[HN Gopher] Czech scientists confirm the existence of the p-hole...
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Czech scientists confirm the existence of the p-hole in molecules
Author : jakubmazanec
Score : 104 points
Date : 2023-09-05 16:03 UTC (6 hours ago)
(HTM) web link (www.avcr.cz)
(TXT) w3m dump (www.avcr.cz)
| fooker wrote:
| Does this have real consequences for material science or
| chemistry?
|
| It's difficult to gauge the actual impact from the hyperbole in
| the article (similar to discovery of black holes, etc).
| gus_massa wrote:
| IIUC:
|
| For Material Science: very little
|
| For Chemistry: Reading the paper, it looks like DFT[1] gets the
| same result than the experiments. It's nice to confirm DFT in a
| weird scenario, but it's not groundbreaking. There are a few
| versions and parameters to tweak in DFT, so it may help to
| choose the right one for similar molecules, but I'm not an
| expert in DFT.
|
| Black holes: That was totally hyperbole. I chuckle. It looks
| like people have been using pi-holes to predict the strength of
| the bound between molecules [2]. It's nice to be able to "see"
| them in a real example, but doesn't look groundbreaking. (There
| is always a small possibility that this technique is improved
| and in a few years everyone is using it to identify molecules
| or something like that. I don't expect that, but you never
| know. Sometimes experimental results create a complete new
| branch.)
|
| [1] https://en.wikipedia.org/wiki/Density_functional_theory
|
| [2] I made a search in google, and I cherry-picked these
| articles https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003638/
| https://pubs.rsc.org/en/content/articlelanding/2021/cp/d1cp0...
| downWidOutaFite wrote:
| This is experimental confirmation of existing accepted theories
|
| "The confirmation of the existence of the p-hole, as well as
| the s-hole before it, fully demonstrates the quality of the
| theoretical predictions of quantum chemistry, which have
| accounted for both phenomena for decades."
| calibas wrote:
| For anyone confused by the comments here: https://pi-hole.net/
| [deleted]
| dang wrote:
| They're flagged; let's resist now. This kind of thing is sort
| of at the midpoint between these two HN guidelines:
|
| " _Please don 't pick the most provocative thing in an article
| or post to complain about in the thread. Find something
| interesting to respond to instead._"
|
| " _Please don 't complain about tangential annoyances--e.g.
| article or website formats, name collisions, or back-button
| breakage. They're too common to be interesting._"
|
| https://news.ycombinator.com/newsguidelines.html
| kzrdude wrote:
| And https://www.collinsdictionary.com/dictionary/english/pie-
| hol...
| [deleted]
| [deleted]
| [deleted]
| [deleted]
| [deleted]
| pr8dan wrote:
| [flagged]
| kennyadam wrote:
| You thought they were using a DNS-based as filter with
| molecules?
| zamadatix wrote:
| It's a pun on the DNS filtering software pi-hole.
|
| As nerdy as HN is it's safe to assume this is on the front
| page because the name sounds funny not because the majority
| are secretly spending years of their lives going deep into
| things like molecular studies posted in Nature.
| Etheryte wrote:
| Alternatively, people upvote things which are
| intellectually interesting. Discoveries like this are
| interesting to read about even if you're not a molecular
| scientist.
| whatshisface wrote:
| Molecular scientists are called chemists
| Etheryte wrote:
| Not necessarily, while there is considerable overlap,
| molecular physics is considered a field of its own.
| adelarsq wrote:
| Can someone explain why this discovery is linked with black holes
| discovery? It's just for the experimental research or its there
| something more?
| malux85 wrote:
| I think they are drawing on the similarity that both things
| (pi-hole and black holes) were theorized long before they were
| proven -
|
| but I dont think this is a very good addition to the article,
| it just confuses concepts that aren't related
| Old_Paris wrote:
| It's just a matter of time till the existence of the k-hole get's
| confirmed.
| nathan_douglas wrote:
| I experimentally verified that years in the past, when I was
| shacked up with some dolphins and a flexible assistant.
|
| I'm able to continually confirm the existence of a near
| infinite number of a-holes, though.
| [deleted]
| wkat4242 wrote:
| [flagged]
| gilleain wrote:
| So I'm aware of aromatic interactions in proteins and DNA
| <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530875> and
| electron holes - <https://en.wikipedia.org/wiki/Electron_hole>
| which is a quasiparticle.
|
| Is this research then relevant to charges moving through DNA or
| proteins?
| 19h wrote:
| [flagged]
| [deleted]
| rebolek wrote:
| Czechia is the world's largest electron microscopes producer so
| it's nice to see that the microscopes are useful in domestic
| research too.
| [deleted]
| tifik wrote:
| Link directly to the Nature article for those curious (or, like
| me, if you just want to see the pictures):
| https://www.nature.com/articles/s41467-023-40593-3
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(page generated 2023-09-05 23:02 UTC)