[HN Gopher] Giving T cells extra batteries supercharges them aga...
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       Giving T cells extra batteries supercharges them against cancer
        
       Author : peutetre
       Score  : 164 points
       Date   : 2024-09-24 12:51 UTC (10 hours ago)
        
 (HTM) web link (newatlas.com)
 (TXT) w3m dump (newatlas.com)
        
       | Zelphyr wrote:
       | This is why good quality nutrition is so important. It's like
       | giving all of our cells--not just T cells--extra batteries.
        
         | tjohns wrote:
         | To be fair, I'd prefer not to give the cancer cells extra
         | batteries.
        
           | Zelphyr wrote:
           | In truth, it's usually the opposite when our bodies are
           | fueled properly.
        
             | hansvm wrote:
             | I thought I remembered something about certain nutrients
             | (magnesium?) being something you could intentionally reduce
             | to slow down cancer growth -- kind of like a DIY
             | chemotherapy; your cells need Mg to grow and multiply, but
             | cancer cells need it more. Paired with other treatments,
             | where applicable, the reduced nutrient diet had positive
             | clinical outcomes.
        
             | parineum wrote:
             | Define "quality nutrition" and cite a source.
        
               | bitcoin_anon wrote:
               | My health has been improving by eating according to this
               | book:
               | 
               | https://a.co/d/2dHgtQr
        
               | fhieufn wrote:
               | "Quality nutrition" is any scientifically backed research
               | results on good health.
               | 
               | Here is a resource that uses research to back up its
               | claims:
               | https://www.efsa.europa.eu/en/topics/topic/dietary-
               | reference...
               | 
               | And it has a good tool to find and meet those results:
               | https://multimedia.efsa.europa.eu/drvs/index.htm
        
             | nradov wrote:
             | Really? Most clinical trials for nutritional therapy as a
             | cancer treatment haven't produced significant results.
        
               | fhieufn wrote:
               | This is a surprising position.
               | 
               | Can you link to any?
               | 
               | Everything I have read on the subject says obesity, a
               | nutritional imbalance, is one of the main contributors to
               | cancer growth, and specifically a reduction in sugar and
               | meat have significant positive results in combating
               | cancer's growth.
               | 
               | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559313/
               | 
               | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775518/
               | 
               | https://onlinelibrary.wiley.com/doi/epdf/10.1002/04708699
               | 76....
        
               | nradov wrote:
               | There is no reliable evidence that red meat consumption
               | increases cancer risk. You are spreading medical
               | misinformation by incorrectly interpreting low-quality
               | observational studies.
        
               | ericmcer wrote:
               | Weird I feel like I read the opposite, that a high
               | protein/fat diet would slow cancer because it thrives on
               | glucose, so cutting carbs/sugar was key.
               | 
               | It seems counter intuitive to me that meat & sugar would
               | both be correlated because they are almost opposites from
               | a metabolic standpoint. One is pure fat/protein and one
               | is just glucose.
        
               | adamredwoods wrote:
               | We might know what causes some growth, but it's not
               | homogeneous, and we certainly can't stop it with diet
               | alone once it starts.
               | 
               | https://www.fredhutch.org/en/news/center-
               | news/2019/10/keto-f...
               | 
               | >> But Mukherjee's August 2018 paper in Nature also found
               | that a ketogenic diet was helpful -- even "synergistic"
               | -- with certain cancers and certain treatments. At least
               | in mice.
               | 
               | >> "It's probably most helpful in cancers that utilize
               | the PIK3CA / AKT / MTOR pathway [an intracellular
               | signaling pathway]"
        
           | adamredwoods wrote:
           | A common goal, but tumors mutate and bypass a lot of normal
           | cell functions. Keep in mind that when dying cancer patients
           | starve in the end, the tumors don't slow.
           | 
           | https://medicine.wustl.edu/news/study-unveils-new-way-
           | starve...
           | 
           | https://news.feinberg.northwestern.edu/2024/05/02/drug-
           | shows...
           | 
           | https://news.cancerresearchuk.org/2023/01/30/starving-
           | cancer...
        
         | vaylian wrote:
         | How is this related to the number of mitochondria in a cell?
        
           | agumonkey wrote:
           | I believe that the opposite is useful, fasting -> autophagy
           | -> improved mitochondrial health (not sure). Maybe that's
           | what parent tried to say.
        
         | 1oooqooq wrote:
         | nah. let's base the entire world diet on numbers of calories,
         | provided by crops which are collected annually or biannually so
         | we can have an efficient futures market :thumbsupemoji
        
           | tekla wrote:
           | Yep, we prefer to keep people alive first since its hard to
           | care about the health and well being of dead people.
        
       | Laaas wrote:
       | > The team cultured BMSCs and T cells together, and after 48
       | hours found that up to a quarter of the T cells had gained extra
       | mitochondria. The researchers dubbed these juiced up immune cells
       | Mito+.
       | 
       | What an incredibly simple idea. Just scale it up.
        
         | gorkish wrote:
         | How many do you have to have before you can start using the
         | Force?
        
           | ImHereToVote wrote:
           | "The midichlorian is the forcehouse of the cell."
        
           | CoastalCoder wrote:
           | "Whatever the stupid, lazy writers at Disney needed it to be
           | this week." - The Critical Drinker*
           | 
           | * I imagine
        
             | rpmisms wrote:
             | That's probably what he would say. The actual minimum to be
             | able to use the force is a 7000 midichlorian count.
        
               | politician wrote:
               | I thought it was over 9000.
        
             | adamc wrote:
             | Totally a tangent, but he's right about that. It was a flaw
             | in Harry Potter as well. There was no logical system to how
             | magic worked; spells did whatever plot requirements said
             | they did. And it detracts from the sense of realism in a
             | world when the magic just does whatever is needed at the
             | moment.
        
               | dylan604 wrote:
               | But. It's. Magic.
               | 
               | Magic can do anything. That's why it's magic. How does it
               | work? Magic. It's a perfectly complete circle in logic.
        
               | Aerroon wrote:
               | Well, magic still needs to follow some kind of rules for
               | it to be usable. Otherwise "magic" would just be
               | something random (or maybe chaotic - we just haven't
               | figured out the rules well enough).
        
               | mrkstu wrote:
               | Or, you can do the Brandon Sanderson thing, and have a
               | comprehensive system that has limits and a consistent
               | expression of magical power.
        
               | dylan604 wrote:
               | but then it's no longer magic. it now becomes some sort
               | of metaphysical science. magic is magic. once you
               | understand it, it is no longer magic.
        
               | jajko wrote:
               | Sounds like most religions. And most modern folks having
               | issues with religions they were brought up in don't have
               | _this_ as their main issue with it.
               | 
               | One addresses child's imagination which just wants to be
               | wowed, the other our eternal fear of unknown and death.
        
               | 0cf8612b2e1e wrote:
               | The very much NSFW web comic Oglaf had a strip about
               | this.
               | 
               | In this rare instance, the comic is SFW, but still be
               | wary. https://www.oglaf.com/claret/
        
               | adamc wrote:
               | Compare to, say, "A Wizard of Earthsea", where magic is
               | explained in a different way that points out that while a
               | wizard _could_ transmute one substance into another, no
               | wizard would, because of the far-reaching ramifications.
               | 
               | The system was not fully elucidated by any means, but the
               | subtlety of it was suggested by such things as Ged
               | deducing that the doorkeeper was one of the seven masters
               | of Roke.
        
               | 0cf8612b2e1e wrote:
               | Acknowledging it is a children's book...
               | 
               | I take significantly bigger issue with the lack of
               | societal change from having magic. Way too much of wizard
               | society was "Muggles + occasional party tricks". When you
               | can conjure food, water, automatons, etc from nothing,
               | nature of living would change completely.
               | 
               | You can brew luck? I would be mainlining that stuff every
               | day. Time travel is given to children? Why is there a
               | train when there are a dozen different ways of magicking
               | yourself around the world?
               | 
               | Harry Potter and the Methods of Rationality touched on
               | these inconsistencies.
        
           | highwaylights wrote:
           | Less than you'd think. Not even master Yoda has a
           | mitochondria count that high!
        
           | tomrod wrote:
           | A more direct reference, though maybe obscure these days, is
           | _Parasite_ _Eve_
        
       | gl-prod wrote:
       | Come on, T cells, you can do it
        
       | 1970-01-01 wrote:
       | ..in mice
        
       | dopylitty wrote:
       | >Previous studies have shown that cancer cells can use nanotubes
       | like "tiny tentacles" to slurp up mitochondria from immune cells.
       | 
       | Biology is nuts.
       | 
       | Regarding messing with T-cells I wonder how evolution came up
       | with the current number of mitochondria per cell. Usually with
       | these things there's some kind of push and pull between the
       | benefits of something and the drawbacks. Or sometimes it's just
       | whatever works. I know mitochondria can have some negative
       | impacts on cells sometimes by releasing the byproducts of
       | metabolism (reactive oxygen species) or triggering programmed
       | cell death.
        
         | golergka wrote:
         | Could it be just amount of energy available to the organism?
         | Modern humans are in completely unique position relative to all
         | history of life on Earth, having access to as much food (and
         | energy) as we want, and having a widespread problem of eating
         | too much. Evolution didn't have any chance to catch up with
         | this reality.
        
         | kurthr wrote:
         | I really appreciate the commentary here on HN. The headline was
         | awful enough, but the quotes, really let me know the level of
         | horror movie aesthetic there is in the commentary supposedly
         | about biology.
         | 
         | Thanks, NewAtlas, but it's just not the mixed metaphor I'm
         | looking for.
        
         | wnevets wrote:
         | > Regarding messing with T-cells I wonder how evolution came up
         | with the current number of mitochondria per cell.
         | 
         | An over active immune is generally a bad thing for the host.
         | Maybe a higher number increases auto immune disease?
        
           | devmor wrote:
           | Not just a bad thing - one of the worst possible things.
           | That's how you get chronic inflammation.
        
         | derefr wrote:
         | Dunno about mitochondria as a cell feature specifically. But
         | there exists a similar constraint on the total size of the DNA
         | in the cell nucleus (and therefore the ability of a species to
         | survive polyploid mutations that double-or-more the amount of
         | DNA per cell); and I believe we _do_ (think that we) understand
         | the cause of that one.
         | 
         | This polyploidy constraint only exists for animal cells, not
         | for plant cells. Plants can -- and frequently do! -- get as
         | polyploid as they want; but animals have a ceiling.
         | 
         | And that implies that the constraint has something to do with
         | one of the main differences between plant and animal cells:
         | namely, the fact that animal cells -- specifically, blood cells
         | -- must _move and flow_ along channels composed of other cells;
         | while plant cells are fixed in place by their stiff cellulose
         | membranes, with only fluids and tissues flowing.
         | 
         | The problem animal cells have with polyploidy, is seemingly
         | that it makes their cells _physically larger_ -- and in so
         | doing, causes biological architectural assumptions like  "blood
         | cells can travel through narrow capillaries to deliver oxygen
         | to cells within extremity tissues" to just fail to hold. The
         | capillaries, when composed of larger cells, are narrower; and
         | the blood cells flowing through, composed of larger cells,
         | won't fit.
         | 
         | (Evolution could in theory resolve this single problem by just
         | scaling all features up in size. But that causes far more
         | problems than it solves: the square-cube law requires huge
         | changes to things like muscles and metabolism to keep up with
         | increased size, if it's even possible; and some organs/tissues
         | just _require_ to be a certain size to function -- like the
         | nephrons of the kidneys -- such that these instead need to stay
         | the same size, evolving distinct adaptations to handle the
         | increased size of the cells that travel to /through them.)
        
           | cyberax wrote:
           | > blood cells can travel through narrow capillaries to
           | deliver oxygen to cells within extremity tissues
           | 
           | Mammalian red blood cells do not have DNA or mitochondria.
           | They lose them during the maturation process in the bone
           | marrow.
           | 
           | But apparently this might just be one of the evolution's
           | blind turns. Birds have even faster metabolism with higher
           | oxygen requirements, and their red blood cells have nucleus.
        
             | Vecr wrote:
             | I think derefr might be talking about the cells that form
             | the walls of the capillaries being bigger, so you can't
             | really fit them in the places you need them, and if you
             | tried they'd be too narrow.
             | 
             | Except replace "you" with evolution and delete "tried".
        
             | derefr wrote:
             | When I say "blood cells", I mean "all blood cells", not
             | specifically "red blood cells." Anywhere your blood plasma
             | flows, _all_ types of blood cells are carried along with
             | it.
             | 
             | As such, to prevent infarction, every capillary in your
             | body must be at least wide enough, in its narrowest state,
             | to still accommodate the passage of the _largest_ blood
             | cell type the body produces, in its _largest_ state.
             | (Which, for us humans, is probably something like  "a
             | neutrophil that is bloated from just having consumed a
             | large bacterium.")
        
               | hollerith wrote:
               | The neutrophils and macrophages don't reliably know to
               | exit the bloodstream when they're bloated?
        
               | derefr wrote:
               | Even if they did, they still might have ended up catching
               | and eating the bacterium right at your fingertip. (Heck,
               | that's not even an edge-case -- fingertips and other
               | extremeties served by the tiniest of bloodflow channels,
               | get wounded and infected pretty often!)
               | 
               | Think of it like: what would civic street sizing
               | regulations look like, if fire trucks -- already the
               | longest thing most residential streets need to
               | accommodate -- had to rapidly reconfigure and redeploy
               | into an _even longer_ shape, while sitting there on the
               | street, to do their job; and then were stuck in this
               | state until they made it back to the depot?
        
               | hollerith wrote:
               | I see. Thanks.
        
           | rolisz wrote:
           | From listening to Michael Levin, he describes how in newts
           | you can multiply the DNA of kidney cells (or some tubules
           | around there). The cells become larger, so they adapt by
           | forming the same size of tubule with fewer cells. If you keep
           | duplicating the DNA, at some point a single cell is enough to
           | form the tubule, which it does by bending around.
        
           | shagie wrote:
           | The fun part is scaling the _other_ way... for tiny animals.
           | 
           | https://www.science.org/content/article/scienceshot-
           | amoeba-s...
           | 
           | > You can't shrink down to the size of an amoeba without
           | losing parts of yourself. That's the lesson one researcher is
           | taking away from a microscopic analysis of the fairy wasp
           | (Megaphragma mymaripenne), which at a mere 200 micrometers in
           | length is one of the world's smallest animals (shown compared
           | to a paramecium and amoeba above). When the scientist
           | compared the neurons of adult and pupae fairy wasps, he
           | discovered that more than 95% of adult neurons lack a
           | nucleus.
           | 
           | https://www.sciencedirect.com/science/article/abs/pii/S14678.
           | ..
           | 
           | > The smallest insects are comparable in size to unicellular
           | organisms. Thus, their size affects their structure not only
           | at the organ level, but also at the cellular level. Here we
           | report the first finding of animals with an almost entirely
           | anucleate nervous system. Adults of the smallest flying
           | insects of the parasitic wasp genus Megaphragma (Hymenoptera:
           | Trichogrammatidae) have only 339-372 nuclei in the central
           | nervous system, i.e., their ganglia, including the brain,
           | consist almost exclusively of processes of neurons. In
           | contrast, their pupae have ganglia more typical of other
           | insects, with about 7400 nuclei in the central nervous
           | system. During the final phases of pupal development, most
           | neuronal cell bodies lyse. As adults, these insects have many
           | fewer nucleated neurons, a small number of cell bodies in
           | different stages of lysis, and about 7000 anucleate cells.
           | Although most neurons lack nuclei, these insects exhibit many
           | important behaviors, including flight and searching for
           | hosts.
           | 
           | And the Wikipedia article for the species -
           | https://en.wikipedia.org/wiki/Megaphragma_mymaripenne
           | 
           | In particular:
           | 
           | > Researchers believe the wasp can survive without nuclei
           | because of its short lifespan; the proteins manufactured
           | during the pupal stage last the animal long enough to
           | complete its life journey.
        
             | derefr wrote:
             | Interesting, but not surprising -- DNA, and the cellular
             | nucleus itself, aren't truly _required_ to make our cells
             | "go". (At least over the span of a few days.)
             | 
             | That is, after all, what _radiation poisoning_ is: a
             | complete destruction of your DNA in your cells, while the
             | cells themselves (attempt to) continue to function. And
             | they do! For some number of days. And that 's _without_ any
             | of our evolutionary ancestors ever having been under
             | evolutionary pressure to live without DNA (as far as we
             | know.)
             | 
             | IIRC, cell death from radiation poisoning follows a bathtub
             | curve.
             | 
             | * There's firstly a lot of immediate cell death from
             | apoptosis -- probably due damaged DNA starting to do
             | something that looks like cancer, and autolyse safeguards
             | activating in response. This is what a radiation "burn" is.
             | 
             | * But then, after that, everything's actually fine for a
             | while. You're just sitting there for a few days, operating
             | normally -- despite the majority of your cells now having
             | massive holes shot through their DNA, with any attempt to
             | unzip that DNA to copy it failing.
             | 
             | After that few days, you get massive waves of cell death --
             | the part of radiation poisoning that actually kills you.
             | This likely arrives, due to cells experiencing various
             | inputs that they see as triggers to attempt some kind of
             | state-transition (whether a minor one, between e.g. glucose
             | vs ketone metabolism; or a major one, e.g. into mitosis.)
             | And doing that requires flipping some epigenetic
             | methylation switches to start producing different proteins
             | -- which requires the DNA be un-rolled and re-rolled. The
             | cell tries it; it fails; and there's no "error handling"
             | for the case of "you started a state transition but can't
             | connect to the blueprint database", so the cell just
             | "deadlocks" in a volatile state -- e.g. one where
             | metabolism is shut down, so purine waste builds up until
             | the cell lyses for chemical reasons.
             | 
             | So it's not too surprising that an organism could evolve to
             | just _intentionally not trigger_ such cellular state-
             | transitions -- likely no longer expressing any of the
             | state-transition  "machinery" at all. Such an organism
             | would get quite far with their cells just "doing the thing
             | they were programmed to do", without a nucleus. Even
             | cellular metabolism would continue!
             | 
             | There'd just be nowhere to get "replacement parts" for
             | proteins as the original proteins break down or get
             | oxidized by some radical -- thus the lifespan limit.
             | 
             | Also, something not mentioned in what you linked, but which
             | seems like an obvious corollary: I would guess that such
             | organisms would likely be "metabolically fragile." I.e.,
             | they likely have dropped anything like adrenaline
             | signalling, as the whole point of that is to get cells to
             | state-transition. So they'll be a bit like a person taking
             | alpha-blockers, who gets winded extremely easily because
             | the drugs are preventing their cells from "gearing up." For
             | this organism, there _are_ no other gears to switch to. The
             | organism is a fixie.
        
               | shagie wrote:
               | > IIRC, cell death from radiation poisoning follows a
               | bathtub curve.
               | 
               | https://en.wikipedia.org/wiki/Lia_radiological_accident
               | (this one is safe)
               | 
               | https://www-
               | pub.iaea.org/MTCD/Publications/PDF/Pub1660web-81... (this
               | is NSFL beyond a certain point)
               | 
               | > On a cold day of 2 December 2001, three inhabitants of
               | Lia (later designated as Patients 1-DN, 2-MG and 3-MB)
               | drove their truck approximately 45-50 km east of Lia to
               | collect firewood. At around 18:00, they found two
               | containers -- metallic, cylindrical objects -- lying on a
               | forest path. Around them, the snow had curiously thawed
               | within a radius of approximately 1 m, and the wet soil
               | was steaming. All three individuals stated that the two,
               | rather heavy, cylindrical objects (8-10 kg, 10 cm x 15
               | cm) were found by chance while carrying out their usual
               | task of collecting firewood.
               | 
               | > One of the three men (Patient 3-MB) picked up one of
               | the cylindrical objects and, finding that it was hot,
               | dropped it immediately. They planned to place the
               | gathered wood in their truck the next morning, and
               | because it was getting dark, they decided to spend the
               | night in the forest, using the hot objects they had
               | discovered as personal heaters.
               | 
               | Section 6 on page 36 is where it gets NSFL. It only gets
               | worse as you continue going through the timeline. There
               | are pictures - they are not for the weak of stomach.
               | 
               | Section 4 is neat from the engineering perspective...
               | "how do you move something that is radioactive enough to
               | melt the snow around it?"
        
         | ceedan wrote:
         | > Regarding messing with T-cells I wonder how evolution came up
         | with the current number of mitochondria per cell.
         | 
         | Cells can increase their number of mitochondria in response to
         | things (mitochondrial biogenesis). I don't know anything about
         | how that works out in the immune system, but have read about it
         | related to fat cells and exercise.
         | 
         | This was also my first thought, and it seems like "giving them
         | extra batteries" accomplishes the same outcome
        
         | ben_w wrote:
         | > I wonder how evolution came up with the current number of
         | mitochondria per cell
         | 
         | One of my probably-wrong ideas that I can't usefully ask* is if
         | chronic fatigue/post-acute infection syndromes may be due to
         | insufficient mitochondria for whatever reason.
         | 
         | * if I ask StackExchange, I'll probably phrase it wrong enough
         | to have it closed; if I ask an LLM then it will probably make
         | something up because if the answer exists at all it is probably
         | behind a paywall, and even if it isn't they do that 10-20% of
         | them time anyway.
        
           | wizzwizz4 wrote:
           | Closure on a Stack Exchange site isn't supposed to be
           | permanent: it just means "this question isn't answerable (by
           | us) yet". Maybe try, and see what happens?
        
         | agumonkey wrote:
         | > Biology is nuts.
         | 
         | for this particular case I 100% agree. I grew up to accept a
         | wide range of complexity at the cell level, but this blew
         | through the roof.
        
       | VyseofArcadia wrote:
       | Incredible result, but my god do I hate this kind of headline.
        
         | kthartic wrote:
         | Why? As a laymen (who knows nothing about "T cells") the
         | analogy helps
        
       | phkahler wrote:
       | Batteries == Mitochondira
       | 
       | So I wondered how one could increase the number of mitochondria
       | and quickly found this nice piece from 2017 about promoting
       | mitochondrial fission in mid-life (ok in fruit flys):
       | 
       | https://www.nature.com/articles/s41467-017-00525-4
       | 
       | I'm pretty sure maintaining mitochondrial health will help a lot
       | of health problems. They seem to come up every little while in
       | regard to _many_ different pathologies.
        
         | rKarpinski wrote:
         | > So I wondered how one could increase the number of
         | mitochondria
         | 
         | Lots of Zone-2 training. Inigo San-Milan & George Brooks are
         | the two researchers to look at this for in humans.
        
           | ceedan wrote:
           | Their research seems to be in relation to muscle and fat -
           | not the immune system and cancer. I wouldn't expect zone 2
           | training to improve "T cell exhaustion" where mitochondria
           | are stolen from T-cells by cancer cells.
           | 
           | > Previous studies have shown that cancer cells can use
           | nanotubes like "tiny tentacles" to slurp up mitochondria from
           | immune cells.
        
         | aidenn0 wrote:
         | Yeah, batteries was a funny metaphor given that everybody from
         | my generation learned that Mitochondria are the "powerhouse of
         | the cell" in Junior High.
        
           | andrewflnr wrote:
           | From the headline, I was almost sure it was going to be about
           | giving T-cells ATP, which is much more commonly (and
           | appropriately) analogized to biological batteries.
        
         | anigbrowl wrote:
         | Completely spitballing here, but if bone marrow cells help
         | charge up mitochondria (as this new study suggests), then
         | strong healthy bones are a good defense against cancer.
         | Resistance training (weightlifting being the most common
         | variety) is well known to improve bone health so maybe this is
         | another reason to practice it.
        
           | amelius wrote:
           | Maybe the reason elephants don't get more cancer despite
           | their comparatively large cell count.
        
             | privacyking wrote:
             | They don't get cancer because they have a metric f ton of
             | tumour suppressor genes copies, and we have relatively few
             | and so it's easier for all of ours to get knocked off to
             | form a cancer
        
       | aidenn0 wrote:
       | In America, batteries are have cells. In Soviet Russa^W^W Poorly
       | Written Headlines, cells have batteries.
        
       | ugh123 wrote:
       | Great! When can I buy Mitochondria Supplements at the grocery
       | store? /s
        
       | dazzlevolta wrote:
       | For what type(s) of cancer does this seem to be promising?
        
         | adamredwoods wrote:
         | Mostly blood cancers. It's not quite there for solid tumors.
         | 
         | https://www.cancer.gov/about-cancer/treatment/types/immunoth...
        
       | alexey-salmin wrote:
       | > Intriguingly, Mito+ cells could multiply quickly and pass their
       | extra mitochondria to the new cells.
       | 
       | Is this accurate? I thought T cells can't multiply.
        
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