[HN Gopher] First 'tooth regrowth' medicine moves toward clinica...
___________________________________________________________________
First 'tooth regrowth' medicine moves toward clinical trials in
Japan
Author : elorant
Score : 422 points
Date : 2023-07-02 17:33 UTC (5 hours ago)
(HTM) web link (mainichi.jp)
(TXT) w3m dump (mainichi.jp)
| rilindo wrote:
| [flagged]
| jimlongton wrote:
| > A new UCL paper has revealed that the wide-spread belief that
| the British have poorer teeth than our American cousins is, in
| fact, a myth.
|
| > The research led by Richard Watt, Professor of Dental Public
| Health in the Department of Epidemiology and Public Health,
| found that the mean number of missing teeth a person has is
| significantly higher in the US.
|
| https://www.ucl.ac.uk/eastman/news/2015/dec/us-vs-uk-who-has...
| blcknight wrote:
| [flagged]
| rilindo wrote:
| Given the health care in the US, that isn't surprising.
| [deleted]
| dan-robertson wrote:
| I think the idea that people have in terrible teeth in the UK
| is a bit outdated, but did you look carefully at the study?
|
| The 'better teeth' you report is 7 missing teeth on average
| in the uk vs 7.3 in the US. Both of those numbers seem high
| to me: you'd need to have all wisdom teeth plus three more
| removed for example. It made me wonder whether that average
| was biased by old people[1] with many missing teeth[2], who I
| think aren't that relevant to the idea about teeth being bad
| in one country rather than another.
|
| For the 'oral health impacts' measure, which corresponds to a
| questionnaire, OHIP-14[3], with questions like 'have you been
| self-conscious because of your teeth, mouth or dentures?' The
| score for the UK is lower than the US here, though I guess
| the measure is less objective and you can imagine cultural
| factors would impact the answers (eg maybe people from one
| country would downplay things more, or if worse teeth are
| more socially acceptable in the country, people there may be
| less likely to be embarrassed about their teeth.
|
| I think the kind of 'bad teeth' more common in the U.K. is
| crookedness (eg overlapping incisors or over/underbite) and
| teeth being more yellow. The paper notes that they weren't
| able to measure things like that.
|
| My general impression is that bad teeth in the US (on someone
| who grew up there) are a pretty strong signal that someone
| grew up poor, and this is a little less the case for the UK.
|
| [1] the paper claims these are 'age-standardised' numbers. I
| don't really know what that means but I guess that it means
| the number is mostly meaningful for comparing the countries
| rather than what people in those countries are like. For ages
| 25-44, they report averages of 3.7(UK) vs 4.6, which still
| looks a bit high to me. There's about five times the rate of
| toothless mess in the US for that age group which made me
| think there might be some small population in the US with
| many missing teeth that isn't so large in the UK, but the
| paper found the same income-based inequality in number of
| missing teeth
|
| [2] The paper claims to have gotten similar results when
| excluding the toothless
|
| [3] Slade GD; Derivation and validation of a short-fortn oral
| health impact profile. Community Dentistry and Oral
| Epidemiology 1997; 25; 284-90.
| mejutoco wrote:
| I looked it up, because I was curious about the ranking per
| country, not only US vs UK.
|
| Uk is 4th best according to this ranking
|
| https://www.yongeeglintondental.com/2018/07/23/healthy-
| prima...
| xeromal wrote:
| Missing teeth != Poor teeth.
|
| Pretty sure the joke is just that british have tea-stained
| brown teeth.
|
| Also, pretty sure it's just a joke in the same realm that
| rednecks from appalachia carry a piece of hay in their mouth.
| [deleted]
| wpietri wrote:
| I am glad they did this work, but I don't think it gets at
| what's behind the joke about British teeth.
|
| For me, the exemplar is the Austin Powers jokes about his
| teeth. It's not that the average Brit has fewer teeth than
| the average American. It's that a person who American would
| expect, for reasons of class and style, to have an engineered
| smile (very white, very even teeth) instead had a perfectly
| natural one. Even the movie suggested that the stereotype was
| somewhat outdated. But to the extent we still have the
| stereotype, it's about upper- and upper-middle-class use of
| orthodontia and whitening. Plus the distinctive American
| emphasis on the big smile, which to a lot of non-Americans
| can seem mildly deranged.
| catiopatio wrote:
| I always assumed this was a comment on the level of dental
| care provided by the NHS.
|
| For example, they'll happily provide you a root canal without
| a crown - a crown costs significantly extra.
|
| I doubt many dentists in the US would be comfortable
| providing that standard of care.
| pessimizer wrote:
| I'm pretty sure it's now based on the observation that very
| wealthy and important people in Britain don't have giant
| blinding veneers.
|
| Americans think that the class terror that forces them to
| spend thousands or tens of thousands on their children's
| teeth (and their own) is universal, rather than a norm that
| we find ourselves locked into now. Americans with anything
| going on with their teeth look poor or disreputable, and it
| severely hurts your job chances.
|
| Rich British people are just like _" do you know who I
| am?"_
| jahnu wrote:
| https://www.nhs.uk/nhs-services/dentists/what-dental-
| service...
|
| PS300 seems not very significant if we are comparing the US
| to the UK in this discussion.
| catiopatio wrote:
| A PS300 optional surcharge to perform what US dentistry
| rightfully considers the baseline standard of care is
| going to result in a lot of people's teeth having subpar
| function and appearance.
| jahnu wrote:
| But they don't pay for almost anything routine in the UK.
| In the US my understanding is you are not typically
| getting any free dental care. PS300 is not a major
| expense for a typical person in the UK.
| catiopatio wrote:
| I didn't claim it was an unaffordable expense.
|
| I claimed that treating it as an opt-in extra, for
| additional charge -- instead of the baseline standard of
| care -- results in a lot fewer people receiving it, and
| thus, a lot more people with subpar dental function and
| appearance.
|
| In other words, to save money, the NHS provides a lower
| standard of care as its baseline. Hence the popular idea
| that British dentistry is subpar.
| timonoko wrote:
| In medieval times they used to rob teeth from healthy young
| subjects. It was possible to "implant" those teeth just by
| jamming them by force into gums. Success rate unknown.
|
| So you could grow teeth in-vitro from patient's own stemcells and
| then implant those. I would be safer and not much testing needed.
| maxloh wrote:
| Does our technology advanced enough to grow teeth from stem
| cells?
| dt3ft wrote:
| There seems to be more useful info here:
| https://www.colgate.com/en-us/oral-health/dental-
| visits/can-...
| timonoko wrote:
| Dedicated teeth farming is little difficult I reckon. But we
| can clone a whole body just for spare parts. I bet some rich
| bastard is already doing that.
| borissk wrote:
| Interesting. Why do you think it's not being done?
| timonoko wrote:
| Dont know. Few years back there was even talk about growing
| new fingers by preventing the growth of scarring tissue. What
| ever happened to that project?
| penguin_booze wrote:
| Oh, good. Now, do 'hair'.
| pknomad wrote:
| People are making progress on that front too:
| https://news.uci.edu/2022/06/30/uci-led-team-discovers-signa...
| w4lker wrote:
| Wow, I 've never thought that I would see that in life
| [deleted]
| bot12345 wrote:
| This is a very interesting development in dental care. Looking
| forward to seeing the results of the clinical trials.
| amelius wrote:
| Can't we somehow transplant the gene from rodents that makes
| their teeth regrow during their entire lives?
| TheAceOfHearts wrote:
| Hopefully this ends up going somewhere. We've been hearing for
| decades how there's certain bacteria that nearly removes the
| requirement to brush your teeth regularly, but it never seems to
| reach the general public. Exciting times ahead if we can
| ultimately destroy the need for the dental care industry. In a
| few decades having to brush your teeth regularly will probably be
| regarded as an antiquated practice.
| andyjohnson0 wrote:
| There would preaumably still be a need for brushing for hygiene
| reasons, as well as gum health, even if tooth decay was a
| solved problem.
| letitbeirie wrote:
| Yeah even if the bacterium magically took care of gum health,
| it would need to somehow be able to dissolve tartar (calcium
| phosphate) without dissolving teeth (also calcium phosphate).
| westurner wrote:
| "Anti-USAG-1 therapy for tooth regeneration through enhanced BMP"
| (2021) https://www.science.org/doi/10.1126/sciadv.abf1798
|
| https://scholar.google.com/scholar?cites=6855835701389665111...
| westurner wrote:
| From "Reactivating Dormant Cells in the Retina Brings New Hope
| for Vision Regeneration" (2023)
| https://news.ycombinator.com/item?id=35871917: direct neuronal
| reprogramming (for retinal growth), Tissue NanoTransfection,
| Muller glia
|
| "TNT" out of Ohio State:
| https://en.wikipedia.org/wiki/Tissue_nanotransfection ; direct
| (epithelial,) stroma reprogramming
|
| Regenerative medicine:
| https://en.wikipedia.org/wiki/Regenerative_medicine
|
| From https://www.ada.org/en/resources/research/health-policy-
| inst... :
|
| > _What share of U.S. children and adults have dental
| benefits?_
|
| > _Dental benefits coverage varies by age. For children ages
| 2-18, 51.3 percent have private dental benefits, 38.5 percent
| have dental benefits through Medicaid or the Children's Health
| Insurance Program (CHIP), and 10.3 percent do not have dental
| benefits. For adults ages 19-64, 59.0 percent have private
| dental benefits, 7.4 percent have dental benefits through
| Medicaid, and 33.6 percent do not have dental benefits. Source:
| Dental Benefits Coverage in the U.S._
|
| TIL about Dental lasers:
| https://en.wikipedia.org/wiki/Dental_laser
|
| What percentage of dentists offices have lasers in the United
| States?
| https://www.google.com/search?q=what+percentage+of+dentist+o...
|
| FWIU, dental lasers cost from $4-40K per unit, per station in
| the office; and they may be tuned for specific applications or
| general purpose. There's a waveguide to guide the beam; and
| there are new waveguide methods for steering photon beams
| through opaque tissue (with e.g. dual beams).
|
| "Scientists Have Discovered a Drug [Tideglusib] That Fixes
| Cavities and Regrows Teeth" (2017) that's already FDA approved
| for Alzheimer's but there are yet no clinical trials of it as a
| cavity fill?? https://futurism.com/neoscope/scientists-have-
| discovered-thi...
|
| Tideglusib: https://en.wikipedia.org/wiki/Tideglusib
|
| Can teeth be grown in molds from e.g. stem cells, or
| nanotransfected tissue with/without a 3-d printed scaffold or
| [...]?
|
| Dental care probably has direct returns in labor productivity?
| myself248 wrote:
| On the other side of things, why don't we use little bits of
| botox to prevent wisdom teeth from growing in the first place?
| jurassicfoxy wrote:
| Maybe you just came up with a good idea for a PhD in dentistry.
| myself248 wrote:
| I'm already full-up on hobbies, jobs, and callings,
| thankyouverymuch!
| tgv wrote:
| Don't get your hopes up, and keep brushing your teeth: "The tooth
| regrowth medicine is intended for people who lack a full set of
| adult teeth due to congenital factors (anodontia)". There is a
| vague hope to develop it so that people who lose teeth can use it
| to regrow, but that seems to be another ball game.
| troft wrote:
| Sharks don't need this kind of therapy. I don't understand your
| pessimism.
| swayvil wrote:
| I have a friend with notoothia. Only in one tooth tho. And ya,
| it's weird looking. She got an implant. One of those titanium
| screws. It works but the gum is weird and the tooth is
| missized.
|
| Would she switch it for a grown tooth given the option? I
| dunno.
| mnau wrote:
| Certain-not-to-be-named-due-to-spam-filter-medicament-on-V was
| intended for heart related chest pain.
|
| My wallet doesn't ask for who it was intended. It asks: Will it
| work and can I buy it?
| Y_Y wrote:
| You've just got to format it as an email address: vi@g.ra
| pengaru wrote:
| I get the impression that they're targeting the easy case first
| since stimulating tooth growth there is causing what was
| supposed to happen anyways, with less likelihood of conflict
| with the existing teeth.
|
| But the article makes it sound plausible that it'd work for
| normal adults too in that new tooth growth would occur. It's
| just unclear how/if they guide that growth to a specific area,
| or if it has to be wholesale replacement of the set of teeth
| like losing your baby teeth.
|
| Maybe what will happen is once you get to a certain point of
| dental misery you just get on the medicine blocking USAG-1 and
| have all the remaining teeth pulled, then wait for the new
| teeth to grow in...
| mcswell wrote:
| This is all hypothetical, of course, but: you don't have to
| lose all your baby teeth in order for your adult teeth to
| come in. Somehow an adult tooth coming in causes the baby
| tooth's root to dissolve (if that's the right word) and then
| pushes the remaining baby tooth out of the way. So you might
| not need to lose your adult teeth in order for the next-gen
| teeth to come in.
| im3w1l wrote:
| Some animals have continuosly growing teeth. Maybe with the
| right chemicals that could be encouraged in humans too.
| Loughla wrote:
| It seems like turning on a switch for continuously growing
| anything is a recipe for cancer. Modern medicine and what
| it accomplishes continues to absolutely astound me with
| what is possible.
| therein wrote:
| An unconditional one is but selectivity and reversibility
| is the key. Nothing makes that unachievable, just more
| complicated.
|
| Teeth growth is a good target for such experimentation.
| Given its relatively easily operable nature allowing
| convenient observation of progress and intervention if
| needed.
|
| We already can accelerate the regrowth of fingernails
| after losing one. This is the next easiest target if you
| ask me.
| pengaru wrote:
| A shorter path to market might be to grow replacements in
| a sacrificial host using harvested stem cells from the
| recipient. Transplanting into the socket once
| sufficiently developed, with some of the magic sauce
| topically applied at the interface to promote it all
| taking root and growing into its new home...
|
| It sounded like they were doing experiments with
| transplants as well in one of the papers I skimmed.
|
| I might actually prefer that approach if it had a high
| success rate, to replace a thoroughly trashed tooth.
| Seems preferable to exposing oneself to the new treatment
| for the entire duration of tooth development. Especially
| if all you need is one replacement...
| fendy3002 wrote:
| CMIIW, but when baby teeth is already grown (appear), the
| other adult set is actually kept hidden inside, not that it
| grow.
|
| I guess it won't be simply as stimulate teeth growth like
| nail.
| lelanthran wrote:
| > CMIIW, but when baby teeth is already grown (appear), the
| other adult set is actually kept hidden inside, not that it
| grow.
|
| Yup. See this skull of a child with the adult teeth ready
| to come out and push the baby teeth out of the way
| (warning, some people find the image very repulsive, even
| though it's basically a textbook picture of a skull):
|
| https://skeptics.stackexchange.com/questions/9541/is-this-
| im...
| dotnet00 wrote:
| I think it comes off as more repulsive because we're not
| used to seeing those parts of the skull cut away, putting
| it in the uncanny valley. What helped me to not be as
| repulsed by it was realizing that those parts of the
| skull aren't meant to be "uncovered" to show the adult
| teeth in the first place.
| toyg wrote:
| The human body is so amazing... It evolved to ship ready-
| made replacement parts to ensure the product would
| complete its deployment (reaching puberty and reproducing
| for a decade or two).
| dghughes wrote:
| I have GERD and the only reason I found out was my dentist told
| me. It was because my teeth became so sensitive a room
| temperature banana was too cold. Lots of pain and still. It's
| from coughing due to acid reflux and acid splash up onto my
| teeth. It can also get into my lungs and over time damage them
| too by causing scarring.
| manmal wrote:
| Did you have no idea at all, as in, you never felt heartburn
| in the evening? I wonder if eating the last meal at eg 4PM
| wouldn't improve this considerably.
| withinboredom wrote:
| As someone else who has some serious GERD, no, you don't
| really notice. It's like boiling a frog (unless you get an
| acute version). You just suddenly realize: hey, I seem to
| be having heartburn all the time, I don't remember it being
| like this... maybe I should go to the doc? And then you're
| fine for a few days and put it off.
|
| And no, eating at different times won't magically make your
| sphincter to your stomach close any tighter.
| manmal wrote:
| > eating at different times won't magically make your
| sphincter to your stomach close any tighter
|
| Stomach acid is also produced as reaction to food intake
| and other signals. Less acid => less reflux?
|
| BTW probiotics have been found potentially effective by
| this systematic review:
| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019778/
|
| This is probably not as simple as blaming the
| dysfunctional sphincter.
|
| IMO early time restricted feeding shouldn't be dismissed
| so quickly, it's potentially a fix for a number of
| systemic and gastric/enteric issues. The evidence is
| still weak but promising. The most important part here is
| ,,early" - intermittent fasting usually has an eating
| window in the afternoon and maybe right until bed time.
| According to some (weak) studies, moving the eating
| window to the morning and early afternoon has vastly
| different effects.
| jaggederest wrote:
| > Less acid => less reflux?
|
| Weirdly, I've also heard from people in that situation
| that more acid => less reflux because the sphincter only
| closes in high-pH environments. So one of the things
| prescribed can be hydrochloric acid supplements. Some
| people swear by them.
| refulgentis wrote:
| You're 100% right, I got the doctor rush to prescribe
| treatment on this when I was 24. Was never enough
|
| Finally instilled some healthy habits by 32, namely no
| excessively large meals and no eating big meals ~3 hours
| before bed and it magically disappeared.
|
| I just had my first bout in a while yesterday - 2 smalls
| pizza is still 2 pizzas folks!
| xupybd wrote:
| My reflux seems to have gone now that I'm on CPAP for my
| Apnea. No idea if that would apply to anyone else but I still
| thought it was worth sharing.
| water-data-dude wrote:
| Bummer, I was hoping for shark teeth powers
| Tagbert wrote:
| This will give you the regrowth but the teeth will look like
| shark teeth. That might cause some odd looks and be careful
| not to bite your tongue. You'll only be able to do that once!
| :-)
| Electricniko wrote:
| Tongue replacement is already a thing, oddly enough.
| withinboredom wrote:
| Ha! I bit off my tongue from falling a pretty good
| height. My knee came up and hit my chin, forcibly closing
| my mouth on my screaming face.
|
| When I could finally move again (was paralyzed for a
| bit), and got to the hospital, they just told me to keep
| my mouth shut. Apparently, your tongue is just a muscle,
| so it will reattach itself.
|
| It was a shitty few weeks, but at least I didn't break
| any bones or land on my head.
| Reason077 wrote:
| Ouch! I did something similar snowboarding in my early
| 20s. Landed a badly timed jump on to hard, flat snow and
| slammed my knee into my chin. Thankfully did not catch my
| tongue, but shattered several teeth!
|
| I remember wondering how I'd ended up with a mouthful of
| sand and grit. It wasn't sand.
| ooterness wrote:
| I'm fine with this.
| [deleted]
| eikenberry wrote:
| Seems like it shouldn't be referred to as a "regrowth" medicine
| when you're talking about something that didn't grow in the
| first place.
| refulgentis wrote:
| That has a fascinating answer but requires R, no TL;DR from
| me :)
| pessimizer wrote:
| > for people who lack a full set of adult teeth due to
| congenital factors (anodontia)
|
| I've got this, and 1% of people have this. I'd have to imagine
| that most of them would have obliterated the spot where they
| could grow these hypothetical new teeth by getting implants,
| though. So, I'd even think that it's really a treatment for
| children.
|
| When I was a small child, it was already absolutely certain
| that I wasn't ever going to get my lateral incisors.
| bch wrote:
| I've had "Maryland Bridges" in mine for years (apparently
| longer than the bridges are typically expected to last (?)),
| so there are some of us adults around...
|
| But sadly for me: Once confirmed to have no
| ill effects on the human body, it will be aimed at treating
| children aged 2 to 6 who exhibit anodontia.
| nntwozz wrote:
| Sounds exciting and less of a hassle than CRISPR-Cas9 genome
| editing shark DNA (sharks regrow teeth when needed). They lose at
| least 30.000 teeth over a lifetime...
| amelius wrote:
| From a Google search:
|
| > Unlike humans, all sharks are born with teeth. They grow in
| conveyor-belt rows, with the biggest teeth facing outwards.
| Over time, the smaller teeth in the back move up, replacing the
| front ones. Most sharks have between 5-15 rows, and the whale
| shark has a whopping 3,000 teeth in its mouth!
|
| Not sure if you'd want that!
| lockhouse wrote:
| Try our new plasmid Shark Bite by Ryan Industries...Regrow
| teeth whenever they're needed!
| tandr wrote:
| (In reaally small letters below)
|
| Consumer warning: might cause drowsiness, or anxiety. Teeth
| growth is guaranteed, but the location of newly grown teeth
| is not. Consult your doctor if you have high blood pressure,
| pregnant, or breastfeeding. Do not take with alcohol.
| ACV001 wrote:
| This is not only not dentist's dream, but this is their nightmare
| as well as others' like toothpaste producers.
| mock-possum wrote:
| I mean there are other good reasons to brush your teeth apart
| from just tooth decay. Your gums are important too - also if
| you're ever going to kiss anyone, they're probably going to
| prefer your mouth not smell and taste like a decaying corpse.
| andai wrote:
| Change is the state.
|
| Embrace Tooth Regrowth Serum Salesman.
| endisneigh wrote:
| It's not the same thing but you can currently buy novamin and
| nano hydroxyapatite based pastes which help to remineralize
| enamel (they do not regrown teeth completely).
|
| On the note of dental hygiene I recommend, in addition to the
| standard stuff:
|
| 1. Rising your mouth with water immediately after eating. If
| you're at a restaurant just drink some water, swish rigorously
| for 15 seconds and swallow.
|
| 2. Flossing regularly soon after eating. Couple with a water
| flosser if possible.
| eclipticplane wrote:
| Where can you buy said pastes or products in the USA?
| soligern wrote:
| You can get the Indian version of sensodyne with novamin on
| Amazon. It's not particularly cheap though.
| PixelForg wrote:
| > Couple with a water flosser if possible.
|
| Aren't they generally less effective than flossing with
| threads?
| endisneigh wrote:
| Nah basically the same
|
| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236551/
|
| I'd still use both as the abrasive action is likely to catch
| some things water cannot. And water able to reach areas more
| easily string cannot.
| Laaas wrote:
| Doesn't this also happen from just eating?
| moffkalast wrote:
| Have you seen your enamel improve using those? I've used a
| Sensodyne one for a year with zero results and switched back.
| My dentist seemed unsurprised by those results, so the effect
| is probably miniscule in general if there's any at all.
| endisneigh wrote:
| Unless you bought the foreign one you didn't get novamin. Try
| again with David's with uses nano hydroxyapatite and can be
| bought in the USA
| moffkalast wrote:
| Well I'm in Europe, so I'm not sure if I can buy the same
| ones. It had novamin listed on the packaging ingredients so
| unless they're blatantly lying, it had it.
| endisneigh wrote:
| Heh, touche. The European one should have novamin. The
| effect isn't supposed to be drastic. In fact I stopped
| using novamin as well because the studies I read didn't
| show substantial difference vs fluoride toothpaste. I
| assume your dentist didn't notice much? I'd still give
| nano hydroxyapatite a try.
| [deleted]
| adastra22 wrote:
| Yes. Sensodyne is worthless in my experience, but brushing
| with a toothpaste I bought in Japan to restore enamel really
| worked. It had very immediate effects and my teeth kept the
| protective enamel even after I ran out.
| jacoblambda wrote:
| Yep that'll happen depending where you live.
|
| Sensodyne has a bioglass (sometimes called hydroxyapatite,
| NOVAMIN, or Biomin) which is what you are describing
| however it's excluded from the Sensodyne sold in the US.
| The reason why is a long story [1] but if you want "good"
| Sensodyne you have to import it from literally anywhere
| else or buy a no-flouride biomin version (made by Dr.
| Collins who decided to go through the FDA process) in the
| US. Both are luckily pretty easy to get on Amazon however
| there's a bit of a markup.
|
| 1. https://medium.com/@ravenstine/the-curious-history-of-
| novami...
| amelius wrote:
| Could you provide more information, like a brand name?
| adastra22 wrote:
| "APAGARD Premio" is what it says on the tube.
| Hydroxyapatite.
| amelius wrote:
| Thanks!
| Faaak wrote:
| There are various sensodyne pastes. The one with novamin (in
| Europe) is called "repair and protect
| jrockway wrote:
| For me, this kind of toothpaste was much worse for
| sensitivity than a high-fluoride toothpaste you can get
| prescribed by your dentist. (It's a prescription, but it's
| inexpensive.)
| jacoblambda wrote:
| The bioglass toothpastes (i.e. the ones that contain
| NOVAMIN or Biomin) are doing something different than high-
| flouride toothpastes.
|
| The biolgass ones aren't really "restoring enamel" but they
| "refill" (remineralise) the enamel with all the minerals
| that slowly leach out before the enamel actually wears
| away.
|
| The flouride toothpastes act by hardening the structures
| those other minerals make up which increases the resistance
| of your teeth.
|
| They both do different things but they work well together.
| In the US you won't find them both in the same toothpaste
| (only Biomin C/without flouride is FDA approved) but
| outside the US you can find Sensodyne with NOVAMIN and
| flouride as well as Biomin F (with flouride).
|
| So depending where you live, you might want to give them
| another shot but making sure you use both bioglass and
| flouride (I personally do a dot on my toothbrush of both
| Dr. Collins Biomin Restore and Colgate PreviDent 1.1% NaF
| 5% KNO3). At least for me it has worked a lot better than
| just doing one or the other.
| patientpatient wrote:
| I have thought about this in regards to combining
| stannous fluoride with hydroxapatite due to the synergy
| between fluoride and hydroxyapatite (Although I believe
| most studies which have found this synergy used sodium
| fluoride, not the traditionally superior stannous
| fluoride, so not sure if the synergy will uphold). I
| think there are only a few toothpastes on the market with
| a proper concentration of both sodium fluoride and
| hydroxyapatite, have not seen any mouth rinses with both.
| The problem with mixing mouthrinses or toothpastes is
| that you will inevitably reduce the concentrations of
| both active ingredients, in absolute quantity they will
| be the same, but I wonder if they will become overwhelmed
| and nullified by the relatively larger quantity of non
| active ingredients. IIRC hydroxyapatite in toothpaste is
| rated 10% max in EU, and it's also most effective at that
| amount, for mouth rinses it is 0.465 %. It would actually
| be easier to find some high fluoride toothpaste that
| would suffer less from dilution, I've heard
| recommendations of around 1500ppm, so if I am not
| mistaken getting a 3000ppm toothpaste would allow for ok
| dilution if only you had another with 20% hydroxyapatite
| in a 1:1 ratio. Overall the solution I am settling on is
| fluoride rinses when waking up and going to bed, and
| hydroxyapatite toothpaste twice a day, no clue about the
| synergy there, but seems reasonable as most
| hydroxyapatite pastes are filling the no fluoride market
| niche, which comes with the nice benefit that they aren't
| filled with a bunch of other trash inactive ingredients,
| meanwhile fluoride mouth rinse less affected by such
| things compared to fluoride toothpastes.
| jrockway wrote:
| Ah, just mix 'em on the brush? Good idea. I will try
| that.
| 01100011 wrote:
| They've worked for me several times over the years when I had
| sensitivity issues. Takes a month or so to notice and you
| should be careful not to drink water for a while after you
| use them.
| wredue wrote:
| You're not supposed to drink water or use mouth wash for a
| while after using fluoride toothpaste either.
| mdorazio wrote:
| I'll offer another point in support of your experience. I
| purchased the non-US Sensodyne, verified it had Novamin, used
| the entire tube as directed with no water drinking for at
| least half an hour afterward, and saw zero results.
| Buttons840 wrote:
| I wonder how teeth regrowth would work? Our adult teeth don't
| "push out" like it seems, but our body "grows out and around" the
| adult teeth formed from early age (maybe even birth? I'm no
| expert). You can look up pictures of baby skulls where the adult
| teeth are visible deep in the bone; a baby's adult teeth are
| formed already, and located in the bone around the lower nose
| area, some almost on the side of the nose; the baby will grow
| into them.
|
| https://en.m.wikipedia.org/wiki/Deciduous_teeth
| taurusnoises wrote:
| Thank you for ruining my mind with this imagery.
| NetBeck wrote:
| From what I found on teeth development:
|
| >The first stage begins in the fetus at about 6 weeks of age.
| This is when the basic substance of the tooth forms.
|
| >Next, the hard tissue that surrounds the teeth is formed,
| around 3 to 4 months of gestation.[0]
|
| [0] https://www.hopkinsmedicine.org/health/wellness-and-
| preventi...
| adastra22 wrote:
| The tooth forms at some point.
___________________________________________________________________
(page generated 2023-07-02 23:00 UTC)