[HN Gopher] Post-operative cognitive dysfunction is exacerbated ...
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Post-operative cognitive dysfunction is exacerbated by high-fat
diet
Author : gnabgib
Score : 10 points
Date : 2024-03-31 20:24 UTC (2 hours ago)
(HTM) web link (www.sciencedirect.com)
(TXT) w3m dump (www.sciencedirect.com)
| Handprint4469 wrote:
| ...in rats: Subjects were young adult (3-5
| months) and aged (22-24 months) male F344xBN F1 rats obtained
| from the National Institute on Aging rodent colony managed by
| Charles River. F344xBN F1 rats are particularly useful for the
| study of aging and aging-associated conditions as aged rats of
| this strain remain relatively healthy and show good cognitive
| function at baseline. Unfortunately, female rats of this strain
| were not available from this or any other vendor at the time
| these studies were completed.
| talldrinkofwhat wrote:
| Isn't the real mis-step of this study that they put the rats on
| a HFD 3 (three!) days before testing? I thought it was common
| knowledge that the transitory periods of ketosis elevate blood
| lipids until your body adapts to its new food source / arrives
| at a new equilibrium. I would think their conclusion should be
|
| "Taken together, the present data indicate that (!__consumption
| of__) -> <__transition onto__> a HFD prior to laparotomy
| prolongs the neuroinflammatory response to surgery and induces
| persistent memory deficits in young adult and aged rats. We
| demonstrated that both age groups who ate HFD for 3 days prior
| to surgery displayed robust cued-fear memory deficits, and aged
| rats additionally exhibited contextual memory deficits. These
| memory impairments were associated with exaggerated and
| prolonged (3 weeks post-surgery)"
|
| Which is just another way to say, don't inflame your entire
| body with a new diet prior to undergoing surgery (which in and
| of itself is massively stressful).
| hx8 wrote:
| > We have previously shown that surgery alone, or 3-days of
| HFD can each evoke sufficient neuroinflammation to cause
| memory deficits in aged, but not young rats.
|
| The surgery + transition onto HFD seem to be more damaging
| than either one alone, which makes sense that doing two
| harmful things is worse than doing one harmful thing.
| leoh wrote:
| Dude. "In rats" is such an easy cliche. Should we create an LLM
| to post it on every HN story regarding animal studies? Rats are
| a decent model. Would you prefer we test hypotheses on your
| body to get started instead? Let's look at the experimental
| methods and develop better intuitions about what can reasonably
| hypothetically extrapolated to humans and what doesn't instead
| of just saying "in rats."
| ineedaj0b wrote:
| When you remove a rats arm, it cannot use it. This effect does
| not occur in humans because when you amputate a human's arm
| they can still use it.
|
| Rats are unlike humans so feel free to amputate your arm. You
| will still be able use it because rats are not humans duh
| gumby wrote:
| Instead of DHA supplimentation, have the patient go on a low fat
| diet for three days before anesthesia.
|
| Or, possibly, not worry about it -- how many patients expect to
| make difficult post-operative decisions? They expect to be woozy
| due to painkillers anyway.
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