[HN Gopher] Merged magnetic resonance and light sheet microscopy...
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       Merged magnetic resonance and light sheet microscopy of the whole
       mouse brain
        
       Author : belter
       Score  : 45 points
       Date   : 2023-06-18 11:57 UTC (1 days ago)
        
 (HTM) web link (www.pnas.org)
 (TXT) w3m dump (www.pnas.org)
        
       | azalemeth wrote:
       | These sorts of studies have been performed before -- for example,
       | in the human brain of ALS patients pre and post-mortem (albeit
       | with histology rather than light sheet microscopy) [1] with a
       | fairly sophisticated automated image processing pipeline [2]; or
       | more broadly with a wider range of causes of death [3]. There's
       | even an "open brain bank" for the resulting data -- [4] -- and it
       | looks to be rather well populated in the other species section
       | [5]. I wonder if the authors of this work (who have produced
       | beautiful data!) will be contributing to it -- I can't find a
       | link to the atlases themselves.
       | 
       | Remember, with MR at thermal equilibrium the total amount of
       | signal you can have is, all other things equal, proportional to
       | the square root of scan time - their acquisition time is 245
       | hours!
       | 
       | [1]
       | https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286...
       | [2]
       | https://www.sciencedirect.com/science/article/pii/S105381192...
       | [3]
       | https://www.sciencedirect.com/science/article/pii/S105381191...
       | [4] https://elifesciences.org/articles/73153 [5]
       | https://open.win.ox.ac.uk/DigitalBrainBank/
        
         | cydodon wrote:
         | If I got this right, the authors have the data accessible here
         | for now: [...]The data is stored in H5 format to enable
         | interactive examination using Neuroglancer
         | (https://github.com/google/neuroglancer;
         | https://zenodo.org/record/5573294#.ZCrkIezMIvo)
        
       | yair99dd wrote:
       | What viewer is used on such Dataset? Is it available.
        
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       (page generated 2023-06-19 23:02 UTC)