[HN Gopher] Wet-lab innovations will lead the AI revolution in b...
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Wet-lab innovations will lead the AI revolution in biology
Author : lysozyme
Score : 14 points
Date : 2024-08-12 23:31 UTC (23 hours ago)
(HTM) web link (substack.com)
(TXT) w3m dump (substack.com)
| jdeaton wrote:
| > people unacquainted with biology have a false perception of how
| low-throughput biology experimentation is. In many ways, it can
| be. But the underlying physics of microbiology lends itself very
| well to experiments that could allow one to collect tens-of-
| thousands, if not millions, of measurements in a singular
| experiment. It just needs to be cleverly set up.
|
| I think this passage gets to the fundamental rift of disagreement
| in perspective between those focused purely on computational
| advances versus innovating in wet lab techniques.
|
| Why? Because years of peoples' careers have been wasted waiting
| on promises from molecular biologists claiming they will make
| these "clever" high-throughput experiments work. In my
| experience, they'll spend months to years concocting a Rube
| Goldberg machine of chained molecular biology steps, each of
| which has (at best) a 90% success rate. You don't have to chain
| many of these together before your "clever" setup has a ~0%
| probability of successfully gathering data.
| bartread wrote:
| You have just very eloquently expressed why I left a career in
| biochemistry behind after undergrad. Realistically I had no
| business doing that degree in the first place: I simply don't
| have the patience for the lab work grind.
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