[HN Gopher] Mechanism behind aspirin protective effect against c...
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       Mechanism behind aspirin protective effect against colorectal
       cancer identified
        
       Author : antiviral
       Score  : 75 points
       Date   : 2023-11-14 17:51 UTC (5 hours ago)
        
 (HTM) web link (www.technologynetworks.com)
 (TXT) w3m dump (www.technologynetworks.com)
        
       | antiviral wrote:
       | "Colorectal cancer (bowel cancer) is the third most common form
       | of cancer worldwide, with around 1.9 million newly diagnosed
       | cases and 900,000 deaths every year. Therefore, preventive
       | substances represent an urgent clinical need.
       | Aspirin/acetylsalicylic acid has proven to be one of the most
       | promising candidates for the prevention of colorectal cancer.
       | Among other findings, studies have shown that when patients with
       | cardiovascular diseases took low doses of aspirin over several
       | years, it reduced their risk of colorectal cancer. Furthermore,
       | aspirin can inhibit the progression of colorectal cancer. Now a
       | team led by Heiko Hermeking, Professor of Experimental and
       | Molecular Pathology at LMU, has investigated which molecular
       | mechanisms mediate these effects."
        
       | blakesterz wrote:
       | I was curious:                 "The jury is still out on whether
       | aspirin has a future as a way to reduce the risk of cancers other
       | than colorectal. Findings that regular aspirin use is associated
       | with a reduced risk of other cancers "have been hit or miss,"...
       | 
       | https://www.cancer.gov/about-cancer/causes-prevention/resear...
        
       | elromulous wrote:
       | This is encouraging. As someone with ulcerative colitis, I'm at
       | increased risk for colorectal cancer, and cannot take NSAIDs, due
       | to them paradoxically causing flare ups.
        
         | Obscurity4340 wrote:
         | What are your intestines/gut made of? How come they never like
         | rupture or leak?
        
       | glonq wrote:
       | > Furthermore, aspirin can inhibit the progression of colorectal
       | cancer
       | 
       | Cool! Might be too little too late for me, but hopefully this can
       | help improve prognoses for other people soon.
        
         | jjkeddo199 wrote:
         | Sorry to hear, wishing you well.
        
       | candiddevmike wrote:
       | Don't read this and start taking daily aspirin without talking to
       | your doctor. Aspirin isn't like a vitamin, it can cause serious
       | problems with daily usage.
        
         | AstralStorm wrote:
         | Well. A lot of people could benefit from a cardiovascular
         | protective dose of aspirin. Like everything, it has side
         | effects.
         | 
         | Now whether that actually does anything to cancer risk or if
         | it's too low... Needs further research.
        
           | vidarh wrote:
           | Yes, but it's not a great idea to start that either without
           | talking to your doctor first. There are sufficient potential
           | risks with ongoing aspirin use that it's not a given that it
           | will be a net benefit for you even though it is for a lot of
           | people.
        
         | esafak wrote:
         | Namely?
        
           | singlow wrote:
           | Ulcers, bleeding, hemorrhagic stroke, kidney or liver
           | failure, other allergic reactions and interactions with other
           | drugs.
        
             | NotGMan wrote:
             | Sounds kinda like the standard american diet.
        
               | vidarh wrote:
               | And _when_ dietary issues or any number of other things
               | causes gastric issues or any number of the other things
               | on that list, there 's a very real risk that nsaids can
               | make them _significantly worse_ for some patients.
               | 
               | You'll want to know if you're at risk before you start
               | taking it regularly.
        
         | astrange wrote:
         | Maybe you can just put it in the other end?
        
           | voisin wrote:
           | That's what she said. - Michael Scott
        
         | idonotknowwhy wrote:
         | How did you know what I was planning??
        
       | car wrote:
       | _" Aspirin induces the production of two tumor-suppressive
       | microRNA molecules (miRNAs) called miR-34a and miR-34b/c. To do
       | this, aspirin binds to and activates the enzyme AMPK, which in
       | turn alters the transcription factor NRF2 such that it migrates
       | into the cell nucleus and activates the expression of the miR-34
       | genes. For this activation to succeed, aspirin additionally
       | suppresses the oncogene product c-MYC, which otherwise inhibits
       | NRF2."_
        
       | DoreenMichele wrote:
       | Cool. Now let's identify the root cause of the tumors.
       | 
       | Based on some cancers being caused by viruses, I'm guessing
       | viruses would be a good place to start looking.
        
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       (page generated 2023-11-14 23:02 UTC)