[HN Gopher] A Trial HIV Vaccine Triggered Elusive and Essential ...
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A Trial HIV Vaccine Triggered Elusive and Essential Antibodies in
Humans
Author : geox
Score : 155 points
Date : 2024-05-17 15:15 UTC (7 hours ago)
(HTM) web link (corporate.dukehealth.org)
(TXT) w3m dump (corporate.dukehealth.org)
| chasil wrote:
| > Other features of the vaccine were also promising, most notably
| how the crucial immune cells remained in a state of development
| that allowed them to continue acquiring mutations, so they could
| evolve along with the ever-changing virus.
|
| As I understand it, somatic hypermutation is a process that only
| occurs within germinal centers.
|
| Is that what is happening here?
| jcims wrote:
| Animation of how HIV infects a single T-cell
|
| https://vimeo.com/260291607
| obloid wrote:
| Very interesting, thanks for posting.
| knodi wrote:
| Wow!
| jcims wrote:
| The music is amazing.
| taf2 wrote:
| That is really impressive animation, now I'd love to see this
| animation updated to include how the Vaccine works
| gen220 wrote:
| Can you post this as a new submission? I want to read
| knowledgeable peoples' responses to it! :)
|
| Viruses are incredible. This video does a great job of
| illustrating how HIV in particular seems to hijack so many
| essential systems. I now feel like I have a deeper appreciation
| for why "cures" for viruses are like a holy grail technology -
| how could you even prevent something like this without
| collateral damage to some perfectly healthy + necessary
| process? They're so tangential to how our cells _need_ to work
| that they 're almost parallel.
| jb1991 wrote:
| Here you go: https://news.ycombinator.com/item?id=40393107
| liendolucas wrote:
| For me the most incredible part of the video is the
| transcription process. Looks like the head of a Turing machine
| going through the "tape". Really amazing that something like
| this occurs in the body at a nanometric scale.
| op00to wrote:
| This video invokes fear in me. Like, those alien machines
| (viruses) are doing their weirdo stuff countless times a second
| in my body. Horrifying.
| Terr_ wrote:
| If it helps, consider that "your body" is the-same-or-more
| dangerously impressive, with layers of hideously effective
| defenses to displace or starve or murder anything that gets
| close, a swarming hive of unfathomable nanotechnology
| winnowed over millions of years of adversity between the many
| inheritors of an ancient grey-goo apocalypse.
|
| Just from one eldritch hive-mind to another.
| op00to wrote:
| I'm not afraid of the viruses per se, I trust in my immune
| system. It's more the extreme intricacy of the whole damn
| meatbag. Kinda like looking up at the stars in an ultra-
| dark environment and seeing more stars than you've ever
| seen before. I get a little dizzy. Don't get me started on
| math.
| _Microft wrote:
| Maybe you are talking about "awe"?
|
| https://en.wikipedia.org/wiki/Awe
| op00to wrote:
| Yup!
| postalrat wrote:
| That's why I consider biology a type of alien technology
| that we've been trying to reverse engineer but are still
| a ways away.
| yazzku wrote:
| Damn... And proteins are not living organisms, but the video
| makes them look like autonomous agents and even states thing
| like "the virus recruits new proteins". Is this mostly an
| anthropomorphization of the events, or did I miss the
| relevant episode of biology?
| nwiswell wrote:
| > Is this mostly an anthropomorphization of the events
|
| Yes.
|
| Basically everything is bumping around until the desired
| reaction or configuration is obtained. The irrelevant
| proteins are generally not shown.
|
| The length scales involved are extremely short so the
| chaotic soup works itself into configuration shockingly
| quickly.
|
| There are also membranes, vesicles, and organelles (e.g.
| Golgi) that partition, package, and redistribute proteins
| so that they tend to be more concentrated where required.
| NoMoreNicksLeft wrote:
| > Basically everything is bumping around until the
| desired reaction or configuration is obtained.
|
| Dare I say it? _That sounds alot like what we do in the
| office most of the time._
| op00to wrote:
| Protein folding freaks me out too.
| deepfriedchokes wrote:
| The music sure doesn't help!
| ugh123 wrote:
| There should be yearly awards for good science animations and
| learning tools like this
| surfingdino wrote:
| There is https://www.nikonsmallworld.com/galleries/small-
| world-in-mot...
| tejohnso wrote:
| The level of detail in the knowledge of the process is
| astounding. Having never studied anything like this, at every
| stage I kept thinking: how do we know all of this?
| andylynch wrote:
| Easy, thousands of smart, motivated people, billions of
| dollars invested and decades of work!
| hansoolo wrote:
| Watching the video I did indeed feel like "this is insane!"
| all the way through...
| jimbokun wrote:
| Feels like a heist movie. Breaking into the cell and hijacking
| it's machinery to make more of itself.
| ezekiel68 wrote:
| Very promising outcome. But I wonder they/why we are just
| learning about this now when it seems that the inoculations
| occurred in 2017?
| giantg2 wrote:
| It's not really valuable if the immunity isn't very durable.
| There are already short duration things like PREP. If it's been
| 5 years (2019), that's a big deal.
| Traubenfuchs wrote:
| There is a injectable every 2 months solution now.
|
| https://www.fda.gov/news-events/press-announcements/fda-
| appr...
| giantg2 wrote:
| Yeah, that's why I'm saying years long protection would be
| a huge shift from the current short term stuff.
| xutopia wrote:
| I am not an immunologist... I don't understand biology very well.
| How significant is this? Is it even trustworthy?
| BikiniPrince wrote:
| The fact they can trigger antibodies on a stable portion of the
| virus is impressive. Near the end, it sounds like a multi
| pronged approach is needed to deal with variations. I'm not an
| immunologist, but it was pretty light. If they are in trials
| does that indicate they have a white paper?
| giantg2 wrote:
| "If they are in trials does that indicate they have a white
| paper?"
|
| I would think they'd have to in order to have the trial. It
| probably is not for public distribution though.
| carbocation wrote:
| Does this university press release name-check Cell but not link
| to the article? A bit frustrating.
| safeharbourio wrote:
| https://doi.org/10.1016/j.cell.2024.04.033
| hi-v-rocknroll wrote:
| Perhaps this could be a beneficial prophylaxis. And having
| another treatment that uses CRISPR to remove the provirus is also
| an essential to have a durable cure for patients already
| infected. https://www.bbc.com/news/health-68609297
| rsingla wrote:
| I wonder about the potential for varied immune responses across
| different populations.
| PakG1 wrote:
| I'm not an expert on this stuff at all, so assume I'm stupid and
| ignorant when I write the following. As I understand it, HIV has
| actually been useful to develop a delivery mechanism for some
| therapies that have excellent potential. Would this kind of
| vaccine cause such therapies to become ineffective?
| ejstronge wrote:
| Here is the Cell article:
| https://www.cell.com/cell/fulltext/S0092-8674(24)00459-8
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