[HN Gopher] Diabetes Breakthrough: New Treatment Eliminates Insu...
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Diabetes Breakthrough: New Treatment Eliminates Insulin for 86% of
Patients
Author : amichail
Score : 63 points
Date : 2024-10-17 20:46 UTC (2 hours ago)
(HTM) web link (scitechdaily.com)
(TXT) w3m dump (scitechdaily.com)
| janice1999 wrote:
| Paper: https://pubmed.ncbi.nlm.nih.gov/38692517/
|
| > Recellularization via electroporation therapy (ReCET) is a
| novel endoscopic procedure that uses electroporation to induce
| cellular apoptosis and subsequent reepithelization.
| arcticbull wrote:
| ... plus GLP-1.
|
| GLP-1s baseline eliminate insulin for about ~40% of people.
| This boosts that number to 86%.
|
| Note that Tirzepatide also reduces the chance of developing
| type 2 in the first place by 94%, and I suspect that newer
| generation receptor agonists will see higher insulin
| discontinuation rates in general.
|
| Very cool stuff all around. Might finally be able to put this
| whole obesity-and-diabetes thing to bed.
| metadat wrote:
| Tirzepatide side effects sound pretty nasty, though less so
| than dying in a diabetic coma.
|
| https://en.wikipedia.org/wiki/Tirzepatide
| arcticbull wrote:
| Directionally each generation of these drugs targets more
| receptors and has fewer side effects. Tirzepatide is also
| amazing in that people lost an average of 20.9% of their
| body weight in studies. [1]
|
| [1] https://www.nejm.org/doi/full/10.1056/NEJMoa2206038
| metadat wrote:
| What if I didn't want to lose weight? Would I be a bad
| candidate?
| tssva wrote:
| The side effects are usually short lived. I'm on
| tirzepatide and had some mild digestive issues for the 1st
| 3 - 4 weeks and haven't had any since then. My side effects
| when starting metformin were worse.
| looperhacks wrote:
| Note: This is about diabetes type 2, not type 1. Might be worth
| to editorialize the heading in this case.
| wwilim wrote:
| eh, I had a brief glimmer of hope
| tj-teej wrote:
| As a T1D I empathize so strongly with this comment.
|
| There was a promising example in China where Scientists cured
| a single woman who had T1D. It's n=1, but the first step to a
| cure is curing someone :)
|
| Source: https://www.nature.com/articles/d41586-024-03129-3
| 1123581321 wrote:
| n=3 but the other two haven't been monitored for a year
| yet. Promising.
| mapt wrote:
| Immunology & autoimmune attack is still a wild country
| where discoveries are being made regularly and only a
| handful of people have even a rough grasp of the terrain.
| dyauspitr wrote:
| Something that works for 95% of people with diabetes then.
| Fantastic!
| tzs wrote:
| Don't only something like 25% of type 2 diabetics take
| insulin?
| coldcode wrote:
| Most people with T2D do not take insulin, it's only useful
| if your body cannot make a sufficient amount. In my case I
| have no need for it, the cells became resistant to the
| effects of insulin. 25% is probably a decent estimate.
| jasonpeacock wrote:
| How long does this cure last until the unhealthy diet & lifestyle
| that originally caused the insulin resistance bring it back
| again?
|
| It's frustrating, as Type 2 diabetes is 100% manageable through
| diet. You don't even have to exercise, just eat healthy. Today,
| with the use of continuous glucose monitors, you have all the
| data you need to make informed diet decisions - you know exactly
| what "eat healthy" means for your body.
| sctb wrote:
| Not sarcasm: I'm sure it would be frustrating to see so much
| scientific and commercial effort going into treating TIID
| pharmacologically when you believe the solution is trivial. But
| you could also consider all of these developments as evidence
| that the prescription of "just eat healthy" isn't broadly
| useful.
| jasonpeacock wrote:
| 100% agree, it's a modern cultural problem. We look for drug
| and technology solutions because "doing the right thing" is
| hard.
| baq wrote:
| GLP-1 drugs don't make you burn fat, they make you eat
| healthy (or healthier, at least). That's why they're so
| amazingly effective and the reason why is even more amazing
| - they hack your reward subsystem.
| mapt wrote:
| When you say "it's a modern cultural problem", do you mean,
| as most people appear to mean, "This is not a social
| problem worth solving, these people deserve it for their
| moral failings, and their death is a useful example for the
| rest of us"?
|
| Most people don't actually say it out loud, but this is all
| directly implied by the "personal responsibility" retort
| that is wildly popular among people who don't actually
| suffer from a given malady, in response to attempts to
| address it collectively.
| meiraleal wrote:
| > But you could also consider all of these developments as
| evidence that the prescription of "just eat healthy" isn't
| broadly useful.
|
| As programmers, we usually prefer to remove code to remove
| bug than adding patches on top of old code. Let's not pretend
| that the same logic does not apply here.
|
| That's clearly double unhealthy behavior and will bring
| unintended consequences. Which might be better than the
| current predicament but still let's not pretend this is not a
| "monkeypatch".
| nessguy wrote:
| Considering the article mentions ReCET and semaglutide,
| presumably most people in the study weren't resuming the
| unhealthy diet.
|
| Semaglutide is ozempic. By itself it can be enough to help
| people get their A1C down through healthier diets.
|
| For me to find the study especially interesting, I'd have to
| see a comparison between ReCET + semaglutide vs just
| semaglutide. And upon re-reading I see that's their plan.
|
| > "We are currently conducting the EMINENT-2 trial with the
| same inclusion and exclusion criteria and administration of
| semaglutide, but with either a sham procedure or ReCET. This
| study will also include mechanistic assessments to evaluate the
| underlying mechanism of ReCET."
| waldrews wrote:
| s/Broken ankles are 100% manageable by not walking where you
| could slip and fall. If only today's society made informed
| decisions about their walking habits, we wouldn't need all
| these artificial casts and surgeries. How long does a cured
| ankle last till the lifestyle of walking around breaks it
| again?/
| stavros wrote:
| Well, shit. I can't believe it never occurred to these obese
| people to just eat right!
|
| You, sir, are a modern messiah. Well done.
| dyauspitr wrote:
| I didn't seem to get this from the article but this this involve
| taking semaglutide for the rest of your life or the diabetes
| returns?
| purpleblue wrote:
| Big Pharma is going to get rid of this immediately.
| jokoon wrote:
| sir this is not reddit
| mnw21cam wrote:
| I wouldn't ignore the effect that having surgery and then two
| weeks of a strictly controlled food intake has. That might
| account for a large proportion of the success rate. I heard about
| a study that found that the fasting required for bariatric
| surgery actually provides a large proportion of the benefit of
| the procedure.
|
| If you catch type 2 diabetes before it gets so bad that it has
| killed off the beta cells, then your best treatment is to fast
| for a while. After a couple of days, you should notice a massive
| improvement in glucose control. A week of fasting a couple of
| times a year might be all it takes to give you a complete cure.
| YMMV, but in my opinion (and that of a whole load of people who
| know what they're talking about) it's better than filling
| yourself with drugs.
|
| After the beta cells have been killed off by overwork, yeah, you
| need insulin. But you can still reduce the amount you need by
| losing weight.
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