[HN Gopher] Early Improvements with Atogepant for the Preventive...
       ___________________________________________________________________
        
       Early Improvements with Atogepant for the Preventive Treatment of
       Migraine
        
       Author : taubek
       Score  : 11 points
       Date   : 2024-12-26 16:40 UTC (6 hours ago)
        
 (HTM) web link (www.neurology.org)
 (TXT) w3m dump (www.neurology.org)
        
       | mmastrac wrote:
       | Looks like a CGRP blocker
       | (https://en.wikipedia.org/wiki/Calcitonin_gene-related_peptid...)
       | sold under the name Qulipta
       | (https://en.wikipedia.org/wiki/Atogepant):
       | 
       | > Since the discovery of calcitonin gene-related peptide (CGRP)
       | in 1982, its integral role in migraine pathophysiology,
       | specifically migraine pain, has been demonstrated through
       | cumulative scientific discoveries that have led to the
       | development and approval of migraine-specific therapeutics.
       | Today, eight drugs, including monoclonal antibodies and small
       | molecule CGRP receptor antagonists, known as gepants, have
       | received approval for acute or preventive treatment of migraine.
       | The primary mechanism of these drugs is to block CGRP signaling,
       | thus preventing CGRP-mediated nociception and neurogenic
       | inflammation. Here, we focus on atogepant, a highly potent and
       | selective gepant and the first and only oral medication approved
       | for the preventive treatment of both episodic and chronic
       | migraine in adults. In this article, we summarize the role of
       | CGRP in migraine pathophysiology and the mechanism of action of
       | atogepant. In addition, we provide an overview of atogepant's
       | pharmacology and the key clinical trials and outcomes that have
       | demonstrated the safety and efficacy of atogepant.
       | 
       | https://pmc.ncbi.nlm.nih.gov/articles/PMC10777605/
        
       ___________________________________________________________________
       (page generated 2024-12-26 23:01 UTC)