[HN Gopher] Microgravity-induced muscle atrophy: Implications fo...
       ___________________________________________________________________
        
       Microgravity-induced muscle atrophy: Implications for long-duration
       spaceflights
        
       Author : KasianFranks
       Score  : 38 points
       Date   : 2023-10-11 02:19 UTC (13 hours ago)
        
 (HTM) web link (journals.physiology.org)
 (TXT) w3m dump (journals.physiology.org)
        
       | Brometheus wrote:
       | Don't live in microgravity.
        
       | amelius wrote:
       | Here's my design for solving this problem.
       | 
       | Instead of sending one rocket, you send two. You link them with
       | steel cables. Then you rotate them around to generate the
       | required gravity.
        
         | stoneman24 wrote:
         | Yep, see Netflix film Stowaway for example. Once we get Spacex
         | Starship working, fit 2 of them with Hab modules in the nose.
         | Launch them and connect together at the nose and spin at
         | different rates for moon gravity (G/6) and Mars gravity G/3).
         | Use steel cables to increase radius and reduce required spin
         | rate.
         | 
         | A relatively cheap (for space) setup to get some good actual
         | measurements.
        
           | uoaei wrote:
           | The whole "space is big" thing applies here, you can keep
           | those two bodies super far apart. I don't really see a good
           | reason for that tbh but it's possible. Though if the mission
           | depends on those two bodies traveling together, you better
           | have tons of redundancy or some propulsion systems to recover
           | in case the cable snaps.
        
             | stoneman24 wrote:
             | Was really thinking of an earth orbiting laboratory setup
             | with a radius of about 250m and rotation speeds of about
             | 2-3 rpm. Need to model it when I have some time. Just to
             | gain actual data on different gravities and durations. The
             | starship has plenty of room for the habs to run experiments
             | on plants and people. Each one has propulsion in case of a
             | cable failure. You're correct, the cable snapping would be
             | big concern.
        
         | bjelkeman-again wrote:
         | > Artificial gravity is provided to the crew on the way out to
         | Mars by tethering off the burnt out Ares upper stage and
         | spinning up at 1 rpm.
         | 
         | From
         | 
         | Mars Direct: A Simple, Robust, and Cost Effective Architecture
         | for the Space Exploration Initiative, by Robert Zubrin,
         | February 1991
         | 
         | DOI:10.2514/6.1991-329
        
       | temptemptemp111 wrote:
       | [dead]
        
       | [deleted]
        
       | suzzer99 wrote:
       | This seems like a real problem for older astronauts who will
       | never be able to gain that muscle back.
       | 
       | Muscle mass is so vital for long term health. 70-year-olds
       | confined to bed rest for just two weeks have been observed to
       | lose significant muscle mass that they most likely will never get
       | back.
       | 
       | Obviously most astronauts are younger than 70. But they're also
       | losing a lot more muscle mass and bone density.
        
         | inglor_cz wrote:
         | Progress in stem cell treatments might be able to treat that
         | muscle mass loss. We are getting closer to regenerating tissues
         | at will, although obviously the main effort is concentrated on
         | the cardiovascular system and nerves.
        
         | voldacar wrote:
         | You could just give the 70 year olds testosterone replacement
         | and they would gain it back and more, probably
        
       | MilStdJunkie wrote:
       | One of the saddest parts of the science fiction novel _Aurora_ is
       | that natural born human populations will have serious problems
       | permanently separated from the larger ecosystem they're evolved
       | for.
       | 
       | It's a valid hypothesis. Humanity would need to have an entire
       | engineered biosphere to replace the biome living in our guts, our
       | eyes, our . . everywhere. And anywhere we find that's close
       | enough to Earth to live in, will have . . _something_ else . .
       | almost certainly[1] already there.
       | 
       | Kim Stanley Robinson isn't an easy read if you're on the other
       | side of the political spectrum, but Aurora is comparatively free
       | of his standard preachiness, at least in my ears. I actually
       | disagree with his primary thesis of Aurora, and the novel suffers
       | from some fundamental problems as a story, but the point is still
       | salient. Humans will have to build their own Earth, wherever they
       | end up, either out there or back here. I have a funny feeling we
       | won't learn to treasure our own planet until we find out how much
       | work it is to live on another.
       | 
       | [1] Particularly given the extraordinarily early date of the
       | first Terran lifeforms. It doesn't seem to take too much to get
       | the ball rolling, unless the panspermia theories actually turn
       | out to hold some water.
        
         | pyinstallwoes wrote:
         | They don't call it Spaceship Earth for nothing!
        
         | diogenes4 wrote:
         | > I have a funny feeling we won't learn to treasure our own
         | planet until we find out how much work it is to live on
         | another.
         | 
         | Optimistic! I have a feeling we won't learn to treasure our own
         | planet until we _fail_ to reach another. The problems here are
         | simply too massive for us to coordinate spreading to other
         | places.
        
           | shiroiuma wrote:
           | We'll learn to treasure our own planet when the ecosystem
           | becomes uninhabitable for us and we start going extinct.
        
         | kzrdude wrote:
         | "Earth is our spaceship"
        
         | shiroiuma wrote:
         | >And anywhere we find that's close enough to Earth to live in,
         | will have . . something else . . almost certainly[1] already
         | there.
         | 
         | *No* place is going to be "close enough" to Earth to live in:
         | the closest star system is 4 light-years away, and will take
         | tens of thousands of years to travel to with anything remotely
         | like current technology. The only way we're going to find
         | another planet "close enough to Earth to live in" is if we
         | invent a real, working, practical FTL drive. That's not
         | terribly likely. Well, there is one other possibility: some
         | glowing blue alien substance called "protomolecule" is
         | discovered in our solar system and somehow (through a long,
         | twisting plot arc) takes over an asteroid with 100k people,
         | assimilates their biological matter, crashes on Venus, then
         | travels to the outer system and builds a Ring Gate. Anyway...
         | 
         | Basically, we're stuck with this planet, the not-at-all-like-
         | Earth worlds near it, and the other resources of this system.
         | 
         | The only real way we're going to create a viable, Earth-like
         | colony is to build an O'Neal Cylinder.
        
           | MilStdJunkie wrote:
           | Sibling is right, "close enough" == "habitable surface that
           | humans can live on without some life support".
           | 
           | Aurora uses the generation ship model of transport, which . .
           | does not go _ideally_. Many problems unforeseen for hundreds
           | of years of travel in the utter empty (you hope desperately
           | that it is empty). It 's also a fast but not relativistic
           | ship, .07C, at exorbitant energy costs. Hope you like the
           | moon / mercury covered in purple lasers. Relativistic lower-
           | mass vessels with the same technology, I guess, but the
           | impact threat goes through the roof, and it's not a
           | settlement ship. A better way to make the Aurora-style
           | project is a small ship with frozen embryos that get birthed
           | insitu by machines of loving grace. Then you can go faster,
           | smaller.
           | 
           | But it's all talk talk. We're technically capable of doing
           | these things, but I'm not sure we're socially capable of even
           | lunar settlement at this stage of our history. Let alone
           | Mars, the outer system. The Expanse was, in its own way,
           | optimistic about our future. They just had to get medieval to
           | get Earth's gas balance (and probably phosphorous! and who
           | knows what else) back in the normal range.
           | 
           | Heh heh you know it's funny but if we took the solar system
           | as it exists right now, a floating settlement higher up in
           | the Venutian cloud layers would be closest[1] to fitting that
           | bill, in terms of kgs of crap you need to carry around
           | outside with you. Just, yknow, not anyone's typical idea of a
           | "settlement".
           | 
           | [1] And yet so very damn far away.
        
           | jonathanlydall wrote:
           | I read their "close enough" as in regards to similarity of
           | climate/environment, not in regards physical distance of the
           | other planet from Earth.
        
           | chr1 wrote:
           | > The only way we're going to find another planet "close
           | enough to Earth to live in" is if we invent a real, working,
           | practical FTL drive.
           | 
           | That is not the only way, extending lifespan would work as
           | well
        
       | dmarchand90 wrote:
       | I wonder if you could bypass these issues with strength training
       | machines designed for space. E.g a squat machine that pushes down
       | from above, cable tension based arm movements, etc. I bet if
       | you're clever you can probably have a small room that can get the
       | essential exercises in and takes up a similar amount of room as a
       | toilet
        
         | HPsquared wrote:
         | The ISS has a space barbell:
         | 
         | https://en.wikipedia.org/wiki/Advanced_Resistive_Exercise_De...
        
           | dmarchand90 wrote:
           | Now I'm curious how the results of study posted would be
           | mitigated by the space barbell
        
             | HPsquared wrote:
             | I guess the problem remains that the legs still don't need
             | to lift the body weight.
             | 
             | For example in a barbell squat, your shoulders lift the
             | bar, but your legs lift that weight plus your bodyweight.
             | In space, bodyweight is not a factor so your legs only have
             | the same load as the shoulders. So upper body / shoulder
             | might end up being the limiting factor, not giving the legs
             | the same amount of load they would under gravity.
        
               | vmfunction wrote:
               | You can always just train like some anime character or
               | kung fu masters:
               | 
               | https://www.youtube.com/watch?v=crKohKpVoAM
        
               | freilanzer wrote:
               | That could be solved via a vest that you wear, that has
               | additional cables pulling with a force of the bodyweight.
               | That way you could also do pull ups with your bodyweight.
        
       | 3seashells wrote:
       | Could Ems or sleeping in a spinning drum overcome this?
        
         | inamberclad wrote:
         | EMS = electro muscular stimulation? No, not 100%. Astronauts
         | have very good resistance training onboard the ISS at this
         | point. Some of them come back to earth stronger than they left.
         | However, it turns out that your body also needs skeletal
         | loading in order to produce strong bones. That kind of loading
         | comes from having large forces distributed through the entire
         | body. NASA tried a variety of shortcuts around resistance
         | training, but none of them were satisfactory.
         | 
         | A spinning drum is probably the best method short of artificial
         | gravity, but it has a couple problems. A rotating reference
         | frame creates some pretty non-intuitive effects
         | (https://www.youtube.com/watch?v=bJ_seXo-Enc). Research is
         | ongoing about just how fast a human can be spun for a long
         | duration, although data is hard to come by. We also don't know
         | how low of a gravity a human can stay healthy in without
         | intervention like serious exercise. If it turns out that you
         | need 1G, that involves a much larger spinning drum than a G/3
         | (Mars) or G/6 (Moon) environment. The problem is that we really
         | have no way to simulate those environments for a human.
        
           | RetroTechie wrote:
           | Given the travel time, any visit to Mars would probably not
           | be short-stay like 1 day. More likely weeks, months or
           | longer.
           | 
           | So you'd have Mars G for time on the surface anyway.
           | 
           | And besides: a few astronauts have already done long duration
           | microgravity, returned to Earth & lived to tell.
        
           | mealkh wrote:
           | What about flywheel training? You can do deadlifts, squats
           | etc with it that will produce large spinal/skeletal load even
           | in the absence of planetary gravity due to the inertia.
           | Something like https://exerflysport.com/ or
           | https://exxentric.com/store/kbox/
        
       | iampivot wrote:
       | I wonder if it's really required to have 1g gravity in order to
       | avoid this. It's much easier to artificially create, say 1/6g
       | (moon) gravity by rotation than 1g, since rotational speed
       | required is quite a bit slower.
        
         | uoaei wrote:
         | I wonder how much the rotation speed really matters. It comes
         | down to the tensile strength of the material required to hold
         | everything together I suppose but most metals should be able to
         | handle 1g just fine. Once it's rotating you don't need much
         | energy to keep it going, just enough to overcome any frictional
         | losses from whatever interfaces happen to be required.
        
           | iampivot wrote:
           | There's also the issue of dizziness if rotating fast with a
           | small radius.
        
         | leoff wrote:
         | Could one become stronger by living in 2g?
        
           | heavenlyblue wrote:
           | would that be similar to weari nb a backpack having weight
           | same to your body?
        
             | reportgunner wrote:
             | Not too similar, imagine all the liquids in your body while
             | running at 2g.
        
           | stoneman24 wrote:
           | To echo some of the points from the aurora book, I think that
           | the human body is really well optimised for 1G environments.
           | We know that there are issues in zero gravity. As you adapt
           | to 2G, you may well get stronger but the stress and strains
           | may have a severe effect on health, life expectancy. Hate to
           | think about the effects on your blood pressure etc
           | 
           | Your great grand kids might eventually cope.
        
           | narag wrote:
           | That's actually seen in anime. In Dragon Ball Z, Goku trained
           | in 100 G. I remember thinking it was clever. It reminded me
           | of Spain national football team training for some weeks in La
           | Paz previous to Mexico World Cup in 1986. The idea is
           | enduring harder conditions (> altitude -> less oxygen) to
           | overcompensate.
        
       ___________________________________________________________________
       (page generated 2023-10-11 16:01 UTC)