[HN Gopher] CRISPR used to 'reprogram' cancer cells into healthy...
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CRISPR used to 'reprogram' cancer cells into healthy muscle in the
lab
Author : rbanffy
Score : 166 points
Date : 2023-09-09 12:20 UTC (10 hours ago)
(HTM) web link (www.livescience.com)
(TXT) w3m dump (www.livescience.com)
| [deleted]
| darkclouds wrote:
| MSTN codes for myostatin, a myokine that is produced and released
| by myocytes and acts on muscle cells to inhibit muscle growth,
| myostatin gene defects (missing genes/myostatin knockout) are
| seen in whippets and Belgium blue cattle.
|
| PAX3-FOXO1 drives miR-486-5p which induces skeletal muscle
| hypertrophy in myostatin knockout mice and represses miR-221
| which contributes to rhabdomyosarcoma (soft tissue cancer), a
| type of rhabdomyolysis (muscle loss).
|
| Personally I prefer the effect of high doses of manganese
| (chloride) on insulin and the stimulating effect insulin has on
| the immune system.
| GenerWork wrote:
| >Personally I prefer the effect of high doses of manganese
| (chloride) on insulin and the stimulating effect insulin has on
| the immune system.
|
| Could you go into this in a little more detail? Are you saying
| that high doses of manganese will make it easier to build
| muscle?
| darkclouds wrote:
| No I'm saying manganese helps regulates insulin which in turn
| helps modulate parts of the immune system. [1] It helps to
| smooth the blood sugar spike.
|
| Chromium reduces insulin sensitivity which is helpful for
| cells especially muscle which in turn increases stamina.
| There are plenty of studies which call into question the
| RDA's for supplements and there are misleading studies like
| [3].
|
| For example, [2] (Zinc) deficiency during pregnancy causes
| irreversible effects on the newborn such as growth
| impairment, spontaneous abortion, congenital malformations
| and poor birth outcomes.
|
| The same probably exists for other supplements and likewise
| over exposure will also introduce problems like nickel over
| exposure can cause fibrotic lung in animal experiments which
| could explain why some people are born with cystic fibrosis.
|
| In this example [3], the subjects are only consuming
| 200micrograms of chromium. I'm not surprised they didnt see
| any effect, the RDA is 400ug, but some body builders have
| been known to take upto 2.4g aka 2,400mg aka 2,400,000ug and
| have seen effects (cant find the study now), but the weight
| training muddies the water so to speak. And the chromium
| intake assumes there is enough manganese in the diet to help
| produce enough insulin and thus smooth the blood sugar levels
| in the first place.
|
| Zinc plays a role at stabilising cell membranes, it can help
| reduce the need for a vit E intake which also helps protect
| cell membranes and is also heavily concentrated in organs
| like the pancreas.
|
| And whilst non digestive exposure to metals like zinc and
| manganese can cause problems, the digestive system is very
| capable at removing excess intakes via the bile acids,
| helping to reduce any risks.
|
| Zinc, manganese and chromium will all have an effect on the
| immune system, but as manganese is most commonly associated
| with insulin production, I only mentioned the manganese.
|
| This study [4] shows that chromium alters the immune response
| by immunostimulatory or immunosuppressive processes, by
| altering the insulin resistance of cells.
|
| We are very complex chemical reactions, so trying to get the
| right intake seems to be a logical first step and with todays
| technology, and the complete absence of medical experts
| asking about diet in the first place, how can they even do
| their job properly for long term illnesses?
|
| So in this reprogramming of cancer cells, yes its a another
| scientific achievement but is this another achievement once
| the horse has bolted and should we actually be looking more
| at the quality and nutrition of our food and environment in
| order to avoid reactionary medicine?
|
| [1] https://www.medicalnewstoday.com/articles/322946#:~:text=
| %E2...
|
| [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262205/
|
| [3] https://pubmed.ncbi.nlm.nih.gov/9861607/
|
| [4] https://academic.oup.com/femspd/article/34/1/1/498748
| jackothy wrote:
| I'm imagining a future where bodybuilders purposely give
| themselves aggressive cancer so that they can later "reprogram"
| it into additional muscle.
| fnordpiglet wrote:
| Randomly disturbed muscle masses on like your liver and
| wrapping your kidneys doesn't seem like it'll win many
| competitions
| baz00 wrote:
| Leg day, Arm day, Liver day, Kidney day.
| FeteCommuniste wrote:
| Liver King will now have muscles on his liver.
| garba_dlm wrote:
| future problems for future competitions.
|
| see also: crimes of the future movies
| 3seashells wrote:
| It will result in funny twitches once they get the signals
| from vagus and Co. Chest burster cramps after alcohol.
| jayd16 wrote:
| First you cultivate benign mass, then you harvest that mass.
| dahfizz wrote:
| Seems like way more hassle than just taking steroids
| cvccvroomvroom wrote:
| Juicing = shrinking nuts & roid rage.
|
| If a biological male needs more T, clomiphene is the way to
| go.
| voldacar wrote:
| Doesn't it cause eye damage if taken for a long period?
| cvccvroomvroom wrote:
| What's curious is that viral oncology vectors can destroy
| cancer cells so aggressively that it's performed in a hospital
| because it's potentially lethal.
| hanniabu wrote:
| Is that because the die off causes mast cell activation?
| beezlewax wrote:
| I mean so is cancer
| nonrepeating wrote:
| "It's not a tumor!" - Kindergarten Cop.
| mometsi wrote:
| I'm imagining a future where this cancer cell reprogramming
| technology can be used to turn people into dinosaurs.
| ildon wrote:
| Reminds me of I am Legend
| unixhero wrote:
| Ah CRISPR again
| jdjdjdjdjduuuu wrote:
| CRISPR IS the greatest invention since the internet
| bobmaxup wrote:
| https://www.pnas.org/doi/10.1073/pnas.2303859120
| Zaskoda wrote:
| I think this was meant for another post. You're on the CRISPR
| post.
| ryanschaefer wrote:
| This is the paper the article is based on
| biogene wrote:
| >One hurdle that will need to be overcome is that NF-Y also
| regulates important processes in healthy cells, such as
| metabolism and the cell cycle, the series of steps that cells go
| through as they grow and divide. However, Vakoc and team
| hypothesize that because RMS cells are "highly sensitive" to
| changes in PAX3-FOXO1 expression, there could be a "window of
| opportunity" in which a drug inhibits NF-Y long enough for RMS
| cells to differentiate but not so long that healthy tissues get
| damaged.
|
| Author buried the most important "but.." in the last paragraph.
| Lets keep "sciencing", but this is just a catchy headline.
| lumost wrote:
| I'd be curious if one could use CRISPR to reprogram cancer
| cells to the point that the immune system starts killing them
| again. Or did this work not have any targeting?
| moffkalast wrote:
| Tangentially relevant xkcd https://xkcd.com/1217/
| nickdothutton wrote:
| Probably of interest to readers, a 2011 talk from Danny Hillis
| that this article reminded me of.
|
| "Danny Hillis makes a case for the next frontier of cancer
| research: proteomics, the study of proteins in the body. As
| Hillis explains it, genomics shows us a list of the ingredients
| of the body -- while proteomics shows us what those ingredients
| produce. Understanding what's going on in your body at the
| protein level may lead to a new understanding of how cancer
| happens."
|
| https://youtu.be/scITIoJvMJ0?si=boMyciGMFf6X6AQH
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(page generated 2023-09-09 23:01 UTC)