[HN Gopher] Cancer pill AOH1996 shows promise in annihilating al...
___________________________________________________________________
Cancer pill AOH1996 shows promise in annihilating all solid tumours
Author : jjordan
Score : 32 points
Date : 2023-08-01 19:04 UTC (3 hours ago)
(HTM) web link (www.prnewswire.com)
(TXT) w3m dump (www.prnewswire.com)
| thumbsup-_- wrote:
| There is a new cancer cure every year for more than a decade now
| but still nothing really substantiates in terms of saving
| people's lives at scale. This research is promising but authors
| of such news should feel morally obligated to also mention
| realistically how far away in future will be the medicine based
| on this research given that there are people out there with
| limited time on their hands who might start getting their hopes
| up by reading these.
| blacksmith_tb wrote:
| It's understandable to be frustrated by our lack of a magic
| bullet to cure cancer, but unfortunately it's not one disease
| but a whole range of different diseases. That said, I would
| offer Checkpoint Inhibitors[1] as an example of a whole new
| class of meds from recent years that have helped save many,
| many people.
|
| 1: https://www.cancer.gov/about-
| cancer/treatment/types/immunoth...
| Spooky23 wrote:
| That's just not true.
|
| Metastatic melanoma was a death sentence as little as 10 years
| ago. Now, five year survival rates are improving thanks to
| checkpoint inhibitors and improved radiosurgery.
| skerit wrote:
| I'd like to sign up my friend who has about 3 years left for some
| clinical trials.
| voldacar wrote:
| If your friend's life is on the line and the evidence in favor
| of this compound is good enough, just consider skipping the
| process and having someone synthesize it for you.
| 1letterunixname wrote:
| Please don't spread false hope or impossible suggestions.
| This molecule is still investigatory and proprietary, so
| there's no documentation on its structure for replication by
| anyone outside of original authors. Furthermore, it is highly
| unlikely any researcher would jeopardize their reputation and
| livelihood by randomly manufacturing experimental, unproven
| compounds for clinical use.
| sudosysgen wrote:
| For better or for worse, there are services available
| internationally which will manufacture experimental,
| unproven, compounds for unspecified uses.
|
| Additionally, proprietary investigational compounds
| typically have their structure published in patents.
|
| It's still a terribly bad idea to use experimental
| compounds no matter how bad when they haven't even finished
| safety trials - you wouldn't even be able to figure out
| what dosage is going to be effective without killing you.
| It's very easy to do far more harm than good. And typically
| past Phase 1 trials when this is characterized,
| compassionate use becomes a possibility.
| joefigura wrote:
| Link to paper here: https://www.cell.com/cell-chemical-
| biology/fulltext/S2451-94...
| adamredwoods wrote:
| >> However, the cancer-killing pill Malkas has been developing
| over the past two decades, AOH1996, targets a cancerous variant
| of PCNA, a protein that in its mutated form is critical in DNA
| replication and repair of all expanding tumors
|
| But it's still a single pathway. Cancer has abilities to
| circumvent most pathways, after a time.
|
| Targeting multiple pathways will be the answer, but FDA is so
| slow at allowing multiple-target clinical trials. Keytruda thus
| far, has been the best to believe in combining with many other
| products, and get clinical trials going. Sure, they have to
| partner with competitors, but this (multi-pathways) is the true
| path to stopping cancer.
| westcort wrote:
| Too early to draw any conclusions
| 1letterunixname wrote:
| Exactly. It's phase I testing. All they know is it doesn't seem
| to kill mice or some healthy cells in a Petri dish. Despite
| this being apparently a highly-targeted molecule, there is
| always the potential for it to cause side-effects, injuries, or
| fatalities in whole humans. It shows promise but wake me up
| when it passes phase III.
___________________________________________________________________
(page generated 2023-08-01 23:02 UTC)