[HN Gopher] High-Dosage NMN Promotes Ferroptosis to Suppress Lun...
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       High-Dosage NMN Promotes Ferroptosis to Suppress Lung
       Adenocarcinoma in Mice
        
       Author : birriel
       Score  : 26 points
       Date   : 2023-08-19 18:45 UTC (4 hours ago)
        
 (HTM) web link (www.ncbi.nlm.nih.gov)
 (TXT) w3m dump (www.ncbi.nlm.nih.gov)
        
       | RecycledEle wrote:
       | They looked into the effect of NMN (Nicotinamide Mononucleotide)
       | on lung adenocarcinoma (a type of lung cancer) cells.
       | 
       | It may be that high levels of NMN inhibited lung cancer growth by
       | causing cancer cell death via ferroptosis, acting through a
       | pathway involving NAM, SIRT1, AMPK and ACC.
        
         | jandom wrote:
         | Yeah this kind if work is usually meh. It's unclear if the high
         | concentration is physically relevant in humans, plus it's not
         | clear if it causes any other problems, and plus it's not clear
         | how it compares to existing treatments. So maybe promising but
         | v v early
        
           | folli wrote:
           | Obligatory XKCD: https://xkcd.com/1217/
        
           | pankajdoharey wrote:
           | You cannot completely reject it, this is the first step, the
           | next is human clinical trials.
        
       | jimwhite42 wrote:
       | Here are some interesting videos on NMN:
       | https://www.youtube.com/@DrBradStanfield/search?query=nmn
       | 
       | I think the pragmatic position is that NR has better testing in
       | humans and is a bit cheaper, and there's no reason to think that
       | plain Niacin isn't just as good at this point if you can deal
       | with the flush - we don't really have enough solid testing yet,
       | and it's extremely cheap.
        
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       (page generated 2023-08-19 23:00 UTC)