[HN Gopher] Evidence for ~12-h ultradian gene programs in humans
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       Evidence for ~12-h ultradian gene programs in humans
        
       Author : XzetaU8
       Score  : 65 points
       Date   : 2024-08-10 12:13 UTC (10 hours ago)
        
 (HTM) web link (www.nature.com)
 (TXT) w3m dump (www.nature.com)
        
       | Mistletoe wrote:
       | Let me help everyone that doesn't know the word like me.
       | 
       | "Ultradian rhythms are biological cycles that repeat throughout a
       | 24-hour day, with periods ranging from fractions of a second to
       | several hours. They are different from circadian rhythms, which
       | complete one cycle per day, and infradian rhythms, which have
       | periods longer than a day."
        
         | markhahn wrote:
         | https://en.wikipedia.org/wiki/Ultradian_rhythm
         | 
         | in short: cycles faster than a day. ultra- (more, greater),
         | -dian (daily). analagous to circadian (cycle per day).
        
           | morsch wrote:
           | _Approximately_ per day, more specifically. I never made that
           | connection, interesting.
        
           | gnobbler wrote:
           | Ultra feels like an awkward way to phrase it. Faster (tachy?)
           | might make more sense
        
             | kevin_thibedeau wrote:
             | That would mix Greek with Latin.
        
               | shermantanktop wrote:
               | I can't hear you, the television is too loud. Now I'm
               | going to get into my automobile that I bought with
               | cryptocurrency and drive to Minneapolis.
        
               | gnobbler wrote:
               | in medicine, we start our frankenwords with 2 mixed
               | languages and go up from there
        
               | m463 wrote:
               | Pharma goes to infinity (or is it zero?)
        
       | markhahn wrote:
       | Always first look at the raw data.
       | 
       | Look at the scatter of the dots in raw expression plots (figure
       | 1e dots). Maybe that's normal for this field, but adjacent scores
       | are all over the place, usually >50% different. That is: very
       | noisy. Imagine the confidence intervals!
       | 
       | Maybe there's signal there, but to my eye, the basic acquisition
       | technique is horrifyingly noisy.
       | 
       | This is only a short period and trivial N, but I also don't see
       | anything systematic in the raw data related to sleep/wake phases.
        
         | echelon wrote:
         | Only three study participants, bucketing expression into 4-hour
         | intervals, lots of fancy math to massage the data...
         | 
         | I didn't like this paper.
        
         | ineedaj0b wrote:
         | it's certainly a thing. everything has cycles. if it's most
         | animals it'll be in humans. similar to how we knew animals
         | could grow muscle from stretching, but we thought humans
         | didn't.
         | 
         | we now know we can grow muscle from stretching (it's not fun or
         | easy) but it is a thing. needed a better study design. i think
         | these results are from the last 2-3 years.
         | 
         | this is a small study but was probably done for dirt cheap to
         | prove it was somewhat workable. They can acquire better funding
         | now to look for other cycles going on
        
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       (page generated 2024-08-10 23:01 UTC)