[HN Gopher] Mice eating less isoleucine live longer, healthier
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Mice eating less isoleucine live longer, healthier
Author : gardenfelder
Score : 51 points
Date : 2023-11-24 18:48 UTC (4 hours ago)
(HTM) web link (news.wisc.edu)
(TXT) w3m dump (news.wisc.edu)
| gardenfelder wrote:
| ""Very quickly, we saw the mice on the reduced isoleucine diet
| lose adiposity -- their bodies got leaner, they lost fat," says
| Lamming, while the bodies of the mice on the low-amino-acid diet
| also got leaner to start, but eventually regained weight and
| fat."
| JumpCrisscross wrote:
| Good follow-up would be with Furanomycin, an isoleucine
| antagonist [1].
|
| [1] https://pubs.acs.org/doi/abs/10.1021/jm00318a035
| mahrain wrote:
| Saving you a Wikipedia search: " Foods that have high amounts of
| isoleucine include eggs, soy protein, seaweed, turkey, chicken,
| lamb, cheese, and fish."
|
| https://en.wikipedia.org/wiki/Isoleucine?wprov=sfti1#Nutriti...
| unsupp0rted wrote:
| So 100% of my protein sources
| 317070 wrote:
| It's as if proteins contain a lot of amino acids.
| FartyMcFarter wrote:
| You need it to survive. It's an essential amino acid.
| lucisferre wrote:
| So everything except beef, pork, nuts and grains in terms of
| protein sources?
| croes wrote:
| Isn't that the food normally linked with the longevity of
| people of the Mediterranean areas?
| api wrote:
| Yes, this study comes with the standard "in mice" caveat. We
| don't know if this would replicate in humans. It is
| interesting though if for no other reason than to illustrate
| that all calorie sources are not equivalent.
| robwwilliams wrote:
| Even in mice there is a large sex difference.Most
| beneficial in males.
| hombre_fatal wrote:
| It doesn't make sense to me to focus-fire a single nutrient of
| a food, find some reason to not maximize it in mice, and then
| use that to avoid whole foods that contain that nutrient,
| especially as a human.
|
| A food could have all sorts of individual nutrients that look
| bad in isolation while the food only improves human health
| outcomes when put to the test.
| riazrizvi wrote:
| From the summary of the paper
|
| > Restriction of the branched-chain amino acids (BCAAs)
| leucine, isoleucine, and valine recapitulates many of these
| benefits in young C57BL/6J mice
|
| So maybe stop using that BCAA supplement?
| FartyMcFarter wrote:
| These days BCAAs have the reputation of being pretty useless
| anyway, unless your diet is very poor. You get enough BCAAs
| from complete protein sources.
| robwwilliams wrote:
| Turkey should not be high on this list. This source is
| comparatively low in isoleucine according to Dudley Lamming--
| the senior author, sand here is a site to check other meats:
|
| tools.myfooddata.com
| jcutrell wrote:
| How does this square with the fact that isoleucine is important
| for muscle mass development?
| XorNot wrote:
| It doesn't. And honestly the result should be treated
| skeptically until someone replicates it.
|
| Mice studies like this have a ton caveats: the animal lives 3
| years versus the human 100 years.
|
| Research like this is better for understanding biochemical
| pathways then whole organism affects, especially since "aging"
| isn't a well defined phenomenon (it's a grab bag of other
| things we want to prevent).
| globular-toast wrote:
| That muscle mass development has nothing to do with living
| healthier or longer?
| DonHopkins wrote:
| Why will I live longer and healthier if I eat mice???
| bell-cot wrote:
| Despite common folk wisdom about "nine lives", field data
| strongly suggests that no individual living on an all-mouse
| diet has survived beyond age 40.
| tcbawo wrote:
| This reminds me of a cartoon I saw recently: "Every single
| person that confuses correlation and causation ends up
| dying!"
| twic wrote:
| Except that the mTOR pathway also promotes growth and
| preservation of muscle tissue, and we know that muscle tissue is
| rather important to quality of life and avoidance of injury in
| old age.
| heroiccocoa wrote:
| Manipulating the mTOR pathway involves making a trade-off based
| on your preferred type of death: on the one hand we have
| frailty, hip fractures, muscle wasting, etc, and in the other
| metabolic diseases, cancer, CVD, alzheimer's, diabetes etc.
|
| But, you can probably still grow strong enough from life-long
| resistance training a few times a week+eating enough other
| (plant) protein. I believe that this is the modern longevity
| recipe from what we have learned so far from the
| mTOR/fasting/leucine/isoleucine/methionine research. I hope we
| soon learn more about optimizing anabolism/autophagy in a
| targeted way instead of the entire body, that's what it all
| seems to boil down to.
| monkeycantype wrote:
| Very well articulated, You've given me that strange feeling
| that happens when some once expresses cohesively a set of
| ideas you're still trying to map
| manmal wrote:
| There might be a timing aspect to it - eg by boosting mTOR
| only in the morning (protein rich breakfast etc).
| robwwilliams wrote:
| This is a great study. And Thanksgiving is a perfect time for a
| low isoleucine dinner---turkey is about as low as you can get.
| LegitShady wrote:
| Important news for mice everywhere. Maybe we can make engine
| wiring harnesses out of isoleucine in the future.
| cosmin800 wrote:
| We all know mice are the perfect human model.
| whatscooking wrote:
| Metabolism is pretty conserved across organisms, so it's not
| even that bad
| XorNot wrote:
| Yes but longevity isn't.
| whatscooking wrote:
| All these anti-aging posts make me cringe. Face it, you're going
| to die one day. You want to be healthier? Eat a healthy diet and
| exercise instead of looking for shortcuts
| ironmagma wrote:
| > healthy diet
|
| Easy to say that phrase, much harder to elucidate exactly what
| it means. And how will we find out what it means without
| studying it?
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