[HN Gopher] Lidocaine induces apoptosis in head and neck squamou...
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Lidocaine induces apoptosis in head and neck squamous cell
carcinoma
Author : bookofjoe
Score : 52 points
Date : 2023-11-29 15:38 UTC (7 hours ago)
(HTM) web link (www.cell.com)
(TXT) w3m dump (www.cell.com)
| whatshisface wrote:
| I wonder if an ultra-bitter agent would activate "bitter taste
| receptor 14" more than Lidocaine.
| goldenkey wrote:
| Explains a bit or two about bitter almond, doesn't it?
| throwaway958773 wrote:
| And "having a bitter pill to swallow"
| mattmaroon wrote:
| It is believed that we evolved to taste bitterness because a
| lot of natural poisons are bitter. When people say something is
| an acquired taste, they are almost always referring to
| something bitter.
|
| In many cultures bitter things are commonly eaten so people get
| past it even in childhood but in ones where they aren't (like
| America) you find many adults who don't enjoy bitter tastes.
| sonicanatidae wrote:
| Cilantro is literally soap. It's akin someone cooking up a
| nice bar of Dove and serving it to me.
|
| I will accept no arguments otherwise.
| labster wrote:
| This is the word of truth. Cilantro mutants of the world,
| unite!
| sonicanatidae wrote:
| We're getting close in our development of a spray that
| only attacks Cilandro plants. The current issue is the
| fire. Fire is the only way to truly kill Cilandro (other
| than nuking it from Orbit), but the fires tend to get out
| of hand, very, very fast.
|
| As soon as we get over this final hurdle, you'll see the
| Cilandro of the world, ablaze and good riddance.
|
| FFS, why is there even a type of soap that looks like a
| plant?
| kbos87 wrote:
| I'm a cilantro lover and it's just interesting how
| different my characterization probably is from yours. I
| wouldn't classify it as bitter in the least bit. To me,
| it's the purest taste of "freshness". I don't know how to
| better explain it.
| sonicanatidae wrote:
| To me, it's like licking soap and as far as I'm concerned
| youre just an agent for Big Cilantro. ;)
| angiosperm wrote:
| There is an interesting genetic difference between
| cilantro-tolerant and cilantro-averse individuals.
| Similarly, some people smell asparagus in their pee,
| others don't. (The pee smells the same, in both cases.)
| sonicanatidae wrote:
| It is genetics, in my case.
|
| Part of my healthcare IT journey was as the LIMS Admin
| for 2 Tox labs, over the course of about 5 years. One of
| them was working on genetic markers for drug use. For
| example, of the 7 classes of Proton Pump Inhibitors, at
| that time, only 1 works for me. The rest either don't
| work, or work, but with lower efficacy.
|
| The doc, handing it to me said, and I quote, "man, you
| got some weird genes". lol
| thinkingemote wrote:
| Cilantro tastes like how soap smells (to some). Soap
| actually tastes quite horrid and much much different to how
| it smells. It's not literally soap.
| sonicanatidae wrote:
| >I will accept no arguments otherwise.
| notpushkin wrote:
| From a sibling discussion (now dead): apoptosis means programmed
| cell death, so the title is roughly "Lidocaine induces programmed
| cell death in head and neck cancer". Kudos to @QuercusMax.
|
| Quite an interesting development!
| DiscourseFan wrote:
| Damn I guess Freud was right, you _can_ fix almost anything with
| Cocaine!
| unstatusthequo wrote:
| Made me think of this gem:
| https://www.youtube.com/watch?v=zP-C88GJKyU
| garyrob wrote:
| Wow. I had HNSCC years ago, had surgery, had it recur a couple
| years later (same region so I think they didn't get it all the
| first time), had surgery, had it recur yet again five years later
| (again same region), had more surgery. (And radiation and a
| "radiosensitizer" drug.)
|
| I'm now 7 years out from the last time, with no sign of trouble,
| so my odds are good.
|
| I'm hearted to see a positive development like this.
| throaweyprimy wrote:
| Can someone translate this for the layman? Why is this important?
| smt88 wrote:
| Lidocaine is cheap, FDA-approved, well-understood, and
| potentially well-tolerated as a therapy for this type of
| cancer.
|
| When one of the alternatives is traditional chemotherapy,
| finding anything safer and more pleasant is an achievement.
|
| I have no idea if this will be eventually be used widely in
| clinical practice, though.
| sonicanatidae wrote:
| What they are saying here is that Lidocaine, a topical
| anesthetic has shown the ability to kill cancer cells at the
| locations specified. Technically they activate self-death in
| the cells, but it's the same thing, in a practical sense.
|
| Squamous cells: These are flat cells in the upper (outer) part
| of the epidermis, which are constantly shed as new ones form.
| When these cells grow out of control, they can develop into
| squamous cell skin cancer (also called squamous cell
| carcinoma).
|
| Apoptosis - death of cells.
|
| The current procedure is to simply cut away the cancerous
| cells. I know, I've had 2 removed. One was on my middle right
| finger and due to its location, I had to see a surgeon that
| specialized in hands. Hands are complex and since my career
| requires full movement (typing), it was important for me to
| maintain 100% motion, which I do.
|
| When it can't be cut away, it's Chemo, which is almost as bad
| as the problem.
|
| This would be a great thing if it proves out, reliably.
| Treating cancers in the nasal passages, for example, is very
| tough.
|
| Note: I'm not a doctor, I just work with them, and personally
| experienced these types of cancers this twice in my life,
| albeit in more easily treatable locations.
| DarmokJalad1701 wrote:
| > I know, I've had 2 removed. One was on my middle right
| finger and due to its location, I had to see a surgeon that
| specialized in hands.
|
| How did you discover these? Did they obviously look like
| trouble?
| sonicanatidae wrote:
| They do. They look something like a mole, but not dark.
| They are commonly a slightly more redish version of your
| current skin color and it's a literal bump on your skin.
| One of the things I noticed is they have a bumpy outer
| appearance. Like the little dots on a basketball. As they
| grow, they get taller and wider.
|
| It was tiny at first and I just ignored it. About 3-4
| months into it, it was larger and didn't appear to be going
| away, so I did a doc visit. They took a sample and tested
| it. It was POS for cancerous cells. Next up was treatment,
| but again, in my case, it was a fairly straight-forward,
| keep cutting until we get it all.
|
| The finger was a little different in that the mass was
| large enough that it required a skin graft from my forearm
| to fully close the removal site.
|
| The skin graft now, is about 1/2 across and about an inch
| long. I think the reason for this is if they had just
| closed it, the skin would have been tight and would likely
| have restricted movement.
| stonemetal12 wrote:
| I can get Lidocaine at CVS for 10$ without a prescription.
| kalupa wrote:
| so, uh, "freeze" the cancer? wild
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(page generated 2023-11-29 23:02 UTC)