[HN Gopher] High-resolution postmortem human brain MRI at 7 tesla
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High-resolution postmortem human brain MRI at 7 tesla
This tool provides performs segmentation, parcellation and
registration of ultra high-resolution (< 300 microns) postmortem
human brain hemisphere at 7 tesla t2w MRI. This pipeline leverages
advances in both deep learning and classical surface-based modeling
techniques. The developed method allows us to perform vertex-wise
analysis in the template space and thereby link morphometry
measures with pathology measurements derived from histology.
Author : pulks
Score : 117 points
Date : 2024-10-25 18:44 UTC (4 days ago)
(HTM) web link (pulkit-khandelwal.github.io)
(TXT) w3m dump (pulkit-khandelwal.github.io)
| dang wrote:
| We changed the url from https://github.com/Pulkit-
| Khandelwal/purple-mri to the project page, which is a bit more
| explanatory. Readers may want to look at both, of course.
| SubiculumCode wrote:
| 7T is so rad.
|
| edit: I know it was a lazy comment. but I did truly mean it. I
| did high-resolution imaging of the hippocampal subfields in my
| PhD dissertation, and I wished so much to have access to a 7T for
| structural imaging of those subfields...So powerful.
| HarryHirsch wrote:
| For those using a smaller bore diameter, 7 T is 300 MHz proton
| frequency, and the engineering challenges to maintain a
| homogeneous field over 600 mm are immense.
| Traubenfuchs wrote:
| The Biospec 15.2 Tesla MRI is now sold for more than 10
| years...
| selectodude wrote:
| It has an 11cm bore. You can't fit a brain inside it. 7T is
| the cutting edge of useful MRI.
| Traubenfuchs wrote:
| We can cut it in 8 brain cubes.
| gorkish wrote:
| For anyone whose brain is still in their head and/or doesn't have
| 7T data, there is also FreeSurfer[1] to play with.
|
| I only really know about the physics of MRI, so I admit I don't
| fully understand what the advantage of this project is against
| other work; I assume it would have a lot to do with the fact that
| the data is so much higher resolution and can identify finer
| structure within the brain.
|
| [1] https://surfer.nmr.mgh.harvard.edu/
| TechDebtDevin wrote:
| Dang this sucks, I had all the files from my brain MRI when I
| got Dengue Fever but my laptop recently got stolen out of my
| car and the CD they gave it to me on was in it. This would have
| been fun to mess with. The MRI facility is in another country
| so not sure how easy it would be to get them to send me the
| data again (although they should I gave them 3k dollars).
| throwup238 wrote:
| Just ask them. I don't know which country it's in but they
| may be legally obligated to send it to you (maybe for a
| modest fee), regardless of which country you're from. They
| usually are in developed countries but YMMV everywhere else.
| gorkish wrote:
| Every country is different but I'd be surprised if they don't
| still have it.
|
| The irony is they will probably still have to burn it on a CD
| and mail it to you. Good old DICOM!
| TechDebtDevin wrote:
| Yeah I'm going to try and get it now. That sucks though,
| because that laptop was the last device I had that had a cd
| drive! Maybe an excuse to finally get one of those modded
| vintage Thinkpads with modern mobo/cpu.
| robotnikman wrote:
| There's always USB CD/DVD drives you can use, or I've
| even seen external USB enclosures for Desktop and Laptop
| CD/DVD drive form factors which you can just shove one
| into.
| foobarian wrote:
| Ironically an external USB DVD reader will probably be
| cheaper than getting your hands on that CD...
| jonnycomputer wrote:
| Almost certainly you can probably get it from them again.
| gorkish wrote:
| > admit I don't fully understand what the advantage of this
| project is against other work
|
| Replying to myself here; seems that the combination of being ex
| vivo and 7T means that the resolution increase over a typical
| in vivo patient scan is really really tremendous since your
| dead brain is happy to remain completely still through multi-
| hour sequences. The resolution you can get is primarily
| dependent on field strength but like many things in signal
| processing, you can trade integration time for higher
| resolution to a point. So this dataset is at about 100micron
| while 7T in vivo can only get down to maybe 300-1000micron
| (best case depending on patient movement)
| Lerc wrote:
| I find myself dwelling on Karaoke/Cold Lazarus more and more as
| technology progresses.
|
| It seems to exist on Youtube.
| https://www.youtube.com/watch?v=IwYlzSQTL2A&list=PLmRu2axUu2...
|
| It's hard to say how it's relevant without spoiling it too much
| though.
| aftbit wrote:
| There is something a bit spooky about looking at a dead brain. To
| think that a person lived in that their entire life, and now it's
| just lying on a table not doing anything.
|
| I guess that's true for whole bodies and all of their parts too,
| but something about the abstraction of removing the skin, bones,
| face, etc that we are used to interacting and distilling to the
| seat of consciousness and emotions makes it spookier.
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(page generated 2024-10-29 23:02 UTC)