[HN Gopher] Ozempic keeps wowing: trial data show benefits for k...
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Ozempic keeps wowing: trial data show benefits for kidney disease
Author : pseudolus
Score : 38 points
Date : 2024-05-24 15:36 UTC (7 hours ago)
(HTM) web link (www.nature.com)
(TXT) w3m dump (www.nature.com)
| neverokay wrote:
| Ozempic? Or just eating less?
| Rinzler89 wrote:
| Eating less and exercising is tyranny and commie propaganda.
| What is this, North Korea? People should be free to eat as much
| as they want. If they want to balloon to 400lbs, it's their god
| given right.
|
| /s See the latest South Park episode
| artninja1988 wrote:
| Doesn't ozempic just make you feel full more easily and help
| you eat less?
| mensetmanusman wrote:
| 'Just' is doing a lot here.
| eganist wrote:
| Probably the latter, but "just eating less" is next to
| impossible for a non-trivial minority of people much the way
| "just stopping heroin" would be for someone battling addiction.
|
| An aid to help clear the noise in the brain seems to be
| unsurprisingly useful, then, in achieving these outcomes.
| chatmasta wrote:
| Sure, but Ozempic is not the only drug that suppresses
| appetite. So if the underlying benefits are from "just eating
| less," then the study should also examine the effects of
| other pharmaceutical interventions that suppress appetite.
| eganist wrote:
| Funding tends to be a constraint with larger studies, and
| it's best to keep studies focused anyway -- less
| confounding variables.
|
| Here, I'll pontificate a bit. For instance, study 1 finds
| that Ozempic is associated with a reduced risk of X. Study
| 2 is now funded to see if the association can be
| experimentally reproduced to establish a causative
| relationship. Competing institution gets Study 3 funded to
| test competing drug Mounjaro, reaches same conclusion.
| Study 4 by another institution finds same conclusion with a
| drug that acts in an entirely different manner, Buproprion.
| Study 5 by yet another institution finds similar results
| with amphetamines. Study 6 is funded on the premise that
| there's an underlying mechanism that needs to be explored,
| gets funding to study caloric restriction, gets similar
| results. Meanwhile, study 2 finds a causative relationship
| between Ozempic and X, concluding experimentally that
| Ozempic achieves X by inducing calorie restriction, which
| concurs with study 6.
|
| I'm oversimplifying. But you see where I'm going with this.
| Much easier to both control and fund the smaller studies
| than a giant one, and you develop more knowledge in the
| process.
|
| ---
|
| Also, I'm not an academic, so I could be wildly off base.
| Would appreciate a gut check by someone who actually does
| this for a living.
| ilikeitdark wrote:
| I'm starting to think somebody has a bunch of truckloads of this
| stuff they gotta unload.
| KptMarchewa wrote:
| Yes, Novo Nordisk. Largest EU company.
| Am4TIfIsER0ppos wrote:
| Last I heard they couldn't make it fast enough to meet demand
| from fatties causing at least one government to ask doctors
| to only prescribe it to diabetics.
| im3w1l wrote:
| There is a global shortage.
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