consuming than stopping by the
               | store for 5 minutes on the way home, and it requires
               | extreme motivation. Hardly an improvement i'd say.
        
               | imp0cat wrote:
               | one can go to the gym
               | 
               | And by that you mean drive to the gym, right? ;)
        
               | bluefirebrand wrote:
               | > running errands with your own two feet every day by
               | walking, cycling, etc keeps people healthy and lean. this
               | country has a major car problem
               | 
               | I did live this exact lifestyle in my 20s. I was
               | definitely more active but my diet was way worse. I was
               | closer to a lot of restaurants, and I was closer to a lot
               | of bakeries and convenience stores and such as well.
               | 
               | A healthy lifestyle also requires a healthy diet and city
               | living gave me far too much easy access to snacks and
               | junk food. A lot of "it's only 5 minutes to go buy a
               | snack". Daily stops for coffee that often included a
               | pasty
               | 
               | Yeah, the walkable city does mean people are more active
               | 
               | It doesn't necessarily mean they are much more healthy.
               | It still requires other forms of self control (which I
               | admit, I struggled with)
        
               | globular-toast wrote:
               | I don't believe it. If you lived right next door to the
               | grocery shop would you still only go once a week and
               | stock up?
               | 
               | Nobody wants less flexibility, rigid plans and higher
               | maintenance costs. I think what you really want is a big
               | house with lots of space away from other people and since
               | you can't have your cake and eat it too you've sacrificed
               | everything else.
        
               | bluefirebrand wrote:
               | You got me
               | 
               | I actually did live in an apartment a block away from a
               | grocery store and yes, you're right. I would not trade my
               | current house for having a grocery store that close
               | 
               | Because living in apartments sucks
               | 
               | But even if I did live in my current house with a grocery
               | store right next door, I still would prefer to go as few
               | times a week as possible. Planning ahead and limiting how
               | often I am at stores helps me tremendously with sticking
               | to a budget, which is also something I place a lot of
               | value on
               | 
               | When I lived close to a grocery store not only did I
               | spend more because the prices were higher, I also made
               | more frequent trips for things on a whim, like snacks and
               | treats. It was a much more expensive lifestyle
               | 
               | Maybe other people don't have that same struggle with
               | convenience, but I do. By making the barrier higher, my
               | life is more affordable and I eat less junk food for sure
               | 
               | This is all just my experience though
        
               | epistasis wrote:
               | Well good news, nothing is stoping you from bringing home
               | a full cartful of groceries that walking distance either.
               | You just have more options.
               | 
               | Now, if you are really attached to your car and are only
               | open to using your car for groceries, stay in suburbia,
               | it's oversupplied through centralized planning and not at
               | risk of going anywhere!
        
               | bluefirebrand wrote:
               | > Well good news, nothing is stoping you from bringing
               | home a full cartful of groceries that walking distance
               | either
               | 
               | Dunno about you but I only have two hands and can only
               | carry so much at one time
               | 
               | I could have bought and brought a wagon or something I
               | suppose, but that presents its own problems.
               | 
               | Where do I store the wagon in my tiny apartment?
               | 
               | What do I do with it when I'm actually in the store
               | shopping, to make sure no one steals it while I'm in the
               | store? I can't bring it into the store, it's too bulky
               | for narrow urban grocery store aisles
               | 
               | How do I get my wagon full of groceries to my apartment,
               | with no elevator?
               | 
               | Actually how do I get my empty wagon up to my apartment
               | even, it's not going to manage narrow stairwells very
               | easily even empty. So even if I leave it at the bottom
               | and carry my groceries up by hand, I still have to get
               | the wagon itself upstairs somehow
               | 
               | And then I also own a wagon that takes up my limited
               | apartment space, which I only use to get groceries and
               | provides no other utility for my life.
               | 
               | Unlike a car which I use all the time and only one of
               | those uses is getting groceries
        
               | ergl wrote:
               | Have you never heard of a shopping caddy?
               | https://en.wikipedia.org/wiki/Shopping_caddy
               | 
               | They're incredibly popular here, and yes, all
               | supermarkets will have a lock stand near the checkout
               | area so you can leave them there and easily reach for
               | them as you're bagging your groceries. They're also
               | foldable and/or small enough to fit in almost any closet.
        
             | nozzlegear wrote:
             | My grocery store is literally in another town 20 miles
             | away. I have an EV but apparently those are even worse for
             | microplastic generation. Am I screwed?
        
               | raddan wrote:
               | An EV is objectively not worse for the environment. And
               | virtually all vehicles contain large amounts of plastic
               | (eg PVC). I recently heard model year 2024 vehicles are
               | ~30% plastic by weight.
               | 
               | I'd wait until somebody can clearly state what the
               | demonstrated harms of microplastics are before you
               | conclude that there's nothing you can do. An EV reduces
               | emissions that we KNOW are bad, and over their lifetimes,
               | the reduction is huge compared to an ICE vehicle. If
               | you're worried, though, walk or bike whenever you can.
               | 
               | Biking to grocery store is not an option for you, but you
               | can still make a difference if you think about it. Eg, go
               | to the store less frequently. Switch to a chest freezer
               | for perishables. And so on. Draw up an energy budget and
               | do the math.
               | 
               | There is a cost to human life, sure. But you can make it
               | work if you really care enough. You are definitely not
               | screwed.
        
           | shironandonon_ wrote:
           | Doesn't work. It's in the rainwater. No rainwater on earth is
           | safe to drink.
           | 
           | https://www.bbc.com/news/science-environment-62391069
        
             | mythrwy wrote:
             | Does osmosis remove? Is it in all groundwater?
             | 
             | Because I have a well. A deep one. And an osmosis system.
        
               | idiotsecant wrote:
               | Do you consume drinks? Meat? Produce? All these things
               | are chock full of their own micro plastics. It's
               | unavoidable. We can probably reduce contamination but our
               | children's children's children won't be free of it, not
               | until organisms evolve to efficiently eat it. Then we'll
               | have whole other sets of problems.
        
               | mythrwy wrote:
               | Do I consume drinks? No, except water and instant coffee,
               | no soda, no beer. Meat? Yes in small quantities and much
               | of it comes from the local environment. I grow most of my
               | own produce, with RO water.
               | 
               | Yes they are unavoidable, just the plastic containers etc
               | probably give some and I do eat candies and imported
               | bananas and bread etc. But pretty sure I get a lot lower
               | dose than most people.
               | 
               | However I'm not sure it matters that much until a
               | mechanism of actual damage is established.
        
               | raddan wrote:
               | > However I'm not sure it matters that much until a
               | mechanism of actual damage is established.
               | 
               | This is the thing about all the microplastics articles I
               | see popping up: they rarely include any description of
               | harm. If they even mention it, it is only speculative, as
               | in this article. Until I read a scientific article about
               | real harms, I am going to regard most of the
               | microplastics news as fearmongering. Humanity has been
               | surrounded by vast quantities of plastic for decades; if
               | there was a big effect, wouldn't we have seen it by now?
               | If it has big effects, those effects would be surprising,
               | which means that the evidence would have to be strong. I
               | don't see a lot of strong evidence.
               | 
               | If anyone reading this has a paper like this, please
               | share.
        
               | albertsondev wrote:
               | That is perhaps the most insidious property of all when
               | it comes to microplastics--it's incredibly difficult to
               | work that out.
               | 
               | We don't have control groups, they're found in virtually
               | every complex organism on Earth, including (best we can
               | tell) all humans, so we can't form a control group. We've
               | only recently really started to notice, care, or study
               | them, so we don't have strong historical data to compare
               | against. We don't have many isolated populations
               | (especially of large enough size) where microplastic
               | bioaccumulation is the only major difference in how their
               | lives have changed in biologically relevant ways over the
               | decades, so we can't effectively isolate the effects of
               | microplastics from other confounding factors.
               | 
               | So you have these things that basically became completely
               | ubiquitous--an unavoidable fact of not just human life,
               | but all complex life on Earth--before anyone realized,
               | with several other major global factors shifting
               | concurrently. The end result is that, by the tools and
               | methods with which we perform science, it's nearly
               | impossible to study their exact effects. Maybe they're a
               | slow-burning apocalypse subtly disrupting the mechanisms
               | of life at their most fundamental levels and only getting
               | worse with time, or maybe they do nothing or next to
               | nothing like having a glass of sherry with your Sunday
               | brunch once a week, or maybe they're somewhere in that
               | vast, murky expanse in between the two extremes. Hell,
               | there might even be a net benefit somehow. We just plain
               | don't know, and don't know how we could know, so
               | speculation is just about all we've got at present, and
               | without knowing it's really hard to say if the messaging
               | and literature surrounding the subject is aggressively
               | over-alarmist or recklessly under-alarmist. The best
               | we've really got is the simple fact that we notice them
               | now, and thus have the chance to pay close attention,
               | part of which is regularly taking basic measurements like
               | these to try and correlate trends.
               | 
               | About all we do know is that they weren't here before,
               | and "before" encompasses 99.9999% of all life that we
               | know to have ever existed, so it's definitely weird and
               | maybe probably bad.
               | 
               | There's definitely criticism to be had with the broader
               | state of public health and science communication that
               | harm, or at least the understanding that "we have
               | literally no idea what the broader implications of this
               | are but they're maybe probably not good", are considered
               | to be implicit, either due to fallacious appeal to nature
               | or the simple fact that alarmist headlines catch more
               | attention, generating more traffic and revenue, and thus
               | acceptance rates and grant money downstream. Which is, I
               | think, the real core of the issue.
        
               | mrguyorama wrote:
               | There is no strong evidence of anything yet, but consider
               | how long it took to "prove" to society's satisfaction
               | that cigarettes are harmful, despite most scientists
               | finding the lung cancer connection quite clear from
               | pretty early. Comprehensive and long term data takes a
               | long time. It could be worth it to be cautious in the
               | meantime.
               | 
               | If microplastics are making our lives 10% worse in some
               | dimension, we will have to stumble onto what that
               | dimension would be basically by luck and then spend at
               | least a decade rigorously studying it before we could
               | make useful assertions.
               | 
               | The hubub about microplastics is that, we don't have
               | great civilization wide health data on most health
               | dimensions, so we don't even have good baselines to
               | figure whether we have regressed in many ways. IF there
               | is a negative effect, _it will effect everyone all over
               | the planet and there is no escape_
               | 
               | It's an extreme corner of the likelihood/amount of harm
               | graph, and some people think that corner of the graph
               | warrants caution even before harm is proven.
               | 
               | It's the same situation we faced with leaded gasoline,
               | and the US is pretty bad when it comes to those kinds of
               | "mild, diffuse harm that mostly affects people who can't
               | afford whatever system the wealthy use to avoid the harm"
               | problems.
               | 
               | It's not fearmongering, we are literally gambling that
               | microplastics have minimal harm right now.
        
               | UniverseHacker wrote:
               | > I grow most of my own produce, with RO water
               | 
               | Do you really grow enough food to make up most of your
               | diet on RO water? And is this specifically to avoid
               | microplastic exposure, or what?
        
               | mythrwy wrote:
               | I grow around 1/3 of my own food. Yes all with RO water.
               | I'd like to get above 50%.
               | 
               | Specifically produce, however we grow most of what we
               | eat. We pressure can, dehydrate and ferment to preserve.
               | I have background and decades of experience in growing,
               | which is to say it's more than just standard hobby garden
               | level.
               | 
               | The RO water is not to avoid microplastics (although that
               | might a side benefit) but rather that the water is highly
               | mineralized. It would be a long post to explain why I do
               | this. Some is theoretical health concerns, some is more
               | practical.
        
               | timeon wrote:
               | This is really interesting. Do you have suggestions how
               | to use RO in garden scale? (Like link where could I
               | start)
        
               | mythrwy wrote:
               | I built my own RO system it cost around $1500 including a
               | water softener. There are some ongoing supplies every
               | year, maybe $200 or less.
               | 
               | I don't have any links I just figured it out, but it's
               | not super complicated. I made it out of undersink RO
               | membrane housings (housings from those little RO systems
               | you can buy for around $300 that do a couple of gallons a
               | day). The membranes have pressure pumps in front of them
               | that get it up to a couple hundred gallons RO water total
               | a day.
               | 
               | Basic steps are 1) Soften the water, 2) Pass it through
               | very tight filters (like 1 micron), I also carbon filter
               | for organic contaminants, 3) Booster pumps put water
               | through osmosis membranes and from there into a storage
               | tank.
               | 
               | I just used plastic totes with gravel in the bottom to
               | house the membranes and booster pumps.
               | 
               | I should write up a blog post on it one day because
               | professionally installed osmosis can be expensive.
        
               | timeon wrote:
               | Thanks!
        
               | UniverseHacker wrote:
               | Interesting, thanks!
        
               | card_zero wrote:
               | I guess the polyamide filter in that system isn't putting
               | microplastic particles in the water? Probably not.
        
               | tocs3 wrote:
               | 6 months ago on HN "Boiling and filtering can remove
               | microplastics from drinking water: study:
               | 
               | https://news.ycombinator.com/item?id=41193531
        
               | sebmellen wrote:
               | Nanofiltration or reverse osmosis will be most effective:
               | https://www.epa.gov/sciencematters/reducing-pfas-
               | drinking-wa... (save the site while the EPA still
               | exists!)
        
         | hammock wrote:
         | And we need more lightweight cars , not heavier, since tire
         | wear is proportional to vehicle weight to the fourth power.
         | Ironically, CAFE regulations and EV incentives both did the
         | opposite
        
           | kijin wrote:
           | > tire wear is proportional to vehicle weight to the fourth
           | power.
           | 
           | Does this mean that a bus that weighs 10 times as much as a
           | small car will produce 10000 times as much tire dust? If it
           | does, I'm not sure if investing in buses will reduce tire
           | dust at all. A bus can replace a lot of cars, but 10000 is a
           | stretch. We need more trains.
        
             | penjelly wrote:
             | trams were popular in tons of places before, I understand
             | they improved traffic significantly compared even to today,
             | and they'd still have a positive effect now, I think. But
             | most places shifted towards a car centric focus and we lost
             | those.
        
             | zamadatix wrote:
             | I think the root observation here comes from
             | https://en.wikipedia.org/wiki/Fourth_power_law which really
             | talks about the inferred stress to the road for given
             | weight on the axle, not tire wear based on vehicle weight.
             | The above seems to be using a simplification based on
             | passenger cars staying with 4 tires across 2 axles but how
             | this relates to tire wear is going to be a bit more
             | complicated when you start talking about vehicles which can
             | have more axles, more tires per axle, and significantly
             | larger tires.
             | 
             | I'd believe buses have a lot of tire wear compared to an
             | individual car but I wouldn't use that relation as proof of
             | just how many times so.
        
           | ethagnawl wrote:
           | I'm not sure why you're being down voted for suggesting a
           | practical and fact based solution. The USA is, regrettably,
           | not making a pivot towards public transportation anytime in
           | the near future. So, lighter cars are one way to address this
           | issue.
           | 
           | You didn't expound upon your point about the unintended
           | consequences of CAFE standards but they're very real. Instead
           | of making smaller and more efficient sedans per the
           | guidelines, car makers opted start making all of their
           | vehicles "light trucks" -- 80%+ of new vehicles are SUVs or
           | bubbly looking "crossovers" -- which are not subject to the
           | same demanding standards. Small sedans also cost less and
           | would require ongoing R&D to continue to meet the CAFE
           | standards. The end result, as this thread is interested, is
           | heavier vehicles with bigger tires and more plastic in the
           | environment and our brains.
        
             | linotype wrote:
             | Los Angeles would be very difficult to transition at this
             | point, it's just too low density. It was better 100 years
             | ago than it is now.
        
               | lenerdenator wrote:
               | Or Kansas City. Or St. Louis. Or Detroit. Or Chicago,
               | even.
               | 
               | Pretty much any major American city is less dense than it
               | was 100 years ago. It was cheaper to build out than it
               | was to build up.
        
               | wongarsu wrote:
               | From an infrastructure perspective building out instead
               | of up is incredibly expensive. Not just transport but
               | also water, sewage, electricity and internet.
        
               | lenerdenator wrote:
               | I should specify: it's more expensive _for the developers
               | and their home-buying customers_ to build up instead of
               | out.
               | 
               | All of that stuff you listed comes from tax dollars, and
               | people ultimately care less about that than what's coming
               | out of their pockets for a home purchase. Well, until
               | it's unsustainable, anyways.
        
               | tstrimple wrote:
               | Yes exactly. Building is cheap in the US relatively
               | speaking. There are tons of grants and government money
               | to help move things along. Those avenues don't really
               | exist for _maintaining_ things that were built with
               | grants and outside funds. So we see TONS of expansion
               | followed up with almost no maintenance and suburbs and
               | less populated places literally cannot afford to maintain
               | the services that they utilize. The burden is almost
               | entirely shifted onto renters in urban areas instead.
               | 
               | In this country we have this ideal of a rugged
               | individualist whose out there living off the land and
               | making his own way. Never will this rugged individualist
               | acknowledge that he's dependent on 10x as many miles of
               | roads as his urban counterpart. Never will this rugged
               | individualist acknowledge that providing him with
               | internet access on the state's dollar costs orders of
               | magnitude more than someone living in a sustainable
               | location. Same with delivery costs and literally every
               | other thing this person consumes. They get to pretend to
               | be a self-reliant individualist while leaching off of the
               | tax dollars of urban residents who cost a fraction of the
               | amount to support.
        
               | robertlagrant wrote:
               | > Never will this rugged individualist acknowledge that
               | providing him with internet access on the state's dollar
               | costs orders of magnitude more than someone living in a
               | sustainable location
               | 
               | Thankfully we have Starlink to replace pork consumption
               | with actual services.
        
               | peterbecich wrote:
               | I find it interesting that at a certain time in Los
               | Angeles, a segment of society could afford a craftsman
               | cottage house, but not afford an automobile. This was the
               | prime era of the Pacific Electric streetcar suburb, say
               | around 1890-1920. Today, obviously, anyone who can afford
               | a house anywhere in the country can afford an automobile.
               | 
               | The end of the Pacific Electric system was not a
               | conspiracy theory by tire companies or anything like
               | that; the price of the cars dropped and that's what
               | consumers preferred, i.m.o.
        
               | newsclues wrote:
               | Fires can solve that.
        
               | lmm wrote:
               | Los Angeles is one of few US cities that is managing to
               | build at least some new transit lines. Increasing density
               | in desirable cities is actually pretty easy, all you have
               | to is make it legal (by-right zoning) and then the market
               | will do the immensely productive and profitable thing.
        
             | borski wrote:
             | You're right, but the thing that leads us to lighter EVs is
             | solid state batteries.
        
               | cosmic_cheese wrote:
               | Yeah, I'd expect EVs to get lighter over time as
               | technology progresses. Car bloat is a much bigger
               | problem. Totally insane that little practical city cars
               | like the Honda Fit have gone practically extinct in the
               | US in favor of bigger, heavier cars that don't even
               | necessarily bring improved cargo capacity for all that
               | extra bulk.
        
               | ethagnawl wrote:
               | I have a 2018 Fit and it's a fantastic car. It gets 36
               | MPG and has much more interior space than it would seem.
               | I've had taller people ride in it comfortably and its
               | crowning achievement was fitting a hot water heater in
               | the cargo area with the rear seat split -- without having
               | to remove the child car seat on the other side. Pair a
               | roof rack and you _really_ don 't need more -- especially
               | day-to-day.
               | 
               | It's a crying shame that they've stopped selling them in
               | the US. Marketing (the real men need their Rams, thank
               | you very much!) and the CAFE loophole seem to have won
               | the day, though, and we're all worse off for it.
        
               | njarboe wrote:
               | Marketing does seem to work, especially over generations.
               | I think the main reason trucks/SUVs were marketed so much
               | was because of a 25% tax on imported light trucks and not
               | cars. The so called "chicken tax"[1] was imposed on light
               | trucks in 1964 and is still with us today.
               | 
               | [1] https://en.wikipedia.org/wiki/Chicken_tax
        
               | mrguyorama wrote:
               | A big reason car companies push trucks so much is that
               | they are more profitable per unit. Demand is extremely
               | limited in terms of quantity, because you can only really
               | sell about 1-2 cars per family, per about 10 years.
               | 
               | That means, all else being equal, a car company makes
               | more profit selling a vehicle that has a higher profit
               | margin. The $80k trucks my family members buy do not cost
               | 3X as much to manufacture as say, a nice Camry, but the
               | price you pay is about 3X. This means the
               | dealer/manufacturer just outright make more money if a
               | higher percentage of people buy trucks instead of small
               | cars.
               | 
               | Consumers have "signaled" that they will be fine paying
               | three times as much for the same exact feature set (no,
               | they are not hauling anything, and there certainly isn't
               | a massively higher percentage of Americans doing truck
               | things than 50 years ago), even using longer term loans
               | to make it happen.
               | 
               | When the car market has been basically saturated for
               | decades, how else do you "make line go up" than selling
               | the same product (transportation) for more money?
        
               | ethagnawl wrote:
               | > The $80k trucks my family members buy do not cost 3X as
               | much to manufacture as say, a nice Camry, but the price
               | you pay is about 3X.
               | 
               | > ... even using longer term loans to make it happen.
               | 
               | I don't understand how so many people are driving these
               | vehicles. Not only are they 2-3x as expensive to buy or
               | lease but they're also 2-3x more expensive to fuel and
               | maintain. (Probably to insure, too?) I don't have any
               | data to back this up but my intuition tells me that these
               | vehicles and their loans could be the cause of the next
               | subprime mortgage-esque financial crisis.
        
               | cosmic_cheese wrote:
               | It really is difficult to imagine a better vehicle for
               | suburb/city usage than the Fit, unless you have a bunch
               | of kids/people to move in which case I'd skip
               | crossovers/SUVs entirely and go straight to minivans
               | (which are also better than SUVs for most peoples'
               | needs).
        
           | penjelly wrote:
           | EV/hybrid only "zones" in Europe are crazy to me because the
           | electric cars leech more tire carbon into the air anyway.
           | Some regulation seems intelligent on the surface, but the
           | devil is in the details.
        
             | hatthew wrote:
             | Solid/particulate pollution from tires is definitely a
             | problem, but in terms of carbon specifically isn't it many
             | orders of magnitude less than the carbon from gas engines
             | or electric power plants?
        
               | penjelly wrote:
               | > These particles can include synthetic rubber, plastics,
               | carbon black, and trace metals (like zinc)
               | 
               | you're correct. I mistakenly thought it was only carbon
               | coming off the tires. So yeah, EVs have a significantly
               | lower carbon output that ICE vehicles. My point still
               | stands but thanks for the callout.
        
             | dashundchen wrote:
             | EV/hybrids also have regenerative brakes so emit less brake
             | dust. Between emissions, tires, and brakes I'd be curious
             | to see how it balances out.
             | 
             | But really cycling and transit are the way to go to make
             | cities more liveable. Personal cars take too much space in
             | a city and ruin the built environment for everyone not in
             | one.
        
             | DoingIsLearning wrote:
             | Excessive NO2 emissions spewed by diesel engines not
             | meeting regulations very literally removed years from our
             | collective life spans in city centres across the world.
             | 
             | Despite their own health hazards no amount of tire
             | particulate from EV's can achieve that level of widespread
             | public health impact.
        
             | audunw wrote:
             | These zones are generally densely populated areas, and in
             | Europe they usually have low speed limits, and roads design
             | to encourage driving at low speeds.
             | 
             | To think that the minuscule difference in tire dust is
             | significant at all, compared to the pollutants that EVs
             | completely eliminates, is absolutely ridiculous.
             | 
             | The devil is in the details, yes. Have you considered that
             | the policy makers have actually looked into the details?
             | Have you looked into the details? Have you read any
             | detailed reports about tire wear or did you just make up a
             | problem based on your own intuition? Because I've seen
             | reports from EV fleet operators that indicate that they see
             | no difference in tire wear. Most likely the added weight
             | (which isn't all that much for modern, smaller EVs.. you
             | know, the ones that people actually drive in urban/suburban
             | areas in Europe) as a factor is drowned by other larger
             | factors.
             | 
             | And we're not that far away from EVs with the same or lower
             | weight than their ICE counterparts, so getting these kinds
             | of policies in place has some forward-looking aspects to
             | them as well.
        
           | joseangel_sc wrote:
           | I don't think this is entirely true but we need more research
           | https://youtu.be/FcnuaM-xdHw?si=6bvFQdUjHi28CugV
        
           | repiret wrote:
           | Do you have a citation for the vehicle weight to the fourth
           | figure? There is about a 2X variation in the weight of the
           | vehicles I've owned, but even accounting for differences in
           | tire size, I can't come up with a 16x difference in how often
           | I change the tires.
           | 
           | Thinking about it a different way, there isn't much
           | difference in recommended tire pressure among the autos I've
           | owned. That means that the pressure between the road and the
           | tire is relatively constant but the surface area of contact
           | is directly proportional to vehicle weight. For a fixed
           | contact pressure, I am struggling to imagine a physical
           | process by which the rubber loss is not proportional to the
           | contact area.
        
             | darkmighty wrote:
             | I know this figure comes from road wear. I don't know if it
             | applies to tire wear, and indeed I suspect it doesn't, if
             | only because tires tend to scale with vehicle weight as you
             | mentioned. I think road wear may be associated with
             | structural cracking of the road which may not change
             | significantly with tire area.
        
             | daemonologist wrote:
             | The fourth power law is usually applied to deformation of
             | asphalt roadways (here's a citation for that:
             | https://www.researchgate.net/profile/Maxwell-
             | Lay/publication...); I haven't heard it applied to tires
             | before. If I had to guess I'd agree with you - I would
             | expect a smaller exponent, particularly if the tires are
             | designed for the given load.
        
             | kirubakaran wrote:
             | https://en.wikipedia.org/wiki/Fourth_power_law
        
               | repiret wrote:
               | That says nothing about tire wear.
        
             | Etheryte wrote:
             | Most studies I've seen on this topic agree that the amount
             | of pollution created is not linear, and this also makes
             | intuitive sense. The heavier your vehicle, the wider and/or
             | larger diameter your tires need to be to give it the
             | required amount of grip. If those bigger tires wear out in
             | the same time as your smaller vehicle tires, you've already
             | created considerably more pollution.
        
             | enragedcacti wrote:
             | This Engineering Explained video seems pretty thorough. The
             | short of it is that your intuition is in the right
             | direction, its definitely not to the fourth power of
             | weight. Vehicle weight does contribute to wear but
             | according to Continental its less important than driving
             | style and road curviness.
             | 
             | https://www.youtube.com/watch?v=hvIcVmSzSEg
        
           | twelvechairs wrote:
           | Roads and road standards are a tragedy of the commons. People
           | keep buying bigger cars and demanding more, wider lanes and
           | parking spaces because they don't take any of the burden
           | individually - it's the taxpayers as a whole that foot the
           | bill.
           | 
           | Paradoxically most of the 'small government' types are often
           | the biggest road users.
        
             | sooheon wrote:
             | The solution to tragedies of the commons is to internalize
             | externalities. Tax should scale with carbon use, congestion
             | contribution, and microplastic emission.
        
             | robertlagrant wrote:
             | > Paradoxically most of the 'small government' types are
             | often the biggest road users.
             | 
             | I think it's "limited government". I'm pretty sure they
             | would prefer roads get more spending.
        
           | guelo wrote:
           | None of these things are going to happen. Voters keep voting
           | with their votes and their wallets that they want bigger cars
           | and don't care about climate change. Meanwhile reactionary
           | billionaires have hijacked most of our mass media as we blow
           | by the 1.5degC Paris agreement and Trump dismantles our
           | science institutions.
        
           | Lanolderen wrote:
           | Also motorcycles/scooters. Unless you have children or live
           | in a place with serious snow a motorcycle and a car sharing
           | app/rentals for when you need to haul a sofa or something is
           | a great combo.
           | 
           | Cheap, easy maintenance, good fuel economy and speed, traffic
           | jam immunity..
        
         | throwaway81523 wrote:
         | How did the amount of brain microplastic manage to double
         | between 2016 and 2025? The amount of cars hasn't changed that
         | much.
        
           | JKCalhoun wrote:
           | User hammock, in this thread, may have suggested an answer.
        
           | markerz wrote:
           | Perhaps you're thinking our body is at equilibrium with the
           | amount of plastic in our environment, but the reality may be
           | that our body accumulates microplastics from the environment
           | and they become concentrated over time. Kind of like how we
           | can't get rid of heavy metals from our body, so eating lots
           | of fish accumulates mercury to toxic levels. But eating fish
           | is a conscious decision whereas microplastic exposure is an
           | unavoidable fact of life now.
        
             | njarboe wrote:
             | You can probably reduce microplastic consumption, but it is
             | quite a pain and more expensive. Try buying everything at
             | the store not wrapped/bottled in plastic. This does not
             | even work as well as you might think as many things are
             | wrapped in plastic and then presented as if they were not.
             | For example, breakfast sausages in the meat display at my
             | local Whole Foods are wrapped in paper when they give it to
             | you, but come to the store in ~1lb plastic wrapped
             | packages.
        
           | meindnoch wrote:
           | The weight of the average car is steadily increasing though.
           | SUVs, electrics, giant trucks, etc.
        
           | o_nate wrote:
           | Perhaps the proportion of synthetic rubber (vs natural
           | rubber) is increasing in tires?
        
         | newsclues wrote:
         | I love breathing brake dust too!
        
         | 7e wrote:
         | Or one could just mandate that tires contain only biodegradable
         | ingredients. That seems an inevitable step since wheel isn't
         | going away no matter what the level of public transportation
         | is. Some public transit, like busses and some subways, use
         | rubber tires today.
        
           | 7e wrote:
           | Downvotes for suggesting biodegradable tires. What a site of
           | wankers we have here.
        
         | CommanderData wrote:
         | Government could force car tyre companies to invest in
         | developing plastic free tyre alternatives?
         | 
         | If there's no regulation then there's no will or urgency to
         | waste money doing so.
        
         | meindnoch wrote:
         | Mass _rail_ transit.
        
           | Kapura wrote:
           | Didn't want to come off as too foamer ;)
        
         | niceice wrote:
         | What percentage is that?
        
       | timr wrote:
       | This paper came up as a pre-print. You can't make the
       | extrapolation that the headline is making - they're using gas
       | chromatography to estimate quantities from 1-2mg samples, and
       | then extrapolating to get to these scary sounding whole-organ
       | estimates. If you look at the paper [1], you'll see that the
       | microplastics in _in situ_ samples are not discernible by light
       | microscopy, and that there was a ~25% variation in _within
       | sample_ measurement of the GC [2], indicating a great deal of
       | uncertainty in the precision of the fundamental measurement (the
       | authors brush this off; see quote below).
       | 
       | Basically, you've got an extremely sensitive measurement system
       | being used to make tiny measurements, and then they extrapolate
       | these measurements by a huge factor to get to ug/g estimates.
       | Further extrapolating (to the weight of an organ, say) when you
       | know that there's 25% inter-sample variation, is just guaranteed
       | to be nonsense.
       | 
       | [1] https://www.nature.com/articles/s41591-024-03453-1
       | 
       | [2] _" Both analytical laboratories (UNM and OSU) observed a ~25%
       | within-sample coefficient of variation, which does not alter the
       | conclusions regarding temporal trends or accumulation in brains
       | relative to other tissues, given the magnitude of those
       | effects."_
        
         | rthomas6 wrote:
         | Well, it still tells us something. What are the upper and lower
         | bounds of whole brain microplastic content, given that 25%
         | variation?
        
           | timr wrote:
           | I couldn't begin to tell you [1]. It's not a 25% variation,
           | once you've extrapolated from the samples by 10,000x (or
           | whatever). The 25% inter-sample error was on a few replicas
           | of teeny tiny measurements. The post-extrapolation error bars
           | are so wide that they're meaningless.
           | 
           | The Smithsonian magazine article is garbage. Ignore it. The
           | paper is saying that they see _longitudinal trends_ in
           | plastic bioaccumulation in various cadaver tissues, and this
           | is plausible. But no, you don 't have a plastic spoon in your
           | head. That's just panic porn.
           | 
           | [1] Actually...I just asked Gemini and it reminded me that
           | the expected variance of a draw from a distribution, scaled
           | by factor C, should have a variance of _the scaled sample
           | distribution_ that grows with C^2. So, if we scale up the
           | measurement by a factor of 10,000, we 'd expect the variance
           | of the scaled estimate to be proportional to 10,000^2.
        
             | drawkward wrote:
             | Why yes, i think i will believe the random internet
             | commenter.
        
               | LoganDark wrote:
               | Practically every internet commenter is random.
        
               | drawkward wrote:
               | Which is fine in plenty of contexts. Rebutting this
               | particular article? Nah.
        
               | robertlagrant wrote:
               | Evaluate things based on reasoning, not source.
        
               | drawkward wrote:
               | Evaluate based on both. Why remove any explanatory
               | variables?
               | 
               | And for what it is worth, the paper itself has plenty of
               | other interesting findings that OP fails to discuss or
               | rebut at all. OP asks an LLM some very basic statistics
               | questions, putting into question their ability to
               | credibly apply and interpret the LLM's findings.
               | 
               | My interpretation of _that_ evidence is that OP, a random
               | internet commenter, just doesn 't think it is credible
               | that plastics are harmful to humans, and is grasping at
               | plastic straws with cherry picked evidence and poor
               | rebuttals to reach that "fact based" conclusion.
        
             | edouard-harris wrote:
             | I may be misunderstanding you, but it sounds like you're
             | claiming that they had e.g. 10 tiny samples of tissue, that
             | their measurements had an average 25% variation across
             | those 10 samples, and that therefore the whole brain
             | estimate (mass 10,000x that of a single sample) therefore
             | has a much greater uncertainty. But doesn't the standard
             | error of the mean get _reduced_ by the square root of the
             | number of samples? i.e. if you had 10 samples with 25%
             | variation across samples, and you 're taking their mean,
             | the error of that mean should be 25% / sqrt(10) = 8%. And
             | that should be the relative error for the scaled up whole-
             | brain microplastic concentration as well. Or is there some
             | other source of variation that I'm missing?
        
               | timr wrote:
               | You're talking about reduction in statistical variance
               | due to replication of measurement (and then averaging).
               | I'm talking about what happens when they _extrapolate
               | from that value_ by a huge factor (which is what they 've
               | done, and the silly article does egregiously).
               | 
               | The paper isn't clear what they mean when they said "~25%
               | within-sample coefficient of variation", so I can't
               | directly address what you're asking, but it's tangential
               | to the point I'm making. My naive interpretation is that
               | they did an ANOVA, and reported the within-group
               | variance, or something similar.
               | 
               | All I'm saying in my footnote is that, whatever the final
               | point estimate, scaling it by a factor of C will affect
               | the variance of the final sample distribution by C^2. So
               | for example, if you have an 8% variance on the
               | measurement at ug/g, and you scale it by 1300 (for 1300g;
               | what the interwebs tells me is the mass of a standard
               | human brain), then you'd expect the variance of the
               | scaled measurement to be 1300^2 * 8%.
               | 
               | That makes a ton of assumptions that probably don't hold
               | in practice -- and I expect the real error to be larger
               | -- but illustrates the point.
        
               | myrmidon wrote:
               | I think there is some kind of mixup, you can not scale up
               | the variance _percentages_ quadratically:
               | 
               | If you do a small-scale measurement, say you get result
               | of 5g, with a standard deviation of 0.2g. That means the
               | variance is 0.04 g^2.
               | 
               | If you then scale the setup up by 1000 (=> getting 5kg as
               | expected value), then the variance scales to 1000^2 *
               | 0.04 = 40000 g^2.
               | 
               | BUT the standard deviation is still 200g. The relative
               | uncertainty is NOT increasing quadratically!
               | 
               | (another sanity check: if you change the units by a
               | factor of 1000, your variance must not increase,
               | relatively).
               | 
               | But maybe I misunderstood your point?
        
               | timr wrote:
               | > If you then scale the setup up by 1000 (=> getting 5kg
               | as expected value), then the variance scales to 1000^2 *
               | 0.04 = 40000 g^2.
               | 
               | They didn't "scale the setup". They made a small-scale
               | measurement, then extrapolated from that result by many
               | orders of magnitude. They didn't grind up whole brains
               | and measure the plastic content.
               | 
               | Imagine the experiment as a draw from a normal
               | distribution (the distribution is irrelevant; it's just
               | easier to visualize). You then multiply that sample by
               | 10,000. What is the variance of the resulting sample
               | distribution?
        
               | myrmidon wrote:
               | > What is the variance of the resulting sample
               | distribution?
               | 
               | Relatively? The same. Yes it scales quadratically, but
               | that is just because variance has such a weird unit.
               | 
               | Just consider standard deviation (which has the same
               | physical unit as what you are measuring, and can be
               | substituted for variance conceptually): This increases
               | linearly when you scale up the sample.
               | 
               | An example: Say you take 20 blood samples (5 ml), and
               | find that they contain 4.5 ml water, with a standard
               | deviation of 0.1 ml over your samples.
               | 
               | From that, your best guess for the whole human (5 liters,
               | i.e. x1000) has to be 4.5 liters water, with standard
               | deviation scaled up to 0.1 liters (or what would you
               | argue for, and why?)
        
             | drawkward wrote:
             | ...so you are saying that the probability distribution
             | indicates that there is a 50% probability that there _more_
             | than a spoon 's worth of plastic in our brain?
        
         | userbinator wrote:
         | IMHO the more important part is they used _pyrolysis_ gas
         | chromatography, which breaks down _all_ polymer chains.
         | 
         | Besides man-made plastics, guess what else has long hydrocarbon
         | chains, occurs naturally in humans and other biological matter,
         | and behaves similarly under pyrolysis...
         | 
         | https://en.wikipedia.org/wiki/Fatty_acid
         | 
         | Here's an interesting related article:
         | https://www.oaepublish.com/articles/jeea.2022.04
         | 
         |  _Analysis of saturated, monounsaturated and polyunsaturated
         | fats was demonstrated to form the same pyrolysis products as
         | PE_
        
           | timr wrote:
           | To their credit, they do discuss this in the results. I
           | suspect the reviewers had the same concerns.
           | 
           | Their response is not especially convincing, IMO, but they do
           | at least discuss it.
        
       | jondwillis wrote:
       | Really regretting chewing on all of those straws as a kid, eating
       | hot food out of all of those takeout trays, keeping my car
       | windows open, living near roads... and...
        
         | _sys49152 wrote:
         | I rode a hard plastic bike seat on my bmx to school and back
         | everyday. eyes emoji. my kids i shoot out will be g.i. joe
         | figurines
        
       | odyssey7 wrote:
       | Is there no molecule that could be designed which would break
       | down microplastics throughout the body, without harming
       | biological materials? Or even just the blood stream?
       | 
       | I'm not a chemist, but it seems like if this can be done it would
       | be huge.
        
         | ed_mercer wrote:
         | Even if you could invent it, I don't think there would be
         | demand for it (yet)
        
       | deadbabe wrote:
       | Imagine if microplastics in the brain could somehow be utilized
       | by neurons for really long term memory storage or something.
        
         | TZubiri wrote:
         | No
        
       | SV_BubbleTime wrote:
       | Nonsense article, you could fit way more than that.
        
       | mondobe wrote:
       | Perfect, I was hoping to increase my neuroplasticity.
        
         | knowitnone wrote:
         | I recognize and acknowledge your humorous post.
        
           | Sparkyte wrote:
           | It totally struck my funny bone. It was very humerus.
        
         | HaZeust wrote:
         | Nice.
        
       | booleandilemma wrote:
       | Does it have a negative effect on us though?
       | 
       | I mean, assuming I do have a spoon's worth of microplastics in my
       | brain, I don't notice any impairment.
       | 
       | I write JavaScript just fine.
        
       | latentcall wrote:
       | So are we okay with this? We don't want to hurt industries or the
       | market so we should accept this, right? I think it's extremely
       | important that Nestle and Coca Cola continue to be successful. I
       | certainly don't mind eating plastic if it means the market does
       | well.
       | 
       | Okay I'm sorry for the snark but when these articles come up some
       | are like "the studies are inconclusive of the effects" but I'm
       | just like "there's plastic in your brain!"
        
       | yapyap wrote:
       | baity headlines that scare the shit out of you, exactly what I'm
       | NOT looking for on HN
        
       | synergy20 wrote:
       | why did not they got flushed by our digestive system,yes micro
       | plastics are tiny,still they are too large to get into arteries
       | and veins thus no way to reach the brain?
        
         | stevenwoo wrote:
         | Nanoplastics can be so small that they can get inside most
         | cells even blood cell so could pass through gut lining and
         | blood brain barrier and sometimes are shaped like the key/lock
         | our body already uses for certain intracellular chemical
         | interactions and interferes with the correct molecules doing
         | work, so they can be both inert for the most part and harmful
         | because our cells just don't just eject them automatically -
         | though there also appears to be some max amount based on
         | exposure level. The vast majority we might eat is excreted in
         | bowel movements and urine and it still accumulates in tissue
         | due to ubiquity. article for laypeople
         | https://www.npr.org/sections/shots-health-news/2024/12/18/nx...
        
           | synergy20 wrote:
           | Great to know the insights! It seems inevitable though as
           | plastics are everywhere.
        
       | kaiwen1 wrote:
       | Pre-print paper that concludes "may", so by implication, also
       | "may not".
       | 
       | And also may, or may not, be harmful.
        
       | renewiltord wrote:
       | Sounds like methodological error. Like your black spatulas.
       | Somewhere they've divided by zero, clamped, and averaged or
       | something dumb like that.
        
       | purplezooey wrote:
       | Well, Vonnegut was right. It's just a dog's breakfast.
        
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