[HN Gopher] HORNET: RNA structure visualization method correlate...
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HORNET: RNA structure visualization method correlates sequence and
3D topology
Author : bryanrasmussen
Score : 38 points
Date : 2025-01-03 19:45 UTC (2 days ago)
(HTM) web link (phys.org)
(TXT) w3m dump (phys.org)
| bryanrasmussen wrote:
| original title: Introducing HORNET, a novel RNA structure
| visualization method that correlates sequence and 3D topology
| finlecture wrote:
| Fascinating advancement with HORNET for RNA structure
| visualization! This method bridges a significant gap in
| structural biology, opening doors for further research and
| applications.
| SteveVeilStream wrote:
| The more I learn about epigenetics, RNA, and DNA, the more
| convinced I am that we need to be investing much more heavily in
| this area. There are a lot of barriers. It starts with our
| education system where people need to be in school until they are
| far too old until they reach the edge of the state of the art. I
| think it's time to rethink parts of high school and university so
| that people can specialize in this area sooner. Funding is
| another major hurdle. A lot of traditional sources of funding
| don't map well to these problem areas where the risk and reward
| are both very high and the holding periods are long.
| throwaway48476 wrote:
| Life sciences are hard because it's very labor intensive which
| means expensive. That's not going to change any time soon.
| asdff wrote:
| The labor is paid less than people flipping burgers usually.
| Post docs make less than fast food managers. Grad students
| less than the line cooks. And a lot of undergrads are
| "volunteering" or have half their wage paid by federal work
| study. A lot of labs their reagent costs are very low and
| they might used shared university equipment that's already
| had a grant written to purchase it by the institution. It
| probably costs orders of magnitude more to outfit the kitchen
| at a mcdonalds than it does an average academic lab.
| asdff wrote:
| Having gone through it I think the biggest hurdle is the 12ish
| credit hour paradigm in undergrad. You learn so much faster in
| grad school because you can actually dig in and focus on one
| subject or really one project within that subject at once. As a
| TA it was pretty common to hear students didn't study at all
| for my exam because they had a chemistry exam that seemed more
| challenging and worthy of cramming, so as bio majors they
| failed the bio exam to cram for a chemistry prerequisite they
| might not have passed either. And I can tell you from
| experience that whatever they toil over in the library for that
| chemistry class that absolutely none of that will be used in
| their careers in biology or medicine. You don't need to
| memorize how a paladium catalyst works in any job on this earth
| perhaps, but you need to do that and be able to see through
| basically a riddle on top of that to pass your ochem
| requirement, along with a dozen other similarly inane synthesis
| exercises you forget as soon as the term ends.
|
| And what is worse, many students fail their ochem and the
| weight of that on their gpa sometimes forces a pivot out of the
| field entirely. Another potentially good scientist lost to
| unhelpful process.
| dpflan wrote:
| Link to Nature publication:
| https://www.nature.com/articles/s41586-024-07559-x
| aszantu wrote:
| Article doesn't talk about accuracy, which should always be
| included when ai is used,imo
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