[HN Gopher] Experimental Alzheimer's Vaccine Shows Promise in Mice
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Experimental Alzheimer's Vaccine Shows Promise in Mice
Author : gumby
Score : 51 points
Date : 2023-08-03 18:28 UTC (4 hours ago)
(HTM) web link (gizmodo.com)
(TXT) w3m dump (gizmodo.com)
| fragmede wrote:
| [flagged]
| knodi123 wrote:
| Maybe you should say something about welcoming immortal mouse
| overlords? Just a thought.
| throwaway743 wrote:
| Please don't. It's sad enough seeing the hn comment sections
| degrade into looking like reddit's
| fragmede wrote:
| > Please don't post comments saying that HN is turning into
| Reddit. It's a semi-noob illusion, as old as the hills.
|
| https://news.ycombinator.com/newsguidelines.html
| jsisto wrote:
| This is great news for mice with Alzheimer's
| BSEdlMMldESB wrote:
| [flagged]
| lame-robot-hoax wrote:
| What
| BSEdlMMldESB wrote:
| I peered behind the curtain and I cannot lie to myself
| reissbaker wrote:
| We've cured "Alzheimer's in mice" over and over again. Sadly our
| mouse model for Alzheimer's has not proven to be a good model for
| Alzheimer's in humans.
| [deleted]
| angiosperm wrote:
| They bred up a mouse that gets something that looks like
| Alzheimer's, and is very easy to cure it in. In the US, most of
| two billion dollars annually goes for grants just to study
| _this mouse_. Vanishingly few grantees ever so much as peek at
| anything in or from human patients. Of course there is plenty
| still to learn about that mouse, as about any organism, but
| what has been far more thoroughly demonstrated than most
| medical results is that, appearances aside, Alzheimer 's in
| that mouse is very unlike in humans.
|
| The only intervention I know of that shows robust results
| preventing Alzheimers is having been recently vaccinated. It
| doesn't seem to matter much for what, but several population
| studies, involving tens of thousands of patients and
| controlling for lifestyle confounders, show a reliable 40%
| reduction in dementia risk for people recently vaccinated for
| TDaP. Nobody will talk about it, apparently because it is
| embarrassing to have no clue why it works. (Pressed, people
| mumble about inflammation.) And, of course, no money is spent
| figuring it out, or figuring out why vaccination doesn't seem
| to help the other 60%.
|
| Work in other countries has implicated herpes virus, and got
| good outcomes from valacyclovir, again provoking little
| interest from US researchers.
|
| Whenever it, somehow, becomes possible to divert those two
| billion dollars to somewhere they might do some good for
| Alzheimer's patients, a whole population of biochemists who
| only know about brain metabolism in _that mouse_ will need to
| find something else to do. In the meantime, they get to
| allocate the money to themselves.
| resoluteteeth wrote:
| I definitely wouldn't hold my breath on this vaccine working
| but it's different from the drugs targeting beta amyloid
| plaques and it's still possible it will work.
|
| Even if the animal model they tested it using is suspect, the
| theory behind drug itself (targeting senescent cells) is
| plausible.
|
| I wouldn't give it more than a 10% chance but without other
| effective alzheimer's drugs even a small chance like that is
| absolutely still worth doing clinical trials on.
| kjksf wrote:
| It merely slows progress of Alzheimer i.e. stops progress of
| brain inflammation.
|
| Strange that they call it a vaccine.
|
| Nomenclature aside, it's even better to not develop the
| inflammation in the first place.
|
| And it can be done with a simple (but difficult) change: stop
| eating insane amounts of sugar and carbs that most people eat in
| standard American / western diet.
|
| This prevents diabetes (because diabetes is "too much glucose in
| your blood" disease and not eating sugar (glucose) and carbs (are
| converted to glucose by our body).
|
| Elevated levels of glucose trigger elevated levels of insulin. If
| it persists for long periods of time, it causes inflammation in
| our body, including brain.
|
| This inflammation caused by diabetes is believed to be main cause
| of Alzheimer. Some scientists even call Alzheimer a Type 3
| diabetes.
|
| As to "insane amounts of sugar": you probably consume insane
| amount of sugar without knowing your doing it.
|
| The optimal amount of glucose in our blood in 3 grams, which is 6
| grams of sugar.
|
| A daily recommended dose of sugar is 25 grams for women and 36
| for men.
|
| A single can of coca-cola is 33 grams of sugar. That's more than
| a daily sugar budget for a woman and almost daily budget for a
| man.
|
| An average consumption by an American is 76.7 grams i.e. 2x daily
| recommended dose.
| lumb63 wrote:
| Do you have any sources documenting the link between diabetes
| and Alzheimer's? This is the first I've heard of that.
| asow92 wrote:
| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246646/
| [deleted]
| kjksf wrote:
| https://www.youtube.com/results?search_query=diabetes+alzhei.
| ..
|
| https://www.webmd.com/alzheimers/alzheimers-diabetes-link
|
| You'll find numerous researches talking about this link.
| saltymug76 wrote:
| I'm glad that in the face of decades of research, you boiled
| avoiding Alzheimer's down to just a few paragraphs. Well done!
| armadsen wrote:
| eFAD (early-onset Alzheimer's disease) runs in my wife's
| family. It's a simple Mendelian dominant genetic trait. If you
| get the mutated gene from your parent, you get Alzheimer's. Not
| "well, you might get it". You get it. Usually in your early to
| mid 50s. Her dad is in his early 60s and is in the late stages
| of the disease. It's far, far more complex a disease than just
| "don't eat sugar".
| Narretz wrote:
| > This inflammation caused by diabetes is believed to be main
| cause of Alzheimer
|
| then please don't start your comment as if this is verifiable
| fact
| asow92 wrote:
| This is a real and open debate.
| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246646/
| PaulKeeble wrote:
| A good solid step. Having produced an animal analogue of
| Alzheimer's and now come to a vaccine against it showing basic
| safety and effectiveness in mice is the step towards human
| trials. Early yet its still years away, but hopefully another
| awful disease is in the process of being reduced.
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(page generated 2023-08-03 23:02 UTC)