[HN Gopher] Trial of Ketamine Masked by Surgical Anesthesia in D...
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       Trial of Ketamine Masked by Surgical Anesthesia in Depressed
       Patients
        
       Author : cpncrunch
       Score  : 4 points
       Date   : 2023-05-06 19:31 UTC (3 hours ago)
        
 (HTM) web link (www.medrxiv.org)
 (TXT) w3m dump (www.medrxiv.org)
        
       | xtalax wrote:
       | Of course this trial is worse than useless if the other reported
       | benefits of ketamine come from the experience had while under the
       | effects, but these authors seem not to have thought of that.
        
         | cpncrunch wrote:
         | What do you mean? Previous trials of ketamine for depression
         | didn't involve anaesthesia. They uses low doses of ketamine:
         | 
         | https://pubmed.ncbi.nlm.nih.gov/26578082/
         | 
         | Also, they didn't use any anaesthetic known to have
         | antidepressant properties:
         | 
         | "Anesthesiologists were asked to minimize use of nitrous oxide
         | (N2O), which has reported antidepressant effects22. Agents used
         | for anesthetic maintenance included intravenous propofol and
         | inhaled sevoflurane or isoflurane"
        
         | olliej wrote:
         | there are plenty of studies in which ketamine has been given
         | without masking, so we have a lot of evidence it does help.
         | You're tacitly assuming that it does, which in the absence of
         | blinding the patients to the use of ketamine there is no
         | evidence for.
        
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       (page generated 2023-05-06 23:02 UTC)