[HN Gopher] New CRISPR systems hold promise for genome editing
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       New CRISPR systems hold promise for genome editing
        
       Author : mfiguiere
       Score  : 71 points
       Date   : 2023-11-25 19:23 UTC (3 hours ago)
        
 (HTM) web link (www.nature.com)
 (TXT) w3m dump (www.nature.com)
        
       | thenerdhead wrote:
       | Pretty exciting given the last type was discovered in 2016.
       | 
       | Science publication here:
       | https://www.science.org/doi/10.1126/science.adi1910
       | 
       | Here's the main takeaway I got:
       | 
       | A fast locality-sensitive hashing-based clustering (FLSHclust)
       | algorithm was developed. This algorithm is parallelized and
       | scales linearly with the size of the dataset, enabling efficient
       | analysis of large sequence databases.
       | 
       | That means it can scale with exponentially growing datasets,
       | discover rare biological systems, provide more options for
       | targeted gene editing, and even lead to novel biotechnologies.
       | 
       | Sounds like a breakthrough to me!
        
       | foota wrote:
       | Wake me up when I can get the short sleep genes :-)
        
         | haraball wrote:
         | They recently discovered the gene for shyness. It was hiding
         | behind two other genes.
        
           | mi_lk wrote:
           | what are other two genes for?
        
           | foota wrote:
           | Turns out the real personality test was a centrifuge.
        
         | nharada wrote:
         | At this point I'll settle for the "good sleep" genes
        
           | foota wrote:
           | If it wasn't clear, this is actually a real thing. See e.g.,
           | https://en.wikipedia.org/wiki/Familial_natural_short_sleep
           | (of course whether it would actually be possible to just pick
           | this up via gene therapy is untested, and I think gene
           | therapies are hard in the brain because of the blood-brain
           | barrier). One of my roommates in college had this and was
           | able to get by fine with 5 hours of sleep a night, I was
           | always envious.
        
         | wavemode wrote:
         | My whole life I've been very well-rested on 6 hours of sleep.
         | Only recently learned it was a genetic anomaly.
        
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       (page generated 2023-11-25 23:00 UTC)