[HN Gopher] An epigenetic editor to silence genes
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       An epigenetic editor to silence genes
        
       Author : Teever
       Score  : 24 points
       Date   : 2024-07-02 19:50 UTC (3 hours ago)
        
 (HTM) web link (www.science.org)
 (TXT) w3m dump (www.science.org)
        
       | ProjectArcturis wrote:
       | Very impressive work. Just in mice so far but this looks very
       | promising for Huntington's in particular.
        
       | dluan wrote:
       | Eric and Sonia are incredible human beings hellbent on a mission.
       | Awe inspiring.
        
       | flobosg wrote:
       | I was reminded of this comment exchange from last May:
       | https://news.ycombinator.com/item?id=40439379#40440171. TIL that,
       | according to this paper, antisense treatment in the brain has
       | some drawbacks:
       | 
       | > Treatment of mice with antisense oligonucleotides (ASOs)
       | targeting the _Prnp_ transcript decreases expression of PrP and
       | extends the survival of mice previously infected with misfolded
       | PrP (6); however, the limited efficacy of ASOs and the
       | requirement for chronic intrathecal dosing highlight the need for
       | a more potent therapy.
        
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       (page generated 2024-07-02 23:00 UTC)