[HN Gopher] Do adenovirus-vector Covid-19 vaccines have benefici...
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Do adenovirus-vector Covid-19 vaccines have beneficial non-specific
effects?
Author : luu
Score : 13 points
Date : 2023-05-10 20:01 UTC (3 hours ago)
(HTM) web link (www.cell.com)
(TXT) w3m dump (www.cell.com)
| rossdavidh wrote:
| It would seem like, if we assume roughly equal health for
| adenovirus-vaccinated vs. mRNA-vaccinated prior to vaccination,
| we should be able to find out if this is a real affect or not by
| now. But, it would take some $$$ to do the research to find out.
| prottog wrote:
| > It is unknown if COVID-19 vaccines have non-specific effects on
| overall survival
|
| > The relative mortality risk for mRNA vaccine vs. placebo was
| 1.03 (0.63-1.71)
|
| Yet the CDC is still recommending[0] to this day that everyone 6
| years and older get an mRNA vaccine; even though this article is
| another piece of data saying that for anyone younger than, say,
| 40 with no significant comorbidities (and therefore very low risk
| of death from Covid), you are better off not.
|
| [0]: https://www.cdc.gov/coronavirus/2019-ncov/vaccines/stay-
| up-t...
| [deleted]
| mikeyouse wrote:
| Do you ever pause to wonder why if "you are better off not"
| getting the vaccine if you're under 40, the CDC still
| recommends that everyone in that age group gets it?
|
| Perhaps your confidence in "better off not" is incorrect?
| Seriously, spend a few minutes looking at the vaccine
| effectiveness tracker -- it's still an absolute no-brainer to
| get vaccinated:
|
| https://covid.cdc.gov/covid-data-tracker/#vaccine-effectiven...
|
| The latest study publish in February shows this again, even
| with the more 'mild' strains circulating today:
| https://www.cdc.gov/mmwr/volumes/72/wr/pdfs/mm7207a3-H.pdf
| PraetorianGourd wrote:
| Does COVID impact Europeans differently? The European
| equivalent to the CDC does not recommend additional boosters
| to those under 60[0].
|
| I get this is a still novel virus but the divergence in
| guidance gives me pause, and I think that it is reasonable to
| step back and consider the bigger picture.
|
| [0] https://www.ecdc.europa.eu/en/news-events/ecdc-and-ema-
| updat...
| mikeyouse wrote:
| The problem comes from people misunderstanding domain-
| specific issues.. the CDC and ECDC largely agree here! And
| neither of them echo anything resembling "you are better
| off not" getting the vaccine if you're under 40. It's a
| silly premise with absolutely no support.
|
| The ECDC guidance in that link is against _second boosters_
| which would be the 4th shot in the series.
|
| The CDC's guidance is that everyone has a single shot of
| the "updated" vaccine which has higher efficacy against
| omicron/later strains -- no matter how many vaccines
| they've previously had.
|
| Since Europe generally had higher vaccine uptake, their
| level of protection is already at a higher level than the
| US - so the differing recommendations seem to suit the
| respective populations pretty well.
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