[HN Gopher] Tea as Hepatoprotective Agent: A Revisit
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Tea as Hepatoprotective Agent: A Revisit
Author : anjel
Score : 50 points
Date : 2023-07-06 18:19 UTC (4 hours ago)
(HTM) web link (sci-hub.se)
(TXT) w3m dump (sci-hub.se)
| gumby wrote:
| I've been a dedicated tea drinker since my teens, so this is
| great news.
|
| OTOH what I worry about is oesophageal cancer. Not sure of the
| prevalence.
| azeirah wrote:
| Don't know any stats from the top of my head, but I recall that
| oesophageal cancer is caused by drinking _hot_ tea, not by
| drinking tea per se.
| gumby wrote:
| > drinking _hot_ tea, not by drinking tea per se.
|
| It is unclear to me that there is any way to drink tea than
| other than piping hot.
|
| I have heard horror stories that suggest people have
| attempted to drink cold tea but I figure such tales are
| merely intended to provoke disgust.
| qzw wrote:
| Cold tea does indeed provoke disgust. _Iced_ tea, on the
| other hand, is quite its own art form.
| tom_ wrote:
| I've always found tea acceptable at a wide range of
| temperatures. Room temperature to boiling, it's all good,
| same as water. (But _not_ same as red wine or beer, the
| other 2 types of liquid I will drink.)
|
| I do admit this rule does very much not apply when mixing
| tea with milk!
| jemmyw wrote:
| I usually cool my tea with a splash of milk. But I do then
| drink it very quickly at an elevated temperature.
| Cerium wrote:
| Avoid drinking liquids hotter than 140 f.
|
| One interesting "test" - take a sip of the liquid, and it
| does not seem that hot, put your finger in your mouth with
| the liquid and your finger might feel too hot.
| karencarits wrote:
| 140 degrees Fahrenheit = 60 degrees Celsius
| mmh0000 wrote:
| 140 degrees Fahrenheit = 344 kelvin
| tom_ wrote:
| Apparently it's more like 333 K.
| malfist wrote:
| Yeah but it's a dry kelvin
| simondotau wrote:
| As another data point, this is generally hotter than most
| "hot" water taps in your kitchen or bathroom.
| anjel wrote:
| https://pubmed.ncbi.nlm.nih.gov/32740163/
|
| Compared to those who consumed <300 g/month tea leaves at
| <=65degC, those who consumed more than 300 g/month tea leave at
| >65degC had a more than 1.8-fold higher risk of esophageal
| squamous cell carcinoma for both green tea and black tea.
| amanj41 wrote:
| As someone who doesn't know much about epidemiology, is 180%
| relative risk considered scary for something with a fairly
| low prevalence such as esophageal cancer?
| Aerbil313 wrote:
| We are the most tea-drinking country in the world afaik,
| Turkey. We're fine, but one particular city (Erzurum) has a
| weird tradition of putting a sugar under the tongue and
| drinking the tea very hot to (probably?) dissolve it easily.
| They drink it almost out of the teapot, boiling-hot. They
| have very high rates of esophagous cancer.
| FollowingTheDao wrote:
| I have a Partial Purine nucleoside phosphorylase (PNP)
| deficiency. It is a primary immunodeficiency. I cannot drink tea,
| and green tea is the wqrst for me since catechins (primarily
| EGCG) inhibits the PNP enzyme[1] as do quite a few other
| "healthy" foods like curcumin.
|
| It is best to know yourself and if tea makes you feel worse it
| might not be good for you.
|
| [1]
| https://www.researchgate.net/publication/262327467_Natural_p...
| kyleyeats wrote:
| As someone with iron overload who benefits from green tea: It's
| powerful stuff. One of the only chelators you can get that
| targets the brain. I have the opposite effect and a green tea
| addiction.
| et2o wrote:
| Thanks for sharing. I'm a doctor. If you don't mind sharing,
| out of curiosity how were you diagnosed with this? Not one of
| the primary immunodeficiencies I see tested, but I'm not a
| medical geneticist or pediatrician.
| FollowingTheDao wrote:
| Hey doc. Well, I had consistently low WBC counts
| (leukopenia), skin infections, sinus infections, lung
| infections (and nodules), as well as recurrent fungal
| infections. Doctors offered no explanation.
|
| In 2014 I had my genome run on 23andMe and through digging
| and getting a second genome run I confirmed that I was
| homozygous for rs1049564 (and other SNPs) in my PNP gene.
|
| I was finally able to push for a PNP activity test which
| revealed low activity. I do not think the doctors would have
| ever tested for this.
|
| Here is the paper that persuaded them to do the test:
| https://www.researchgate.net/figure/Purine-nucleoside-
| phosph...
|
| Since it is only a partial deficiency it did not cause
| catastrophic effects as a child, but as I got older it became
| worse.
|
| Here is a paper talking about the partial deficiency:
| https://pubmed.ncbi.nlm.nih.gov/32695102/
|
| I also have neurological issues (mood disorder) that I blame
| on the same deficiency.
| ricksunny wrote:
| Wow. I applaud this effort.
|
| Been working on studying pharmacogenetics /
| pharmacogenomics / toxicogenomics focused on phenols such
| as catechins in tea. (Activity 'C' of https://docs.google.c
| om/document/d/11f2bzMRbAgCJyoaEmxXKVytl... )
|
| Would love to understand how you researched this, as
| locating relevant research literature has been challenging.
|
| (updating my user page with contact)
| FollowingTheDao wrote:
| Hey Rick, it took a lot of time and a lot of emails to
| people researching the topic. But the key was the
| doctor's constantly diagnosing me and then diagnosing me
| with Lupus. Finding the link with Lupus and PNP SNPs was
| the key. The Lupus diagnosis was always back and forth
| because apparently PNP deficiency lowers immunoglobulin
| levels as well and that is the test that gets you in the
| door to the rheum only when it is high.
|
| Many other phenol's and polyphenols seem to give me
| issues as well.
|
| Also, you might take a look at the interaction between
| riboflavin and catechins. There is something going on
| there I do not quite understand:
|
| https://www.mdpi.com/1422-0067/9/10/1908
|
| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837740/
| Alex3917 wrote:
| Interesting, considering how many people get liver damage from
| taking green tea extract and EGCg.
| atomicnumber3 wrote:
| The dose makes the poison I suppose. Also I wonder who drinks
| more water than those who drink it flavored by leaves? I wonder
| if just drinking a lot of water is part of the effect.
| stefantalpalaru wrote:
| [dead]
| darkclouds wrote:
| Do a few grams worth of beta alanine, say up to 10grams and then
| tell me if you want to drink black tea!
| jsf01 wrote:
| What's the connection between beta alanine and tea? Is it just
| the caffeine in the tea that causes some effect when they're
| used in combination?
| jerry1979 wrote:
| What will happen if someone tries this?
| switchbak wrote:
| I've experienced tingling sensations, like pins and needles,
| not sure if that's what they're referring to.
| FollowingTheDao wrote:
| Taking beta-alanine will increase Carnosine synthase activity
| and probably lead to a depletion of magnesium and/or
| manganese since they are the co-factors for the enzyme. So
| this effect will differ based on genetic and nutrition.
|
| https://www.uniprot.org/uniprotkb/A5YM72/entry
| LegitShady wrote:
| I don't know about how interacts with tea, but gym bro forums
| have talked about itching and anal itching in particular.
| Maybe the tea makes that worse? No idea.
| dredmorbius wrote:
| Meta: I'd not realised that Sci-Hub was a permitted site on HN.
| It appears that it has been since at least 2019 looking at the
| site submission history link.
|
| I'm not in the least displeased to learn this.
| jeffbee wrote:
| If this is the meta-thread ... this presentation is horrible
| for mobile and defeats HN's forewarning about PDFs.
| CodeSgt wrote:
| Just curious, why did you think it wouldn't be?
| discordance wrote:
| " Hepatoprotection or antihepatotoxicity is the ability of a
| chemical substance to prevent damage to the liver. This is
| opposite to hepatotoxicity."
|
| https://en.m.wikipedia.org/wiki/Hepatoprotection
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