[HN Gopher] Bone tissue reparation using coral and marine sponges
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Bone tissue reparation using coral and marine sponges
Author : alexandrehtrb
Score : 133 points
Date : 2024-07-04 23:42 UTC (23 hours ago)
(HTM) web link (web.stanford.edu)
(TXT) w3m dump (web.stanford.edu)
| warmedcookie wrote:
| Part of the crew. Part of the ship.
| hinkley wrote:
| I lost a tooth after the pandemic. To seat an implant they pack
| the void with one of several things, including sterilized cadaver
| bone, then wait for the oocytes to colonize and make new bone.
|
| I got a synthetic bone sand. Little bits of it migrated like
| glass slivers would but otherwise it wasn't bad and at least I
| didn't have dead people in my mouth.
|
| Obviously this is a bit of a different scenario given the fairly
| substantial differences in the shape of the wound, but I wonder
| how much longer we will need to use naturally occurring materials
| versus synthesized ones, made in a sterile environment.
| Scoundreller wrote:
| I uhhh, don't think oocyte is the right word. Osteoblast maybe?
| 77pt77 wrote:
| definitely not oocyte
| jlund-molfese wrote:
| OP probably meant to type osteocyte and it got autocorrected
| to something else
| shiroiushi wrote:
| Autocorrect is one of the biggest misnomers in all of
| history, I think; in fact, it's downright Orwellian. It
| should be called "auto-incorrect".
| yieldcrv wrote:
| generative grammar
| TeMPOraL wrote:
| Right. It's all fun and games until it decides to
| "correct" drug names in your doctor's notes.
| WilTimSon wrote:
| I highly doubt software that doctors use for patient
| notes and prescriptions would even have the option to
| enable autocorrect. If it does, that's a giant oversight
| on the devs' part.
| hinkley wrote:
| I've seen some dumb shit in my days. But I'm glad you
| still see good in the world.
| TeMPOraL wrote:
| Global autoincorrect in MacOS supposedly did that in
| recent years, according to some post by Scott Alexander I
| read a while ago.
| hinkley wrote:
| If I could find the motherfucker who replaces "its" with
| "it's" every goddamned time I mean its, his mother
| fucking days would be over.
| throwway120385 wrote:
| We should also defenestrate whoever corrects the previous
| word or phrase based on what you just typed in iOS. The
| amount of times I've meant something very technical or
| specific to a field that a programmer in silicon valley
| has never heard of and then had that corrected to
| something else totally meaningless by the second or third
| word is an infuriating waste of time.
| 0cf8612b2e1e wrote:
| That behavior is so infuriating! Especially since I
| frequently fail to notice it because I am focused on the
| current word, not the one I had already confirmed as
| correct.
| hinkley wrote:
| Typing on phone, late at night. Always a gamble.
| throwup238 wrote:
| This is why I don't eat out.
| hinkley wrote:
| I already made the "dead people in my mouth" comment so I
| can't exactly fault you for this. But someone else can!
| hinkley wrote:
| Yes, that was supposed to be "osteocyte" but it's far too late
| now.
| tuatoru wrote:
| "Reparation"? That means the act of paying back, making amends,
| compensating a second party for a wrong done them.
|
| What happened to "repair" as a noun? "Bone tissue repair".
| ImHereToVote wrote:
| OP is Scandinavian.
| tuatoru wrote:
| Yes, but OP is using a word and phrase taken directly from
| the introduction to the article. I expect better from
| Stanford.edu.
| viciousvoxel wrote:
| It's not a major error -- the words are etymological
| siblings and it's clear what was meant. Repair translates
| to something resembling "reparation" in most romance
| languages so it's an easy translation mistake to make.
| hinkley wrote:
| I worked recently with a guy who learned all of his big
| words from books. Very, very old books.
|
| It was exhausting. And English is my first language. I
| felt sorry for my Indian coworkers. Jesus man, stop
| trying to look smart and just talk like a normal person.
| The intelligence is in the ideas not the words used to
| convey them.
| elric wrote:
| > Jesus man, stop trying to look smart and just talk like
| a normal person.
|
| What is normal to one person may not be normal to
| another. Especially when someone learns a language from
| books without much human interaction.
| HPsquared wrote:
| It is in Wiktionary as an archaic usage. It makes sense, I
| think, just an uncommon usage. Singular Vs plural.
| entropyie wrote:
| I suspected this page was written in MS FrontPage, and a quick
| peek at the source code seems to confirm it! I love to see old
| pages still online. Netscape Composer got me through the 90s/00s
| skhr0680 wrote:
| Frontpage 2002 or 2003 to be exact. I didn't know that it A)
| lasted that long and B) used that much CSS
| db48x wrote:
| s/reparation/repair/g
| birriel wrote:
| From a cosmetic point of view, almost everybody exclusively
| focuses on the skin to counter aging, when they should be at
| least as concerned with bone density.
|
| Lots of people have perfect skin, but they still look old. Why?
| Bone morphology. The zygomatic bone erodes, and the orbital gaps
| widen. The mandible degrades and pivots down and backwards (jaw
| rotation). Issues like resorption are currently very challenging.
| Skin is comparatively much easier. Also (and besides well-known
| interventions like collagen, retinoids, HA, and dermarolling),
| Epidermal and Keratinocyte Growth Factors are already very cheap,
| and showing much promise.
| Luc wrote:
| This interested me, but I had to look up some of it:
|
| Zygomatic bone: cheeck bone,
| https://en.wikipedia.org/wiki/Zygomatic_bone
|
| Orbital gaps: hollow areas around the eyes
|
| Mandible: lower jaw, https://en.wikipedia.org/wiki/Mandible
|
| Resorption: a process in which a substance is lost by being
| destroyed and then absorbed by the body.
|
| HA: hyaluronic acid
| dustypotato wrote:
| Thank you. I thought i was dumb
| utensil4778 wrote:
| For anyone else wondering: your body is continually pulling
| calcium from your bones for metabolic processes. Usually it
| gets replaced when you consume something with calcium in it.
|
| It makes sense to have somewhere to store extra nutrients so
| you can keep functioning for a long time between taking in
| those specific nutrients again.
|
| Your body does this with a lot of your organs. Fat is
| obviously calorie storage, but muscles can also be resorbed
| for energy under starvation conditions (or just when they're
| under used). Your kidneys can resorb water from stored urine,
| and your intestines pull most water out of what you consume.
| Most neurotransmitters and hormones get recycled at various
| rates and turned into new molecules.
|
| I'm sure there's more, but that's all I know of offhand.
| Xenoamorphous wrote:
| And what be done about bone density? I guess exercise would
| help but not with the bones in the head?
| amelius wrote:
| From [1]:
|
| > Animal and human studies suggest that high-frequency, low-
| magnitude vibration therapy improves bone strength by
| increasing bone formation and decreasing bone resorption.
|
| So you could apply vibration to the head bones. Not sure
| about any side effects.
|
| [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458848/
| arghwhat wrote:
| Before you apply vibrations to your skull, note that it
| contains other things than bones that might be less
| thrilled about said vibrations.
|
| Or more thrilled, who knows - be careful out there, and if
| you do something stupid, take notes and share the results
| for our entertainment^W learning!
| amelius wrote:
| Well, I apply a vibrating device to my skull every
| morning and evening (indirectly).
|
| It's my electric toothbrush :)
| elric wrote:
| Indeed. Wasn't there an article just a few days ago about
| Navy Seals (?) suffering brain injury from being too
| close to artillery being fired or some such? The
| vibrations in the skull were thought to be the culprit.
| hinkley wrote:
| I have been getting ads lately for an aerobic step with a
| vibrating motor built into it, for this very purpose. It
| might have been on Peacock, and if so it was during Tour de
| France footage.
|
| It's a small effect but real, and it's passive from the
| patient's standpoint and we always seem to find that to be
| a selling point. This research was, if I recall, originally
| done for NASA and studied sheep. Shake a Sheep for Science!
| lemonberry wrote:
| Humming?? No mention of bone density in this article, but
| there may be some benefits: https://theconversation.com/is-
| humming-healthy-mmm-heres-wha...
| aszantu wrote:
| vibration does something, secret tip for migraines is
| massage wand to the face, almost as good as using it in
| other places
| smallerize wrote:
| You can get a concussion pretty rapidly from vibrating your
| head.
|
| https://twitter.runhello.com/mcclure111/status/837481339989
| 3...
|
| https://twitter.runhello.com/mcclure111/status/110880835115
| 0...
| arthur2e5 wrote:
| resistance training is indeed the recommendation for non-head
| bones, if you're looking for a confirmation:
|
| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279907/
| User23 wrote:
| Bone density is definitely an adaption from resistance
| exercise.
|
| I don't know any specific studies, but I would expect that
| the bone density improvements are in some sense systemic in
| that the metabolic changes that increase bone density will
| have spillover effects to bones not directly involved in some
| given movement.
| elric wrote:
| Regarding the jaw bones: chewing. And keeping your teeth
| healthy: missing teeth can result in loss of bone density.
| hggh wrote:
| (2014) [0]
|
| [0]
| https://web.archive.org/web/20141013021330/https://web.stanf...
| jwilk wrote:
| (2005) according to the HTTP headers: Last-
| Modified: Fri, 09 Dec 2005 22:37:30 GMT
| whizzter wrote:
| These kinds of ideas to use stem-cells with foreign materials
| seemed in vogue back then, no idea how feasible they are in
| reality but an improvised similar technique for tracheae was
| how Paolo Macchiarini first got hyped and then convicted (He
| went on to try it on humans despite skipping animal trials of
| the technique).
|
| https://en.wikipedia.org/wiki/Paolo_Macchiarini
| hinkley wrote:
| > Macchiarini was convicted of unethically performing
| experimental surgeries, even on relatively healthy
| patients, resulting in fatalities for seven of the eight
| patients who received one of his synthetic trachea
| transplants.
|
| Fuuuuck. I think I heard about this guy before he went mad
| scientist, but not after.
| whizzter wrote:
| Yeah, the early hopeful news spread widely but the
| scandal and fallout certainly kept things in the news
| over here for a long time.
|
| There's a Netflix pop-documentary called "Bad Surgeon"
| with a that does cover the viewpoint of the colleagues
| that turned whistleblowers (and the persecution they
| endured before media and prosecutors started looking into
| it) even if much of the focus is on his many concurrent
| women (the main one believing she's going to be wed by
| the pope).
| nonameiguess wrote:
| It's a shame Nature seems to keep these articles locked up
| forever. I found the first reference, which is a study from 2000,
| which is still paywalled and I can't read it. I'd be curious to
| know how state of the art has changed since this. I had a two
| level lumbar interbody fusion seven years ago, the procedure in
| which discs are removed and replaced by metal spacers that get
| seeded with a bone graft. Within about 18 months, you've got one
| solid bone. They seeded it with my own bone, sawed off of my
| pelvis, plus some kind of growth-stimulating protein. Beats me
| whether that was coral-derived or synthetic or what. I didn't
| think to ask. In any case, it certainly worked. It takes a while,
| but x-rays today look ridiculous. The bone is enormous,
| effectively growing around the original screws and rods that held
| everything in place while the bone was growing.
|
| I guess the scaffold matrix in me must have been of the coating
| variety. As far as I was told, the spacers were just the same
| titanium alloy as the screws and rods, which for some reason
| don't set off metal detectors, which makes me wonder why nobody
| makes knives and guns out of the same material.
|
| It'd be nice if they put a date on this page. The other
| references I could find were from 2011 and 1987.
| failrate wrote:
| My left thumb was reconstructed with coral fragments about 27
| years ago. The bone exploded due to the growth of a benign cyst.
| 6 weeks in a cast to stabilize, then surgery to scoop out the
| cyst and replace the material. Then 6 more weeks in a cast. When
| discussing replacement materials, my doctor offered cadaver graft
| or self transplant (surgically removing bone from my wrist or hip
| to build a graft). I was deep into Steve Haworth at the time, who
| was experimenting with implant materials including coral, so I
| asked about coral. Without missing a beat, the doctor said they
| could definitely do that. I asked if it was expensive, and he
| said no. I asked if it had a high rate of rejection, and he said
| it was comparable to self transplant.
|
| Why was it not the first suggestion? Why did he not even mention
| it in the first place? Sadly, I forgot to ask these questions.
|
| Tl;dr I had a coral graft, and it worked great.
| alexandrehtrb wrote:
| That's very interesting! Good to hear it!
| Izikiel43 wrote:
| So you have a sea thumb?
| spondylosaurus wrote:
| I went to school with a kid who got some scoliosis surgery that
| involved coral but can't remember exactly how. It seemed to go
| well though!
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