[HN Gopher] Longevity study across 5 species found a new pathway...
___________________________________________________________________
Longevity study across 5 species found a new pathway to reverse
aging
Author : Brajeshwar
Score : 89 points
Date : 2023-04-23 16:47 UTC (6 hours ago)
(HTM) web link (singularityhub.com)
(TXT) w3m dump (singularityhub.com)
| markus_zhang wrote:
| I have read quite a few longevity research paper on HN alone. Is
| there anything we can put to use other than common sense (no
| smoke, alcohol, etc)?
| halfjoking wrote:
| Get good at fasting. Caloric restriction is the only thing
| proven to increase longevity, other than basic things like
| healthy eating and exercise.
| markus_zhang wrote:
| Yeah I did read about those and tried a couple of times
| without much success, totally my fault though.
|
| It's a bit tough for me at the moment as I WFH and $wifie is
| horrified by the idea of fasting, but well if I don't get
| fired over next two weeks I'll start going into the office.
| nikhilsimha wrote:
| It does get easier with repetition (mentally and socially).
|
| I do a water fast on thursdays (~36 hrs). I find that to be
| much easier than intermittent fasting mentally somehow.
| probablynish wrote:
| Other than no smoke, alcohol, the basics to aim for would be:
| good quality 8 hours sleep every day, a few hours exercise a
| week (mix of strength and cardio), healthy-ish diet (minimize
| sugar and processed foods), look after your mental health.
|
| For more detail, Peter Attia's new book 'Outlive' is a good
| introduction to some of the more involved steps you can take
| (wear a CGM to fine tune your diet for metabolic health, do
| more exercise and target it more specifically).
|
| Attia does have some recommendations on protein (eat a lot, eat
| meat) that conflict with other longevity researchers'
| suggestions ( https://www.valterlongo.com/daily-longevity-diet-
| for-adults/ ) so take that with a pinch of (metaphorical) salt.
| lottin wrote:
| I don't know why sugar intake needs to be minimized. Sugar is
| simply a carbo-hydrate, I don't think it's special in this
| regard. But maybe I'm missing something.
| gdy wrote:
| High glycemic index
| xenonite wrote:
| Some argue that all carbohydrates can be problematic. If
| you like, you may read literature on low-carb high-fat keto
| diets.
| kccoder wrote:
| I've always wondered about the 8 hours of sleep thing. I
| rarely get more than 5.5 hours a night, but I'm not tired.
| I'm a healthy weight, eat reasonably, and work out 10-15
| times a week (cycling, running, lifting, and playing the
| drums (which is surprisingly good low-level cardio (avg hr
| 125ish (resting hr normally in the 40s))). No, I'm not a lisp
| programmer.
|
| Do you think I should be aiming for more sleep?
| Kuinox wrote:
| It's very difficult to know if you are tired or not.
|
| When you feel tired, it means you are _very_ tired right
| now.
|
| People who are sleep deprived and rate themselves as not
| tired shows poorer intellectual performance in tests.
| etiam wrote:
| This one looked interesting and is probably quite actionable.
|
| https://news.ycombinator.com/item?id=18252469
| justrealist wrote:
| Almost certainly get on Metformin, and preponderance of
| evidence is that NMN helps too. Most everything else is
| guesswork.
| Teknoman117 wrote:
| The major problems with Metformin are that it frequently
| makes people nauseous, it causes sperm damage in men (effects
| go away when you cease taking it + about 3 months), and in
| rare cases can cause lactic acidosis if you consume alcohol.
|
| Admittedly, I got put on it because my blood work wasn't
| going in the right direction, but it has noticably increased
| my ability to lose weight. Not exactly scientific, but in my
| first 5 months of trying to lose, I was down 30 pounds, in
| the next 5 months after starting it, I lost about 50 and was
| less strict about my diet. I was even doing less cardio
| because I had primary shifted to lifting weights.
|
| Now I'm down a full 100 pounds, admittedly with another ~100
| to lose, but I really can't describe how much better I feel.
| Combine that with moving to have a regular social life, I
| feel like my life is headed in the right direction for the
| first time since college.
| AnimalMuppet wrote:
| Can you explain how metformin is supposed to help? And NMN
| (maybe start by defining it, as I've never heard of it)?
| CommanderData wrote:
| Metformin has a pretty bad side effects with low term use,
| induced Vitamin B deficiency being the notable.
| falcor84 wrote:
| > Scientists have long suspected that transcription may go awry
| with aging, but the new study offers proof that it doesn't--with
| a twist. In all five of the species tested, as the organism grew
| older the process surprisingly sped up. But like trying to type
| faster when blindfolded, error rates also shot up.
|
| I got incredibly annoyed at this piece of writing, and the
| article as a whole, trying to make it "fun and exciting" to the
| detriment of being clear. In the case of this particular problem,
| the short of version is "as individuals grow older, transcription
| speeds up, which leads to increased error rates". There is no
| "twist" - the process does indeed go awry.
| SanderNL wrote:
| My plebeian mind finds it interesting the process quality
| itself is still the same, only the speed changes. This changes
| the problem from "change fundamental quality of the process" to
| "change the speed of the process", which, again to my unwashed
| and illiterate eyes, seems like an useful and possibly exciting
| distinction.
| GenerocUsername wrote:
| But it might not be that simple. Perhaps it's 'faster'
| because it's doing less error checking.
| derefr wrote:
| My understanding of how the development of cancer works is
| that all the error-checking mechanisms in a cell have to
| become damaged, before a cell can be damaged in such a way
| that it mutates into a cancer cell, because if they _aren
| 't_ all damaged before that, then one of them will find the
| "error" going on, and self-destruct the cell.
|
| Cancer itself, then, is a constructive proof that DNA
| damage can disable DNA-transcription-time error-checking
| mechanisms.
|
| The question in my mind, then, is whether those safety
| mechanisms are "blocking" / "synchronous" steps done during
| DNA transcription, such that disabling them would make DNA
| transcription occur faster. _If_ they are, that would
| neatly explain the observed effect.
| CSSer wrote:
| Plus the whole point of touch typing is that seeing the
| keyboard doesn't matter...
| m3kw9 wrote:
| Do it
| helph67 wrote:
| Some may care to consider this 2015 article.
| https://www.health.harvard.edu/staying-healthy/mediterranean...
| hbarka wrote:
| How? Article was hand-wavy I couldn't get a conclusion.
| aantix wrote:
| I brought this up in an earlier discussion..
|
| >In one test, the team tapped into two well-known treatments for
| delaying aging: inhibiting insulin signaling and caloric
| restriction.
|
| Does this mean that the newer diet medications like Semaglutide
| could be accelerating aging since they increase the secretion of
| insulin from the beta cells?
| mentos wrote:
| My laymen's guess is the insulin is correlation and not
| causation. It's probably just that eating more food leads to
| more cell turn over and aging.
| derefr wrote:
| My understanding is that a eukaryotic cell is a state machine
| with multiple major "modes", where various
| https://en.wikipedia.org/wiki/Tyrosine_kinase -es act as
| "transition functions" between those modes.
|
| You can almost think of a cell "switching modes" in this way
| as it "booting into a different OS": the DNA of the cell gets
| re-phosphorylated, which means different sections of the DNA
| become active and begin being transcribed into proteins.
|
| And it's this re-phosphorylization process during each
| cellular "mode switch" that is the primary contributor to the
| consumption of telomere end-caps on the ends of your DNA; and
| so is the primary driver of cellular senescence.
|
| Which means that the more frequently you do things that make
| your cells switch modes, the sooner those cells will break
| down.
|
| I'm not sure what-all set of "modes" cells switch between --
| it's probably different per specialized cell type.
|
| But I would hypothesize that "glucose metabolism" vs "ketone
| metabolism" is a pretty universal mode switch for most cell
| types; which would, if true, neatly explain the life-
| extending benefits of intermittent fasting (your cells stay
| in the ketone mode for longer, rather than flapping
| constantly between the ketone and glucose modes); and also
| the negative impact of insulin (insulin being the signal
| observed by cells that causes them to trigger a mode-switch
| into the "glucose metabolism" mode, if they're not already in
| it.)
| [deleted]
___________________________________________________________________
(page generated 2023-04-23 23:01 UTC)