[HN Gopher] Inside the Wuhan lab weeks before Covid
       ___________________________________________________________________
        
       Inside the Wuhan lab weeks before Covid
        
       Author : ricksunny
       Score  : 324 points
       Date   : 2023-06-10 23:13 UTC (23 hours ago)
        
 (HTM) web link (www.thetimes.co.uk)
 (TXT) w3m dump (www.thetimes.co.uk)
        
       | th0ma5 wrote:
       | [flagged]
        
         | fuckyah wrote:
         | [dead]
        
         | TimTheTinker wrote:
         | Did you read TA? It summarizes existing known info, but it also
         | includes new, original research.
        
           | th0ma5 wrote:
           | [flagged]
        
             | yawnxyz wrote:
             | I love how people who don't read the article ask "did you
             | read the article". Agree there's nothing new here, and most
             | things presented as new are mostly conjecture or hear say
        
           | pcrh wrote:
           | I read the article, it fails to correctly summarize, and also
           | misrepresents existing known info.
        
       | mannyv wrote:
       | If there is any truth to this it'll come out once the regime
       | changes...and the new regime will use this info to discredit the
       | old regime.
        
       | pcrh wrote:
       | After a quick read of the article, it presents no new data, and
       | is replete with innuendo pointing at the Wuhan lab, rather than
       | any direct evidence.
       | 
       | Most importantly, the general reader should know that all labs
       | researching viruses do research on dangerous viruses. After all
       | there is no incentive to research benign viruses. So the fact
       | that the Wuhan lab worked on coronaviruses is not in itself an
       | indication of any ill-intent. Additionally, the closest relative
       | to SARSCov2 that has been identified (RaTG13) was found in a cave
       | in Mojiang county in Yunnan, over 1,000 km away, with no evidence
       | that it was ever studied in the Wuhan lab. Further, genetic
       | clocks show that RaTG13 and SARSCoV2 diverged almost 50 years
       | ago.
       | 
       | The map presented upfront from is also misleading, the early
       | cases clustered around the market not the lab [0]. Furthermore,
       | several different isolates were found in the market, indicating
       | that SARSCoV2 had been circulating _before_ the epidemic took
       | off.
       | 
       | [0] The Huanan Seafood Wholesale Market in Wuhan was the early
       | epicenter of the COVID-19 pandemic.
       | https://www.science.org/doi/10.1126/science.abp8715
        
         | Biorealism wrote:
         | The thing with Wuhan Institute of Virology is they were
         | particularly studying the spillover risk of SARS-related
         | coronaviruses. The nearest relatives to SARS-CoV-2 are found in
         | Yunnan and Laos. One clear link with Wuhan is the fact Wuhan
         | Institute of Virology sampled both locations.
         | 
         | You can't read much into the early case data that David Relman
         | described as "hopelessly impoverished". There were likely much
         | earlier cases based on excess mortality data (a key reason WHO
         | haven't accepted market origin). Also, there is a clear
         | sampling bias in the cases in the article cited above.
         | https://journals.asm.org/doi/10.1128/mbio.00313-23
        
         | [deleted]
        
         | randomperson01 wrote:
         | There is no reason to suspect Ill intent. Accidents happen. It
         | is well known the WIV were doing gain of function research on
         | SARS-related CoVs. It is also known that the WIV were partners
         | in a proposal to insert human specific cleavage sites into
         | SARS+related CoVs
         | https://theintercept.com/2021/09/23/coronavirus-research-gra...
         | 
         | The probability that a novel SARS-related CoV would emerge
         | naturally in the city in China that was used as a
         | seropositivity control -and the location of the worlds largest
         | SARS-related related research lab, and which had very low
         | wildlife consumption compared to Southern coastal cities is <
         | 1/1000
         | 
         | There is no evidence for any infected animals at the Huanan
         | market
         | https://www.biorxiv.org/content/10.1101/2023.04.25.538336v2
         | 
         | There was a known ascertainment bias towards reporting
         | associated with the market
         | https://journals.asm.org/doi/10.1128/mbio.00313-23
         | 
         | The modelling by Pekar et al inferring multiple spillovers at
         | the market was flawed
         | https://www.biorxiv.org/content/10.1101/2022.10.10.511625v1
         | 
         | Prior to the pandemic, the State department literally warned
         | the US govt. a SARS-related accident was a real risk at the WIV
         | https://www.washingtonpost.com/opinions/2020/04/14/state-dep...
        
         | ratg13 wrote:
         | _> Additionally, the closest relative to SARSCov2 that has been
         | identified (RaTG13)_
         | 
         | As of 2022, this is no longer true.
         | 
         | https://en.m.wikipedia.org/wiki/RaTG13
        
           | eganp wrote:
           | IIRC, this is still true if you exclude the spike protein and
           | use a higher similarity threshold.
           | 
           | Why would one do that? Well, two reasons. First, the spike
           | more variable as it is subject to greater evolutionary
           | pressure as the major component of the viral surface. Second,
           | in coronavirus reverse genetics typically the virus is
           | segmented into multiple pieces, most of which compose the
           | non-spike backbone and a subset which compose the spike
           | protein. This is intentional to enable the swapping of spike
           | proteins. So, if SARS-CoV-2 is spike-swap or spike variant
           | assembly, a RaTG13-like virus could be the "backbone" of
           | SARS-CoV-2.
           | 
           | Moreover, a hypothetical SARS-CoV-2 backbone could exist in
           | the viral sequences list the WIV took down in Sept. 2019.
           | They sequenced RaTG13 a few years prior. The lab's raison
           | d'etre is collecting and sequencing coronaviruses poised for
           | spillover. And, with modern DNA synthesis technology, it's
           | not difficult to print out arbitrary backbone contigs for a
           | viral assembly.
        
           | zosima wrote:
           | And crucially, researchers from the Wuhan lab were studying
           | bat virus samples from Laos, before covid.
           | 
           | https://www.business-standard.com/amp/article/current-
           | affair...
        
             | pcrh wrote:
             | Those viruses are _slightly_ more related to SARSCoV2 than
             | RaTG13, however note 1) that they were found even further
             | away from Wuhan than was RaTG13 and 2) that they still
             | remain too different from SARSCoV2 to be its direct
             | ancestor.
             | 
             | One of the things we know for sure is that that about 50
             | years of evolutionary changes separate RaTG13 and BANAL-52
             | from SARSCoV2, so they are not its direct ancestors.
        
               | dotandgtfo wrote:
               | >50 years of evolutionary changes separate RaTG13 and
               | BANAL-52 from SARSCoV2
               | 
               | Do you have a source for this?
               | 
               | Also, I'm no biologist, but is comparing the base rate of
               | evolutionary changes still relevant if SARSCoV2 wasn't of
               | natural origins? E.g. through creating chimeras or
               | 'serial passaging' as described in this article? Wouldn't
               | that create an environment where 50 years could pass in a
               | way shorter timeframe?
        
               | pcrh wrote:
               | This is the study I alluded to:
               | 
               | >Evolutionary origins of the SARS-CoV-2 sarbecovirus
               | lineage responsible for the COVID- 19 pandemic
               | 
               | >Divergence dates between SARS-CoV-2 and the bat
               | sarbecovirus reservoir were estimated as 1948 (95%
               | highest posterior density (HPD): 1879-1999), 1969 (95%
               | HPD: 1930-2000) and 1982 (95% HPD: 1948-2009), indicating
               | that the lineage giving rise to SARS-CoV-2 has been
               | circulating unnoticed in bats for decades.
               | 
               | https://www.nature.com/articles/s41564-020-0771-4
               | 
               | You should also know that SARSCoV2 1) is not a chimeric
               | virus, and 2) that the present study includes viruses
               | linked to RaTGP13 but more distant from SARSCoV2, i.e. it
               | includes evidence from viruses unassociated with the
               | pandemic.
        
               | Vecr wrote:
               | What about Ralph Baric's method for splicing viruses?
               | It's apparently really hard or impossible to detect, and
               | that's plausibly something that could be used to make a
               | chimeric coronavirus.
        
               | denton-scratch wrote:
               | The distance from Wuhan of the discovery site of RaTG13
               | is irrelevant, if (as the article implies) a senior team
               | at the Wuhan lab were working on RaTG13.
               | 
               | The article is not suggesting that Covid19 evolved from
               | RaTG13; it is suggesting that Covid19 is a chimaera made
               | with RaTG13.
        
               | th0ma5 wrote:
               | That's a bold thing to say in a non scientific paper with
               | no sources except they aren't asserting anything like
               | that as a provable fact, though.
        
               | denton-scratch wrote:
               | The NYT is a reputable organ, known for checking it's
               | sources. Unlike Wikipedia, newspapers don't generally
               | cite their sources; but if a reliable source states
               | something like that as fact, they've probably checked.
               | You're right: they haven't said they can prove it.
               | 
               | [Of course, it could be propaganda, government or
               | otherwise; or it could be a damned lie concocted by the
               | reporter or editor. They've said they have sources, they
               | haven't named them, so it's not unreasonable to suppose
               | they have sources that don't want to be named.]
        
               | zosima wrote:
               | There may have been brought even closer relatives of
               | covid-19 to Wuhan by lab personnel.
               | 
               | We don't know as for unknown reasons the database of
               | specimens collected by the Wuhan lab was taken down in
               | September 2019.
               | 
               | The distance in years between two viral strains you
               | mention makes no sense at all, as the mutation rate is
               | extremely dependent on environment.
        
               | epups wrote:
               | I don't understand this line of argument. The facts are
               | that 1) the virus outbreak was in Wuhan, 2) that there ws
               | a local lab working on virus samples that come from all
               | over the world and 3) as far as we know, the particular
               | strain that affected Wuhan is not local. Altogether, this
               | should add confidence to the lab leak theory, not detract
               | from it.
        
               | th0ma5 wrote:
               | The causality also supports that dangerous viruses spill
               | into the human population in this area, so put a lab
               | there to try to catch them.
        
               | mensetmanusman wrote:
               | A particular city center?
        
               | epups wrote:
               | Ok but in that scenario, a natural emergence would have
               | come from a strain from Wuhan, while the lab leak theory
               | explains why a virus from relatively far away had an
               | outbreak in Wuhan.
        
               | Biorealism wrote:
               | The nearest relatives to SARS-CoV-2 are found in Yunnan
               | and Laos. Both areas WIV sampled prior to the pandemic
               | and they haven't shared their records with WHO or the
               | NIH.
        
               | Biorealism wrote:
               | Yes, the article suggests they had a closer precursor.
               | The nearest relatives to SARS-CoV-2 are found in Yunnan
               | and Laos. They are both areas WIV sampled in studying the
               | spillover risk of SARS-related coronaviruses. They
               | haven't shared their records with WHO or the NIH.
        
         | canadianfella wrote:
         | [dead]
        
         | BryantD wrote:
         | What a terrible article.
         | 
         | "Thirty-five-year-old scientists don't get very sick with
         | influenza."
         | 
         | The rate of hospitalization among 18-49 year olds with flu in
         | the US was 54.1 per 100K in 2019-20. It's rare, sure, but that
         | kind of absolute statement from an anonymous researcher doesn't
         | instill confidence.
        
           | jakear wrote:
           | [flagged]
        
             | BryantD wrote:
             | That point is inaccurate. I quoted the stats; they are what
             | they are.
        
               | jakear wrote:
               | Stats say nothing of relative severity, why do you think
               | they're relevant in any way?
               | 
               | Edit: is your argument seriously "uhm actually, event X
               | happens 0.054% of the time, so when you said {more rare
               | version of X} doesn't happen you're wrong"
        
               | BryantD wrote:
               | Um, those are the numbers for hospitalization. So yes,
               | there's information about severity there.
               | 
               | And yep, that's my argument! The frequency of deadly
               | viruses escaping from a bio lab is even _lower_ , so if
               | we're going to eliminate possibilities based on
               | percentages there are a few others that should get thrown
               | out.
               | 
               | It's a minor point but, as I said, it's sloppy reasoning.
               | If the anonymous researcher had said "low probability" I
               | wouldn't care. Instead, this reads like someone who's
               | willing to hand wave specifics for the sake of rhetoric.
        
               | jakear wrote:
               | Hospitalization doesn't mean severity. It has more to do
               | with your confidence in your immune system and health
               | insurance than anything else, though the hospital's extra
               | capacity and desire to make a buck off you is up there
               | too.
               | 
               | But if you're here to be put off by the smallest use of
               | rhetoric, sure pop off on that.
        
               | BryantD wrote:
               | If I reversed it and said "this can't be a lab leak
               | because lab leaks never happen," would that be okay?
               | They're certainly rarer than serious cases of flu among
               | adults in the age range.
               | 
               | It's a contentious, difficult debate. I do actually think
               | it's bad to dismiss arguments you disagree with with
               | casual rhetoric.
        
               | jakear wrote:
               | If that rhetorical device led me to research and discover
               | reputable data suggesting the frequency of such
               | occurrences was indeed so minuscule as to be disregarded
               | entirely, I'd welcome it upsetting my preconceived
               | notions.
        
             | andsoitis wrote:
             | > The point is the young and healthy don't get very sick.
             | You get it, have the sniffles for a day or two, and move on
             | with your life. Same for covid. We could have just embraced
             | that blessing and let children continue to go to school and
             | not experience massive declines in intelligence. But here
             | we are. "Think of the really old people" was truly
             | hilarious. Indeed, all we could do was "think" when my
             | grandpa died alone because visiting the nursing home was
             | banned.
             | 
             | One thing to consider is not so much an individual's health
             | and risk of getting serious ill, but rather that as the
             | numbers grow geometrically, health care systems like
             | hospitals can (and in fact, did) become severely
             | overwhelmed.
             | 
             | Even with measures in place, here in Los Angeles we were at
             | a point where for example if you had a heart attack at
             | home, an ambulance / hospital couldn't deal with you.m
             | https://www.cnn.com/2021/01/05/us/los-angeles-county-
             | califor...
        
               | jakear wrote:
               | What really happened, as stated in the very source you
               | gave, was that if you had a heart attack at home an
               | ambulance _would_ come to "deal with you" (because of
               | course they would), but if they attempted to resuscitate
               | you for 20 minutes and you still didn't recover they
               | wouldn't then take you to the hospital.
               | 
               | You should know the survival rate of a heart attack is
               | far far lower than most expect, _especially_ after 20
               | minutes of failed active attempts to resuscitate. The
               | only real reason to take someone into a hospital after
               | that is if they're hypothermic or just so you can say "we
               | did everything we could".
               | 
               | https://www.reuters.com/article/us-health-cpr-
               | expectations-i...
        
               | andsoitis wrote:
               | > What really happened.... an ambulance would come to
               | "deal with you"
               | 
               | At one point, LA had to resort to Fire Trucks because
               | ambulances were unavailable.
               | 
               | If you don't think health care services were severely
               | stretched, in some cases beyond breaking point (incl.
               | staff unavailability because they themselves were sick),
               | I really don't know what to say. This happened in New
               | York as well.
               | 
               | Of course there are also other places where that wasn't
               | the case, so there you could be less conservative with
               | restrictions, but you may not know the risk in advance.
        
               | jakear wrote:
               | Fire trucks and ambulances both feature staff trained as
               | EMT's. The provisioning of the vehicles might be slightly
               | different, but the medical training is the same. And I'm
               | sure the provisioning could be adjusted based on the
               | circumstances.
               | 
               | Staff being unavailable because they're sick is quite
               | literally "normal day to day operations" that _every_
               | company must be able to account for, not "beyond the
               | breaking point".
               | 
               | But if you "don't know what to say" beyond vague
               | emotional appeals unsupported by the very sources you
               | claim to cite, I'm glad we agree on that at least.
        
               | fzeroracer wrote:
               | There are many [1] many [2] many [3] many [4] many [5]
               | many [6] many [7] examples of people who died as a result
               | of our hospital systems being overloaded and being forced
               | to ration care. This is what was meant by the geometric
               | growth of hospital patients and how many hospital systems
               | were close to outright breaking. You are ultimately
               | factually wrong and extremely unaware of how much stress
               | this put on our hospital systems and how many people died
               | because of what you were suggesting. Now imagine how much
               | worse it would've been if we did nothing.
               | 
               | [1] https://www.npr.org/sections/coronavirus-live-
               | updates/2021/0...
               | 
               | [2] https://www.politico.com/news/agenda/2021/10/26/lack-
               | hospita...
               | 
               | [3] https://www.cbsnews.com/news/covid-us-hospital-icu-
               | bed-short...
               | 
               | [4] https://www.whsv.com/2021/08/27/man-dies-waiting-icu-
               | bed-fam...
               | 
               | [5] https://www.businessinsider.com/man-covid-dead-
               | doctors-icu-b...
               | 
               | [6] https://www.ketv.com/article/auburn-man-dies-in-des-
               | moines-h...
               | 
               | [7] https://www.newsweek.com/kansas-man-dies-after-
               | waiting-icu-b...
        
           | lifelong wrote:
           | > What a terrible article.
           | 
           | > "Thirty-five-year-old scientists don't get very sick with
           | influenza."
           | 
           | > It's rare, sure
           | 
           | Then what makes an article terrible when you agree with the
           | statement?
        
             | th0ma5 wrote:
             | They did not agree with the statement.
        
             | Natsu wrote:
             | It really shouldn't be phrased as an absolute. But read
             | charitably, when you have low N combined with rates that
             | low, to expect that you wouldn't see noticeable illness in
             | a small group of young, healthy people.
        
         | pbreit wrote:
         | "not in itself an indication of any ill-intent"
         | 
         | Was that even insinuated?
         | 
         | "no evidence that it was ever studied in the Wuhan lab"
         | 
         | Wut?
         | 
         | "Between 1 July and 1 October 2012, we received 13 serum
         | samples collected from 4 patients"
         | 
         | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744119/
        
         | willyt wrote:
         | The Times is not a great source. It's just tabloid style
         | journalism targeted at a higher 'reading age'. Can't remember
         | the exact figures but something like 16 compared to 'The Sun'
         | which targets 10. A better source would be The Telegraph, if
         | you like your opinion pieces right leaning. The Economist, The
         | Financial Time and The Guardian are also good sources if we're
         | talking about British newspapers here.
        
           | barneygale wrote:
           | The Telegraph published a supplement written by the Chinese
           | government until April 2020:
           | https://www.theguardian.com/media/2020/apr/14/daily-
           | telegrap...
        
         | inciampati wrote:
         | No, not all labs working on viruses do research on dangerous
         | viruses. Bacteriophages for instance, are a deep research
         | topic, and (aside from potential effects on our microbiome) are
         | completely benign to humans. That's just one of many
         | counterexamples.
        
           | th0ma5 wrote:
           | [flagged]
        
             | inciampati wrote:
             | They prefaced the statement with "most importantly" so it
             | seems they thought it was their key point.
        
               | th0ma5 wrote:
               | What secure labs don't work on dangerous viruses? I guess
               | I now wonder about your correction heh.
        
           | bryanlarsen wrote:
           | [flagged]
        
             | asynchronous wrote:
             | [flagged]
        
               | foldr wrote:
               | These coincidences can happen. For example, Russian
               | disinformation exploited the coincidental location of the
               | Salisbury poisonings (near Porton Down).
        
               | andsoitis wrote:
               | > what ended up leaking from the lab was a coronavirus
               | 
               | Did a coronavirus leak from the lab?
        
         | himinlomax wrote:
         | The problem with Wuhan lab is that the Chinese dictatorship
         | blocks any independent inquiry into it. If they had nothing to
         | hide, they wouldn't be hiding everything. If that was a
         | criminal case, this kind of behavior would be taken as a
         | evidence of guilt.
        
           | sgift wrote:
           | > If they had nothing to hide, they wouldn't be hiding
           | everything. If that was a criminal case, this kind of
           | behavior would be taken as a evidence of guilt.
           | 
           | No, it would not. First, dictatorships hide things all the
           | time, whether there is something or nothing. It's just how
           | they operate. (Many democratic governments do to btw. How
           | often do we need freedom of information requests just to find
           | out that it was totally benign, the government just stone-
           | walled because they could).
           | 
           | Second, not saying anything is _not_ evidence of guilt in any
           | criminal case in the civilized world. Everyone has the right
           | to silence.
        
             | Ithnolog wrote:
             | Governments aren't people. They don't have rights. Same for
             | corporations.
        
             | himinlomax wrote:
             | "Your honor, you can't blame my client for messing the
             | victim's body, he's a known necrophiliac, and since the
             | evidence is tainted you can't prove he was the murderer."
             | 
             | Top notch defense right there.
        
               | th0ma5 wrote:
               | Pretty gross, but yeah a defense like that would lower
               | charges to manslaughter.
        
             | Biorealism wrote:
             | They have witheld records from the NIH which funded some of
             | their SARS-related coronaviruses spillover research. They
             | eventually terminated their subaward last year as a result.
             | WHO has also been asking for lab data. Given the nearest
             | relatives to SARS-CoV-2 are found in Yunnan and Laos where
             | the WIV sampled it seems fairly clear what happened here.
             | 
             | https://thebulletin.org/2022/08/nih-to-terminate-
             | ecohealth-a...
        
         | zosima wrote:
         | The Huanan Seafood market paper has been heavily critized.
         | 
         | Especially the fact that covid was not found in a single animal
         | sample does make the evidence rather weak.
         | 
         | In addition it seems that the lack of sampling from outside the
         | market and the fact that the market is a busy place in the
         | center of the city where the virus would likely be once it's
         | spreading from person to person , does not really lend support
         | to the conclusions in the paper at all.
        
           | pcrh wrote:
           | >The Origins of Covid-19 -- Why It Matters (and Why It
           | Doesn't)
           | 
           | >More than half of the earliest Covid-19 cases were connected
           | to the Huanan market, and epidemiologic mapping revealed that
           | the concentration of cases was centered there. In January
           | 2020, Chinese officials cleared the market without testing
           | live animals, but positive environmental samples, including
           | those from an animal cage and a hair-and-feather-removal
           | machine, indicated the presence of both SARS-CoV-2 and Covid-
           | susceptible animals.5 Recently released findings included
           | raccoon dog DNA, pointing to a possible SARS-CoV-2
           | progenitor.
           | 
           | https://www.nejm.org/doi/10.1056/NEJMp2305081
        
             | reuben_scratton wrote:
             | [flagged]
        
               | th0ma5 wrote:
               | Saying something is obvious doesn't make it true.
        
               | [deleted]
        
               | toast0 wrote:
               | > Humans brought the virus to the market. It's
               | screamingly obvious and always has been.
               | 
               | Well of course, the racoon dogs et al all come in via
               | human transport.
               | 
               | Testing infrastructure was poor, and maybe it still is.
               | Chinese government interest was not in finding facts, but
               | in taking action to 'solve the problem'. It's hard to
               | find facts when the people with power just want the
               | problem to go away. IMHO, that doesn't weigh in favor of
               | either explaination. The wuhan local government and the
               | chinese national government would have likely taken the
               | same actions regardless of the source, because they're
               | both not very interested in facts.
               | 
               | US health authorities pushing on the market theory are
               | just doing their typical behavior of taking what little
               | information is available and pushing it with no nuance. I
               | enjoyed seeing the cdc stickers telling me not to use a
               | mask out in public areas when the cdc was requiring them;
               | the congitive dissonance was so palpable.
        
           | lamontcg wrote:
           | They found racoon dog DNA, along with other susceptible
           | animals, comingled with SARS-CoV-2 in samples from the
           | market:
           | 
           | https://www.nytimes.com/2023/03/21/science/covid-raccoon-
           | dog...
           | 
           | And the behavior of China behind that whole story looks very
           | much like China tried to cover up the existence of
           | susceptible animals at the market.
        
             | Biorealism wrote:
             | That was written before Jesse Bloom reanalyzed the data and
             | found a negative correlation with raccoon dogs.
             | 
             | https://news.yahoo.com/raccoon-dogs-did-not-start-
             | covid-19-n...
        
           | BryantD wrote:
           | Just to be clear, there weren't animal samples available for
           | testing. It's not that they tested a bunch of animals and
           | didn't find covid. I know that's what you meant but not
           | everyone is familiar with the paper and it's important to be
           | meticulous here.
           | 
           | https://www.science.org/doi/10.1126/science.abp8715
        
             | giarc wrote:
             | I don't actually think that is what they meant. If there
             | are no animals to even sample, you don't describe that as
             | "that covid was not found in a single animal sample". No
             | one would phrase it that way.
        
               | BryantD wrote:
               | Easier on my general well-being to just assume positive
               | intent. (As is obvious from my comment history I don't
               | always succeed there, but I do try.)
        
               | HWR_14 wrote:
               | That you have been able to maintain assuming positive
               | intent with regard to COVID comments for this long is
               | kind of amazing.
        
           | smohare wrote:
           | [dead]
        
         | revelio wrote:
         | The article is only facts and direct evidence. Where is the
         | innuendo? It covers specific experiments they were doing, in
         | order and in detail, complete with specific biological
         | information and funding sources. It also provides extensive
         | evidence of constant coverups by the lab, like this one:
         | 
         |  _There was also no mention of the mouse deaths in the grant
         | renewal application Daszak filed to the NIH later that year. In
         | this account, he said the mice had experienced "mild Sars-like
         | clinical signs" when they were infected with the mutant virus.
         | It had actually killed six of the eight infected humanised
         | mice. Daszak eventually provided details of the experiment's
         | deadly results to the US authorities in a report after the
         | Covid-19 pandemic. He now says his 2018 statement about the
         | "mild" illness was based on preliminary results -- even though
         | the experiment in which the mice died had taken place several
         | months before he issued the statement_
         | 
         | So these people are all known liars. The US Government banned
         | GoF research, they got around it by claiming their work was
         | urgent and safe, they ignored reporting requirements, when they
         | finally did report what they said was a lie, and now they're
         | still lying to try and cover previous lies.
         | 
         | So when these people say they want to insert furin cleavage
         | sites into coronaviruses, a coronavirus appears right next door
         | that has a FCS - the first one ever seen - and they say, oh
         | well we changed our minds and never did it, well, with
         | overwhelming probability they're lying again.
        
           | chihuahua wrote:
           | And of course Daszak is known for loudly proclaiming that no
           | one is allowed to even think about whether Covid-19 could
           | have been leaked from a lab. His credibility is reduced, to
           | put it mildly.
        
         | amoss wrote:
         | The map showing the clustering around the lab is not labelled
         | in the article. It looks like the map from the senate report
         | which used internet search history. I recall that their point
         | in the original report was that there was a cluster of internet
         | searches for flu-like symptoms clustered around the institute,
         | rather than the market.
         | 
         | There is no new direct evidence in the article, simply the
         | weight of existing indirect evidence synthesized together.
         | There does not seem to be another hypothosis for how the virus
         | emerged that has as much indirect evidence pointing towards it?
         | 
         | The main gist of the article is:
         | 
         | * The institute applied for funding for a specific piece of
         | research (inserting a furin cleavage site).
         | 
         | * The institute claims it did not perform the research.
         | 
         | * Covid is what we would expect if somebody did perform that
         | research.
         | 
         | * The research would have been performed at the time and place
         | where covid emerged.
         | 
         | It is not direct evidence, but under a weaker burden of proof
         | (e.g. balance of probabilities) it is fairly convincing.
        
           | ricksunny wrote:
           | Chief among key _new_ assertions the parent article makes,
           | 
           | https://twitter.com/BlockedVirology/status/16676623250907463.
           | ..
           | 
           | * WIV added FCS's to coronavirus(es?) exactly as described in
           | DEFUSE, according to a US lab collaborator.
           | 
           | * Zhou Yusen "fell" off the roof of the WIV in May 2020
           | 
           | * WIV was working on a 'closer [than published] unpublished
           | variant'
           | 
           | * Of all caves/mines, only scholarly attempts to access the
           | Mojiang mine made touched off access denial and confiscation
           | of samples from other mines from the authorities. While
           | alluded to in the past, (https://apnews.com/article/united-
           | nations-coronavirus-pandem... ) this is the first time to my
           | awareness that the Mojiang mine has been uniquely &
           | unequivocally associated with the authorities' clamp-down
           | efforts, that too with attribution to Alice C Hughes, PhD
        
             | samspenc wrote:
             | > Zhou Yusen "fell" off the roof of the WIV in May 2020
             | 
             | I mean, this is a pretty significant and concerning new
             | finding right? Someone associated with the lab researching
             | COVID early on just mysteriously disappearing in China?
        
             | ricksunny wrote:
             | * an item covered that isn't strictly _new_ but is probably
             | unfamiliar to many even so, is: Of the researchers who the
             | Jan 2021 State Dep Fact Sheet described as having fell sick
             | with  'Covid-like symptoms' in Nov 2019 * they were taken
             | to hospital, desoite being in their 30's and 40's (age) *
             | one of their relatives died * they were working on advanced
             | coronavirus research in the laboratory
             | 
             | The WaPo journalist Josh Rogin who is known for maintainibg
             | quality confidential sources in DC, had long ago tweeted
             | the above. While some aspects may have been covered in
             | intervening press, this is the first time to my knowledge
             | all of tbese items are asserted explicitly with a quote
             | attributed to one of the anonymous investigators.
             | 
             | --- my take fwiw: While intriguing, vis-a-vis a seasonal
             | illness null hypothesis, it's never been discussed whether
             | they were unique cases at that time with such symptoms
             | (more likely covid), or if many others both in and out of
             | the WIV had similar symtoms at the time (more likely
             | seasonal illness)
        
           | thevagrant wrote:
           | Research applications, in particular to obtain funding.
           | 
           | It is common for researchers to apply to grants/funding for
           | work they are already doing. They tweak the research
           | application to meet whatever the funding criteria is using
           | knowledge they have from existing experiments.
        
           | pera wrote:
           | The map in the senate report comes from this paper:
           | 
           | https://www.mdpi.com/2220-9964/9/6/402
           | 
           | if I understand correctly it concludes that the cluster
           | correlates with population density and a concentration of
           | elderly population in that area.
           | 
           | Unfortunately that wasn't mentioned in the senate report (nor
           | in the news article)
        
           | lamontcg wrote:
           | > It is not direct evidence, but under a weaker burden of
           | proof (e.g. balance of probabilities) it is fairly
           | convincing.
           | 
           | - We have a bunch of evidence of WIV engineering SARS-1-like
           | viruses because they talked about it before the pandemic.
           | 
           | - We have zero evidence of them ever doing experiments on
           | live SARS-2-like virus
           | 
           | - We have zero evidence of the existence of a SARS-2-like
           | progenitor virus
           | 
           | - Before the pandemic they had no reason to be more secretive
           | of any SARS-2-like work than their SARS-1-like work
           | 
           | - The spread of SARS-CoV-2 looks exactly like it originated
           | in the Seafood market.
           | 
           | - If it was transported to the seafood market by someone who
           | worked at the lab that is highly coincidental that the place
           | they infected first just happened to be the most likely place
           | for zoonotic spillover
           | 
           | - The hypothetical infected labworker didn't spread it all
           | over their residence or create any other superspreading
           | incidents clustered elsewhere around Wuhan
           | 
           | On the balance of probabilities I'm going with zoonotic
           | spillover. The coincidence that the lab happened to be in the
           | city is much less of a coincidence than the lab causing a
           | leak of a virus that there's zero evidence the lab ever had,
           | causing a pandemic that looks exactly like it came from
           | zoonotic spillover.
        
             | Biorealism wrote:
             | The nearest relatives to SARS-CoV-2 are found in Yunnan and
             | Laos. The only known link to Wuhan is the Wuhan Institute
             | of Virology sampled both areas.
             | 
             | They refuse to share their records with WHO or the NIH.
             | That's a crucial caveat when saying there is no evidence
             | they held a precursor. We don't know as they have refused
             | to share their database.
             | 
             | The Times article is interesting as it suggests the work in
             | DEFUSE to add furin cleavage sites went ahead and they
             | passaged the virus in humanized mice. This would explain
             | the furin site not seen in other sarbecoviruses and why
             | humans topped the list for binding affinity from the
             | outset.
             | 
             | Note the cases near the market are based on what David
             | Relman described as "hopelessly impoverished" early case
             | data. There was also sampling bias in retrospectively
             | counting cases as market link was often required. WHO
             | hasn't accepted market origin in part as there were likely
             | much earlier cases than those in December linked to the
             | market where no animals tested positive.
        
               | inciampati wrote:
               | > why humans topped the list for binding affinity from
               | the outset
               | 
               | This is an unbelievable coincidence that makes the
               | zoonotic spillover hypothesis laughable. To a biologist,
               | the likelihood of this happening by chance is clear:
               | virtually 0. But explaining the size of the space of
               | optimal solutions to a given binding problem versus the
               | space of good solutions to the general public, well,
               | that's really hard too. So an obvious and completely non-
               | circumstantial piece of evidence is the last one in the
               | public's mind. And we are still acting like there is a
               | question of where the virus came from, and we will be for
               | decades, or at least until the average level of biology
               | education is raised by a few sharp degrees.
        
               | randomperson01 wrote:
               | [dead]
        
             | varelse wrote:
             | [dead]
        
             | sokoloff wrote:
             | > If it was transported to the seafood market by someone
             | who worked at the lab that is highly coincidental that the
             | place they infected first just happened to be the most
             | likely place for zoonotic spillover
             | 
             | If we're going with highly coincidental pairings, it seems
             | like we can't ignore "the disease originated in the only
             | city in China to have an institute that specializes in
             | virology, viral pathology and virus technology."
             | 
             | I'm not convinced of any particular conclusion as to
             | COVID's origin, but I don't down-weight the coincidence of
             | the city of origin hosting WIV nearly as much as you appear
             | to.
        
         | secondcoming wrote:
         | Some janitor or whatever sold an infected animal to the market.
        
           | Clubber wrote:
           | It could be as simple as someone got infected in the lab and
           | went to the market.
        
             | Pigalowda wrote:
             | Right? As if any handling or safety gear and equipment is
             | 100% perfect. Never any needle stick or glove failures.
             | Respirators and protective clothing always 100% perfect.
             | Everyone perfectly followed all lab safety precautions with
             | no absent minded failures. Just perfect all the time
             | forever.
             | 
             | I've always thought it was a handling contamination that
             | got into community spread. It's a very parsimonious
             | explanation.
        
         | dehrmann wrote:
         | > all labs researching viruses do research on dangerous viruses
         | 
         | There should be more attention on this. We're busy worrying
         | about AI that can troll at a college level, while scientists
         | are _still_ busy making frankenviruses after a pandemic
         | plausibly caused by a lab leak.
        
         | denton-scratch wrote:
         | The article implies (but doesn't state) that RaTG13, although
         | discovered in the Mojiang cave, was worked on in the Wuhan lab.
         | It does state that it was being worked-on by Shi Zhengli
         | ("Batwoman") and her team at the lab.
        
         | onethought wrote:
         | Exactly. The lab leak theory is a story of cherry picking
         | evidence to match your conclusion.
         | 
         | Why was the wet market on the other side of the city the only
         | identified outbreak site if it came from the lab? There
         | were/are many markets on the other side of the river that would
         | be much more relevant to residents living and working on that
         | side.
         | 
         | People looking up flu symptoms in the middle of winter is not
         | evidence of anything abnormal.
         | 
         | I don't understand the intellectual effort going into the lab
         | leak theory... it feels like some kind of state run propaganda
         | piece, I assume to just keep a negative view on China in
         | people's minds. It's crazy given that whatever the truth there
         | is no consequence... literally an inconsequential endeavour
        
           | pessimizer wrote:
           | > I assume to just keep a negative view on China in people's
           | minds.
           | 
           | America was involved with that lab, too. It should really be
           | the rest of the world with a negative view of America and
           | China.
        
           | adh636 wrote:
           | Trying to better under the origins of a global pandemic is
           | not an inconsequential endeavor.
        
             | onethought wrote:
             | That's not what people are doing, they are trying to prove
             | a lab leak theory, else all this effort would be in "how'd
             | it get to that wet market" if you can't answer that, then
             | you do not have a logical chain to its true origin lab leak
             | or not.
        
         | darkerside wrote:
         | > The map presented upfront from is also misleading, the early
         | cases clustered around the market not the lab
         | 
         | Is this a case of yet another heat map being a population
         | density map? I assume the wet market is a popular local
         | destination and gathering place, while the lab is not. You
         | would expect there to be more cases where there are more
         | people.
         | 
         | I speculate in ignorance of the actual social dynamics in the
         | city of Wuhan.
        
         | beebmam wrote:
         | It is excusable for a lab to accidentally leak a contaminant.
         | It is not excusable to cover it up and prevent a full
         | investigation, like China has done.
        
           | th0ma5 wrote:
           | [flagged]
        
             | Biorealism wrote:
             | The NIH terminated the Wuhan Institute of Virology's
             | subaward for continued refusal to share records last year.
             | WHO is still pleading with the PRC to share data on both
             | the animal trade and Wuhan labs.
             | 
             | https://thebulletin.org/2022/08/nih-to-terminate-
             | ecohealth-a...
        
           | jesusofnazarath wrote:
           | [dead]
        
         | HardlyCurious wrote:
         | Actually, the closest natural viruses to covid were sent to
         | Wuhan for study. I mean, that is what the Wuhan institute of
         | coronaviruses was built to do right?
         | 
         | The indirect evidence of a lab leak theory is overwhelming
         | frankly. And it doesn't require any malice. No one credible is
         | saying china intentionally released the virus or built it with
         | the intention of building a weapon.
         | 
         | Gain of function research is real, scientists intentionally
         | make viruses which _could_ start a pandemic. They do this for
         | the purposes of knowledge and preparedness for the inevitable
         | natural spillover events that will happen. It isn 't nefarious.
         | 
         | But it is risky, and there many people now and before who
         | thought it was a practice that should be curtailed because of
         | the risk.
        
           | makmanalp wrote:
           | > Actually, the closest natural viruses to covid were sent to
           | Wuhan for study
           | 
           | Please don't "actually" something with an uncited statement
           | without backing it up with any sort of detail. A news
           | article? Anything, honestly.
           | 
           | > that is what the Wuhan institute of coronaviruses was built
           | to do right?
           | 
           | Really? It's "Wuhan institute of virology". Not
           | "coronaviruses". Right?
           | 
           | I have no specific horse in this race but I feel like I'm
           | losing my mind every time I read any discussion on this
           | subject because there's always folks throwing around random
           | statements as if they're established fact and I feel like at
           | this point, on this specific subject, on this website, we
           | should know better, geez.
        
           | godelski wrote:
           | > No one credible is saying china intentionally released the
           | virus or built it with the intention of building a weapon.
           | 
           | To add to this, most countries have turned away from
           | infectious biological weapons because they are near
           | impossible to control. The the release of them might harm
           | your enemies, but at a serious cost to yourself. It is like
           | trying to cut off your enemy's leg by cutting off your own
           | arm. It ends up kinda being like MAD except you're also the
           | aggressor. The threat of a infectious weapon is not from
           | other nations, but from a terrorist organization (which of
           | course dramatically reduces risk). Not to say that this can't
           | happen, but it is well known enough that were a contagious
           | disease to get out, it would be more likely accidental. It
           | would also be odd to release the disease into your own
           | community first. I'm not saying it was or wasn't a lab leak
           | or bioweapon, but if we're discussing weapon vs accident,
           | there's good reason to believe a weapon is unlikely. Gain of
           | research has significant value outside weapons and this also
           | shows you why the weapon arguments against GoF aren't of high
           | concern to those that are close to the work. Contagion
           | weapons are the weapons of those with nothing left to lose
           | (which aren't big/rich countries, even in dire
           | circumstances).
        
           | nextos wrote:
           | I think it is also worth adding that there is good evidence
           | of some lab leaks that caused pandemics in the past.
           | 
           | See for example:
           | https://en.wikipedia.org/wiki/2007_United_Kingdom_foot-
           | and-m...
           | 
           | In my opinion, gain of function is too dangerous with current
           | security measures, and we should consider a moratorium. Lab
           | biocontainment is exceptionally hard.
        
             | arcticbull wrote:
             | More specifically there were a few lab escapes of
             | coronaviruses (SARS) in China that Beijing copped to in the
             | early 2000s [1]. It happens to everyone, way more than it
             | should. Yes, including America. [2]
             | 
             | [edit] To be clear, I'm not saying this definitely did or
             | did not happen, I don't know. I'm saying if it came out
             | later that it did, I wouldn't be surprised.
             | 
             | [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096887/
             | 
             | [2] https://en.wikipedia.org/wiki/List_of_laboratory_biosec
             | urity...
        
             | whyenot wrote:
             | In the mid 1960s, my mom worked in an infectious disease
             | lab. One day, her and her colleagues were tasked with
             | cleaning out a freezer full of samples. Shortly thereafter
             | her and everyone else in the lab got a flu-like illness
             | that did not clear up for many days.
             | 
             | It really makes me wonder how many lab leaks may have
             | happened during this time period when we started collecting
             | and storing samples but we didn't yet have the ability to
             | track diseases like we do today.
        
             | MathMonkeyMan wrote:
             | I saw an interview with a virologist, but I don't remember
             | where (somewhere on YouTube). He said that there _is_ a
             | moratorium on gain of function research, but that it's a
             | joke because virology is pretty much about studying gain of
             | function.
        
               | nextos wrote:
               | There was a NIH moratorium, but it was lifted in 2017.
               | 
               | I don't agree about the point of virology being just
               | about studying gain of function. There are tons of things
               | you can study in virology without needing to create novel
               | viruses.
        
               | MathMonkeyMan wrote:
               | Fair enough, I know almost nothing about it.
        
           | [deleted]
        
         | prepend wrote:
         | > indication of any ill-intent
         | 
         | I don't think ill-intent is the accusation, I think the
         | argument is that the lab has poor safety protocols and made
         | errors. I haven't studied the "lab leak theory" extensively,
         | but everything I read seems to be about lab failures resulting
         | in a leak, not anything purposeful or ill-intentioned.
        
           | kcplate wrote:
           | This is the straw man that people who want to argue against
           | the possibility lab leak use to try and ad hominem the person
           | arguing for the possibility.
        
           | denton-scratch wrote:
           | The article claims that Chinese army researchers were at the
           | lab researching viral weapons. That sounds like ill-intent to
           | me.
           | 
           | It also states that Covid-19 is the only Coronavirus
           | discovered with a furin cleavage site on the spike, and that
           | the lab had applied for funding to research the insertion of
           | such a site.
           | 
           | I don't think anyone is suggesting that the lab deliberately
           | launched a pandemic by deliberately releasing the pathogen
           | _on its own doorstep_.
        
             | Ireallyapart wrote:
             | > The article claims that Chinese army researchers were at
             | the lab researching viral weapons. That sounds like ill-
             | intent to me.
             | 
             | The US does weapons research it does not mean ill intent.
             | The Chinese does weapons research for the same reason the
             | US does it.
        
             | rossdavidh wrote:
             | Well, no one knowledgeable about the field. I have,
             | unfortunately, heard otherwise intelligent people saying
             | that the Chinese government doesn't mind sacrificing it's
             | own people, and did launch it in its own city on purpose
             | (which is, to be clear, ridiculous).
             | 
             | "Never ascribe to conspiracy, what is adequately explained
             | by incompetence".
             | 
             | I think the evidence is pretty clear that at least the
             | Chinese government believes that the covid-19 virus came
             | from their lab (they could, of course, be mistaken about
             | that).
        
               | staunton wrote:
               | > I think the evidence is pretty clear that at least the
               | Chinese government believes that the covid-19 virus came
               | from their lab
               | 
               | What evidence are you referring to?
        
           | revelio wrote:
           | Unfortunately, the article states explicitly that there was
           | ill intent and extensive PLA involvement with the lab.
           | 
           |  _The military was also given positions of responsibility in
           | the Wuhan institute, according to a US Senate report. A book
           | published in 2015 by the military academy discusses how Sars
           | viruses represent a "new era of genetic weapons" that can be
           | "artificially manipulated into an emerging human disease
           | virus, then weaponised and unleashed".
           | 
           | The authors are PLA researchers, and one of the book's
           | editors has collaborated on numerous scientific papers with
           | Wuhan scientists. They discuss how Sars can be weaponised by
           | fusing it with other viruses and "serial passaging" the
           | resulting mutant to make it more dangerous.
           | 
           | The investigators believe the Chinese military had taken an
           | interest in developing a vaccine for the viruses so they
           | could be used as potential bioweapons. If a country could
           | inoculate its population against its own secret virus, it
           | might have a weapon to shift the balance of world power._
        
             | bostonsre wrote:
             | If true, it's probably good that they were incompetent in
             | leaking the virus and incompetent in making a vaccine to
             | front run the virus. Wonder if that would have started
             | world war 3 of they successfully vaccinated their
             | population then either accidentally or on purpose released
             | the virus.
        
         | Amezarak wrote:
         | > Additionally, the closest relative to SARSCov2 that has been
         | identified (RaTG13) was found in a cave in Mojiang county in
         | Yunnan, over 1,000 km away, with no evidence that it was ever
         | studied in the Wuhan lab.
         | 
         | Maybe I'm deeply confused, but the Wuhan lab was reported by
         | NYMag to be the one that _discovered_ RaTG13.
         | 
         | https://nymag.com/intelligencer/article/coronavirus-lab-esca...
         | 
         | > How Did It Get Out? 1. The Tongguan Mine Shaft in Mojiang,
         | Yunnan, where, in 2013, fragments of RaTG13, the closest known
         | relative of SARSCoV-2, were recovered and transported to the
         | Wuhan Institute of Virology; 2. The Wuhan Institute of
         | Virology, where Shi Zhengli's team brought the RaTG13 sample,
         | sequenced its genome, then took it out of the freezer several
         | times in recent years;
        
         | jug wrote:
         | Also, before one draws conclusions based on the _kind_ of virus
         | that is researched, coronaviruses aren't even uncommon. So
         | better evidence is clearly necessary than innuendo.
        
           | Biorealism wrote:
           | It's not just a coronavirus, it's a sarbecovirus with a furin
           | cleavage site never seen before in sarbecoviruses. The
           | nearest relatives to SARS-CoV-2 are found in Yunnan and Laos.
           | The only link with Wuhan is WIV's sampling in both locations.
           | 
           | In 2018, WIV was part of a proposal with EcoHealth Alliance
           | and UNC to add furin cleavage sites into novel SARS-related
           | bat coronaviruses. DARPA declined to fund it. This
           | investigation suggests the work went ahead. Something Nick
           | Patterson suggested often occurs even when funding is
           | declined. WIV had both NIAID and CAS grants to study
           | spillover risk of SARS-related coronaviruses. They were also
           | doing classified work with the PLA from 2017.
        
         | AbrahamParangi wrote:
         | I'm sure most of this is true or at least true-ish but to be
         | appropriately skeptical, all evidence which has a Chinese
         | source here should be considered as potentially made up.
         | 
         | Regardless of whether or not there was a coverup, the Chinese
         | government has certainly _acted like_ it was covering something
         | up.
         | 
         | The circumstantial evidence is sort of ridiculous here though.
         | An institute with weak safety controls experimenting with
         | creating novel pathogens has an outbreak of a novel pathogen
         | next door? No no, it's because of climate change (an actual
         | argument I have seen).
        
           | lamontcg wrote:
           | > the Chinese government has certainly acted like it was
           | covering something up.
           | 
           | Yes, they covered up the existence of racoon dogs and other
           | susceptible animals at the market.
        
           | oneshtein wrote:
           | They may cover up something completely orthogonal to Covid.
           | For example, they may cover up a corruption scheme, to steal
           | money granted for research, or they acted as proxy for
           | Russians, to spy at USA, or they mismanaged facility and
           | leaked virus from the lab in Wuhan second time, AFTER the
           | initial outbreak (1.5-2.5 month of delay between projected
           | start of epidemic in mid-September-mid-October and start of
           | epidemic in Wuhan in December must be explained somehow),
           | etc.
        
           | snowwrestler wrote:
           | The "circumstantial evidence" is only novel if the event in
           | question is novel, which the emergence of a new strain of a
           | virus is not.
           | 
           | It is certain that a new strain of some virus is emerging
           | right now next to a lab that works with viruses, because that
           | is a thing that happens continuously in nature, and labs
           | exist within nature. It's also likely that such a new strain
           | will not cause human illness, as most viruses do not.
           | 
           | SARS-COV-2 only looks novel to humans because it made a lot
           | of humans sick. There were tons of allegations that HIV was
           | created in a lab too. This says more about our self-regard
           | than about the virus itself.
        
             | JPLeRouzic wrote:
             | > " _There were tons of allegations that HIV was created in
             | a lab too._ "
             | 
             | Scientists' best guess is that the precursor of the most
             | common "M" virus jumped from the Cameroon chimps to humans
             | sometime before 1931.
             | 
             | https://www.pbs.org/wgbh/pages/frontline/aids/virus/origins
             | ....
        
             | AbrahamParangi wrote:
             | This would all be more compelling if the WIV were not
             | _explicitly experimenting with creating viruses like SARS-
             | COV-2_! If HIV had emerged proximal to _a lab experimenting
             | with creating viruses like HIV_ then that lab origin theory
             | would be much more credible!
        
               | snowwrestler wrote:
               | Saying "viruses like SARS-COV-2" only makes sense for
               | broad applications of the word "like."
               | 
               | As other comments have pointed out, while that lab was
               | working with coronaviruses, none of the strains were
               | genetically close to SARS-COV-2. Coronavirus is a broad
               | category of viruses.
        
               | AbrahamParangi wrote:
               | Betacoronaviruses with SARS-like attributes and natural
               | reservoirs in bats is supposed to be a "broad application
               | of the word 'like'"? Bit of a stretch, no?
        
         | living_room_pc wrote:
         | > Most importantly, the general reader should know that all
         | labs researching viruses do research on dangerous viruses.
         | After all there is no incentive to research benign viruses.
         | 
         | That is completely untrue. Agricultural labs for instance
         | research plant viruses which are _incompatible_ with humans
         | completely. Still these plant virus would have to be researched
         | under stringent isolation because of the damage they may pose
         | to crops.
         | 
         | > Most importantly, the general reader should know
         | 
         | Speak on our level, don't baby us.
        
           | th0ma5 wrote:
           | [flagged]
        
           | pcrh wrote:
           | Agricultural viruses are dangerous to human food security. At
           | least the ones under study usually are.
        
             | peteradio wrote:
             | > Most importantly, the general reader should know that all
             | labs researching viruses do research on dangerous viruses.
             | After all there is no incentive to research benign viruses.
             | So the fact that the Wuhan lab worked on coronaviruses is
             | not in itself an indication of any ill-intent.
             | 
             | What exactly are you trying to say here anyway? If they
             | were researching some other virus type it wouldn't be
             | getting a look. But they were researching coronavirus.
        
         | ajross wrote:
         | My position hasn't changed for years: if covid was really a lab
         | creation we'd know, because someone would have told us. An
         | email dump, a memo, a document, an interview. _Something_ would
         | have leaked out. The incentives are just too high and the
         | access is too pervasive[1] to believe otherwise.
         | 
         | Is it possible? Sure! Is it likewise possible that some of the
         | circumstantial claims about WIV are true? Sure! But if someone
         | made this thing, someone else would have told us by now.
         | 
         | [1] This is science! There are notes and logs and backups and
         | email and chat and whiteboard photos and conference attendees
         | and visiting scholars, all spread around a population all
         | trained to compete with each other.
        
           | kevinmchugh wrote:
           | Shouldn't an oppressive regime change the math here? The
           | ability to suppress potential whistleblowers means the
           | absence of whistleblowers isn't all that convincing. Compared
           | to moon landing conspiracy theories, where this argument is
           | very convincing imo
        
             | ajross wrote:
             | Again, these are scientists. You really don't think one of
             | them could move to a post at Stanford or wherever and spill
             | the tea? No one has an old copy of an incriminating memo
             | they can forward to a friend in Taipei? And regardless, the
             | PRC does _not_ in fact have a great record in the opsec
             | department even within its military and espionage arms. How
             | many  "Chinese spies" get arrested every year?
             | 
             | Part of any conspiracy theory is positing a great
             | totalitarian enemy who is able to keep all these important
             | truths from The People. The PRC is economically large and
             | somewhat questionably ambitious. It's absolutely not the
             | kind of super state people want to imagine.
        
               | bostonsre wrote:
               | If the military was indeed involved, then it seems highly
               | plausible that they would have been able to keep
               | communications under control and that they would be able
               | to repress a few dozen workers. Threats against them and
               | their families would probably work pretty well.
        
               | kevinmchugh wrote:
               | > You really don't think one of them could move to a post
               | at Stanford or wherever and spill the tea?
               | 
               | When? There's a pretty short window where a WIV scientist
               | might have known the subject they were studying had
               | escaped the lab before the PRC did. Certainly by January
               | 2020 the PRC could've clamped down on those scientists.
               | 
               | Spies caught outside the country don't tell me much about
               | internal operations.
               | 
               | ETA: I think my thinking here is pretty colored by Tank
               | Man, whose name is unknown. The CCP claims they don't
               | know anything about him. Even if that's true, presumably
               | he had friends, family, and fellow protestors who have
               | decided it would be a very bad idea to even give his
               | name.
        
           | Biorealism wrote:
           | It took over a decade to confirm the Sverdlovsk anthrax
           | outbreak was the result of an outbreak. In that case
           | intelligence did suspect an accidental cause although
           | scientists argued contaminated meat was the cause.
           | Information can be tightly controlled under authoritarian
           | regimes. Recall those who even reported the outbreak in the
           | community faced recriminations.
           | 
           | What is known is the nearest relatives to SARS-CoV-2 are
           | found in Yunnan and Laos. Both areas WIV sampled and they
           | refuse to share their records with WHO or the NIH.
        
           | toomim wrote:
           | We still don't know what happened to JFK, 60 years later.
        
             | th0ma5 wrote:
             | This is a really great point. And it may not be knowable
             | beyond what we already know.
        
             | ajross wrote:
             | Yikes. I mean, yes, in this sense you're right. We've never
             | found conclusive _disproof_ of the various conspiracy
             | theories around the assassination and have been forced into
             | a consensus that, y 'know, Oswald shot him. But you don't
             | believe that. And nothing is going to make you. So from
             | you're perspective "we still don't know". WIV is going to
             | be the same. You'll never get the _disproof_ you demand, so
             | you 'll continue to disbelieve the consensus opinion.
             | 
             | Yours is a world where disproof rules, and conspiracies are
             | assumed true until proven false. I'm sure it's
             | entertaining, but it's not "true" any more than mine is.
             | 
             | In my world, Oswald _probably_ shot JFK and covid was
             | _probably_ a natural virus, because those are the
             | hypotheses that demand the least of the existing evidence.
             | I 'm willing to change my priors with more evidence, but
             | not because of the lack of disproof of an entertaining
             | counter-hypothesis.
        
             | latency-guy2 wrote:
             | We also did not know that Cuba housed missles from Russia
             | during the crisis. We also did not know to the extent that
             | Cuba's leadership explicitly did have plans to strike the
             | US alongside their Soviet allies.
             | 
             | It took until 1992 for what appears to be the truth to be
             | discovered, 3 decades with far more people involved in the
             | process, and a much darker outcome than a man being
             | assassinated.
        
           | Etherlord87 wrote:
           | What is the time limit a secret of this magnitude could
           | survive without being revealed by someone? A year, two years?
           | If we look at our history, we will only see secrets that were
           | revealed within that maximum period?
           | 
           | Snowden revealed quite shocking information, and I think it
           | is safe to say the secret of mass surveillance was going on
           | for much longer than 4 years.
        
             | ajross wrote:
             | And if such information pops up, I will (with great
             | surprise) re-evaluate my priors. Nonetheless I think
             | history bears out my intuition here. The _overwhelming_
             | majority of conspiracies likes this, especially ones in
             | fundamentally civilian organizations like science labs, don
             | 't survive a year if that.
        
               | ergodic1 wrote:
               | Making the claim that you know the proportion of
               | conspiracies that get reported implies you know the
               | number of conspiracies not reported.
               | 
               | Im not aware of any way you could know that or the
               | relative proportion of each.
               | 
               | Where do you get your certainty here?
        
           | randomperson01 wrote:
           | Just like someone leaked out about the Sverdlovsk lab
           | accident - how many years did that take?
           | 
           | http://web.archive.org/web/20210621032149/https://www.nytime.
           | ..
        
           | hackinthebochs wrote:
           | It's amazing how easily some people deploy unfalsifiable
           | theories to justify a presupposition.
        
         | stainablesteel wrote:
         | [flagged]
        
       | fuckyah wrote:
       | [dead]
        
       | hayst4ck wrote:
       | If anyone's in for a long read, despite the hokey sounding name,
       | I found this to be one of the best contemporaneous explorations
       | of Covid in china that I've seen to date:
       | 
       | https://project-evidence.github.io/
        
         | th0ma5 wrote:
         | [flagged]
        
           | cheaprentalyeti wrote:
           | Because if we're relying on the people who are funding
           | bioweapons research in hostile countries to tell us how to
           | treat said viruses, under the delusion that they'd learn
           | something useful, it's the kind of thing we need to know
           | about before waking up three years later and finding out (per
           | the Northwestern study) that we could have avoided a lot of
           | deaths by simply following the sort of treatment regimen we
           | used for more common flu varieties and given the patients
           | azithromycin.
        
             | th0ma5 wrote:
             | Why not do something about this directly. This lab leak
             | wild goose chase isn't required.
        
           | khazhoux wrote:
           | For one, if it was proven that a lab leak was the cause of
           | such global destruction, that may encourage stronger lab
           | regulations in the future.
        
             | th0ma5 wrote:
             | We can and should do that anyway, why do we need a smoking
             | gun, I mean, beyond the pandemic we had.
        
               | khazhoux wrote:
               | I'd avoid loaded terms like "smoking gun" in this
               | discussion. My point is that if the pandemic was caused
               | by a leak, then that would be a prior that could aid in
               | future decision-making.
               | 
               | I don't understand your position that we should not seek
               | the truth. Somehow knowing the truth about a past event
               | can have no bearing on the future?
        
               | th0ma5 wrote:
               | I don't think it is ultimately knowable in a way that is
               | helpful. We need to act as if any of the possibilities
               | happened because any of them could.
               | 
               | I guess I also don't see why articles like this are
               | needed to work on pandemic prevention.
               | 
               | I can totally see why people need them for at the very
               | least getting clicks and attention.
        
               | kortilla wrote:
               | It's possible aliens came from space and dropped the
               | virus off to see how we would handle it. How much effort
               | should we put into preventing that pandemic path?
               | 
               | Nearly every airline regulation that results in air
               | travel being so safe today is because we spend such an
               | enormous amount of resources investigating the root
               | causes of accidents with the NTSB. Try suggesting to them
               | "it doesn't matter why the plane crashed, let's just push
               | for generic improvements to planes". You'll get
               | (rightfully so) laughed out of the room.
        
               | th0ma5 wrote:
               | The limit is five why's and often you can't even get
               | that. Planes still crash. Perhaps we've pulled on this
               | thread as much as we can. Especially with long ass
               | articles like this that say nothing new.
               | 
               | Seriously, what are we expecting to learn. This is like a
               | plane at the bottom of the ocean never to be found. We'll
               | never know what happened to this plane, and we don't have
               | to.
               | 
               | We know that situation was probably poor pilot mental
               | health but pilots still have to lie about
               | antidepressants. We don't need to find that plane to fix
               | that.
        
               | khazhoux wrote:
               | > We'll never know what happened to this plane,
               | 
               | You've decided the truth is unknowable, no good would
               | come from knowing the truth, and searching for the truth
               | is itself causing harm.
        
               | th0ma5 wrote:
               | Well we stopped looking for it though
        
           | hayst4ck wrote:
           | Because exploring the truth is a worthwhile endeavor
           | particularly in the face of an oppressive regime that made it
           | very clear they did not want the truth to be explored.
           | 
           | Just to be clear what I posted seemed like Chinese people
           | exploring what actually happened more than a blame based
           | document or fear mongering based document.
           | 
           | I would really encourage you to give it a chance because it
           | is very impressive investigative work and, really, an
           | impressive exercise of investigative journalism from a
           | country that hates investigative journalists.
        
             | th0ma5 wrote:
             | [flagged]
        
               | xcv123 wrote:
               | You are spamming this thread. Looks like you are working
               | for the CCP. Don't make it too obvious.
        
               | th0ma5 wrote:
               | Lol. If the treatment of their own people wasn't bad
               | enough and it took a pandemic conspiracy theory to hate
               | them, then I feel like you need to read more.
        
               | [deleted]
        
               | hayst4ck wrote:
               | The purpose of that article is not to bring down china.
               | It's not ideologically opposed to china. It was not some
               | conservative agenda article. It's a group of people who
               | want to understand what happened. The article comes from
               | a stance of curiosity. What I linked is very compatible
               | with the HN mindset and not particularly ideological.
               | 
               | You clearly have not read it because your comment makes
               | no sense in the context of that article.
               | 
               | If you don't want to be curious then don't be.
        
               | th0ma5 wrote:
               | [flagged]
        
         | randomperson01 wrote:
         | Its a good compilation that I saw in mid 2020 that was one of
         | the sources of data leading me to question the zoonotic
         | spillover hypothesis that I had read in Zhou et al (RaTG13
         | paper) and Anderson et al. That the WIV was conducting exactly
         | the type of research that could have led to a highly human
         | infectious novel SARS-CoV was poo-pood and cast as a conspiracy
         | theory. As Ian Lipkin stated following the Fauci teleconference
         | "we have a nightmare of circumstantial evidence to deal with"
        
           | [deleted]
        
           | ricksunny wrote:
           | And helpful that it's hosted on GitHub. PRC can't block
           | Github on a strategic level. So content can be hosted there
           | that gets through the GFW that PRC netizens can see.
        
       | throwawayio wrote:
       | [flagged]
        
         | chihuahua wrote:
         | Peter Daszak says no.
        
       | anonzzzies wrote:
       | [flagged]
        
         | soeptical wrote:
         | Daszak/ecohealth alliance and by extension NIH and us govt are
         | also culpable for a Wuhan lab originating virus
        
           | maeil wrote:
           | You're right that Daszak and the Ecohealth Alliance are
           | culpable, but it must be noted that various USG orgs were not
           | supportive of his actions
           | 
           | > _The report he finally did submit stated that scientists
           | planned to create an infectious clone of Middle East
           | Respiratory Syndrome (MERS), a novel coronavirus found in
           | dromedaries that had emerged in Saudi Arabia in 2012 and
           | killed 35% of the humans it infected. The report also made
           | clear that the NIH grant had already been used to construct
           | two chimeric coronaviruses similar to the one that caused
           | Severe Acute Respiratory Syndrome (SARS), which emerged in
           | 2002 and went on to cause at least 774 deaths worldwide. (A
           | chimeric virus is one that combines fragments of different
           | viruses.) These revelations prompted the NIH's grant
           | specialists to ask a critical question: Should the work be
           | subject to a federal moratorium on what was called gain-of-
           | function research?_
           | 
           | > _But the [2015 research paper he
           | cited](https://www.nature.com/articles/nm.3985) was not
           | particularly reassuring. In it, Shi Zhengli and a preeminent
           | coronavirus researcher at the University of North Carolina,
           | Ralph Baric, mixed components of SARS-like viruses from
           | different species, and created a novel chimera that was able
           | to directly infect human cells. (Baric did not respond to
           | written questions seeking comment.)_
           | 
           | > _If anything, the MERS study Daszak proposed was even
           | riskier. So he pitched a compromise to the NIH: that if any
           | of the recombined strains showed 10 times greater growth than
           | a natural virus, "we will immediately: i) stop all
           | experiments with the mutant, ii) inform our NIAID Program
           | Officer and the UNC [Institutional Biosafety Committee] of
           | these results and iii) participate in decision making trees
           | to decide appropriate paths forward."_
           | 
           | > _This mention of UNC brought a puzzled response from an NIH
           | program officer, who pointed out that the proposal had said
           | the research would be performed at the WIV. "Can you clarify
           | where the work with the chimeric viruses will actually be
           | performed?" the officer wrote. Ten days later, with still no
           | response from Daszak, the program officer emailed him again.
           | On June 27, Daszak responded, buoyant as ever:_
           | 
           | > _"You are correct to identify a mistake in our letter. UNC
           | has no oversight of the chimera work, all of which will be
           | conducted at the Wuhan Institute of Virology.... We will
           | clarify tonight with Prof. Zhengli Shi exactly who will be
           | notified if we see enhanced replication...my understanding is
           | that I will be notified straight away, as [principal
           | investigator], and that I can then notify you at NIAID.
           | Apologies for the error!"_
           | 
           | > _Allowing such risky research to go forward at the Wuhan
           | Institute of Virology was "simply crazy, in my opinion," says
           | Jack Nunberg, director of the Montana Biotechnology Center.
           | "Reasons are lack of oversight, lack of regulation, the
           | environment in China," where scientists who publish in
           | prestigious journals get rewarded by the government, creating
           | dangerous incentives. "So that is what really elevates it to
           | the realm of, 'No, this shouldn't happen.'"_
           | 
           | In general, his actions make clear he's much more aligned
           | with the Chinese government than the US, so extending Daszak
           | to US govt purely based off of nationality seems unjust.
           | 
           | > _On January 30, Daszak went on CGTN America, the U.S.
           | outpost for Chinese state television, and said two things
           | that proved to be spectacularly wrong. "I'm very
           | optimistic...that this outbreak will begin to slow down," he
           | said. "We're seeing a small amount of human-to-human
           | transmission in other countries, but it's not uncontrollable.
           | " He went on to conclude that the Chinese government was
           | taking all necessary steps "to be open and transparent, and
           | work with WHO, and talk to scientists from around the world,
           | and where necessary, bring them in to help. They're doing
           | that. It's exactly what needs to happen."_
        
             | Ins43b wrote:
             | [flagged]
        
         | th0ma5 wrote:
         | [flagged]
        
       | LeonB wrote:
       | Early on the article makes a conjecture that others also make
       | which I think is part of why the topic is so hot:
       | 
       | "Whether the virus emerged as a result of a leak from a
       | laboratory or from nature has become one the most controversial
       | problems in science."
       | 
       | The words "in science" are my problem here: people thinking this
       | is a "scientific" question.
       | 
       | It's a history question, a political question, and could be made
       | into a forensic question. But science does not ask this kind of
       | question!
       | 
       | Is it possible for a lab to leak a virus? That's a question
       | science can ask, but it doesn't answer this one.
       | 
       | So we end up with a belief that scientists can answer this
       | question... but it isn't a "scientific" question in the first
       | place.
        
         | rich_sasha wrote:
         | > But science does not ask this kind of question!
         | 
         | I disagree, it _is_ a scientific question. Whether we can
         | answer it in isolation of politics and prejudice is the
         | question for me.
         | 
         | But if you observe some gravitational waves in a single event,
         | you can correlate it to optical or radio observations, you can
         | try to analyse the signals to match them to existing hypotheses
         | of gravitational waves origination etc. The singularity of the
         | event doesn't make it not science. Same as the emergence of a
         | novel virus.
         | 
         | It is just a shame that most of the evidence is subjective and
         | non-scientific. But the _question_ itself is well posed
         | scientific endeavour.
        
         | switch007 wrote:
         | I interpreted it as "in the scientific community".
        
         | seydor wrote:
         | why not? it is an important scientific question to guide
         | research to mitigate the virus and prevent similar future
         | disasters
        
           | th0ma5 wrote:
           | [flagged]
        
             | throwaway2990 wrote:
             | The lab leak theory started in China. It has never been
             | about xenophobia. The only people pushing the whole
             | xenophobia thing was the CCP. Chinese news called it wuhan
             | virus long after it was given the name Covid-19.
             | 
             | So stop trying to protect the CCP.
        
               | th0ma5 wrote:
               | Protect them from what? Being blamed? What does that do
               | except stoke fear? There are actual things to talk about
               | like their aggressive naval horseshit why do we have to
               | make them nefarious mind controllers or secret world
               | saboteurs or whatever this lab leak hypothesis is
               | supposed to prove.
        
               | throwaway2990 wrote:
               | Knowing how the virus leaked allows us to figure out how
               | to try and prevent it happening again.
               | 
               | When you cover it up, prevent investigations, destroy
               | data, and try to blame the rest of the world. That does
               | not help understand how we can prevent it happening
               | again.
               | 
               | If China was open and honest from day 1, countries would
               | have actually tried to help. But instead all the CCP did
               | was hide it and blame everyone else.
               | 
               | It's clear that you side with the CCP. You don't want to
               | prevent another pandemic or make sure people are safe.
               | All you seem to want to do is defend them and get angry
               | at everyone who wants to discuss the issue.
        
               | camillomiller wrote:
               | Yeah, in fact being honest, sincere and collaborative
               | with foreign powers is the tenet of NSA, CIA, and all
               | major security agencies in the USA, right?
        
               | th0ma5 wrote:
               | I agree sort of with this sentiment, but it ultimately
               | doesn't matter even if it is that china is covering up
               | their bioweapon accident just like anyone might. We'll
               | never know, and we don't need that to hold them
               | accountable for many many many other wrongs, and we don't
               | need it to start working to prevent the next pandemic
               | either.
        
               | th0ma5 wrote:
               | I don't side with them, I side with reason.
               | 
               | 1. Lab leak hypothesis being proven is not a requirement
               | for any kind of prevention
               | 
               | 2. If everyone was honest all the time life would be
               | roses
               | 
               | 3. These lab leak articles don't make anyone safer they
               | just cause conspiratorial thinking.
               | 
               | I don't trust the China for shit, but I'm sick of
               | Americans suckered in by lazy bullshit thinking. I can't
               | think of anything positive to say about China, but you
               | can't say this because it is all a dead end useless thing
               | that serves no purpose.
               | 
               | How about putting back in our observers like Trump kicked
               | out, arguably hobbling our view into what was going on.
               | We still have not done this. Instead we're here dicking
               | off about shit that doesn't matter. Way to be people.
        
               | [deleted]
        
             | computerfriend wrote:
             | Don't ascribe motive ("cause xenophobic feelings") unless
             | you can back it up.
        
               | th0ma5 wrote:
               | That's the very point I'm trying to make about this
               | dubious article and all the people posting conspiracy
               | theories here. How can we say they aren't trying to cause
               | xenophobic feelings?
        
               | at_compile_time wrote:
               | Ah, so when people disagree with you, it's because
               | they're conspiracy theorists and you're ready to make
               | wild assumptions about their motives. How perfectly
               | reasonable of you.
        
               | th0ma5 wrote:
               | This article literally explores and lays out theories
               | about how potentially events and people could've
               | conspired to our present day. I don't think that is
               | intellectually helpful.
        
               | computerfriend wrote:
               | If you can't say either way, don't say it at all.
        
               | th0ma5 wrote:
               | Yes exactly ... If you can't prove the lab leak stop
               | writing articles about it, people.
        
               | computerfriend wrote:
               | Don't accuse people of xenophobia, is my point.
        
               | th0ma5 wrote:
               | Sure yes, that is a fair point, but this conversation
               | doesn't ascribe that kind of limitation in the argument,
               | because we're already talking about other motivations.
               | Maybe (probably lol) they were negligent, maybe it was an
               | accident, my point is if we are also trying to get people
               | to think for a moment "or maybe they did it on purpose"
               | then it follows that people are pushing that idea, if
               | false, for xenophobic reasons.
        
               | [deleted]
        
         | arisAlexis wrote:
         | "Is it possible for a lab to leak a virus? "
         | 
         | What do you mean? Ofc it's possible and has been done hundreds
         | of times in the past with different viruses and lab security
         | levels.
        
         | qup wrote:
         | Please, scientists, no need to peer review Wuhan.
        
         | stewbrew wrote:
         | Of course it could be a scientific to estimate the probability
         | that ...
        
         | pyuser583 wrote:
         | There was a peer reviewed paper earlier in the pandemic where
         | scientists used their knowledge of viral anatomy to argue it
         | wasn't engineered.
         | 
         | Subsequent scientific have disagreed.
         | 
         | But this isn't purely historical.
        
           | throwaway2990 wrote:
           | The one with Peter Daszak who was hand picked by the CCP for
           | the investigation and money trail back to the CCP??
        
           | LanceH wrote:
           | Apologies to those accused of being conspiracy theorists,
           | xenophobic, and spreading misinformation will be going out
           | shortly.
        
             | camillomiller wrote:
             | They will not, because those accusations came from people
             | who intended to use them to discredit Chinese people in
             | general, or that closely associate the leak with the
             | Chinese way of doing things and so on. These accusation led
             | to racist attacks against Asian people all over the us.
        
               | kcplate wrote:
               | Ok, so the original motivations for some making that
               | claim were suspect. Should that automatically excuse or
               | prevent discussion that better safety protocols should be
               | used or a better "ways of doing things" should be
               | undertaken when handling viruses and pathogens that are
               | capable of killing 7M people? I think it's a valid topic
               | and important one that should be verboten lest the next
               | time we accidentally kill 14M with carelessness as the
               | cause.
        
               | plagiarist wrote:
               | If the people making that claim had been sane, instead of
               | pushing it in the middle of; "it's not deadly, just a
               | flu," "masks do nothing," "maybe a bit of bleach is fine
               | in the lungs," "hydroxychloroquine cures everything,"
               | "no, wait, it is horse paste that cures everything," "the
               | vaccine will kill you in X months, guaranteed," and
               | "GREAT RESET," it'd be easier to transition into a
               | serious discussion about studying deadly viruses in labs.
        
               | Natsu wrote:
               | The middle ground always gets pushed to the extremes when
               | there's a strong push to alienate some views.
               | 
               | Covid was worse than the flu, but the flu is also deadly
               | and we should be paying more attention to vaccinating it.
               | The deaths aren't evenly distributed, either, young
               | healthy people have less to worry about, but "less" isn't
               | "nothing." For masks, you really wanted N95 masks, not
               | cloth, and you still have to avoid large indoor
               | gatherings.
               | 
               | Nobody said that bleach in the lungs was good. Trump
               | mentioned _disinfectant_ presumably butchering a
               | description of the HealLight which would use UV to
               | destroy the virus, effectively  "disinfecting" the lungs.
               | There are always idiots poisoning themselves with bleach,
               | though, but nobody pays much attention to the poison
               | control stats most of the time. HCQ and Ivermectin had
               | some promising studies but no real effectiveness for the
               | things people wanted them for. There probably is some
               | rise in myocarditis due to vaccines... but they're still
               | a lot safer if you look at mortality rates. "Great Reset"
               | was from an actual policy proposal someone put out, but
               | doesn't really stand for the things the conspiracies say
               | it does.
               | 
               | All of these things got pushed into extreme caricatures
               | depending on what side you trust.
        
               | kcplate wrote:
               | I honestly don't see much difference in the level of
               | extremism between everything you listed vs people
               | deciding a specific topic is off limits just because the
               | theory may not be politically correct, or because the alt
               | opinion may have some factual basis.
        
               | plagiarist wrote:
               | Yes, of course, everyone should treat disingenuous
               | propagandists as if they were attempting to have a
               | serious discussion. If anyone objects to that, it is
               | "deciding a topic is off-limits," which is insane. Of
               | course we should let them run their horse paste grift and
               | just patiently repeat over and over, "no, no, studies
               | show it doesn't work. Please wear a mask to reduce
               | spread."
        
               | kcplate wrote:
               | Considering that you are intentionally misconstruing that
               | ivermectin position that folks were discussing at the
               | time using the same tired and dishonest "horse paste"
               | media talking point, I'll assume that "disingenuous
               | propaganda" runs in many directions.
        
             | th0ma5 wrote:
             | [flagged]
        
             | [deleted]
        
           | th0ma5 wrote:
           | [flagged]
        
             | throwaway2990 wrote:
             | Science is in agreement that it is most likely not natural
             | and was engineered. The missing piece is where it
             | originated and majority agree that it most likely
             | originated from the wuhan institute of virology.
        
               | th0ma5 wrote:
               | [flagged]
        
         | spookthesunset wrote:
         | > but it isn't a "scientific" question in the first place.
         | 
         | ... which is true of the pandemic response in general.
         | "Science" doesn't tell society how to react to something.
         | Science is a process to test hypothesizes--it isn't a book of
         | facts or direct answers on the trade-offs of various mitigation
         | techniques. It can only inform, not dictate.
        
         | fsckboy wrote:
         | So, science doesn't have a problem when results of experiments
         | are faked, because science doesn't ask this question, it's a
         | question for politics, forensics, and history? Nice try! Still
         | your move.
        
           | th0ma5 wrote:
           | [flagged]
        
           | oneshtein wrote:
           | Yes, you nailed it properly. If results of experiments cannot
           | be reproduced and confirmed by two independent researchers at
           | least, then it's not a scientific process. History of science
           | is full of fakes.
        
         | yawnxyz wrote:
         | There's a lab at U of A that accidentally infected their
         | student researcher with cholera, and another case of
         | campylobacter.
         | 
         | It's just sloppy work, but when you're there for 12 hours a day
         | for 5-6 days a week, you're bound to get sloppy
        
         | toomim wrote:
         | Is the big bang theory science or history, by that logic?
        
         | th0ma5 wrote:
         | [flagged]
        
         | pbreit wrote:
         | How is science not involved in a major way here? Of course
         | science will continue to play a huge role in the matter.
        
           | mikrotikker wrote:
           | A few possible reasons.
           | 
           | The communist party is sensitive doesn't want it to be known
           | that a Chinese lab leaked a dangerous virus (see also "how
           | does RBMK reactor explode?")
           | 
           | The ecohealth alliance that Fauci and Dazack were involved in
           | don't want it widely known that they had a hand in the WIV
           | GoF (that Obama banned stateside) and worked early in the
           | pandemic to obscure their own involvement in it.
           | 
           | Trump doesn't want it widely known that his administration
           | contributed $100k to the Ecohealth alliance.
           | 
           | Lots of powerful people working to not take responsibility
           | and obfuscate reality.
        
         | baxtr wrote:
         | I think when they say Science they actually mean: the
         | scientific community.
        
           | toomim wrote:
           | Which actually means: a scientific community.
        
       | tuxguy wrote:
       | non-paywall version : https://archive.md/Edw0k
        
       | yyyk wrote:
       | Leaving aside the question of where and how the virus emerged,
       | it's interesting to note that the lab was nigh useless during the
       | pandemic, despite its main specialty was investigating
       | Coronaviruses! It looks like a lot of dangerous research went on,
       | and even if nothing bad happened because of that research,
       | nothing was gained. A lot of risk for nothing.
        
         | calderwoodra wrote:
         | Are you implying the lab shouldn't have existed at all? And/or
         | future coronavirus labs shouldn't exist either?
        
           | Thorentis wrote:
           | They're not implying anything. They're nearly making the
           | observation that the supposed reason this lab existed was to
           | research dangeours viruses like covid, and yet the lab itself
           | did nothing to help during the pandemic.
        
             | wwtdtgotiatl wrote:
             | > yet the lab itself did nothing to help during the
             | pandemic.
             | 
             | Which people in this thread are somehow believing as truth
             | instead of the bald-faced propaganda it is.
             | 
             | Do you actually think a virus research lab in the epicentre
             | of an outbreak would not be put to use?
             | 
             | From Wikipedia:
             | 
             | > As the virus spread worldwide, the institute continued
             | its investigation. In February 2020, a team led by Shi
             | Zhengli at the institute were the first to identify,
             | analyze and name the genetic sequence of the novel
             | coronavirus (2019-nCoV), upload it to public databases for
             | scientists around the world to understand,[28][29][30] and
             | publish papers in Nature.[31] On 19 February 2020, the lab
             | released a letter on its website describing how they
             | successfully obtained the whole virus genome.[32]
             | 
             | https://en.wikipedia.org/wiki/Wuhan_Institute_of_Virology
        
               | yyyk wrote:
               | Gene sequencing is table stakes with modern tech, and
               | many countries did that during the pandemic. We don't
               | need a BSL-4 level lab in the middle of a large city to
               | do a gene sequence. It happened that they published early
               | what many other labs would have done (and did do). On the
               | other hand, the vaccines and effective cures had nothing
               | to do with their work. The benefit/risk ratio seems very
               | poor here.
        
               | MichaelZuo wrote:
               | > It looks like a lot of dangerous research went on, and
               | even if nothing bad happened because of that research,
               | nothing was gained. A lot of risk for nothing.
               | 
               | Your previous comment is clearly incorrect as shown by
               | the parent, something is a lot more than nothing.
        
               | dendriti wrote:
               | So you're not going to admit you were ignorant or just
               | lying?
        
               | DangitBobby wrote:
               | What was gained that would not have been gained without
               | the existence of the lab?
        
               | Thorentis wrote:
               | You really missed the whole point of their post didn't
               | you? If we are going to allow a BSL-4 lab to exist and
               | introduce the risk of possible leaks or other problems,
               | we need to get something in return. That "something"
               | needs to be more than what other lower security labs can
               | already do. It is fascinating that a lab which was
               | supposedly researching coronavirsuses for so long (and
               | which may have led to the outbreak, but regardless) was
               | unable to do anything that other labs could not.
        
               | himinlomax wrote:
               | Afaik they weren't even applying BSL4 security to their
               | coronavirus research. On top of that, before the
               | outbreak, the Pasteur institute, who was incidentally
               | supposed to be a research partner but was kept at arms'
               | length, raised an alarm on their apparent general lack of
               | safety compliance.
               | 
               | That and the fact that the Chinese dicatorship blocking
               | any inquiry into the matter are enough to put the blame
               | on that lab until proven otherwise.
        
           | drexlspivey wrote:
           | They shouldn't perform gain of function research because the
           | risk/reward is comically high
        
           | asynchronous wrote:
           | Heaven forbid we hold people accountable and/or learn from
           | our mistakes as a species.
        
           | jeffrallen wrote:
           | I'd like for high risk biological research to be done under
           | the same security arrangements as nuclear weapons research.
           | Covid and influenza have together killed several orders of
           | magnitude more humans in the last 150 years than nuclear
           | weapons/accidents have. Thus GoF research presents a
           | potential human cost much higher than nuclear weapons, and
           | should be treated as such.
           | 
           | If that makes it "too expensive and slow" then so be it.
           | Perhaps there are some things humans should not be doing.
        
             | NoZebra120vClip wrote:
             | Well, historically, you know, nuclear weapons research
             | involved a lot of cavalier scientists doing dangerous
             | things with limited knowledge, and of course in the early
             | days, there was plenty of above-ground range testing; is
             | that something you want included as well?
             | 
             | If my information is correct, I believe that nearly all
             | nuclear testing these days is 100% simulation on
             | supercomputers, which is as safe as safe can be, as long as
             | you can trust supercomputer simulations to render the
             | correct answer to those trusting researchers.
        
               | Clubber wrote:
               | Not only that, the US is missing 6 nuclear weapons.
               | 
               | https://nationalinterest.org/blog/reboot/us-military-
               | missing...
               | 
               | To add to your point, regardless of safeguards and
               | protocols, accidents happen.
        
           | revelio wrote:
           | That seems reasonable, yes.
        
         | Biorealism wrote:
         | Yes, the whole virus hunting grift that Peter Daszak's
         | EcoHealth Alliance and PREDICT tout has been exposed as
         | ineffective. Now they are doubling down with further funding
         | and blanket denials that it could have come from a lab
         | accident. They never mention the nearest relatives to SARS-
         | CoV-2 are found in Yunnan and Laos. And that happens to be
         | where WIV sampled.
        
         | justanotheratom wrote:
         | "nothing was gained"
         | 
         | I see the irony (gain of function)
        
           | lapama wrote:
           | Gain of risk
        
         | th0ma5 wrote:
         | [flagged]
        
           | xcv123 wrote:
           | SARS-CoV leaked from a Chinese lab in 2004, and it is
           | probable that SARS-CoV-2 leaked from Wuhan in 2019.
           | 
           | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC416634/
        
             | th0ma5 wrote:
             | That article says the first thing you said but not the
             | second.
        
               | xcv123 wrote:
               | [flagged]
        
               | th0ma5 wrote:
               | [flagged]
        
               | xcv123 wrote:
               | [flagged]
        
               | th0ma5 wrote:
               | [flagged]
        
               | xcv123 wrote:
               | No it is not an ad hominem attack to say that your
               | argument is childish and stupid. You're not even having a
               | debate. You're just spamming the forum with drivel.
        
               | th0ma5 wrote:
               | I am trying to say that either it leaked or it didn't,
               | but that we'll never know, but that it doesn't matter
               | anyway.
        
               | prepend wrote:
               | We will know, eventually, hopefully. I think it really
               | matters. To better prevent future pandemics and to
               | establish frameworks for restitution. And it definitely
               | matters for future economic reparations.
               | 
               | If negligence is the cause of a multi-million death,
               | multi-trillion dollar response it needs to be corrected
               | to prevent future similar errors.
        
               | totallychinese wrote:
               | The linked article is from 2004. It clearly says nothing
               | re: point 2.
        
               | [deleted]
        
               | xcv123 wrote:
               | So what? You missed the point or are pretending to ignore
               | it. Another CCP troll.
        
           | akomtu wrote:
           | HN should limit the rate of comments per user per post. This
           | user is seriously worked up to mute this discussion and spams
           | in every comment thread. Edit: this user wrote 26 out of 88
           | comments here.
        
             | yorwba wrote:
             | HN already has a rate limit. You get the message "You're
             | posting too fast" when you exceed it. Though I think it's
             | also tied to karma and might not trigger when all those
             | comments get upvoted. And if you try to downvote them all,
             | you'll run into the protections against mass-downvoting.
             | Tuning the feedback loops to encourage good discussions
             | while damping flamewars is a difficult problem.
        
               | hombre_fatal wrote:
               | Once you have some post history, I'm pretty sure the
               | harsh rate limit, the one that would stop someone from
               | posting in every comment thread, is only triggered
               | manually by the mods if you're a prick (personal
               | experience).
               | 
               | The basic new account rate limit and the one you get from
               | getting downvote quickly are too weak to stop what they
               | are complaining about.
        
             | th0ma5 wrote:
             | And they should ban throwaway accounts too which you can
             | also see spreading more conjecture.
        
       | arisAlexis wrote:
       | I remember still when it was considered a conspiracy theory and
       | we got downvoted here and banned on reddit for even implying the
       | possibility. Unfortunately something similar is happening with AI
       | x-risk right now.
        
         | th0ma5 wrote:
         | [flagged]
        
         | jansan wrote:
         | Same with pointing out at the first studies that indicated that
         | the virus was airborne. I got downvoted to oblivion here for
         | posting a link to the study.
        
           | asynchronous wrote:
           | Despite that becoming at least partially true years later
           | when the CDC admitted it.
        
           | [deleted]
        
           | th0ma5 wrote:
           | [flagged]
        
         | oneshtein wrote:
         | Accusation without evidence is witch-hunting.
         | 
         | We still have no strong evidence for lab leak from BSL4 lab in
         | Wuhan, while we have some evidence (two early strains of SARS-
         | CoV-2: A, then B; B was in Wuhan in December; where and when
         | was parent of A and B?) that suggests start of epidemic outside
         | of China in mid-September 2019. Russians start to delete videos
         | about blast at their BSL4 lab "Vector" in Novosibirsk on Sep 16
         | 2019[0], which suggests that this information may cause harm
         | for them.
         | 
         | So, "Lab leak" theory may be right, while "lab leak from BSL4
         | lab in Wuhan" theory may be wrong.
         | 
         | [0]:
         | https://web.archive.org/web/20200407175030/https://www.youtu...
        
           | arisAlexis wrote:
           | We are playing with words. Accusation vs possibility vs open
           | to options vs etc. The problem is that it was called which
           | hunting anything that was not natural origin.
        
         | asynchronous wrote:
         | I won't forget no matter how many times they try to make me.
         | 
         | What happened several years ago was a clown show of the highest
         | order.
        
       | ricksunny wrote:
       | The sourcing and style will raise eyebrows. The revelations are
       | valuable, and clear enough to be verifiable through one channel
       | or another.
       | 
       | And given that we are at 7 days remaining before the 90-day WIV
       | intel disclosure deadline, old journo hands expect that info
       | leaks are more likely to happen.
       | 
       | https://twitter.com/mbalter/status/1667668700885819395?s=20
        
         | th0ma5 wrote:
         | [flagged]
        
         | [deleted]
        
       | turtleyacht wrote:
       | From the article,
       | 
       | > _You infect the mice, wait a week or so, and then recover the
       | virus from the sickest mice. Then you repeat._
       | 
       | From _The Hardware Hacker_ (2017) by  "bunnie" Huang:
       | 
       | > _So, a single base-pair change--simply flipping two bits--might
       | be all you 'd need to turn the H1N1 swine flu virus into a
       | deadlier variant... for just over $1,000._
       | 
       | > _[Influenza] packs a deadly punch in 3.2 KB... and we [still]
       | haven 't eradicated it. Could influenza do hacks like the one I
       | just described on its own already? The short answer is yes._
       | 
       | > _... on average, every copy of an influenza virus has one
       | random mutation._
       | 
       | > _[H1N1] was probably just a couple of mutations away from being
       | a bigger health problem._
       | 
       | > _... novel H1N1 acquired a mix of RNA snippets that gave it
       | high transmission rates and made it something humans weren 't
       | innately immune to. That's the perfect storm for a pandemic._
       | 
       | > _If there were a computer analogy to this RNA-shuffling model,
       | [random relinking of virus "files" at runtime]... would also
       | proliferate a diverse set of viruses in the wild..._
       | 
       | Fortunately for swine flu at least,
       | 
       | > _... a patient [had] a novel antibody... to confer immunity to
       | all 16 subtypes of influenza A._
       | 
       | Against Covid, research by Dr. Weismann and Dr. Kariko led to the
       | development of the mRNA vaccine:
       | 
       | https://www.bu.edu/articles/2021/how-drew-weissman-and-katal...
        
       | bredren wrote:
       | > Witnesses are said to have told the US investigation that Zhou
       | fell from the roof of the Wuhan institute, although this has not
       | been verified.
       | 
       | This guy who published a suspiciously early patent on a covid 19
       | vaccine fell off a roof three months later?
       | 
       | That's kind of buried in the article a bit but was this claim
       | been made anywhere else?
       | 
       | Also, the section on activity at the lab at the time of the
       | outbreak does not mention analysis of private app data.
       | 
       | IIRC, one of the early discredited reports suggesting lab origin
       | had relied, in-part, on commercially available app data. The kind
       | of adware built into "free" apps that violate user privacy.
       | 
       | This data supposedly showed clear activity supporting a temporary
       | shutdown of the Wuhan lab.
       | 
       | This information always seemed the easiest to latch on to. Not to
       | prove origin but at least offer an important fact for a pattern.
       | 
       | US military bases have had their locations and perimeters out on
       | the public web thanks to fitness apps.
       | 
       | Was the WIV associated app data not real? If it was, why isn't it
       | included in this article?
       | 
       | The article relates a study "by academics at Wuhan University
       | located the hotspots in Wuhan where people were reporting on
       | social media that they needed treatment for Covid."
       | 
       | How would this be more compelling than raw app data showing
       | movement of employees or security workers in and around WIV?
        
         | th0ma5 wrote:
         | [flagged]
        
           | [deleted]
        
         | ricksunny wrote:
         | >This guy who published a suspiciously early patent on a covid
         | 19 vaccine fell off a roof three months later?
         | 
         | >That's kind of buried in the article a bit but was this claim
         | been made anywhere else?
         | 
         | As someone who's followed the debate closely, (with the
         | submission history to demostrate that), I can tell you that the
         | parent article is the first time the assertion that Zhou fell
         | from the roof has ever been made in tbe public-facing side of
         | the debate.
        
       | verisimi wrote:
       | I've never seen a virus in my life! So how did they make one in
       | Wuhan?
       | 
       | I'm pretty convinced that media departments are real though!
        
       | christkv wrote:
       | Nobody will ever want the truth because if it did come from the
       | lab it implicates the Chinese government as well as the US
       | government given that the US funded research in Wuhan through the
       | EcoHealth Alliance to get around the ban on Gain of Function
       | research in the US.
        
       | QuantumGood wrote:
       | Summary: The Case for a Lab Leak, from a Sunday Times
       | investigation (C):
       | 
       | (1) The institute sought funding to research something (A), which
       | Covid could result from. (Said later they didn't do the planned
       | research), but funding from the military appears to have been
       | given.
       | 
       | (1.1) They planned to do the research at the time and approximate
       | place where Covid later emerged.
       | 
       | (2) Protections at the lab were not what they should have been.
       | 
       | (2.2) Lab scientists had previously created a highly infectious
       | super-coronavirus (not Covid-19) with a very high kill-rate that
       | in all probability would never have emerged in nature. Their
       | tests showed no known (at that time) way to effectively limit its
       | spread were it to leak.
       | 
       | (3) NO animal testing was reported in a wide vicinity around the
       | the Hunan market. Samples of Covid found in the market were NOT
       | from animals (B).
       | 
       | (3.1) The market is a busy place in the center of the city where
       | the virus would almost certainly be once it's spreading between
       | people.
       | 
       | (3.2) There is some evidence that researchers from the lab were
       | hospitalized with Covid-like symptoms in November 2019, and one
       | of their relatives died.
       | 
       | (4) The biggest hotspot of people reporting illness via social
       | media (in the month before the province was locked down on
       | January 23) was at the institute, though this was partly hidden
       | in initial reports. The first case in Britain was recorded a week
       | later.
       | 
       | (A) The Wuhan Institute of Virology sought funding for inserting
       | a furin cleavage site. The institute is a 40-minute drive from
       | the Huanan Seafood market.
       | 
       | (B) In January 2020, Chinese officials cleared the market without
       | testing live animals. The presence of SARS-CoV-2 was from
       | environmental samples (animal cage, hair-and-feather-removal
       | machine, etc). Covid-susceptible animals were present but NOT
       | tested. The study of those samples was criticized for not having
       | any animal samples.
       | 
       | (C) Information above drawn from archive.ph/L2BSO and comments
       | and links here in this HN thread.
       | 
       | ---------------------------
       | 
       | "The Sunday Times has reviewed hundreds of documents, including
       | previously confidential reports, internal memos, scientific
       | papers and email correspondence that has been obtained through
       | sources or by freedom of information campaigners in the three
       | years since the pandemic started. We also interviewed the US
       | State Department investigators -- including experts on China,
       | emerging pandemic threats, and biowarfare -- who conducted the
       | first significant US inquiry into the origins of the Covid-19
       | outbreak. The closest relatives to Covid known were too far from
       | Covid to have developed into Covid on their own in a short time.
       | So bringing in dangerous viruses and accidentally leaking them is
       | an unlikely cause." Earlier reporting by the Times:
       | archive.ph/Mkqox
       | 
       | Genome statistical estimates indicate the "relatives" are decades
       | away from Covid. In February 2020, RaTG13 was identified as the
       | closest known relative of SARS-CoV-2, the virus that causes
       | COVID-19, sharing 96.1% nucleotide identity. It was found near
       | the town of Tongguan in Mojiang county in Yunnan, China. However,
       | in 2022, scientists found three closer matches 530 km south, in
       | Feuang, Laos, designated as BANAL-52 (96.8% identity), BANAL-103
       | and BANAL-236. However, it is alleged that one virus at the Wuhan
       | institute was an even closer match to Covid-19 than RaTG13. Note
       | that bat viruses had never been known to harm humans.
       | Intermediate animals apparently catching a virus from bats and
       | passing it to humans had been known to happen.
       | 
       | In the lead-up to the pandemic, the Wuhan institute frequently
       | experimented on coronaviruses alongside the Academy of Military
       | Medical Sciences, a research arm of the People's Liberation Army
       | (PLA). In published papers, military scientists are listed as
       | working for the Beijing Institute of Microbiology and
       | Epidemiology, which is the military academy's base.
        
         | QuantumGood wrote:
         | Overly-speculative information supporting a lab leak:
         | 
         | "Scientists with close relationships with the Wuhan Institute
         | of Virology said it was their belief that there was vaccine
         | research going on in the fall of 2019, pertinent to Covid-19
         | vaccination"
         | 
         | "Investigators believe the Chinese military had taken an
         | interest in developing a vaccine for the viruses so they could
         | be used as potential bioweapons. If a country could inoculate
         | its population against its own secret virus, it might have a
         | weapon to shift the balance of world power."
         | 
         | In May 2020, one of the key researchers died from unconfirmed
         | causes at age 54.
         | 
         | "On November 19, the safety director of the Chinese Academy of
         | Sciences made a visit, according to the institute's website. He
         | addressed a meeting of the institute's leadership with
         | important 'oral and written' instructions from China's
         | president, Xi Jinping, regarding 'a complex and grave
         | situation'. "
         | 
         | "In the first months of the pandemic, many Chinese scientists
         | visited bat caves in Yunnan to see whether they could find a
         | place where Covid may have originated.... 7 scientists
         | attempting to visit were told the Moijang mine (known source of
         | at least one Covid-like coronavirus) was closed, so they
         | sampled bats in another abandoned copper mine nearby. On the
         | first day of their work, police arrived, seized the samples and
         | took them to their station, where they were interrogated and
         | detained for 48 hours. Officers also went to their hotel and
         | seized the samples they had collected from elsewhere. Even
         | though the team had approval to test in the area, they were
         | ordered to leave. Searching for bat viruses was banned in
         | Yunnan in early 2021"
        
       | lifelong wrote:
       | https://www.nih.gov/about-nih/who-we-are/nih-director/statem...
       | 
       | Also posted on HN 2 years ago with ... zero comments"
       | 
       | https://hn.algolia.com/?q=https%3A%2F%2Fwww.nih.gov%2Fabout-...
        
         | th0ma5 wrote:
         | [flagged]
        
       | aaplok wrote:
       | > The investigators believe the Chinese military had taken an
       | interest in developing a vaccine for the viruses so they could be
       | used as potential bioweapons. If a country could inoculate its
       | population against its own secret virus, it might have a weapon
       | to shift the balance of world power.
       | 
       | This part doesn't make sense to me. Coronavirus is known to
       | mutate constantly and rapidly. Having a vaccine against a strand
       | might provide a temporary advantage, but that advantage would
       | subside quickly. Coronaviruses would make poor bioweapons
       | considering how impossible it would be to control them.
       | 
       | If an army wants to develop a virus-based weapon wouldn't there
       | be better viruses to base it from than COVIDs?
        
         | revelio wrote:
         | Viruses mutate because they are constantly exposed to the
         | immune systems of people who were already previously infected,
         | so they have to mutate in order to dodge prior natural
         | immunity. That isn't a concern if most people who get infected
         | die.
         | 
         | Moreover, the first SARS-CoV-2 variant took a long time to
         | start mutating and even then it was only minor mutations. If
         | you release an extremely infectious very deadly virus and you
         | have a vaccine for it, then at that moment it's a Deus Ex
         | scenario and whoever can manufacture the vaccine can take over
         | the world because your enemies are now collapsing and will do
         | anything to obtain the vaccine including giving up their own
         | autonomy. Guess that's the theory, at least.
         | 
         | As to why SARS-CoV-2: because it's airborne and can spread long
         | distances via gas-like clouds (which is why lockdowns, masks,
         | wiping surfaces etc didn't work). You can't really get better
         | if you want to very rapidly infect a whole country.
        
         | 2devnull wrote:
         | Governments investigate imperfect weapons. Consider LSD.
        
           | th0ma5 wrote:
           | [flagged]
        
       | johnea wrote:
       | Too bad the article is from a UK equivalent to the National
       | Inquirer...
        
         | Biorealism wrote:
         | Nonsense. The Times is one of the main UK publications along
         | with the Guardian and The Telegraph.
        
       | frank_bb wrote:
       | [dead]
        
       | highfrequency wrote:
       | The idea that Covid19 was accidentally leaked from the Wuhan lab
       | has moved from conspiracy theory to mainstream view of many US
       | gov't agencies with the most classified information available to
       | them.
       | 
       | John Ratcliffe, former Director of National Intelligence: "My
       | informed assessment, as a person with as much or more access than
       | anyone to our government's intelligence during the initial year
       | of the virus outbreak and pandemic onset, has been and continues
       | to be that a lab leak is the only explanation credibly supported
       | by our intelligence, by science and by common sense. From a view
       | inside the IC, if our intelligence and evidence supporting a lab
       | leak theory was placed side-by-side with our intelligence and
       | evidence pointing to a naturally occurring "spillover" theory,
       | the lab leak side of the ledger would be long and overwhelming
       | while the "spillover" side would be nearly empty."
       | 
       | https://oversight.house.gov/release/covid-origins-part-2-hea...
       | 
       | The Furin cleavage site is one of the more compelling pieces of
       | evidence. 1.5 years before the outbreak, the Wuhan Institute
       | applied for a grant from Darpa to explore _mutating coronaviruses
       | to make them more infectious to humans_ , particularly through
       | the addition of a Furin cleavage site. (Darpa declined to fund
       | the research).
       | 
       | The Covid-19 virus is notable for being the only coronavirus to
       | have a Furin cleavage site. Not only that, but it appears to be
       | basically a _perfect mutation_ that specifically modifies the 12
       | nucleotides necessary for the Furin site, without modifying other
       | base pairs.
       | 
       | Here's a quote from email excerpt included in the recent Congress
       | hearing:
       | 
       | "Before I left the office for the ball, I aligned nCoV with the
       | 96% bat CoV sequenced at WIV. Except for the RBD the S proteins
       | are essentially identical at the amino acid level - well all but
       | the perfect insertion of 12 nucleotides that adds the furin site.
       | S2 is over its whole length essentially identical. I really can't
       | think of a plausible natural scenario where you get from the bat
       | virus or one very similar to it to nCoV where you insert exactly
       | 4 amino acids 12 nucleotide that all have to be added at the
       | exact same time to gain this function - that and you don't change
       | any other amino acid in S2? I just can't figure out how this gets
       | accomplished in nature. Do the alignment of the spikes at the
       | amino acid level - its stunning. Of course, in the lab it would
       | be easy to generate the perfect 12 base insert that you wanted."
       | 
       | https://oversight.house.gov/wp-content/uploads/2022/01/Lette...
        
         | ricksunny wrote:
         | (That latter quote is Tulane virologist Robert Garry. Like his
         | peers he would go on to downplay the LL hyp in the wake of the
         | Feb 1st conference call organized by then-head of Wellcome
         | Trust Jeremy Farrar.)
        
           | [deleted]
        
       | marsven_422 wrote:
       | [dead]
        
       | smohare wrote:
       | [dead]
        
       | laserbeam wrote:
       | This is the kind of writing you need to properly discuss the lab
       | leak hypothesis. It's not perfect, there are no good links to
       | sources which suggests a lot of it is made up.
       | 
       | However, this kind of writing should only happen after years or
       | months of investigation. You can't do the lab leak panic 2 days
       | into the pandemic. You can't even really do it half way through
       | the pandemic.
       | 
       | I'm glad such investigations are being caried out. I only wish
       | links to whatever is declassified from the investigations to be
       | made public for such publications. Authors need to prove their
       | research effort when it comes to such news.
        
         | oneshtein wrote:
         | > It's not perfect, there are no good links to sources which
         | suggests a lot of it is made up.
         | 
         | Existing evidence points to another lab: BSL4 lab "Vector" in
         | Novosibirsk, Russia. They worked on their "Sputnik" vaccine
         | when blast in laboratory on September 16 2019[2] caused chain
         | of incidents: broken windows, unprotected soldiers break in,
         | which checked rooms for signs of fire, equipment stolen from
         | BSL4 lab by those soldiers[0][1], epidemic of unknown virus in
         | Siberia, Military World Games in Wuhan[3].
         | 
         | [0]: https://www.youtube.com/watch?v=_w7SAeNcXA8
         | 
         | [1]:
         | https://web.archive.org/web/20200407175030/https://www.youtu...
         | 
         | [2]: https://edition.cnn.com/2019/09/17/health/russia-lab-
         | explosi...
         | 
         | [3]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813667/
        
           | th0ma5 wrote:
           | [flagged]
        
         | th0ma5 wrote:
         | [flagged]
        
           | laserbeam wrote:
           | I mean... There are references to names, institutions
           | carrying out certain investigations, references to
           | experiments done prior to the pandemic. Yeah, some of it can
           | be congecture. Which is why I really want the direct links to
           | data, not just mentions to the events.
           | 
           | I'm not sure it's a conspiracy theory. I think it's a
           | legitimate thing to investigate by an international entity
           | like the UN (not the US), and the outcome (if it turns out to
           | be true) should likely be some proportional sanction/payments
           | by China.
        
             | th0ma5 wrote:
             | Sure, but the article is implying there something new that
             | actually would have some kind of bearing or meaning.
        
               | oneshtein wrote:
               | Russians started to clean up evidence, which points to
               | BSL4 lab "Vector".
               | 
               | IMHO, this article is a part of their disinformation
               | campaign. The name of their vaccine "Sputnik V" (Follower
               | 5) suggests that there was "Something","Sputnik I",
               | "Sputnik II", "Sputnik III", "Sputnik IV" before "Sputnik
               | V".
               | 
               | It's impossible for Russians to produce 5 vaccines in row
               | in such short span of time, just few months, which took
               | billions of dollars and year of time for western
               | companies.
               | 
               | IMHO, Russians started developing of their vaccine since
               | SARS-CoV-1 outbreak in 2003.
        
               | alpaca128 wrote:
               | > The name of their vaccine "Sputnik V" (Follower 5)
               | suggests that there was "Something"
               | 
               | No, a regime known for throwing people out of windows if
               | they say one word too much isn't so dumb to hide a hint
               | like that in plain sight.
        
               | dbtc wrote:
               | Or they had 12 teams working in parallel, competition
               | style, and team 5 won.
        
               | th0ma5 wrote:
               | Sounds ominous but also completely devoid of useful
               | explanations, blame, or actionable knowledge.
        
               | throwbadubadu wrote:
               | It was named after the satellite Sputnik 1 and the V is
               | not a roman five but stands for victory, multiple sources
               | consistently claim? Sounds reasonable that this was just
               | PR propaganda to connect to prior great successes in
               | Russia..
               | 
               | (Even without that knowledge I'd find this theory a bit
               | far fetched, there could be many other good reasons for
               | that naming).
        
               | oneshtein wrote:
               | "Sputnik" is a regular Russian word, which means "one who
               | travels together with another" (s-put-nik s-=with,
               | -put-=travel/road/journey, -nik=somebody).
               | 
               | Victory is Latin word. Russian word for victory is
               | "pobeda" (po-beda po-=after, -beda=bad/something very
               | different from good, "after bad times").
               | 
               | It looks like 5 in the name is from Ad5 component of
               | vaccine.
               | 
               | Moreover, the vaccine produced by Vector is called
               | EpiVacCorona[0].
               | 
               | [0]: https://en.wikipedia.org/wiki/EpiVacCorona
        
         | asynchronous wrote:
         | Oh? But we can publish the Lancet document, asserting with
         | ridiculous grandeur that it was NOT a lab leak, a mere 3 months
         | into the pandemic?
         | 
         | The same document that turned out to have been paid for and
         | produced despite having numerous errors and lies, simply to
         | turn a narrative?
         | 
         | Let's hold everyone to the same standard shall we?
        
       | pinewurst wrote:
       | https://archive.ph/L2BSO
        
       | terramex wrote:
       | non-paywall link: https://archive.ph/22j9L
        
         | kazinator wrote:
         | Or: turn on Firefox reader mode, click refresh.
        
           | _nalply wrote:
           | Didn't work for me even after refresh, probably you and me we
           | were disposed differently. Whatever, using archive.
        
       | Xen9 wrote:
       | I personally believe in Rootlclaim's Bayesian analysis
       | (https://www.rootclaim.com/analysis/What-is-the-source-of-COV...)
       | which states that "the virus was developed during gain-of-
       | function research and was released by accident (89% probability)"
       | 
       | This is consistent with David Martin's speech in Europe:
       | https://twitter.com/KimDotcom/status/1661698114917646336
       | 
       | I haven't checked the "publicly available references" but many
       | who inssist on a natural cause read about the bat theory in the
       | first few months and then haven't updated & aren't willing to
       | update their models.
       | 
       | If you find any faults that can really change the results in the
       | analysis Rootclaim made, I would be interested.
        
         | jmull wrote:
         | > If you find any faults that can really change the results in
         | the analysis Rootclaim made, I would be interested.
         | 
         | This is an interesting way to analyze the problem but the set
         | of criteria and weights applied at each step are made up.
         | 
         | The flaw is that you can use this form of analysis to reach any
         | conclusion you want.
         | 
         | For example, the "Already well adapted" section -- a "2x"
         | factor for lab escape. We wouldn't even be thinking about this
         | virus if it wasn't well adapted to spread among humans. So
         | that's baked into the ground and isn't a factor of anything.
         | 
         | Then take "Furin cleavage" -- a whopping 8x factor for lab
         | escape relative to zoonotic. This is the same thing as already
         | well adapted, so now we've got a combined 16x for something
         | that should be 1x.
         | 
         | The weight for "Chimera" -- another whopping 8x for lab escape
         | relative to zoonotic -- seems really high for something that is
         | found both in nature and in labs that merely "seems less likely
         | to combine in nature". We should probably be arguing about
         | whether this is 1.5x or 2x.
         | 
         | The real conclusion is we don't know. The Chinese probably do,
         | but it would be a very closely guarded secret and obviously
         | they would never admit to a lab leak. I lot of people hate
         | ambiguity and want an answer, but in this case it doesn't seem
         | that we are going to get one.
        
           | throwaway290 wrote:
           | > it would be a very closely guarded secret and obviously
           | they would never admit to a lab leak
           | 
           | A complicating factor is that some (much?) of the funding
           | came from the US. Which means admitting to a leak is against
           | the interest of not only Chinese but also the US government
           | which would have a hell of a time explaining to taxpayers how
           | pandemic was engineered on their money doing research banned
           | in the US. (Though I don't think US government played any
           | part in resisting the research tbh, CCP probably did all that
           | at their accord.)
           | 
           | I think all in all we shouldn't give up, and even if we don't
           | find the actual data I don't see the world can be okay
           | without big fat follow up over not some lab making a mistake
           | (humans make those) but all obstruction of research into the
           | origins of what could have been an extinction level event if
           | the virus was a bit better engineered, whether it came from
           | Chinese communist party or US scientists scared for grant
           | money.
        
             | Xen9 wrote:
             | Idea:
             | 
             | Community / site for collective truth-seeking. Possibly
             | integrated with Metaculus.
             | 
             | One can submit new pieces of evidene which would be
             | commentable (in threads), votable, and programmable (to
             | toggle / affect of other submitted evidence threads).
             | 
             | Users can adjust the weights, vote on them (to generate a
             | certain consensus / prediction), and even toggle of pieces
             | of evidence manually.
             | 
             | The site automatically gives the probabilities for
             | different scearions. I don't have an instant vision on how
             | "all" possible scenarios would be chosen.
        
               | ricksunny wrote:
               | Neat idea, if you can keep it from getting gamed.
               | 
               | It sounds a little like this RootClaim (I just learned
               | about here) https://www.rootclaim.com/how-rootclaim-works
               | but with the users adjusting & voting on weights?
               | 
               | This is a strawman demonstrator I'm wware of w r t
               | origins probability surveying & calculation.
               | https://www.getguesstimate.com/models/18631
               | 
               | It's intended for any one user to evaluate ther priors
               | and see how they stack up all together. like that your
               | idea woukd aggregate & have comments & a voting
               | mechanism,
        
             | th0ma5 wrote:
             | [flagged]
        
         | th0ma5 wrote:
         | [flagged]
        
           | cubefox wrote:
           | > But why do you think it is important to prove a lab leak?
           | 
           | Perhaps because it is _slightly_ interesting what caused the
           | worst pandemic since the Spanish flu? Because millions of
           | people died? Because knowing the cause could _perhaps_
           | prevent something similar happen again? Perhaps prevent
           | millions of deaths?
           | 
           | I'm astonished by this question.
        
             | th0ma5 wrote:
             | Sure but what if it just isn't knowable?
        
               | cubefox wrote:
               | Historians are still finding out things that happened
               | hundreds of years ago. Do you really think the origins of
               | Covid are lost in the mists of time?
        
           | nepthar wrote:
           | I'd ask the inverse question to you - why would you think it
           | is unimportant to determine the cause of things that happen
           | in the world?
        
             | th0ma5 wrote:
             | I don't
        
           | peteradio wrote:
           | You can't in one comment complain about investigations using
           | "made up priors" and then in another complain that we are
           | investigating something which could actually provide a
           | measured prior.
        
             | th0ma5 wrote:
             | Could! But hasn't... Otherwise yes good points. I don't see
             | how they measure all the rest of the probabilities and the
             | article seems to be designed to settle arguments among dumb
             | people or something? It is not even remotely scientific.
        
               | peteradio wrote:
               | > I think the whole premise that arbitrary priors and
               | dreaming up probabilities and then washing them all
               | together isn't applicable to a unicorn type event.
               | 
               | Now I believe you said it. Maybe not exactly "made up
               | priors" so pardon me for the misquote. But I'd be
               | interested to see if you can make a distinction.
        
         | some_random wrote:
         | I remember when this was first released, everyone clowned on it
         | (including me) for a few reasons the biggest one being the
         | classic problem with these sorts of Bayesian analyses. That
         | being, the individual weights per piece of evidence are pretty
         | arbitrary.
         | 
         | Meanwhile, it seems quite likely to have produced the correct
         | results so -\\_(tsu)_/-
        
           | th0ma5 wrote:
           | Lol. Not how facts work! I mean, people on here claiming I'm
           | a China troll and hell they probably did do it, but we'll
           | never be able to prove it either way, and more importantly it
           | doesn't matter for us to make changes and to hold China
           | accountable for all kinds of things.
        
         | tsss wrote:
         | Regardless of the merits of the lab leak theory, David Martin
         | is a NWO-level conspiracy theorist who thinks that Pfizer
         | colluded with Bill Gates and the US government and infected the
         | whole world with a virus, on purpose, just to push their
         | vaccine on people. The conference that you allude to has
         | nothing to do with the European union. It was organized by two
         | equally nutty far right EU-politicians in one of the
         | parliament's public rooms to give a false legitimacy to their
         | "conference" and mislead people to think that it was an
         | official event.
        
           | Xen9 wrote:
           | He seems to have worked on projects that are questionable in
           | importance / authenticity but likely to have made profits.
           | Claiming that the video filmed in EU was from an "official EU
           | conference" would be uniformed or mispresenting him, indeed.
           | But I think it's worth watching; Phizer's patent application
           | and other claims he made are interesting and haven't been
           | repeated elsewhere (from my perspective).
        
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