[HN Gopher] Novel link between cell nutrition and identity could...
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       Novel link between cell nutrition and identity could improve
       immunotherapies
        
       Author : gnabgib
       Score  : 13 points
       Date   : 2024-12-12 20:29 UTC (2 hours ago)
        
 (HTM) web link (www.genengnews.com)
 (TXT) w3m dump (www.genengnews.com)
        
       | Jimmc414 wrote:
       | Would love to see the full paper for more details on how, but
       | they determined cells' fighting ability is controlled by their
       | choice of fuel source.
       | 
       | Active T cells prefer to process acetate (via ACSS2 enzyme),
       | while exhausted T cells switch to using citrate (via ACLY
       | enzyme). Appears this choice isn't just about energy - it
       | actually determines cell fate by affecting where acetyl-CoA
       | accumulates in the nucleus, which then controls which genes get
       | turned on or off.
       | 
       | The breakthrough is that this appears to be an active choice by
       | the cell, not just a response to what's available. This means we
       | might be able to prevent T cells from becoming exhausted in
       | cancer treatment by controlling their metabolic preferences.
        
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       (page generated 2024-12-12 23:00 UTC)