[HN Gopher] Rapamycin: One Drug, Many Effects (2014)
___________________________________________________________________
Rapamycin: One Drug, Many Effects (2014)
Author : sandwichsphinx
Score : 24 points
Date : 2024-10-27 17:06 UTC (5 hours ago)
(HTM) web link (www.cell.com)
(TXT) w3m dump (www.cell.com)
| debacle wrote:
| The discovery of rapamycin sounds like something a Joe Rogan
| guest would pontificate about. What an interesting drug.
| adamredwoods wrote:
| Joe Rogan only shows interest to conspiracy and contraversy, so
| I don't think he would invite a guest to pontificate about
| science and medicine that could be benefitial to humankind.
|
| But it is an interesting drug:
|
| >> The protein, now called mTOR, was originally named FRAP by
| Stuart L. Schreiber and RAFT1 by David M. Sabatini;[6][7] FRAP1
| was used as its official gene symbol in humans. Because of
| these different names, mTOR, which had been first used by
| Robert T. Abraham,[6] was increasingly adopted by the community
| of scientists working on the mTOR pathway to refer to the
| protein and in homage to the original discovery of the TOR
| protein in yeast that was named TOR, the Target of Rapamycin,
| by Joe Heitman, Rao Movva, and Mike Hall
| ALittleLight wrote:
| Just googled "Joe Rogan rapamycin". Seems like he talks about
| it in multiple episodes with (at least) doctors Peter Attia
| and David Sinclair.
| bitwize wrote:
| Not surprising. Rogan is also an aging gymbro who would
| definitely be interested in anything that might boost
| performance to youth-like levels.
| Kalanos wrote:
| my opinion is that targeting mTOR is fruitless because it's so
| broad and integral to life that it's like a self-righting ship or
| trying to sink a life preserver.
|
| as described in the conclusion: "This may be explained by the
| inability of rapamycin to completely block mTORC1-mediated
| signaling events, the presence of several feedback loops, and the
| upregulation of compensatory pathways that promote cell survival
| and growth."
|
| targeting mTOR is like saying "let's write a bug that takes down
| Linux"... the community isn't going to let that happen
| Teever wrote:
| Can you elaborate?
|
| It seems to be not fruitless in all the organisms that it has
| worked on so far.
| nabla9 wrote:
| It's everything. It can work against cancer and cause cancer.
| Make you age slower, but kill you faster.
|
| It's immunosuppressant. Suppressing immune system for completely
| health person decreases inflammation that comes with aging.
| Suppressing immune system makes person more vulnerable for
| infections (flu, sepsis, herpes, ...), and wounds heal slower.
| Also cancers.
| api wrote:
| Humans are already among the longest living land mammals and
| rank pretty high among _all_ large animals land or otherwise.
| We 're already evolutionarily optimized for longevity.
|
| Trying to push further out seems to run into a lot of trade-
| offs. It seems from what I've read that there are mechanisms
| that cause aging but also are defenses against cancer, like
| telomere shortening which imposes a cellular division limit.
| The immune system causes inflammation which causes aging but
| turn that off and stuff eats you. And so on...
|
| Not saying it's not possible, just that it's going to require
| more than tweaking a few knobs. I highly doubt there will ever
| be a "longevity pill" that _radically_ extends life span,
| though obviously there are medications that can have some
| positive effect especially on health span. Anything radical
| like taking the average well past 100-120 years is probably
| going to require genetic engineering or radical (and invasive)
| regenerative medicine.
___________________________________________________________________
(page generated 2024-10-27 23:01 UTC)