[HN Gopher] Researchers find a cause of Parkinson's disease, Mit...
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       Researchers find a cause of Parkinson's disease, Mitochondrial DNA
       damage
        
       Author : geox
       Score  : 47 points
       Date   : 2023-10-02 15:16 UTC (7 hours ago)
        
 (HTM) web link (www.eurekalert.org)
 (TXT) w3m dump (www.eurekalert.org)
        
       | cosentiyes wrote:
       | The actual paper title is "Mitochondrial DNA damage triggers
       | spread of Parkinson's disease-like pathology":
       | https://www.nature.com/articles/s41380-023-02251-4. Parkinson's
       | is a notoriously complex disease with multiple etiologies and
       | subtypes. While this is particularly exciting to see (I have a
       | loved one with PD), the EurekAlert article really misses the
       | critical "PD-like" modifier.
        
       | thenerdhead wrote:
       | > "Furthermore, we are dedicated to exploring potential
       | therapeutic strategies aimed at restoring normal mitochondrial
       | function to rectify the mitochondrial dysfunctions implicated in
       | the disease."
       | 
       | I can't help but feel excited. Breakthroughs in Parkinson's,
       | breakthroughs in ME/CFS, breakthroughs in long covid. And the
       | cool part? They all seem to follow similar hypotheses of
       | mitochondrial dysfunction.
       | 
       | https://www.science.org/doi/10.1126/scitranslmed.abq1533
       | 
       | https://www.washingtonpost.com/health/2023/09/17/fatigue-cfs...
        
         | omneity wrote:
         | Can we possibly expect something similar for other
         | neurodegenerative diseases such as Alzheimer's?
        
           | NeuroCoder wrote:
           | We have investigations into mitochondrial genetics and
           | Alzheimer's. There's still a lot to learn but it's probably
           | safe to assume there's a lot more going on. Treatment and
           | even prevention for most will likely rely on attending to
           | more than just mitochondrial abberations.
        
         | im3w1l wrote:
         | Watching from a distance, I think a lot of our fast progress
         | recently is because of better tooling. Better ways to see what
         | is happening at a microlevel, and manipulate it too.
         | 
         | Like someone could run endless experiments on how to "balance
         | the four humors" perfectly and get nowhere with all these
         | diseases, perhaps not even be able to clearly define and
         | distinguish them from one another.
        
           | thenerdhead wrote:
           | Absolutely. It is an exciting time for science. And also for
           | someone who may have one of these unexplainable diseases.
        
             | [deleted]
        
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       (page generated 2023-10-02 23:00 UTC)