[HN Gopher] Why eating less slows ageing: this molecule is key
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Why eating less slows ageing: this molecule is key
Author : XzetaU8
Score : 41 points
Date : 2024-12-21 11:10 UTC (6 hours ago)
(HTM) web link (www.nature.com)
(TXT) w3m dump (www.nature.com)
| ghjfrdghibt wrote:
| _in flies and mice_
| ExecutiveDre wrote:
| 3 meals a day + snacks don't make sense for the body but good for
| business.
| meiraleal wrote:
| Waistline and GDP graphs growing together
| alfiedotwtf wrote:
| "Breakfast is the most important meal of the day"
|
| -- Advertising slogan, Kellogg's 1917
| 2OEH8eoCRo0 wrote:
| That slogan is an oversimplification but if I eat a bowl of
| steel cut at 7am I won't snack or be hungry until 2pm or
| later. Whether or not I eat this will have a strong impact on
| my day. Sounds important IMO
| aziaziazi wrote:
| Steel Cut is non-whole oat cut in small bits for those
| wondering. I had to google, didn't know if you were joking.
| herbst wrote:
| I won't snack or am hungry before 17:00, usually not before
| 20:00 except I do sports or something, then I may need a
| snack around 14:00.
|
| If I do eat early my body takes hours to get to full energy
| again. It literally makes me tired.
|
| My girlfriend doesn't work that way. And I have no idea why
| this works so well for me.
| phil21 wrote:
| Depends on the person. If I eat breakfast I feel like crap
| for 2-3 hours afterwards. I have friends who can't function
| for the day before eating first.
|
| It's certainly not the most important meal of the day in
| general. Especially as a societal meme that came directly
| from an advertising campaign for a cereal manufacturer.
| calebm wrote:
| "Now, a team has found a molecule that could provide caloric
| restriction in a pill"... instead of just restricting calories
| drooby wrote:
| We need to have our cake and eat it too
| amelius wrote:
| Speaking of ageing, what happened with the research around this
| gene:
|
| https://pmc.ncbi.nlm.nih.gov/articles/PMC5403515/
| bhargav wrote:
| A lot of extensive research was done by Dr. Valter Longo and his
| department on similar topics and has made its way into an easily
| digestible book called The Longevity Diet. It changed my
| perspective big time with food.
|
| Highly recommend reading this book for folks that are interested
| in Longevity.
|
| Dr. Longo has also done a few podcasts with Dr. Rhonda Patrick
| (who might be more known to the audience here) you can checkout
| hasbot wrote:
| Thanks! I hadn't heard of The Longevity Diet. Here's a review:
| https://www.verywellhealth.com/the-longevity-diet-plan-overv...
|
| A summary of the diet from the review:
|
| The longevity diet resembles a modified vegan diet in which
| certain seafood and small amounts of meat and dairy are
| allowed. It is as much a lifestyle as an eating plan and can be
| followed for an indefinite amount of time. The guidelines
| include following a five-day fasting-mimicking diet
| periodically throughout the year.
| meiraleal wrote:
| > The guidelines include following a five-day fasting-
| mimicking diet periodically throughout the year.
|
| Including real fasting in a diet beats any of those fad diets
| with fake fasting gimmicks.
| neogodless wrote:
| What is "fasting-mimicking" and what are "fake fasting
| gimmicks"?
| bhargav wrote:
| The Fasting Mimicking concept is there because this method
| was exclusively tested on Cancer patients who are also
| going through Chemo therapy. Having nutrients for these
| patients is important [1]
|
| Is pure Water Fasting superior? Yes. I have done 1 week
| water fasts, back to back for 4 weeks and lost ~30 lbs.
|
| However, I think fasting mimicking may help adherence for
| some people.
|
| 1: https://www.aacr.org/patients-caregivers/progress-
| against-ca...
| EA-3167 wrote:
| When we're talking about longevity, I often think about this
| old comic. It showed two very old women, crumpled in seats in a
| nursing home, and one turns to the other saying, "Just think,
| if hadn't quit smoking and drinking, we might have missed
| this!"
|
| Facetious of course, but the underlying point has merit. Just
| what part of your life are you extending? Are you extending the
| healthy, active period, or just dragging out that bit at the
| end when someone else has to wipe your bottom and feed you
| apple sauce? Especially with the current topic, it seems very
| likely to be the latter, and I'd rather eat the other half of
| my sandwich, and die a few years earlier.
| esperent wrote:
| > Just what part of your life are you extending? Are you
| extending the healthy, active period,
|
| That is the goal of every single person interested in
| longevity.
|
| I have heard the term "extending healthspan" and to me that's
| a much better explanation of what people are trying to do.
| Cpoll wrote:
| > Are you extending the healthy, active period, or just
| dragging out that bit at the end when someone else has to
| wipe your bottom and feed you apple sauce?
|
| It's always both. Mortality isn't an independent counter,
| it's linked to a bunch of predictors that are also predictors
| of health and autonomy.
|
| In other words, if you "eat the other half", you won't just
| die younger, you'll also start eating applesauce sooner.
| lapcat wrote:
| The subtitle:
|
| > A naturally occurring compound involved in digestion lengthens
| lifespan in flies and makes old mice more youthful.
| shrx wrote:
| The molecule, called lithocholic acid, is made by bacteria in the
| gut and aids the digestion of fats.
| pama wrote:
| It is made by a relatively trivial change to CDCA
| (chenodeoxycholic acid), which in turn is made in the liver by
| cholesterol in a number of steps. I love the simplicity of
| stepwise modifications of complex molecules inside the body
| with the help of gut bacteria. True symbiosis.
| hasbot wrote:
| The title implies this works for humans but the article says
| "There is no evidence yet that taking lithocholic acid would have
| the same effect in humans."
| jilwoo wrote:
| Slowing aging is over rated. Ask a farmer or a gardener. Just
| when you think you have worked out how to keep things alive and
| looking healthy, the universe will throw things at you (from a
| very long ever growing list) that can change the story overnight.
| byyoung3 wrote:
| nah I think we can solve it
| hasbot wrote:
| What would a farmer or a gardener have to say about slow aging?
| Cpoll wrote:
| Farmers and gardeners concern themselves with soil depletion
| and genetic diversity, so I'm not sure your point makes any
| sense.
| Qem wrote:
| Now two questions popped in my head:
|
| 1 - Some non-statin antichilesterol drugs work by preventing
| reabsorption of bile acids, causing them to pass through the
| bowels. Can this have the positive side-effect of making
| lithocholic acid precursors more available to the gut flora
| downstream? See
| https://en.m.wikipedia.org/wiki/Bile_acid_sequestrant
|
| 2 - Does this affect those who underwent surgery to remove the
| gallbladder? Say, making caloric restriction more or less
| effective for this population.
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