[HN Gopher] NASA: Mystery of Life's Handedness Deepens
       ___________________________________________________________________
        
       NASA: Mystery of Life's Handedness Deepens
        
       Author : bookofjoe
       Score  : 141 points
       Date   : 2024-11-22 14:35 UTC (3 days ago)
        
 (HTM) web link (www.nasa.gov)
 (TXT) w3m dump (www.nasa.gov)
        
       | robthebrew wrote:
       | https://www.nature.com/articles/s41377-020-00367-8
        
         | __MatrixMan__ wrote:
         | That's a relevant paper, but this is the one which "deepened"
         | the mystery: https://www.nature.com/articles/s41467-024-52362-x
         | 
         | It asserts:
         | 
         | > L-proteins need not emerge from a D-RNA World
         | 
         | So if more than one amino acid chirality could have emerged,
         | why did we get the one we got and not several?
         | 
         | From the paper in the parent comment:
         | 
         | > Achiral linearly polarized light interacts with chiral
         | objects and their enantiomers differently. An interesting
         | example is a light-driven motor. Linearly polarized light can
         | rotate a gammadion-shaped gold structure embedded in a silica
         | block as a motor.
         | 
         | Imagine you were using some kind of optical tweezers to
         | manipulate chiral molecules. I wonder if there's a reason that
         | such a device would work better if you had a sample which had
         | the same chirality. Suppose so...
         | 
         | If one of your samples made its way to Earth and replicated...
         | Well that would be a reason for earth proteins to be biased in
         | one direction, despite the laws of physics not prescribing such
         | a bias.
        
           | madaxe_again wrote:
           | https://en.m.wikipedia.org/wiki/Optical_tweezers
           | 
           | I suppose there's no reason you couldn't use circularly
           | polarised light to achieve the effect you're talking about.
        
       | throwawaymaths wrote:
       | What is the mystery? Perhaps one handedness was just first by
       | chance and won because it self replicated the other handedness
       | away by consuming it as food.
        
         | griffzhowl wrote:
         | Well, that's the question isn't it? Is it just a frozen
         | accident, or is there some nonarbitrary reason for the left-
         | handed molecules to be favoured?
        
           | madaxe_again wrote:
           | Perhaps aliens eat right handed life, but left handed life is
           | poison to them.
           | 
           | Seriously. It would be a pretty good selector, and said
           | "alien" need be no more than a snippet of RNA - and it would
           | be entirely gone from earth now, eliminated by us sinister
           | life forms.
           | 
           | The only evidence would be the ubiquitous absence of
           | R-entantiomers in life.
           | 
           | I think I might be lifting from Asimov - _The Left Hand of
           | the Electron_.
        
             | Terr_ wrote:
             | That kinda kicks the can down the road though, because we
             | are faced with almost the same set of questions except
             | about the hypothetical alien life.
        
           | throwawaymaths wrote:
           | Sure but that might be an unknowable problem. What if the
           | difference in likelihood were 60/40.
           | 
           | You could go down all sorts of rabbit holes and none of them
           | would truly be falsifiable unless you observed an
           | enantiomeric lifeform on some distant planet.
        
         | throwawaymaths wrote:
         | (Comsuming enantiomers and pooping out metabolic fragments in
         | its native chirality)
        
         | alganet wrote:
         | That assumption is even more mysterious.
         | 
         | Why one specific handedness "won"? What caused the other one to
         | be food? How can we be sure it was by chance?
         | 
         | Lots of questions.
        
           | throwawaymaths wrote:
           | > Why one specific handedness "won"?
           | 
           | Place two competitors at the origin on the number line. On
           | any given turn they walk either to the left or to the right,
           | with exactly 50% odds of each. First competitor to +100 wins.
           | 
           | > What caused the other one to be food?
           | 
           | Basic chemistry.
           | 
           | > How can we be sure it was by chance?
           | 
           | We can't. If the odds are sufficiently close, we probably
           | can't be sure it wasn't chance, either. If we go to space and
           | find a planet with life with the other handedness, it was
           | probably chance.
        
             | alganet wrote:
             | I have so many questions.
             | 
             | How do you know the evolutionary model of these early
             | organisms? How do you know that a competition had taken
             | place?
             | 
             | If you can't know if it is by chance of not, why
             | hypothesize it?
        
       | andrewflnr wrote:
       | While all right-handed amino acids would presumably be fine, do
       | we have any idea whether mixed chirality would work? I suspect
       | no, since they presumably have different folding behavior but
       | might be tricky to distinguish chemically during the protein
       | synthesis process, making e.g. different codons for left and
       | right-handed amino acids infeasible to implement. I'd love to
       | hear from a biologist whether any of that is correct.
        
         | fredgrott wrote:
         | fun fact some left handed amino acids are poisonous to most
         | mammals
        
         | gilleain wrote:
         | So a couple of things i remember from back in the old
         | structural bioinformatics days...
         | 
         | Firstly, there are naturally occurring mixed-chirality
         | (alternating) peptides. They are usually circular iirc.
         | 
         | Secondly, no you can't really have larger proteins with both
         | left and right (ignoring glycine). They would not fold into
         | nice helix/sheet strucures and likely just be random coil.
         | 
         | For cells to have mixed populations of all-L and all-R proteins
         | would mean doubling up all the machinery for creating them.
         | 
         | One theory that I thought was reasonable for why there's a
         | monochiral world is that once the arbitrary choice is made (L
         | or R) then that gets 'locked in' by all the machinery around
         | that choice. As in, L 'won'.
        
           | phkahler wrote:
           | >> One theory that I thought was reasonable for why there's a
           | monochiral world is that once the arbitrary choice is made (L
           | or R) then that gets 'locked in' by all the machinery around
           | that choice. As in, L 'won'.
           | 
           | This seems obviously true to me. Mixed doesn't work, so as
           | molecules and systems of molecules started replicating one
           | chirality won out. It's just chance and there's nothing
           | magical about the chirality "chosen" by the process.
        
           | brnaftr361 wrote:
           | My initial hypothesis is that there's something present in
           | the early stages of life that has a higher energy state
           | making it unsustainable for use in a certain conformation and
           | so it was nearly immediately selected out.
           | 
           | E.g. a ring structure whose substituents are affected by
           | steric hindrance in the left-handed scheme.
           | 
           | And the path of least resistance was just to adapt and build
           | around it. Once that precedence was set everything became as
           | such. I expect in the earliest stages of life this would have
           | been an immense factor as metabolism was not nearly as
           | sophisticated as we know it today.
           | 
           | And this selective process may have ocurred well before
           | anything we have observed/modeled, and may well be erased.
           | Which is to say I agree, but with the caveat that it was a
           | substrate-dependent mechanism which selected the downstream
           | components rather than random chance.
        
             | gilleain wrote:
             | Seems quite possible, but the difficulty would be why one
             | enantiomer is less favourable than the other.
             | 
             | Totally agree that it is hard to test these things
             | experimentally, or through historical analysis of
             | structural remnants. I understand there have been efforts
             | to model at a system level these ancient metabolic networks
             | but ... then how do you experimentally validate these
             | models?
        
         | gus_massa wrote:
         | It's a good question, but:
         | 
         | > _might be tricky to distinguish chemically during the protein
         | synthesis process_
         | 
         | No, amino acids are bind to tRNA by special proteins that have
         | handiness and can easily distinguish the L and R version. Most
         | proteins can only operate on one handiness of the target
         | molecule.
         | 
         | > _making e.g. different codons for left and right-handed amino
         | acids infeasible to implement_
         | 
         | No, there are 64 codons and we are using them to map only 20
         | amino acids and a stop signal. So there is a lot of
         | duplication. Some bacterias have one or two more amino acids or
         | a small tweak in one or two of the conversion table, so it's
         | possible to add more stuff there if necessary.
         | 
         | My guess is that mixing L and R amino acid would break
         | ribosomes. The ribosomes read the mRNA and pick the correct
         | tRNA and connect the amino acid that the tRNA has. I guess that
         | the part that makes the connection assumes the correct
         | handiness of the amino acids.
         | 
         | Going down the rabbit hole I found
         | https://en.wikipedia.org/wiki/Nonribosomal_peptide that
         | explains that some peptides (that are like small proteins) are
         | formed by special enzymes instead of ribosomes, and some of
         | them have D-amino acids or other weirs stuff.
        
           | andrewflnr wrote:
           | > No, amino acids are bind to tRNA by special proteins that
           | have handiness and can easily distinguish the L and R
           | version. Most proteins can only operate on one handiness of
           | the target molecule.
           | 
           | Ah, neat. That was the step where I worried about coding
           | being infeasible, too, coding for R amino acids wouldn't do
           | any good if you couldn't distinguish them. I did know there
           | was plenty of room in the encoding scheme.
        
       | westurner wrote:
       | From "Amplification of electromagnetic fields by a rotating body"
       | https://news.ycombinator.com/item?id=41873531 :
       | 
       | > _ScholarlyArticle: "Amplification of electromagnetic fields by
       | a rotating body" (2024)
       | https://www.nature.com/articles/s41467-024-49689-w _
       | 
       | >> _Could this be used as an engine of some kind?_
       | 
       | > _What about helical polarization?_
       | 
       | If there is locomotion due to a dynamic between handed molecules
       | and, say, helically polarized fields; is such handedness a
       | survival selector for life in deep space?
       | 
       | Are chiral molecules more likely to land on earth?
       | 
       | > _" Chiral Colloidal Molecules And Observation of The Propeller
       | Effect" https://pmc.ncbi.nlm.nih.gov/articles/PMC3856768/_
       | 
       | > _Sugar molecules are asymmetrical / handed, per 3blue1brown and
       | Steve Mould. /?
       | https://www.google.com/search?q=Sugar+molecules+are+asymmetr..._
       | _https://www.google.com/search?q=Sugar+molecules+are+asymmetr..._
       | 
       | > _Is there a way to get to get the molecular propeller effect
       | and thereby molecular locomotion, with molecules that contain
       | sugar and a rotating field or a rotating molecule within a
       | field?_
        
         | westurner wrote:
         | Though, a new and plausible terrestrial origin of life
         | hypothesis:
         | 
         | Methane + Gamma radiation => Guanine && Earth thunderstorms =>
         | Gamma Radiation
         | https://news.ycombinator.com/item?id=42131762#42157208 :
         | 
         | > _A terrestrial life origin hypothesis: gamma radiation
         | mutated methane (CH4) into Glycine (the G in ACGT) and then DNA
         | and RNA._
        
       | nativeit wrote:
       | > "We are analyzing OSIRIS-REx samples for the chirality
       | (handedness) of individual amino acids, and in the future,
       | samples from Mars will also be tested in laboratories for
       | evidence of life including ribozymes and proteins," said Dworkin.
       | 
       | I clicked the hyperlink for OSIRIS-REx samples, and it didn't
       | contain any information about what kinds of materials were found,
       | but this statement suggests amino acids were collected from
       | OSIRIS-REx--did I miss this news? Were there proteins found on an
       | asteroid?
        
         | nativeit wrote:
         | Indeed I did miss that, what an incredible find, I can't
         | believe this never broke through into my routine news feeds!
         | 
         | https://www.hou.usra.edu/meetings/lpsc2024/pdf/1219.pdf
        
           | jebarker wrote:
           | How suggestive is this of life elsewhere in the universe?
        
             | staplung wrote:
             | On it's own, probably not that much. We know that amino
             | acids can form in interstellar space and have in fact
             | observed clouds of them in star-forming regions[1]. Finding
             | them on a non-planetary object in our own solar system is
             | certainly very _cool_ but we already knew they existed in
             | _this_ neck of the woods. ;-)
             | 
             | 1: https://www.space.com/amino-acid-tryptophan-perseus-
             | molecula...
        
       | jcims wrote:
       | Only tangentially related, but because they are so amazing here
       | are a few videos that illustrate the process of transcription
       | (creating mRNA from DNA) and translation (creating a protein from
       | mRNA).
       | 
       | https://www.youtube.com/watch?v=SMtWvDbfHLo
       | 
       | https://www.youtube.com/watch?v=TfYf_rPWUdY
       | 
       | The common complaint with these videos is that everything is more
       | complex. One thing that isn't evident is that these specific
       | videos (built mostly by Drew Barry) actually model a lot of other
       | molecules to create a more realistic physical environment with
       | brownian motion and whatnot. Then the irrelevant molecules are
       | simply made transparent in the rendering.
       | 
       | Obviously it's still much much more complex (eg the constant
       | stream of ATP used to drive many of these operations is not
       | illustrated).
       | 
       | There are these and many more great illustrations/explanations at
       | WEHImovies on youtube
       | 
       | https://www.youtube.com/@WEHImovies
        
         | divbzero wrote:
         | We would be remiss to leave out the 1970s classic _Protein
         | Synthesis: An Epic on a Cellular Level_
         | 
         | https://library.ucsd.edu/dc/object/bb90484996
        
         | throwawaymaths wrote:
         | these videos are better than most, but are still bad in one
         | sense, they really fail to capture just how random walk the
         | movements are. For example, in the first video the script says
         | "a mediator protein complex arrives" as if it is directed there
         | by some sort of orchestration agent. It's not. It's more like
         | "a mediator protein complex drunkenly stumbles in and connects
         | after a few thousand misses". Of course it's hard to make that
         | into a captivating video.
         | 
         | As I said, the WEHI movies are pretty good in that at least
         | they add some random walk into the motions. There was a harvard
         | artist-professor (can't remember who) who literally made videos
         | with exact parabolic and helical trajectories and then was
         | crowing about how beautiful the biological system is.
        
           | mongol wrote:
           | Thank you for clarifying what I have wondered. In most of
           | these videos it appears as if the molecules have an intent
           | and act on a plan. It makes me think "how do they know to do
           | that".
        
       | Mistletoe wrote:
       | https://www.smithsonianmag.com/space/must-all-molecules-life...
       | 
       | More explanation here.
       | 
       | >Oftentimes both the left- and right-handed versions of, for
       | example, an amino acid, were found in equal amounts--exactly what
       | might be expected. But in many cases, one or more organic
       | molecule was found with an excess of one hand, sometimes a very
       | large excess. In each of those cases, and in every meteorite
       | studied so far by other researchers in the field, the molecule in
       | excess was the left-handed amino acid that is found exclusively
       | in life on Earth.
        
         | polishdude20 wrote:
         | Could these asteroids be from when the moon was created?
        
           | skykooler wrote:
           | The moon was created far before life formed - the best
           | estimates put its formation about 4.5 billion years ago,
           | while life didn't form until 3.7 billion years ago. So any
           | complex molecules from that process would not be present on
           | asteroids of lunar origin.
        
             | gcanyon wrote:
             | For a really brilliant visualization of the time scale, I
             | can't recommend this Kurzgesagt video highly enough. It's
             | an animation of the condition of the entire history of the
             | Earth, at 1.5 million years per second of video.
             | https://www.youtube.com/watch?v=S7TUe5w6RHo
        
             | singularity2001 wrote:
             | >> The moon was created far before life formed
             | 
             | not in the panspermia theory
        
             | nkrisc wrote:
             | A better way to put it might be that current lineages of
             | life on Earth arose after the moon was created - the
             | assumption being any life that arose before the moon was
             | created would not have survived a fully molten Earth.
        
           | rybosome wrote:
           | Perhaps debris from an asteroid impact.
        
       | mannyv wrote:
       | Isn't it the same reason that the right hand rule works?
        
         | hydrolox wrote:
         | Right hand rule is just an arbitrary decision defining
         | counterclockwise to be positive, but I guess it's true that it
         | could be "less arbitrary" if certain things are more
         | counterclockwise than clockwise
        
       | hoc wrote:
       | Waiting for the
       | 
       | Creator -> left-handed
       | 
       | conclusion...
        
       | divbzero wrote:
       | > _"The findings suggest that life's eventual homochirality might
       | not be a result of chemical determinism but could have emerged
       | through later evolutionary pressures."_
       | 
       | Homochirality resulting from chemical determinism would be the
       | more surprising result to me.
       | 
       | The straightforward explanation is that random perturbations
       | early in the evolution of life broke symmetry and led to
       | homochirality of all descendent life, similar to how random
       | perturbations early in the life of the universe broke symmetry
       | and led to our world being made of particles instead of
       | antiparticles.
        
         | andrewflnr wrote:
         | It's still not obvious how they could be separated at all by
         | pre-biotic processes. You need to go from (in principle anyway)
         | a pretty well-mixed 50-50 mixture to basically only lefties. I
         | believe this is still one of the bigger problems for
         | abiogenesis, and frankly I think you're being too glib about
         | the antimatter problem too. I expect we're eventually going to
         | find out about specific mechanisms that cause those.
        
           | anlsh wrote:
           | A very plausible explanation is that the separation was
           | biotic
        
             | andrewflnr wrote:
             | There's a bootstrapping problem, though.
        
         | JackFr wrote:
         | >The straightforward explanation is that random perturbations
         | early in the evolution of life broke symmetry and led to
         | homochirality of all descendent life, similar to how random
         | perturbations early in the life of the universe broke symmetry
         | and led to our world being made of particles instead of
         | antiparticles.
         | 
         | Straightforward (and plausible) are not the same as true.
         | Random perturbations are a parsimonious explanation, but a
         | deeply unsatisfying one. With respect to matter vs antimatter,
         | my understanding is that this remains an open research question
         | in physics.
        
       | theodorejb wrote:
       | What evidence would it take for more scientists to recognize that
       | perhaps life didn't evolve through some evolutionary process, but
       | was intentionally created? It seems like few ever consider that
       | their starting presupposition may be wrong.
        
         | scrapcode wrote:
         | I certainly am trending that way as I grow older. As I've
         | recently started to re-dive into Christian theology, the fine-
         | tuning argument seems more and more interesting, and it's
         | pretty difficult to find "good" secular arguments against it.
        
           | Terr_ wrote:
           | I don't know, I think the arthropic principle is still going
           | really strong: It's like this because if it wasn't we would
           | be asking different questions or not around to ask at all.
           | 
           | It's hard to consider something "so improbable that it must
           | have been God" when we look out at a universe so
           | incomprehensibly bigger that the real question becomes why we
           | haven't evidence of it happening _more._
        
             | cowl wrote:
             | Anthropic principle is the most useless of all and it's
             | used to avoid explanation instead of trying to find one.
             | Imagine Newton answering to why objects fall with "because
             | if they did not we would be asking different questions"...
             | what a great advance for humanity /s
        
               | recursive wrote:
               | I don't think your fictional Newton is really invoking
               | the anthropic principle.
               | 
               | In all the zillions of galaxies that exist, the ones
               | where intelligent life developed are more likely to be
               | observed by intelligent life. Therefore, intelligent life
               | can't make any arguments based on probability that
               | intelligent life developed, because our observation of
               | the phenomenon is not independent.
               | 
               | And maybe some people have used it to avoid explanation,
               | but it also doesn't really conflict with any effort to
               | explain either.
        
               | cowl wrote:
               | more likely or less likely has nothing to do with
               | observation indipendece. I flip a weighted coin and it's
               | tails 99% of the time, it's the coin that is weighted it
               | has nothing to do with me. The same thing with the
               | parameters of the universe, the fact that life is present
               | on Earth and not on Mercury (to take an exterme example)
               | is not dependent on the observer being intelligent or
               | even alive. even a non intelligent "aparatus" can detect
               | it. it may not "know" to clasify it as life/not life but
               | it can detect the difference.
               | 
               | Saying that we wouldn't be here to ask the question is
               | not an answer to anything because we are here and we need
               | to understand how and why.
        
               | recursive wrote:
               | I think we are vigorously agreeing with each other.
        
               | Terr_ wrote:
               | You're confusing two different kinds of question:
               | 
               | 1. "What the mechanisms or rules that explain or seem to
               | govern this observable phenomenon?"
               | 
               | 2. "The rules behind our own existence seem unique or
               | low-probability, can I use our N=1 sample to safely
               | assume we are _inherently_ special and /or the existence
               | of a god?"
        
               | cowl wrote:
               | Those are the same kind of question. take god or the
               | "special" out of the second one and you will see that is
               | only that part that most react against. Noone reacts with
               | the antropic principle to the Fermi's paradox, noone even
               | reacted with it to the simulation hypotheses that in my
               | view is for all intents and purposes the religious one.
               | but only because it did not contain, by Name, the God, it
               | is acceptable.
        
             | philsnow wrote:
             | I know it was just a typo but "arthropic principle" sounds
             | like something from A Deepness in the Sky
        
               | Terr_ wrote:
               | That would dovetail with:
               | https://en.wikipedia.org/wiki/Carcinisation
        
             | beltsazar wrote:
             | The anthropic principle is ridiculous. Suppose that,
             | against all odds, you survive the worst plane crash in
             | history. Then you ask NTSB what caused the crash and why
             | you survived. They answer:
             | 
             | "Nonsense! You wouldn't have asked the questions if you
             | hadn't survived."
             | 
             | Questions stand alone, regardless of whether someone or
             | something exists to ask them.
        
             | AnimalMuppet wrote:
             | As it's often used, the anthropic principle is fatally
             | flawed.
             | 
             | It often starts with an argument between a creationist
             | (could also be an advocate of intelligent design, but I'll
             | just call them the creationist) and an evolutionist. The
             | creationist says, look, the origin of life by purely
             | naturalistic means is ridiculously improbable (and
             | therefore it's reasonable to consider the possibility that
             | God did it). They trot out some generally-accepted
             | scientific principle, do a back-of-the-envelope
             | calculation, and come up with a number that is, in fact,
             | ridiculously improbable.
             | 
             | The evolutionist responds with the anthropic principle - if
             | no life had arisen in this universe, we would not be here
             | arguing about how life arose. This is clearly logically
             | correct. It is also completely irrelevant.
             | 
             | The creationist didn't argue that life couldn't have arisen
             | in this universe. They argued that it could not have arisen
             | _by purely naturalistic means_. They 're arguing about
             | _how_ , not about _whether_. The creationist might answer:
             | "Yes, I agree that if life had not arisen in this universe,
             | _either by creation or by naturalistic processes_ , then we
             | would not be here having this conversation. But the
             | question is, _which_ way did life begin? " The anthropic
             | principle doesn't address that issue whatsoever.
             | 
             | It doesn't address that issue _unless_ you add an
             | assumption - that life _had_ to begin by purely
             | naturalistic means, that is, that the probability of
             | creation is precisely zero. Then the anthropic principle is
             | relevant, but then there 's a new issue, that of begging
             | the question.
             | 
             | I suspect that this assumption is present on the side of
             | everyone on the evolution side that pulls out the anthropic
             | principle in an argument with a creationist, but I have
             | _never_ heard it explicitly stated. I 'm not even sure the
             | evolutionist realizes they're making an assumption - it's
             | so ingrained in their world view that they can't think that
             | the alternative might be possible.
             | 
             | I grant you that the universe is huge and the evidence
             | available is small. But that can turn into an "evolution of
             | the gaps" argument quite easily, so I'm not sure you want
             | to seriously use it.
        
           | roncesvalles wrote:
           | Aside from the mountain of actual evidence, just to build a
           | philosophical intuition against fine-tuning - you need to
           | appreciate the enormous scale of trial and error at play.
           | 
           | - The Earth seems like the perfect planet but looking out
           | into the sky there are trillions of planets that aren't
           | perfect at all.
           | 
           | - Most likely the universe also appears "perfect" for the
           | same reason - there must be a graveyard of universes where
           | the parameters just didn't work out for life.
           | 
           | - Evolution is much the same - many mutations occur all the
           | time, most are fixed by cellular machinery, most that aren't
           | are deleterious, but once in a while a helpful mutation
           | emerges. Take a moment to understand the timescale involved.
           | Don't just handwave away 3.8 billion years as some number -
           | _feel_ it, starting at 1 year and stepping up each order of
           | magnitude. You will realize that a million years is
           | essentially  "forever ago", and we had 3800 of those to get
           | here. Consider how many species exist that aren't
           | civilizational sentient intelligence.
        
             | myflash13 wrote:
             | You're misunderstanding the point about fine-tuning
             | entirely. It doesn't matter how many billions of years it
             | took, if some of the parameters of fundamental physics were
             | slightly different, even trillions of years would've
             | resulted in nothing.
        
             | beltsazar wrote:
             | Fine tuning for the earth might be able to be explained
             | away most easily, like you said. Fine tuning for the
             | universe, though...
             | 
             | Firstly, we have zero evidence for multiverse. Some
             | scientists even argue that the idea is untestable and
             | unfalsifiable.
             | 
             | When you said:
             | 
             | > there must be a graveyard of universes where the
             | parameters just didn't work out for life
             | 
             | You just committed inverse gambler's fallacy. It's like:
             | 
             | > You wake up with amnesia, with no clue as to how you got
             | where you are. In front of you is a monkey bashing away on
             | a typewriter, writing perfect English. This clearly
             | requires explanation. You might think: "Maybe I'm dreaming
             | ... maybe this is a trained monkey ... maybe it's a robot."
             | What you would not think is "There must be lots of other
             | monkeys around here, mostly writing nonsense." You wouldn't
             | think this because what needs explaining is why this monkey
             | --the only one you've actually observed--is writing
             | English, and postulating other monkeys doesn't explain what
             | this monkey is doing.
             | 
             | -- https://www.scientificamerican.com/article/our-
             | improbable-ex...
        
         | IAmGraydon wrote:
         | I know I really shouldn't take this bait, but...no one has
         | proof either way. That said, we have a massive amount of
         | scientific evidence that shows it could have naturally evolved
         | and zero evidence that something created us. Finding something
         | that we don't understand doesn't mean we have evidence of
         | creation. Ancient civilizations believed that rain came from
         | the gods because they were unaware of how weather combines with
         | the phases of matter and creates atmospheric condensation.
         | 
         | That being the state of things at the moment, I lean towards
         | the evidence. Also, this is a scientific oriented discussion
         | forum, so you must expect that many people here are going to
         | disagree with you. Could you be correct? Sure, but we just
         | don't have reason to believe that at this point.
        
           | luqtas wrote:
           | yeah but what if the creators of life orchestrate the
           | condensation? /s
           | 
           | the amount of text (considering this is a hardware/software
           | community) i read here defending psychoanalys/acupuncture &
           | the likes as well some opinions on ecology/nutrition makes me
           | pretty agnostic of scientific orientation from users... we
           | are (most of the times) just a bunch of laypersons often only
           | reading titles & conclusions of most papers we read
        
           | myflash13 wrote:
           | > we have a massive amount of scientific evidence that shows
           | it could have naturally evolved
           | 
           | Define "naturally". However you define it, that is precisely
           | what some people call "divinely".
        
         | photonthug wrote:
         | For better or worse the standard of evidence for almost
         | everything is more like "smoking gun" than "I found a bullet".
         | In some cases this is bad, in others it is good. Just consider
         | all the criminal matters where the crime is only a crime if you
         | can additionally demonstrate intent, which is strange right,
         | since it doesn't change outcomes / injuries at all. Since
         | sufficiently ancient guns won't even be smoking anymore this
         | will be problematic for creationists even if they are correct,
         | so I think we'd need a new kind of burning bush.
        
         | andrewflnr wrote:
         | Enough evidence to overcome the enormous pile of evidence that
         | life evolved over billions of years. Often literal piles, in
         | the case of geology, but there's a lot of different kinds of
         | interlocking evidence that suggest a pretty clear picture, even
         | if a few puzzle pieces are still missing.
         | 
         | Unless you're thinking of panspermia, in which case most any
         | hard evidence would do. But that doesn't really sound like your
         | thing.
         | 
         | - a former creationist
        
           | myflash13 wrote:
           | It's not just that a few puzzle pieces are missing.
           | Abiogenesis is entirely unproven and nobody has a clue how it
           | works and nobody can demonstrate experimentally any of the
           | hypothetical mechanisms.
        
             | andrewflnr wrote:
             | No, that actually is still "a few puzzle" pieces compared
             | to the entirety of the geologic record, relatively clear
             | progressions of life forms over time that broadly line up
             | with physical and genetic taxonomy. There are some gaps,
             | yeah, but enough to clearly imply that the overall picture
             | is correct.
             | 
             | By contrast, the epistemological picture for creationism is
             | a trash fire. It requires an ever increasing amount of
             | special pleading to explain all the other evidence. And you
             | don't get to complain that "abiogenesis is entirely
             | unproven", about an event that necessarily happened long
             | before recorded history under entirely different
             | conditions, unless your own theory can stand up to a higher
             | standard of evidence. Which it can't. Speaking, again, as
             | someone who grew up under creationism and had to lever
             | myself out of it piece by piece of evidence.
             | 
             | (Oh, and if you think "nobody has a clue" how abiogenesis
             | worked, you're out of date. Try reading about the work of
             | Nick Lane and Jeremy England, IIRC.)
        
               | myflash13 wrote:
               | You don't get to claim that an "event happened long
               | before recorded history under entirely different
               | conditions", because anyone can make that claim. That's
               | not science, not evidence. I can claim the same thing for
               | intentional creation, for example.
               | 
               | If anybody has a clue how abiogenesis works, then they
               | should prove it by doing it. Manufacture some bacteria
               | out of sand. Claiming "it takes a trillion years of
               | primordial soup" is an another wild unsubstantiated claim
               | that anyone can make. That's the same thing as saying:
               | "wait a few centuries and God will show you."
               | 
               | By the way, evidence for natural evolution does not
               | contradict creationism, because God could've created some
               | things through a process of natural evolution -- it's a
               | false dichotomy to assume that evidence for evolution is
               | evidence against creationism; it's not. Whether or not
               | natural evolution happened is tangential to the claim of
               | creationism.
               | 
               | The epistemological picture for creation is quite sound.
               | Fermi's paradox is clear evidence we're special.
               | Logically, we can define God as existence itself, and the
               | existence of "anything" is proof of Him. It simply can't
               | be any other way. The fact that we have intentionality is
               | also proof that intentionality "exists" and that in turn
               | is proof that Existence is intentional.
        
         | bediger4000 wrote:
         | If we decided that life had been deliberately created, we could
         | get some insight into the god or gods who did it. What kind of
         | a diety creates parasites, for example. What kind of pantheon
         | creates a universe with Goedel's Incompleteness built in, or
         | the difficulty of the Busy Beaver game?
         | 
         | Those are fun questions.
        
       | beambot wrote:
       | Sounds a bit like playing with ice-nine...
       | 
       | https://en.m.wikipedia.org/wiki/Ice-nine
        
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