[HN Gopher] Honeybee gene specifies collective behavior, researc...
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       Honeybee gene specifies collective behavior, research shows
        
       Author : wglb
       Score  : 32 points
       Date   : 2024-11-05 21:02 UTC (5 days ago)
        
 (HTM) web link (phys.org)
 (TXT) w3m dump (phys.org)
        
       | hwillis wrote:
       | paper link: https://www.science.org/doi/10.1126/sciadv.adp3953
        
       | akomtu wrote:
       | "Our findings indicate a fundamental genetic program that
       | determines the neuronal circuitry and behavior of worker bees"
       | 
       | This dogma - that bees are little machines "programmed" by
       | genetic code - won't lead very far. A single gene may turn off
       | our auditory system because it controls production of a protein
       | that's necessary for hearing, and loss of hearing would make us
       | less social, but it's a wrong conclusion that the "auditory gene"
       | is what "programs" our social behavior.
       | 
       | IMO, Michael Levin's research is closer to truth. If we
       | extrapolate his ideas to a whole bee colony, we could find that
       | behavior of a bee hive can be changed without messing with genes,
       | although some of the genes make bees receptive to "social cues"
       | that makes such large scale behavior possible.
        
         | mmooss wrote:
         | How do they address that in the paper?
        
         | aithrowawaycomm wrote:
         | I don't think anyone is suggesting all bee behavior is
         | explained by this - bees are highly intelligent and can learn
         | all sorts of weird things about manmade objects, which can't
         | possibly be explained by genetics (except that genetics built a
         | powerful "algorithm"). In nature older bees are more effective
         | workers because they spend their lives learning about the
         | environment, including the hive itself.
         | 
         | What _is_ explained by genetics is why honeybee workers
         | immediately start working for the colony, rather than having an
         | "adolescence" where non-larval bees watch older workers for an
         | extended period, or why honeybee workers almost never wander
         | out of the hive and try to live on their own. That side is
         | clearly somewhat instinctual and must have at a genetic or
         | epigenetic component.
        
         | mglz wrote:
         | Fudnamentally the genes have to code for a biologicaly system
         | that is able to adapt its behaviour well enough to allow for
         | dynamic behaviour while also keeping it on guiderails to make
         | it function as a bee. Importantly a bee emerging from its brood
         | cell immediately gets to work without any training. Where does
         | this information come from if it is not genetic?
        
       | mmooss wrote:
       | In case you want to try honeybee experiments at home ... from the
       | paper:
       | 
       | https://www.science.org/doi/10.1126/sciadv.adp3953
       | 
       | "Honeybee handling procedures
       | 
       | The honeybees were collected from Apis mellifera carnica colonies
       | (western honeybee) at the bee yard of the Heinrich-Heine
       | University, Dusseldorf, Germany. Female eggs were collected from
       | naturally mated queens, which were maintained in small nuc
       | colonies with five combs (Holtermann, Germany). To collect female
       | eggs, the queens were caged in Jenter egg-collecting cages
       | (Jenter queen rearing kit, Karl Jenter GmbH, Frickenhausen,
       | Germany). For the tracking, we collected newly eclosed bees (0 to
       | 24 hours old) from a brood comb that was maintained in an
       | incubator at 34degC. The laboratory rearing of worker bees was
       | done as previously reported (19). We grafted the newly hatched
       | larvae into plastic cups (#4963, Heinrich Holtermann KG, Brockel,
       | Germany) with worker diet # 7 (53% royal jelly, 4% glucose, 8%
       | fructose, 1% yeast extract, and 34% autoclaved water) (74). To
       | obtain bees with fully developed worker characteristics, we
       | experimentally determined the amount of food provided, which was
       | 170 ml per larvae. The larvae were kept at 34degC and 90%
       | relative humidity. The latter was generated using saturated
       | solution of K2SO4 (75). Before defecation, the larvae were
       | transferred onto Kimwipe papers (Delicate Task Wipers, #066664,
       | Kimberly Clark) and were kept in petri dishes for 2 days at 70%
       | relative humidity, which we generated using saturated NaCl2
       | solutions (75). After defecation, the prepupae were separated
       | into plates with 24 wells (#92424, Peter Oehmen GmBH, Essen,
       | Germany) in which filter papers were placed (15 mm, grade 413;
       | VWR, International GmbH, Darmstadt, Germany). Once they started
       | walking, they were marked and maintained in small cages together
       | with eclosed wt workers coming from colonies (#20104;
       | Imkereifachhandel Jasniak, Trossin, Germany) in which water and
       | sugar paste supplemented with pollen (#7032; Heinrich Holtermann
       | KG, Brockel, Germany) was provided. To obtain myrGFP-mutated
       | worker or queen bees, we reared the queens as described (17, 76).
       | To obtain myrGFP worker bees, 12- to 19-day-old myrGFP queens
       | were inseminated with wt drones using standard insemination
       | techniques. The queens were treated with CO2 1 day before
       | insemination. Inseminated queens were maintained in small nucs
       | ("Kieler Begattungskasten," Holtermann, Germany) with wt worker
       | bees. The nucs were kept in a containment so that mutated animals
       | were not able to escape into nature. To obtain newly eclosed
       | dsxmyrGFP/+ worker bees, combs with capped cells were maintained
       | in an incubator at 34degC."
        
       | mmooss wrote:
       | An interesting insight led to their research (from the paper):
       | https://www.science.org/doi/10.1126/sciadv.adp3953
       | 
       | (First, some interesting background:)
       | 
       |  _" The evolutionary transition from solitary to social living in
       | vertebrates and invertebrates led to sophisticated social
       | behaviors. During the past 50 to 150 million years of evolution,
       | sociality in some species became so elaborate that individuals in
       | the group forego reproduction and changed their behavioral
       | performance to embrace collective behavior, while others
       | specialize in reproduction leading to the development of two
       | castes, queen and workers (1, 2). From behavioral activities of
       | hundreds and sometimes ten-thousands of worker individuals, new
       | properties have emerged at the collective level such as shared
       | brood care, warfare, collective thermoregulation, nest building,
       | and farming, which contributed to the spectacular ecological
       | success of the eusocial species (2). The collective tasks and
       | functions cannot be performed by any single individual alone.
       | They require a group and inherited behavioral patterns performed
       | by individual workers."_
       | 
       | (And later ... [I added the paragraph breaks])
       | 
       |  _" In advanced eusocial insect colonies, sophisticated innate
       | behaviors establishing sociality are limited to the worker caste,
       | not to queens. This led to our hypothesis that a dedicated
       | developmental program for social behaviors will be found in the
       | pathway determining the differentiation into the worker castes.
       | ...
       | 
       | Dsx proteins are part of the structurally and functionally
       | conserved doublesex and mab-3-related transcription factor family
       | (Dmrt) and are critical for sex-specific differentiation
       | throughout the animal kingdom (39, 40) and sexual behaviors in
       | insects (9, 41). DsxF is required for the worker-characteristic
       | differentiation of the worker ovary, suggesting that DsxF is a
       | component of the worker caste developmental program (19).
       | 
       | The worker bees do not perform sexual behaviors. However, we
       | found that dsx is also expressed in the worker's brain (42)
       | suggesting that the gene may have another role unrelated to
       | sexual reproduction but related to promoting social living
       | behaviors in the worker caste."_
        
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