[HN Gopher] Clinical trial of mRNA universal influenza vaccine c...
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Clinical trial of mRNA universal influenza vaccine candidate begins
Author : geox
Score : 60 points
Date : 2023-05-15 20:42 UTC (2 hours ago)
(HTM) web link (www.nih.gov)
(TXT) w3m dump (www.nih.gov)
| smallmouth wrote:
| [flagged]
| maxerickson wrote:
| Yeah, that's literally the point of the study, recruiting a
| small group of people to go first and see how it goes.
| JohnFen wrote:
| I was hit hard by my first covid booster, and every traditional
| flu shot I've ever had has made me as sick as I've been from the
| flu itself (which is why I don't get flu shots anymore).
|
| I wonder if an mRNA flu shot would be twice as bad, or better, in
| terms of impact on my health?
| weaksauce wrote:
| there's a lot of people that get a bad cold and think it's the
| flu. the actual flu can be insanely debilitating. (some get a
| lighter infectious dose and they escape a real bad case though)
| valianteffort wrote:
| I got covid in early 2021, and got the J&J shot at the end of
| the year. In both cases I had a fever, except the J&J lasted
| two days vs actual covid that lasted one. I have not been sick
| with covid since then.
|
| I have never had a flu shot, and also never had the flu in over
| thirty years. I just don't see why I should get myself sick to
| risk not getting sick(er)? Anytime I mention this people call
| me antivax.
|
| I was never skeptical about taking shots until the way the
| government handled covid. There is no chance I will take
| something that hasn't been thoroughly tested and proven to
| actually work the way our standard immunization schedule does.
| Someone1234 wrote:
| > which is why I don't get flu shots anymore
|
| You could try one of the non-egg based vaccines and see if that
| helps with your side effects for example Flublok
| Quadrivalent[0]
|
| [0] https://www.cdc.gov/flu/prevent/qa_flublok-vaccine.htm
| JohnFen wrote:
| Yeah, I might. Friends have suggested such alternatives to me
| as well. I'm not opposed, but I also am not highly motivated
| to try, because I haven't actually come down with the flu
| since my children grew up and moved out a couple of decades
| ago.
| theGnuMe wrote:
| That's why the do these studies. But more seriously ask your
| doctor.
| [deleted]
| JoeAltmaier wrote:
| It's funny, flu shots can make you feel sick. That's your body
| reacting and your immune system adjusting.
|
| But compared to _actually getting the flu_ , you get to skip
| the part where the disease eats at your organs and rips through
| your body destroying things.
|
| So yes, you may feel sick after a flu shot. But I consider the
| alternative makes it worthwhile.
| Herring wrote:
| [flagged]
| pil4rin wrote:
| "A universal influenza vaccine would be a major public health
| achievement and could eliminate the need for both annual
| development of seasonal influenza vaccines, as well as the need
| for patients to get a flu shot each year,"
|
| So, one shot and no more flu? ever?
| dannyw wrote:
| *Until the flu variants mutate to be more vaccine resistant.
| CyberDildonics wrote:
| I'm pretty sure that's already the problem.
| jewayne wrote:
| Viruses don't "resist" vaccines, because vaccines don't act
| directly against viruses. We're not talking about antibiotics
| here.
| francisduvivier wrote:
| Well that's how they make it sound, but they actually just said
| not annually.
|
| But it doesn't make a lot of sense to me since influenza will
| be mutating to escape the immune response.
| weaksauce wrote:
| > But it doesn't make a lot of sense to me since influenza
| will be mutating to escape the immune response.
|
| unless there is sufficient number of people that take it and
| it works well enough to eradicate it like say polio was.
| Someone1234 wrote:
| Unfortunately the only real answer to that is: We don't have
| the data on either question yet.
|
| Hemagglutinin has 18 subtypes, this style of vaccines are
| targeting them all, but we don't have data on how complete
| coverage will be (and or how common a mutation exists that
| could allow partial of complete circumvention).
|
| We also don't have data on how long before the immune system
| needs to be retrained (aka re-vaccinated).
|
| This isn't to foo-foo this vaccine; this legitimately could
| create a "universal" vaccine that could last years with only
| some minor reformulation every so often to catch new sub-types
| of HA.
|
| TL;DR: This thing could be great. We'll need more data to know.
| jewayne wrote:
| No. The goal is one shot that doesn't have to change from year
| to year. We already know that the flu doesn't have a long
| enough incubation period for humans to gain lifetime immunity.
| Which means that even if this vaccine works and is effective
| against all flu viruses past, present, and future, it will
| probably still be a good idea to get a universal flu booster
| every year.
| amluto wrote:
| I'm not convinced that mRNA vaccines as they currently exist
| are well suited for repeated boosting against the same virus.
| See, for example:
|
| https://www.science.org/doi/10.1126/sciimmunol.adg7327
|
| And also the quite disappointing efficacy that the CDC
| reports for repeated Covid boosters.
| viraptor wrote:
| "no annual" doesn't mean "just one". Lots of vaccines wear off
| after a few years and need a booster. (There's lots of people
| who don't know about it / don't get reminded and never get
| them)
| ortusdux wrote:
| I'm not a doctor/immunologist, but as I understand it the flu
| shot targets 4-5 different strains. Each year they have to ID
| what they believe will be this season's leading strains, and
| then blend together the mix ahead of time. This takes a lot of
| work, and sometimes they get it wrong and 8th most common
| strain surges and it's a scramble to save lives.
|
| So I think the promise of a 'universal' vaccine means one that
| would target all/most strains.
| ptdn wrote:
| It does mention a hope for long-term durable immune response,
| but the point about being able to pre-emptively roll out a
| universal vaccine is probably more important. This would lower
| the total rate of infections by a lot and allow people to
| reliably get a useful vaccine without waiting to see which
| strains are dominant that year. (Also, an immune response
| doesn't mean complete immunity. mRNA Covid vaccines don't
| prevent you from getting Covid. It lowers the severity and
| spread.)
| mc32 wrote:
| That would be nice... recent history would tell us those claims
| are wildly optimistic.
| viraptor wrote:
| Good to keep in mind, but also those are slightly different
| cases. One is a low number of very recent strains that
| mutated quickly, the other one is a large number of
| established strains we've been researching for ages.
| maxerickson wrote:
| It's easy to nay say, the COVID mRNA vaccines were great,
| it's nuts that people hold them to some imagined standard.
|
| Like a single dose is less effective than multiple doses,
| especially if later doses are targeted at the circulating
| virus, but the first shot has an enormous protective effect,
| alerting the immune system to the type of virus.
| adastra22 wrote:
| Only if you vaccinate all the wild animals that carry it too.
| m3kw9 wrote:
| [flagged]
| ortusdux wrote:
| I wonder if this would be a candidate for nasal delivery?
| CyberDildonics wrote:
| Why would it be and why would that be important if it's
| something you need once every few years?
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