[HN Gopher] FDA says aspartame is safe, disagreeing with WHO fin...
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       FDA says aspartame is safe, disagreeing with WHO finding
        
       Author : hanniabu
       Score  : 59 points
       Date   : 2023-07-14 18:30 UTC (4 hours ago)
        
 (HTM) web link (www.cnbc.com)
 (TXT) w3m dump (www.cnbc.com)
        
       | cwkoss wrote:
       | I would love to see a log of the communications between coca cola
       | execs and the FDA leading up to this announcement.
       | 
       | Even if aspartame is perfectly safe, feels like there is a strong
       | subtext of corporate protectionism to this statement.
        
         | voz_ wrote:
         | Only if you show me the log of wire transfers to WHO execs from
         | the CCP lol
        
       | aspartame wrote:
       | Aspartame is on the WHO list for "possibly" cancer trigger.
       | 
       | Higher up on the list is hot water for "PROBABLY" cancer trigger:
       | https://time.com/4369809/very-hot-drinks-are-probable-cancer...
        
       | greatfilter250 wrote:
       | [dead]
        
       | karmaMeansCool wrote:
       | I stopped drinking alcohol due to the possible cancer link
       | seeming much greater than aspartame's link to cancer. It seems
       | strange that the studies are much more conclusive on alcohol's
       | role with cancer than aspartame, but the concerns are much higher
       | for aspartame than alcohol. Part of me wonders why this is. One
       | possible reason I see is that people's trust in the studies about
       | aspartame are much lower than their trust in the studies about
       | alcohol.
        
         | lukeschlather wrote:
         | > but the concerns are much higher for aspartame than alcohol
         | 
         | This is not true, at least with the WHO. Alcohol is a Group 1
         | carcinogen according to the WHO. It definitely causes cancer.
         | The WHO classifies aspartame in Group 2b "possibly a
         | carcinogen." There's some confusion over how to render
         | uncertainty here, but the WHO does not actually classify
         | aspartame as a carcinogen.
        
           | jemmyw wrote:
           | I think the op meant concerns amongst the general public. Yes
           | food safety experts have more concerns about alcohol but I
           | would guess there are a lot more people who avoid aspartame
           | and still drink alcoholic beverages.
        
       | morninglight wrote:
       | Follow the money -
       | 
       | Where the dollars go: Lobbying a big business for large food and
       | beverage CPGs
       | 
       | https://www.fooddive.com/news/where-the-dollars-go-lobbying-...
        
       | qup wrote:
       | You can believe anything you want, and cite a credible source.
       | 
       | Peak 2023
        
         | add-sub-mul-div wrote:
         | Some questions have fuzzy, ambiguous answers that are subject
         | to interpretation. It was that way last year too. It's not a
         | reason to get frustrated with science. It's an ongoing process.
        
           | belval wrote:
           | I don't think this is "getting frustrated with science" as
           | much as "getting frustrated with the reporting on science".
           | 
           | I don't think people are arguing that doing aspartame
           | research is pointless so much as they are annoyed at the
           | sensationalistic approach taken to report of that research.
           | There is a large difference between "Aspartame may cause
           | cancer" and "Aspartame may cause cancer if you drink 14 cans
           | of diet coke a day".
           | 
           | It's pointless distractions at best and downright fear-
           | mongering at worse in the attempt of getting ad-revenue from
           | clicks.
        
             | add-sub-mul-div wrote:
             | But "You can believe anything you want" is a personal
             | choice, there's extra nuance that explains why two bodies
             | disagree if you want to look for it. Ultimately it's on us
             | to read further than headlines or not.
        
               | belval wrote:
               | This article title is fine in my opinion as it mostly
               | covers the disagreement between two bodies as you said,
               | but before that one I saw at least 2-3 articles this week
               | that were just "WHO says aspartame causes cancer". That's
               | the thing that angers people because it's obviously
               | clickbait
        
           | qup wrote:
           | The answer to the question of whether aspartame is safe for
           | humans is not fuzzy or ambiguous. We haven't found the truth
           | for certain yet, but it will be very black and white
           | eventually.
        
             | add-sub-mul-div wrote:
             | It could be safe for some people and not others. It could
             | be safe in combination with some foods and diets but not
             | others. It could be safe according to one scientist's
             | threshold of acceptable risk but not another's. It could be
             | safe in the sense of being less bad than sugar but not in
             | comparison to drinking water. And so on.
        
       | mytailorisrich wrote:
       | My understanding is that the WHO has maintained its recommended
       | max. daily intake, which is the equivalent of about 10 cans of
       | soft drinks a day... make of that what you will.
        
         | aidenn0 wrote:
         | 7-11 at one point had a 128oz fountain drink which is more than
         | 10 cans of soda (i.e. 120 fl oz).
        
           | freedomben wrote:
           | Yep that's true. In the summer of '04 I worked as a Napa
           | delivery driver, driving parts orders all over the city to
           | mechanic shops as needed. 7-11 had a location right across
           | the street from us, so it was common that we would make a
           | "sev" run in the morning to get everybody caffeinated. The
           | manager there was a badass classic parts guy that was a great
           | guy and who did his job really well, but drank copious
           | amounts of caffeine.
           | 
           | 7-11 started selling an enormous 128 oz mug that we would
           | fill with soda in the morning and drink throughout the day.
           | That was an insane amount of soda. But my boss at the time
           | would have me take his 128 oz mug and fill it with several
           | _pots_ of _coffee_. The clerk at sev would joke about how she
           | had to make a couple of extra pots around 8 am because of my
           | boss, and how  "I know it's still for him even if he's too
           | chicken to come in himself."
           | 
           | To this day I've never known anybody that drank as much
           | caffeine as he did. I'm guessing the nicotine from the chain
           | smoking helped take some of the edge off :-D
           | 
           | Those were different times.
        
         | jackstraw14 wrote:
         | I've worked with folks who sit at their desk and drink diet
         | soda from those giant reusable 64oz cups, all day. When it's
         | all zero calories, I guess I can see how you get there.
        
           | lotsofpulp wrote:
           | That is insane, are they peeing every hour? I feel like at
           | that point it must affect work output.
        
             | fshbbdssbbgdd wrote:
             | The stuff is caffeinated, it probably helps.
        
             | amethyst wrote:
             | time lost maybe nullified by increased focus and lack of
             | fatigue due to the caffeine?
        
         | strict9 wrote:
         | Ask someone who has worked in a restaurant about the habits of
         | diet coke drinkers. They always require 10x or more refills
         | than water or soda.
        
           | [deleted]
        
           | anonporridge wrote:
           | Perhaps that's partially due to a feeling of moral licensing?
           | 
           | e.g. This thing has no calories, therefore I feel justified
           | in overindulging and drinking tons of it to let my primal
           | urge for sweetness go unopposed.
        
       | Clamchop wrote:
       | I have a feeling those with an existing opinion on sweeteners
       | will choose to trust whichever agency agrees with them.
        
       | legitster wrote:
       | > Schubauer-Berigan acknowledged during a press conference with
       | journalists Wednesday that the studies could contain flaws that
       | skewed the results. She said the classification should be viewed
       | as a call to conduct more research into whether aspartame can
       | cause cancer in humans.
       | 
       | > "Aspartame is one of the most studied food additives in the
       | human food supply. FDA scientists do not have safety concerns
       | when aspartame is used under the approved conditions," an agency
       | spokesperson said late Thursday shortly after the WHO released
       | its findings.
       | 
       | I'm going to side with the FDA on this one. Aspartame could
       | possibly hold the title as the _most_ scrutinized chemical in
       | history. So for the WHO to give such a limp wristed statement
       | calling for more research is unbelievably pandering.
       | 
       | It's also vaguely _un-_ scientific. Even with a 99% confidence
       | interval, we _know_ that 1 out of every 100 analysis studies is
       | going to reach a false conclusion. So just based on the sheer
       | number of studies conducted on Aspartame, we _know_ there are
       | going to be links that turn out inconclusive. Latching onto a
       | small number of niche cases and ignoring the preponderance of
       | evidence is essentially calling for infinite research.
       | 
       | The WHO has a tendency to lean overly-cautious. And if we are
       | being fully honest, maybe even a bit Euro-centric and elitist.
       | And given the alternative is _sugar_ which has obvious and known
       | health side effects it 's hard not to see this as some bored
       | staff playing games.
        
         | oxfordmale wrote:
         | A lot of your criticism seems to be playing the man rather than
         | the ball.
         | 
         | The WHO said a person weighing 70kg would need to consume more
         | than between nine and 14 cans of diet soft drink per day to
         | exceed the daily guideline. So basically the FDA and WHO are in
         | agreement, but the WHO uses more cautious language.
        
           | legitster wrote:
           | Sure, but as much as the news is going to pick up this story
           | and blow it out of proportion, I think people should kind of
           | know they are being played with here.
        
             | oxfordmale wrote:
             | WHO can't be held responsible for headlines put out by
             | newspapers.
             | 
             | WHO declared aspartame possibly carcinogenic, putting it in
             | the same class as mobile phone usage That means there is
             | some limited evidence pointing in that direction, but that
             | further studies are needed to confirm this. I don't think
             | this statement is incorrect. In the end is all about the
             | daily dosis, and the possibly increase in cancer (is it
             | 0.005% or 5%).
             | 
             | If you need to drink 40 cans to increase your cancer risk
             | by 0.005%, it would be irrelevant for most people.
        
         | mrleinad wrote:
         | > And given the alternative is sugar
         | 
         | No, the alternative is to learn to enjoy bitter beverages. We
         | don't need sweeteners.
        
           | xen0 wrote:
           | Like alcohol?
        
             | mrleinad wrote:
             | I don't understand your point, but alcohol is not safe
             | either.
        
             | slowmovintarget wrote:
             | Like tea.
        
           | [deleted]
        
           | serf wrote:
           | >the alternative is to learn to enjoy bitter beverages.
           | 
           | people seek replacements when things they like become scarce,
           | not alternatives.
           | 
           | asking the public-at-large to wholly change preference
           | (especially when the preference is compounded by biological
           | bias in the way we experience taste..) will never be
           | effective without extenuating circumstance or market control
           | of some sort.
           | 
           | I sympathize with your point -- people should try to enjoy
           | things without a lot of excess sweetness -- but it doesn't
           | align with reality.
        
           | zer8k wrote:
           | You do realize you can sweeten more than beverages right?
           | What if a diabetic wants a cookie? Or ice cream?
           | 
           | This is why hazard ratios are important.
        
             | mrleinad wrote:
             | > What if a diabetic wants a cookie? Or ice cream?
             | 
             | Diabetics can eat cookies and ice cream, they just need to
             | shoot themselves with insulin afterwards. It's having too
             | much of it the problem.
             | 
             | Besides, if something is bad for you, you avoid it. Period.
             | There are infinite other flavors in life to make it all
             | about that single one. "But I want it" is not a reasonable
             | argument.
        
             | Clamchop wrote:
             | Aspartame and most sweeteners fall apart at high
             | temperatures, limiting their usefulness for a lot of
             | foodstuffs, like cookies.
             | 
             | Which is a shame in my opinion.
        
         | fatfingerd wrote:
         | The only alternative isn't sugar. We need to back away from
         | this whole project. We don't need to have everything taste like
         | candy,
        
           | justrealist wrote:
           | It's not the job of the FDA or WHO to tamper with scientific
           | evidence to push people in that direction. That's how people
           | lose trust in the institutions of science.
        
             | fatfingerd wrote:
             | The WHO should hold back on condemning universal sweetening
             | that will make it impossible for anyone to tally the amount
             | they've consumed because people might go back to sugar?
             | They should lie or they should say this path is also
             | probably unsafe?
             | 
             | I don't really see anything inconsistent with the WHO or
             | the FDA statements. The WHO wants health across
             | contingencies and the FDA wants to sell diabetes causing
             | drinks to the maximum extent that they don't provably hurt
             | health.
        
         | autoexec wrote:
         | > Aspartame could possibly hold the title as the most
         | scrutinized chemical in history.
         | 
         | I don't understand this talking point, but I see it repeated
         | often. Aspartame has only been approved since the 70s and was
         | only discovered in the 1960s. The total of all the years of
         | use/research into Aspartame doesn't even amount to a single
         | human lifespan. It's barely over half of one! How the hell are
         | we supposed to have any idea of the long term effects from
         | that? In terms of "most scrutinized chemical in history" I
         | don't think Aspartame has a chance against chemicals like water
         | or ethanol.
        
           | zer8k wrote:
           | This is simply conjecture but there have been numerous
           | studies done it. Moreover, it's the most consumed artificial
           | sweetener in the world. In this case, you'd think at least
           | some cases of cancer would appear even by chance related to
           | it. Yet, as far as I know, we really haven't seen any that
           | stood up to statistical rigor.
           | 
           | From 1970 to now there have been what...4 generations of
           | aspartame consumers? I'd say that sample size is enough to
           | draw a reasonable conclusion from.
           | 
           | I may be wrong in my assumption here but the amount of
           | aspartame needed to cause these types of things is _insane_.
           | The amount of aspartame you would need to consume to even
           | approach a level considered mildly hazardous with this new
           | data would be 14 sodas.
        
             | autoexec wrote:
             | > From 1970 to now there have been what...4 generations of
             | aspartame consumers?
             | 
             | The few people who started drinking it as teens and adults
             | in the 1970s are now only in their 50s and 60s, and the
             | generations after that have only been drinking it for a few
             | decades. That isn't much data at all to judge long term
             | impacts. 50 years is nothing, and a lot about our
             | consumption of aspartame has changed drastically over that
             | time. In the 1970s people weren't drinking 3-6 cans of diet
             | soda a day. The average American today is drinking a bit
             | less than the 58 gallons of soda a year that we drank in
             | the 90s, but it's still a lot more than was being consumed
             | for the first decade or two since aspartame was added.
             | 
             | Personally, I don't even drink soda and so I have no skin
             | in this game whatsoever. I honestly have no idea what the
             | long term risks of Aspartame are, I just doubt anyone could
             | have much confidence with less than 50 years of research. I
             | can say that it seems highly unlikely that there are dire
             | short term effects at least, but I have nothing but
             | sympathy for those who are skeptical considering that
             | companies routinely buy research to show whatever
             | conclusions they want to see while burying any results that
             | are unfavorable and the FDA often seems to care more about
             | protecting profits than human lives. We've seen again and
             | again that companies are willing to knowingly poison people
             | and that regulatory agencies are ineffective at protecting
             | us from it, so I can't blame anyone for being cautious.
             | 
             | Considering that the WHO's stance of "possible carcinogen"
             | isn't a strong claim in the first place and the
             | recommendation for additional research can't hurt anyway it
             | doesn't seem unreasonable to me.
        
               | edmundsauto wrote:
               | Even given these limitations, if the effect were strong,
               | we would see some of it start to pop up after 50 years.
               | Unless there is reason to think it's a threshold effect -
               | no impact until X level of consumption. I'm not sure
               | whether there is, but even if the impact is "causes
               | cancer after 100 years", we would likely see some signs
               | in some people after 50. It doesn't seem reasonable to me
               | that the volume of studies haven't shown small effects
               | increasing over cohort duration.
               | 
               | The Ockham's Razor here - the bigger the causative
               | effect, the more signal it should have.
        
               | autoexec wrote:
               | > Even given these limitations, if the effect were
               | strong, we would see some of it start to pop up after 50
               | years.
               | 
               | I think that's the argument the WHO is making. That given
               | what we've learned over the last ~50 years it does seem
               | possible that aspartame is increasing the rate of certain
               | cancers. It's a pretty modest claim and they think it's
               | worthy of more research. I find that hard to argue
               | against. What's the harm in a bunch of independent
               | researchers spending some time studying the long term
               | impacts of aspartame? If it turns out the effect is very
               | small, or non-existent it won't change anything. People
               | can just feel more confident about chugging down gallons
               | of diet soda every year. If it turns out that a bunch of
               | people drinking aspartame end up with cancers after 70
               | years when they wouldn't have otherwise, we'd know how to
               | prevent that for the next generation. Scientists get
               | work, we get answers. Seems like a win/win.
        
             | yetanotherloser wrote:
             | There have hardly been 4 generations of aspartame
             | consumers, since quite a few of the 1970s generation are
             | still with us (would it be more or less if they'd had no
             | aspartame? I have no idea, do you?) and mass use didn't
             | kick in until later anyway.
        
         | wila wrote:
         | > maybe even a bit Euro-centric and elitist
         | 
         | Ugh those elite Europeans who want to play it safe.. what's
         | wrong with them?
        
         | slowmovintarget wrote:
         | The WHO seems to be following the science, the FDA seems to be
         | following _cough_ something else.
         | 
         | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227014/
         | 
         | Check the table near the end:
         | 
         | - Genotoxicity
         | 
         | - Neurodegneration
         | 
         | - Neurotransmission disruption
         | 
         | - Hormone disruption (including early menstruation in girls <
         | 10yrs old)
         | 
         | No... It's not safe.
        
         | chrisco255 wrote:
         | I agree, but studies have nowhere close to a 99% confidence
         | interval. Half or more of these types of studies reach false
         | conclusions and are not reproducible.
        
         | wredue wrote:
         | The WHO does have a tendency to lean overly cautious.
         | 
         | But you have to remember that the FDA is not working for YOUR
         | best interest either. When the FDA says that something is
         | "safe", what it actually means is "the economic impacts of this
         | are probably negligible in a lifetime". So if aspartame causes
         | cancer after your career is over, then it's safe according to
         | the FDA.
         | 
         | The WHO isn't under the same lobbying or economic pressures,
         | and approach their statements from entirely different
         | perspectives than the FDA.
        
           | 2OEH8eoCRo0 wrote:
           | Even if true, isn't economic impact just a proxy for human
           | harm since the more working and healthy humans the better?
        
           | JohnFen wrote:
           | I mostly agree. Both agencies have their flaws (what
           | doesn't?) but on the whole, I trust WHO more than the FDA.
           | 
           | Which isn't to say I'll always side with WHO over FDA when
           | they disagree, of course.
        
           | bawolff wrote:
           | > "the economic impacts of this are probably negligible in a
           | lifetime"
           | 
           | I mean, how else would you define "safe"? I have trouble
           | imagining something both unsafe and has no ecconomic impact.
        
           | klodolph wrote:
           | The FDA has a history of being cautious as well. Perhaps even
           | overly cautious.
           | 
           | > So if aspartame causes cancer after your career is over,
           | then it's safe according to the FDA.
           | 
           | I would love to see some kind of foundation for this, to
           | explain where your beliefs about FDA processes are coming
           | from.
        
           | legitster wrote:
           | I mean, it's hard to even know where to grapple with such a
           | polemic statement. But you mean to say that the FDA's mission
           | is to ignore retirees? Retirees being the the most powerful
           | voting block in the country, the top source of campaign
           | contributions, and top recipient of government funds.
           | 
           | Even if I was conspiratorial minded, I would assume the
           | conspiracy works the _other_ way.
        
             | atomicUpdate wrote:
             | That's not what he means. He's referring to the FDA
             | officials retiring, and thus no longer being responsible
             | for any of their decisions on safety anymore, since they're
             | at home relaxing if anything bad happens down the road.
        
               | niam wrote:
               | A plain textual reading of the comment doesn't suggest
               | that at all.
               | 
               | Maybe you're referring to a different thread?
        
               | codyb wrote:
               | Wouldn't they be consuming FDA approved foods and drugs
               | by people as unscrupulous and heartless as them though in
               | this scenario?
               | 
               | Yeesh, these folk are people, I sincerely doubt "nothing
               | bad'll happen until I'm retired" is their general
               | calculus.
        
           | worik wrote:
           | > So if aspartame causes cancer after your career is over,
           | then it's safe according to the FDA.
           | 
           | That is a big claim. It fits my priors. But is there any
           | evidence for it?
        
             | nomel wrote:
             | From what I've seen, it appears that plastics/endocrine
             | disruptors are evidence of this. BPA being a previous
             | example [1], with most other plastics being a current
             | example [2], including the "BPA free" replacements like
             | BPS.
             | 
             | [1] https://www.nrdc.org/press-releases/nrdc-fda-reach-
             | settlemen...
             | 
             | [2] https://sdg.iisd.org/news/household-plastic-products-
             | disrupt...
        
           | criddell wrote:
           | > The WHO does have a tendency to lean overly cautious
           | 
           | Not always. It took them far too long to acknowledge COVID-19
           | could be transmitted through the air.
           | 
           | https://www.nature.com/articles/d41586-022-00925-7
        
             | chrisco255 wrote:
             | That tells you about how much you should listen to their
             | opinions on the causation of cancer, eh?
        
               | [deleted]
        
           | dangus wrote:
           | Not that I don't disagree with the idea of being skeptical
           | about agency motivations and transparency, but this seems
           | like a literal conspiracy theory.
           | 
           | There are all kinds of things that cause or are linked cancer
           | that pretty much have to be legal. Can the government
           | entirely ban motor vehicles or delivery trucks? Would you
           | have the government ban ice cream because obesity causes
           | cancer?
           | 
           | Government agencies like the FDA have to deal with the
           | complexities of the real world. Risk of death is involved
           | with daily life, so they are often tasked with the analysis
           | of risk.
           | 
           | The layperson doesn't really like to hear that they're just a
           | number in a statistics database but it's true.
           | 
           | 40% of people get cancer in their lifetime. So if you have a
           | chemical that increases cancer risk by an insignificant
           | enough percentage, there's a pretty understandable debate on
           | whether banning something like that is an overreach or not.
           | What are the benefits of the chemicals? What are the risks?
        
             | interactivecode wrote:
             | Actually banning fossil fuel cars from dense city centers
             | has been proven to be healthier for the people living
             | there. So yeah would be great if they could ban them
             | everywhere.
        
         | Alex3917 wrote:
         | > Aspartame could possibly hold the title as the most
         | scrutinized chemical in history
         | 
         | You could almost say that it's the Lance Armstrong of food
         | additives.
        
           | fuzzylightbulb wrote:
           | This is genuinely hilarious. Well done.
        
           | yetanotherloser wrote:
           | That's hilarious.
        
       | BrianHenryIE wrote:
       | It is "normal" that the US allows food (additives, at least) that
       | is banned in Europe
       | 
       | https://archive.is/N6JI1
        
         | klodolph wrote:
         | It is also normal that many European foods are banned in the
         | US. For every discussion I see about how the FDA is crazy for
         | letting Americans consume all these various additives, I see
         | another discussion about how the FDA is crazy for banning
         | $EUROPEAN_FOOD. Unpasteurized milk is one of the more common
         | ones people talk about (along with products made from
         | unpasteurized milk). Kinder eggs were another, but the
         | situation has changed. People also scoff at the American habit
         | of refrigerating eggs (which is fine--the choice to refrigerate
         | or not refrigerate eggs just has to be consistent with the ways
         | eggs are prepared for consumers in your country, and in the US,
         | refrigeration is correct, because of the way eggs are treated).
        
           | vikingerik wrote:
           | Kinder eggs didn't change by the rule, the manufacturer just
           | found a workaround. The rule is that a toy can't be inside
           | food. The US version of Kinder eggs (Kinder Joy) comes in two
           | separatable halves so that the toy isn't inside it.
        
         | rconti wrote:
         | That's inherent any time there's any disagreement in any
         | regulation.
        
         | legitster wrote:
         | As a counter: I would strongly recommend people read Derek
         | Lowe's takedown of a lot of these claims:
         | https://corante.com/snake-oil/eight-toxic-foods-a-little-che...
        
         | Semaphor wrote:
         | Tonka beans are legal over here, though.
         | 
         | And while this lists a bunch of things we have issues with,
         | there are also a few others that might eventually get allowed,
         | but take a long time. Like monk fruit and alluose.
        
           | Clamchop wrote:
           | For context, tonka is valued for its coumarin content and
           | coumarin is maligned for its association with the active
           | ingredient in rat poison and some medications, but is a
           | different molecule.
           | 
           | Coumarin is found chiefly in perfumes (functional and fine
           | fragrance) and smells sweet and grassy. In this application,
           | it is sold all over the world, including the US.
           | 
           | As a flavor in food, it is banned in the US.
        
             | Semaphor wrote:
             | And tonka beans kinda taste like a combination of vanilla
             | and something. Like a more complex version of it. Love it
             | for everything sweet and it has almost (it shouldn't be
             | heated) completely replaced vanilla for me.
        
       | bastard_op wrote:
       | If anyone of any reputable standing says something is a potential
       | carcinogen at any level or percentage, why on earth would you
       | continue using it at all? It's well documented aspartame is at
       | worst "not good for you", so why allow it at all? Other than the
       | Coke and Pepsi's that will cry murder and loss of jobs.
        
       | [deleted]
        
       | dang wrote:
       | Recent and related:
       | 
       |  _WHO says soda sweetener aspartame may cause cancer, but it's
       | safe within limits_ -
       | https://news.ycombinator.com/item?id=36717961 - July 2023 (9
       | comments)
       | 
       |  _Aspartame Is a Possible Cause of Cancer in Humans, a WHO Agency
       | Says_ - https://news.ycombinator.com/item?id=36717553 - July 2023
       | (5 comments)
       | 
       |  _The WHO is about to declare aspartame can cause cancer_ -
       | https://news.ycombinator.com/item?id=36644185 - July 2023 (26
       | comments)
       | 
       |  _Aspartame: Once More Unto the Breach_ -
       | https://news.ycombinator.com/item?id=36562739 - July 2023 (199
       | comments)
       | 
       |  _Aspartame is set to be declared a possible carcinogen_ -
       | https://news.ycombinator.com/item?id=36522471 - June 2023 (30
       | comments)
       | 
       |  _Aspartame sweetener to be declared possible cancer risk by WHO,
       | say reports_ - https://news.ycombinator.com/item?id=36519942 -
       | June 2023 (565 comments)
        
       | zwieback wrote:
       | We have an obesity epidemic, not a diet-coke-cancer epidemic in
       | this country. I'd say the occasional can of diet soda is a good
       | tradeoff.
        
         | FollowingTheDao wrote:
         | Sorry, but have you heard about the drastic increase in the
         | rate of young people getting colon cancer?
        
           | [deleted]
        
           | zwieback wrote:
           | Sure, that's scary, but the science linking that to
           | sweeteners is very weak. I'm not pro sweeteners but I'm anti
           | bad public science communications.
        
         | cwkoss wrote:
         | "occasional can of diet soda" is a minimizing strawman.
         | 
         | I recently had a friend quit diet pepsi - he used to drink as
         | many as 18 cans per day. I'm not sure its responsible for
         | federal regulators to call that behavior 'safe', and am glad
         | he's kicked the habit.
        
           | zerocrates wrote:
           | I don't think the regulators would call drinking 18 cans of
           | anything a day "safe." An ingredient being safe doesn't mean
           | you can have unlimited amounts of it with no ill effects;
           | this isn't even true of water.
        
         | lowbloodsugar wrote:
         | An occasional can of regular soda is also fine. The problem is
         | mass consumption of either, and the link between soda and fatty
         | foods. People eating salads aren't drinking a coke of any kind.
         | What goes great with a coke? A giant BBQ pulled pork sandwich
         | with sloppy fries and onion rings.
        
       | kakaface wrote:
       | [flagged]
        
       | neonsunset wrote:
       | Regardless what WHO or FDA say, Aspartame is a hazard for people
       | prone to migraines. It took years for me to find it out and it
       | seems this experience tracks with other posters on HN whenever
       | the topic comes up.
        
       | chomp wrote:
       | > An adult who weighs 70 kilograms, or 154 pounds, would have to
       | drink more than nine to 14 cans of aspartame-containing soda
       | daily to exceed the limit and potentially face health risks.
       | 
       | Okay, but if I consume 9 to 14 cans of sugar-based soda, I don't
       | wind up with the same cancer risk? It's a ludicrous amount of
       | aspartame/soda to be sure, but there -is- something potentially
       | an issue with aspartame somewhere in there.
       | 
       | Yes, "everything causes cancer" but I don't disagree with the
       | WHO's decision. Something's there, even if it's negligible.
        
         | withinrafael wrote:
         | Probably obvious to many, but I wanted to throw out there:
         | after quick audit of my kitchen, I found aspartame in or added
         | to other products (e.g., chewing gum, coffee, smoothie mixes,
         | cereal, ice cream, etc.). So lets make sure we keep that in
         | mind when quantitatively measuring aspartame consumption!
        
           | worik wrote:
           | How many processed foods in your kitchen?
           | 
           | I have zero aspartame. Certainly none in my coffee
           | 
           | It should be food in your kitchen
        
           | anonporridge wrote:
           | Even still, if all of that is replacing sugar and plummeting
           | your risk of diabetes, a small increased risk of cancer after
           | a lifetime of consumption seems like a very acceptable
           | tradeoff.
        
         | pc86 wrote:
         | I wonder what the time-frame for this is. If I drink 14 cans of
         | diet soda once, have I permanently increased my odds of cancer?
         | That seems likely. If I drink 14 cans of _anything_ other than
         | water or maybe coffee every day for 30 years I would expect
         | negative health effects.
         | 
         | It would be great if they had some sort of time-frame.
        
           | tedunangst wrote:
           | If you plan on living 200 years, I guess you'd have to
           | restrict yourself to five cans per day to stay under your
           | lifetime limit.
        
             | kelipso wrote:
             | Cancer risk is accumulative I'm assuming. So you would want
             | to reduce risk as much as possible because there are plenty
             | of other things you're exposed to that increases cancer
             | risk. Can't just look at one substance and it's risk alone.
        
             | pc86 wrote:
             | My point is there is a big difference between and X%
             | increase in cancer being associated with 2-3 cans a day for
             | a year compared to a decade. And who knows if 2-3 cans a
             | day for a year is any safer than 1 can a day for 5 years or
             | a can every other day for 20 years?
        
           | s1artibartfast wrote:
           | I think hot water is also on the carcinogen list.
        
             | [deleted]
        
         | lotsofpulp wrote:
         | > Okay, but if I consume 9 to 14 cans of sugar-based soda, I
         | don't wind up with the same cancer risk?
         | 
         | No, you will end up with type 2 diabetes.
         | 
         | > Something's there, even if it's negligible.
         | 
         | Then what is the point of wasting everyone's time with
         | publicizing it?
         | 
         | Just last weekend, I was with a parent who would not let her
         | kids have sugar free popsicles, but was okay with them
         | regularly eating sugary popsicles.
         | 
         | For some reason, they think that a tiny bit of aspartame has a
         | higher probability of causing her kids greater harm than a ton
         | of refined sugar.
        
           | worik wrote:
           | > For some reason, they think that a tiny bit of aspartame
           | has a higher probability of causing her kids greater harm
           | than a ton of refined sugar.
           | 
           | Or they think like me that when you taste sweet it should be
           | sugar
           | 
           | Human biology is very complex. What we do not know about it
           | is more important than what we do know.
           | 
           | I do not trust novel chemicals that trick a body into
           | thinking it is getting sugar, but it's not.
           | 
           | Better a bit of sugar for real than telling the body that it
           | is getting a lot of sugar and giving it none
        
             | lotsofpulp wrote:
             | Most people are choosing between "a lot of sugar" or "a
             | little bit of low calorie sweetener". The former has known
             | problems. The latter does not.
        
           | habitue wrote:
           | Tbf, unrefined sugar is just as bad as refined sugar
        
             | worik wrote:
             | > Tbf, unrefined sugar is just as bad as refined sugar
             | 
             | Evidence?
        
               | habitue wrote:
               | all the bad parts of sugar are from the sugar part of it,
               | not some magic poison added by "refining"
        
             | lotsofpulp wrote:
             | True. But the decision is usually between consuming a food
             | with low calorie sweetener or with added sugar, which is
             | what I meant to compare.
        
             | neaden wrote:
             | I mean, yeah, don't drink 14 cans of any kind of soda a
             | day.
        
           | chimeracoder wrote:
           | > For some reason, she thinks that a tiny bit of aspartame
           | has a higher probability of causing her kids greater harm
           | than a ton of refined sugar.
           | 
           | Cancer isn't the only risk associated with aspartame.
        
             | lotsofpulp wrote:
             | Which are? I assume any molecule introduced to the body in
             | excess will have a variety of effects. It just seems after
             | decades, there seems to be nothing substantially risky
             | about consuming any of the low calorie sweeteners in a non
             | crazy amount.
             | 
             | Especially since the alternative seems to be people
             | consuming a ton of excess carbohydrates, which have near
             | guaranteed risks.
        
               | loeg wrote:
               | I believe (acute) GI distress is relatively common at
               | higher doses.
        
           | chomp wrote:
           | > No, you will end up with type 2 diabetes. I don't think
           | anyone is talking about diabetes.
           | 
           | > For some reason, she thinks that a tiny bit of aspartame
           | has a higher probability of causing her kids greater harm
           | than a ton of refined sugar.
           | 
           | Agree that sugar is absolutely terrible for you, and
           | aspartame is much less bad. What the WHO's talking about is
           | strictly "possible" cancer risk. Based on my understanding,
           | it's highly likely it's more worth it to face possible cancer
           | risk thank the 100% definitive high risk of disease from
           | sugar in the diet. The main thrust of my point is that
           | there's no reason it shouldn't be on group 2B, and the FDA
           | claiming otherwise is silly.
        
         | habitue wrote:
         | Yeah, there are absolutely people who drink this much
         | aspartame.
         | 
         | Probably we should think of its danger level like Advil: normal
         | sparse amounts are fine. But if you are doing it constantly
         | you're going to have issues.
        
           | s1artibartfast wrote:
           | It doesn't even mean that. 14 cans doesn't cause issues, it
           | is when the FDA thinks risk kicks in. That might still be a 1
           | in a million chance, after hitting the 14 can limit
        
             | habitue wrote:
             | fair
        
       | aa_is_op wrote:
       | Americans will whitelist everything for their big-pharma.
        
         | monetus wrote:
         | https://en.m.wikipedia.org/wiki/Frances_Oldham_Kelsey
        
         | anonporridge wrote:
         | Aspartame is a generic chemical and the US patent expired in
         | 1992.
         | 
         | Which big pharma companies are making big money off it?
        
       | Simulacra wrote:
       | *Be thankful for the American government, it's the best that
       | money can buy."
       | 
       | -Christopher Buckley
        
       | r930 wrote:
       | Aspartame increases dopamine precursors in the nervous system.
       | Some people don't like to have people with lots of dopamine,
       | gives one too many ideas.
        
       | atlex2 wrote:
       | Diet soda and sweeteners behind them are still a scam even if
       | they don't "cause cancer." They're a scam because they still
       | cause insulin response. Pancreas cranks out insulin after tasting
       | the soda, and there no blood sugar to react with. My uncle drank
       | tons of Diet Coke and got pancreatic cancer. Doesn't mean diet
       | soda caused his pancreatic cancer, but he definitely didn't loose
       | weight by drinking the stuff.
        
         | freedomben wrote:
         | > _My uncle drank tons of Diet Coke and got pancreatic cancer.
         | Doesn't mean diet soda caused his pancreatic cancer, but he
         | definitely didn't loose weight by drinking the stuff._
         | 
         | The point for most people of Diet Coke isn't to lose weight.
         | It's to avoid the harm caused by sugar, while still having
         | _something_ to drink. Diet sodas are definitely way, way better
         | for anybody with sugar senstivities or diabetes. Plain water
         | would be better, but that doesn 't make Diet Coke a "scam."
        
           | worik wrote:
           | > The point for most people of Diet Coke isn't to lose
           | weight.
           | 
           | Anecdotally I see different things.
           | 
           | People overweight, or who fear that, use aspartame IMO
        
         | Kirby64 wrote:
         | Provide your sources here.
         | 
         | Even if they do cause an insulin response (which a bunch of
         | people have noted, is not true for many sweeteners), they do
         | not have calories. If your uncle drank sugared soda instead,
         | I'm certain he'd weigh significantly more than his life
         | drinking diet soda.
         | 
         | Diet sodas are a bit of a trap people fall into, though: if you
         | switch to diet soda and don't also fix your otherwise unhealthy
         | diet, then it won't really help you. It's better than drinking
         | sugared soda, but not exactly the whole solution.
        
         | voz_ wrote:
         | Why is everyone spelling lose wrong?
        
         | CPLX wrote:
         | Is there any evidence for this. I see it constantly in internet
         | arguments but never anywhere else.
        
         | selectodude wrote:
         | I have family that died of pancreatic cancer before aspartame
         | existed. So there's a datapoint that undoes your data point.
        
         | autoexec wrote:
         | > They're a scam because they still cause insulin response.
         | 
         | Some sweeteners can cause insulin spikes (sorbitol and xylitol
         | for example), but aspartame does not. There's some evidence
         | that it can still cause insulin resistance though.
        
         | zwieback wrote:
         | Is the science good on this claim? I keep hearing it and we
         | should be more concerned about insulin spikes but is there
         | really a correlation with sweeteners?
        
           | zerocrates wrote:
           | If diet soda really caused a big insulin response while
           | containing no sugar, wouldn't we see things like a heavy
           | binge on diet soda causing hypoglycemia? Which I've never
           | heard of.
        
         | bufferoverflow wrote:
         | Erythritol doesn't cause insulin response.
         | 
         | Stevia doesn't.
         | 
         | Monk fruit extract doesn't.
        
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