[HN Gopher] Micro- and nanoplastics breach the blood-brain barri...
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       Micro- and nanoplastics breach the blood-brain barrier in mice
        
       Author : bookofjoe
       Score  : 162 points
       Date   : 2023-04-23 12:37 UTC (10 hours ago)
        
 (HTM) web link (www.mdpi.com)
 (TXT) w3m dump (www.mdpi.com)
        
       | nahnahg wrote:
       | The problem is not plastic, it is nano particles.
       | 
       | Glass and many other materials that can be nano-ized can do the
       | same.
       | 
       | Polysorbate 80 can open the BBB even more. Just take a vaccine.
        
         | erikpukinskis wrote:
         | > Glass and many other materials that can be nano-ized can do
         | the same.
         | 
         | Isn't that just clay?
        
       | tomalaci wrote:
       | We will need to find methods of removing micro and nanoplastics
       | from our bodies. We are already ingesting them from multiple
       | sources. There is already research about bad effects on male
       | sperm quality [1], DNA damage [2] and more. By the time we clean
       | up this stuff (if ever) in our products and services humanity
       | will already have large concentrations of plastics in them.
       | 
       | [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967748/
       | 
       | [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936647/
        
         | ditn wrote:
         | Regularly donating blood or plasma can reduce PFAS
         | concentrations in the body, I believe the effect is the same on
         | microplastics https://theconversation.com/new-evidence-shows-
         | blood-or-plas...
        
           | CommanderData wrote:
           | This comes up time and time again. I'd feel worse giving
           | someone else toxic blood that can't be fully filtered.
           | 
           | Why isn't blood letting mentioned more?
        
           | godsfshrmn wrote:
           | The only feasible way I see for removal is via donation or
           | some form of hemodialysis. As the saying goes, the solution
           | for pollution is dilution (or at least in the medical sense!)
        
           | bilsbie wrote:
           | How about regular whole blood donations?
        
           | coding123 wrote:
           | Or get a shit ton of labs done
        
           | croes wrote:
           | You mean bloodletting, because you can't use the blood for
           | others.
        
             | daveguy wrote:
             | I don't think anyone would mind taking on some pfas or
             | microplastics from a donor if they're about to bleed out.
             | There are always priorities.
        
               | carlmr wrote:
               | Especially since we all have PFAS and microplastics in us
               | at this point. There is no PFAS- and microplastics-free
               | blood.
        
             | burke wrote:
             | If all donated blood was screened for trace microplastics,
             | I think we'd have an immediate and total donor blood
             | shortage.
        
           | ekanes wrote:
           | Super interesting. But is the blood then cleaned of them, or
           | is this kind of like giving your plastics to someone else? :/
        
             | erikpukinskis wrote:
             | If I was in a need of a blood transfusion I think I'm OK
             | with there being a normal amount of nanoplastics in them.
        
               | ahupp wrote:
               | nit, but this is usually accomplished with plasma
               | donation (plasmapheresis) rather than blood donation. You
               | can donate plasma much more frequently (2x/week) vs blood
               | (once per 2 months), thought the volume taken for each is
               | roughly similar.
        
               | bbarnett wrote:
               | The filters used must be a specific size, so how micro,
               | are micro plastics? If they keep breaking into smaller
               | pieces, wouldn't they be cell sized too? And thus, pass
               | cell sized filters?
        
             | Entinel wrote:
             | If I was in a situation where I needed emergency blood, the
             | level of microplastics in it is the least of my concerns.
        
               | brookst wrote:
               | "Excuse me, did this blood come from a vegan? I couldn't
               | possibly accept blood that isn't 100% organic, free
               | range, and ---" (transcript ends, patient died)
        
         | peteradio wrote:
         | What method could possibly exist that would remove threads of
         | plastic embedded in tissue? Sounds incredibly invasive no
         | matter what i.e a no-go. Don't plan for this stuff to somehow
         | magically remove itself, plan on ingesting small enough amounts
         | in your lifetime to render it a non-issue. If modern life is
         | making that impossible then demand a better modern existence.
         | If that's not possible to make society change for the better (I
         | have my doubts) then accept your fate nobody said life would be
         | fair, perhaps take up religion.
        
           | eurasiantiger wrote:
           | Remember, Morgellon's is a fictitious disease.
        
           | jjtheblunt wrote:
           | > What method could possibly exist that would remove threads
           | of plastic embedded in tissue?
           | 
           | macrophages breaking their bonds? (I'm not sure...that's a
           | question)
        
           | swores wrote:
           | It's hard to say what methods will work, but it's not hard to
           | imagine possibilities - a bacteria or virus (or even a
           | nanobot someday?!) could be discovered / created that eats
           | plastic but does no harm to a human body (or minimal harm
           | that doesn't matter and can easily be removed/killed once
           | it's got all the plastic) - see for example [1] & [2]
           | different types of recently found plastic-eating bacteria for
           | inspiration (the two bacteria types were found to eat
           | different specific types of plastic, I'm not sure if they've
           | tested each on all types of plastic or just published the
           | first known).
           | 
           | Or maybe we discover some sort of light/sound/other
           | wave/something that, like an x-ray, has low enough health
           | risks to be worth sometimes putting through humans, but that
           | somehow does something to plastic that will let the body
           | dispose of it all?
           | 
           | Or maybe some drug gets created that somehow turns on some
           | bodily function that can handle the plastic problem.
           | 
           | Or.... I don't know, I'm no expert, but I bet there's more
           | possibilities.
           | 
           | Of course, would be good to do our best to reduce plastic use
           | altogether anyway, for environmental as well as health
           | reasons!
           | 
           | [1] https://interestingengineering.com/science/bacteria-
           | really-c...
           | 
           | [2] https://www.livescience.com/plastic-eating-bacteria
        
             | peteradio wrote:
             | I love how the solution is to perhaps put nanobots in my
             | brain or just some virus into my brain, this is top tier
             | stuff.
        
               | BobbyJo wrote:
               | Assume magic cow.
        
           | kortex wrote:
           | Engineered antibodies or possibly mRNA vaccine, maybe.
           | Monoclonal antibodies would likely be too expensive for use
           | as a purely ameliorative measure. But if we figure out how to
           | fold proteins on demand, then we can express a sequence and
           | make it like other biologics. That's still a very expensive
           | proposition, but at least it would have economies of scale.
           | Avoidance is the best medicine for sure.
        
           | donny2018 wrote:
           | I'm not a biologist, but AFAIK just stopping new plastics
           | inflow should be enough. The body continuously produces new
           | cells to renew itself, including blood cells and what not,
           | and this new material is plasticless.
           | 
           | Don't take new plastic, and in a few years you should be
           | good.
        
             | dmbche wrote:
             | The problem is that the plastic is not removed. Kind of the
             | same thing as people having shrapnel or bullets lodged in
             | them for life - while your cells regenerate, the object
             | remains and still interacts with you.
        
               | donny2018 wrote:
               | Shrapnel or bullets are large objects and obviously the
               | body can't get rid of them.
               | 
               | Nanoplastic circulates in the bloodstream which is
               | continuously refreshed, or sits somewhere in the cells
               | which are continuously disposed of.
               | 
               | Some toxins or heavy metals can accumulate in bones, but
               | I'm not sure if plastic can do that.
        
               | dmbche wrote:
               | Thanks for clarifying!
        
         | lordnacho wrote:
         | Is this going to end up with a mega lawsuit?
        
           | mock-possum wrote:
           | I mean look at lead.
        
           | DANmode wrote:
           | If knowledge intent is found.
           | 
           | Probably not.
        
         | anaganisk wrote:
         | But will the shareholders be happy with all the stuff that
         | needs to be done.
        
       | user3939382 wrote:
       | I don't need to wait for the science to know that having plastic
       | in our body and blood is bad for our health.
       | 
       | The limited science we do have unsurprisingly indicates that it
       | is.
       | 
       | It's weird to me that a lot of HNers, like I see with western
       | doctors, believe that until something is conclusively proven in
       | peer reviewed research it should be treated as if it doesn't
       | exist at all. IMHO that's irrational and robotic, there are such
       | things as safe assumptions and educated guesses.
        
         | SoftTalker wrote:
         | I think we do need science. We just went through three years of
         | divisive public debate about science vs. "knowing" what is good
         | or bad for our health.
         | 
         | Plastic is pretty chemically inert. We've been using it widely
         | for decades to great benefit and there is no strong evidence
         | that it's harmful. I would not be surprised to find that in the
         | body it's basically benign.
         | 
         | Or maybe not, but I don't see how you can "know" either way,
         | without scientific research.
        
           | dieselgate wrote:
           | I don't disagree with you but Research cannot even directly
           | conclude whether drinking any amount of alcohol is good or
           | bad for human health - such is the case for any study which
           | tries to link Behavior with Health Outcome.
        
             | ddol wrote:
             | > No studies have shown that the potential existence of a
             | protective effect for cardiovascular diseases or type 2
             | diabetes also reduces the risk of cancer for an individual
             | consumer. Evidence does not indicate the existence of a
             | particular threshold at which the carcinogenic effects of
             | alcohol start to manifest in the human body. As such, no
             | safe amount of alcohol consumption for cancers and health
             | can be established.
             | 
             | https://www.thelancet.com/journals/lanpub/article/PIIS2468-
             | 2...
        
               | dieselgate wrote:
               | Indeed but it's complicated. I only mean to suggest one
               | article/publication isn't enough to support or prove a
               | point definitively - rather than get caught in the weeds
               | about "if alcohol really does/n't effect health".
               | Researching health outcomes is very complicated and
               | nuanced but we should certainly continue to do it.
               | 
               | > These findings seemingly contradict a previous GBD
               | estimate published in The Lancet, which emphasised that
               | any alcohol use, regardless of amount, leads to health
               | loss across populations.
               | 
               | https://www.thelancet.com/journals/lancet/article/PIIS014
               | 0-6...
        
           | pohl wrote:
           | > I think we do need science.
           | 
           | I don't understand how one could read user3939382's comment
           | and conclude that the expressed position is that we don't
           | need science.
           | 
           | That's not at all what they said. Rather, they were
           | advocating for the application of the Precautionary Principle
           | _while waiting for science_.
        
         | chmod600 wrote:
         | It's about the burden of proof. If you try to place the
         | burdenof proof on anything that changes the status quo, it
         | causes two problems:
         | 
         | 1. You can't prove a negative.
         | 
         | 2. What constitutes a change from the status quo? The status
         | quo is a vague concept in a dynamic world.
         | 
         | So you have to use some judgement. Plastic is really, really
         | safe in small amounts. Same with CO2 emissions. It's only in
         | huge quantities that they are a problem.
        
           | brookst wrote:
           | > It's only in huge quantities that they are a problem.
           | 
           | This is the critical thing. People are really really bad at
           | nuances like "harmless in small quantities, harmful in
           | large". People tend to want to argue whether X is good or bad
           | in a totally contextless abstract, like sports fans taking
           | fandom too far.
           | 
           | HN doesn't seem better than reddit or fox news in this
           | respect. It seems to be fundamental to human nature. And yes,
           | I know I do it as well. Such a frustrating bug in human
           | cognition.
        
       | dmbche wrote:
       | Why do this science? Are we just feeding mice plastic for kicks?
       | Like yeah who would've known that nanoparticles pass the blood
       | brain barrier - who cares?
       | 
       | Can't we just do some scans/biopsies on humans to assess if we
       | have plastic in the brain and start from there?
       | 
       | How does this experiment further anything? I'm kind of appalled
       | that this is some people's job - it's pointless, stupid and
       | cruel, and done by scientists who get paid the big bucks doing
       | it.
       | 
       | I know I'm a little ranty - but I'm serious. Why do people do
       | these experiments?
        
         | titzer wrote:
         | > and done by scientists who get paid the big bucks doing it.
         | 
         | Uh, no. Grad students make bupkiss while they could easily pull
         | six figures after completing a bachelor's. They do this because
         | they are a curious, masochistic bunch who find working on
         | important problems to be a worthwhile endeavor.
        
           | dmbche wrote:
           | Is it only grad students or is there a lead researcher that
           | asks for grants and such? I'm not a scientist myself, the
           | ones I know are working for the governenent or are
           | professors. While they are not rich they are much better off
           | than the average person.
           | 
           | And is feeding mice plastic and then seeing if they have
           | plastic in them a worty endeavour? It's fine because they
           | aren't paid as well as if they were working corporate?
           | 
           | I'm also aware that a lot of people have to tailor their
           | doctorate work to their advisor, meaning it could very well
           | be that no one doing this experiment was "curious" or
           | believing that it was "important".
           | 
           | I'm sure you know many bitter PhD's that studied things they
           | find utterly pointless today - I had many teachers laughing
           | at their own peer reviewed work.
        
           | dmbche wrote:
           | Like how much is a grad student actually making per year? As
           | a student that will be able to get a PhD or post afterward?
        
             | titzer wrote:
             | It's under $40k, typically.
             | 
             | Here's data for CMU:
             | 
             | https://www.cmu.edu/stugov/gsa/campus-advocacy/stipend-
             | repor...
        
               | dmbche wrote:
               | Thanks for the link, I had looked and in canada it's even
               | lower, at 29,000k for a biology grad student.
               | 
               | While it's not rich people's money, it's more than enough
               | to be very comfortable, especially compared to someone
               | working minimum wage.
               | 
               | I don't feel bad being very critical of how their time is
               | being spent - especially here.
        
         | peteradio wrote:
         | You do these proofs of concept to prove the problem exists.
         | Until there is hard science it can be hard to spur action. I
         | could say, ya know, I believe that if any of these so called
         | microplastics (subtly doubting existence) they would not be
         | absorbed by my body and will simply exit may waste chute
         | (doubting the problem). Now you can say, ya know,
         | akssssssssshuallly studies show that yadda yadda. And then I
         | could say ya IN MICE! And then you could be like oh ya fucko
         | and start forcefeeding me shredded up milk cartons until you
         | dissect my brain a few hours later. Now you've gone ahead and
         | reproduced OP document and thats called SCIENCE!
        
           | dmbche wrote:
           | I understand, but this experiment doesn't prove that the
           | problem exists - I don't know if humans have plastics in
           | their brain.
           | 
           | I'm not a scientist, but couldn't we check cadavers for
           | microplastics? Wouldn't that be more concluent?
        
             | peteradio wrote:
             | No no I'm the one who was supposed to rebut with "In MICE!"
             | 
             | You're right about the cadavers! Maybe such a study exists
             | and we could skip ahead to agreeing its a problem or
             | perhaps we enter the next phase: "are we sure these
             | plastics in my brain are akshuuuaallly a problem, perhaps
             | they are making me less stupid and more healthy MR
             | SCIENTISTS"
        
             | titzer wrote:
             | You know, you too can search the internet. Microplastics
             | are in human blood: https://www.theguardian.com/environment
             | /2022/mar/24/micropla...
             | 
             | The study in question found microplastic in 80% of test
             | subjects. The presence of these particles is likely not
             | new, just that it's been difficult to detect them until
             | now. Buckle up, we're not likely to find out that they give
             | us superhuman abilities.
        
               | dmbche wrote:
               | I'm sorry - I'm refering to the experiment. I personally
               | know that there are microplastics in our blood - I'm
               | saying that this experiment is redundant, as your link
               | arguably supports.
        
               | dmbche wrote:
               | I'm obviously not arguing that microplastics aren't an
               | issue - I'm saying we didn't have to force feed mice
               | plastic to get actionable data to solve the issue.
        
               | titzer wrote:
               | I have not idea what you are arguing anymore, and
               | frankly, it's just a lot of noise at this point. The way
               | we figure out stuff is with experiments, sometimes
               | experiments on animals. You're out here "no need for
               | experiments, this is a waste of money, blah blah blah
               | unethical, I could have told you that, everyone's
               | embezzling money from the government, those rich
               | scientists huminah huminah." I mean, I could argue these
               | points, or you could just stop trolling.
        
               | dmbche wrote:
               | I think there is too little oversight on animal testing
               | and that this experiment is a flagrant example of that.
               | While I understand that some experiment "require" animal
               | testing, I don't see how this one arguably does.
               | 
               | That's not been argued, we're arguing the salaries of the
               | scientists instead - not certain why.
               | 
               | I haven't talked abount embezzeling anything or that
               | experiments are useless - just that I can't see why this
               | one was done, and it makes me weary of most experiments
               | on animals, even more than I normaly am, as they seem
               | much more arbitrary than I would have liked to think.
               | 
               | Thanks for your insight and snarkiness anyway.
        
             | kergonath wrote:
             | We can do that as well, and I am confident some studies are
             | in the works. But we still need to understand what is
             | happening, which require controlled environments and
             | simplified situations where we can study the effect of each
             | parameter one after another.
             | 
             | One does not prevent the other.
        
               | dmbche wrote:
               | I see. I think I'm arguing that we should be more
               | critical of animal studies, as I'm having problems seeing
               | what usable data was extracted from these mice that
               | wouldn't have been found some other way.
               | 
               | Anyhoot!
        
         | kortex wrote:
         | Sure, you first, open up your skull for brain biopsy.
         | 
         | Lab animals are kept in regulated conditions (illegal/unethical
         | behavior under the radar aside), experiments are vetted by
         | institutional review boards, and they live pretty decent lives.
         | There is mandatory sensory stimulation, handling, and
         | socialization.
         | 
         | If you want to get rid of animal models, kiss basically every
         | medical intervention goodbye (drugs, prosthetics, procedures,
         | surgery).
        
           | dmbche wrote:
           | Eh - I don't think that the mice force fed plastic has a
           | pretty decent life, does it? While all the things you write
           | are claims, I doubt you will be very convinced of them if you
           | do any research on the subject. All undercover investigation
           | in labs showed blatant mistreatment in every single case,
           | which I am comfortable with generalising to most other labs,
           | unless proven otherwise.
           | 
           | As for having my brain biopsied - I'm not the one arguing
           | that we have microplastics in the brain. The scientists had
           | this hypothesis, and killed some mice to prove it. I'm saying
           | that they shouldn'y have been allowed to, since the result
           | does not further anything about plastics in human brains, and
           | other options seemed both to provide better human data and be
           | more ethical.
        
             | quonn wrote:
             | It's not more ethical to do research on humans, unless you
             | can be sure these humans do not participate in experiments
             | due to their economic situation.
             | 
             | Anecdotal example: I have met a british guy who makes a
             | living from participating in medical trials. He makes about
             | 10-20k per year if I remember correctly.
        
               | dmbche wrote:
               | I think I'm comfortable arguing that it is much more
               | ethical to do voluntary human testing, as humans will
               | always have more options than animals in cages - unless
               | we are talking something like human trafficking, but I
               | don't think that's what you are bringing up.
               | 
               | As for your example, I too knew someone living a pretty
               | terrible life doing trials for a living, that died sadly.
               | While I understand your point, I'm sure you can think of
               | many avenues for this person to make a living without
               | doing trials - i.e. stocking shelves, working a
               | warehouse, janitorial work, service, etc. If they are
               | under precarious circumstences, there are many options
               | still.
        
         | WanderPanda wrote:
         | Did I miss something about scientists getting payed the big
         | bucks suddenly?
        
           | dmbche wrote:
           | Compared to someone stocking shelves at minimum wage? And
           | with benefits, job security, etc.
           | 
           | I'm sorry if "the big bucks" sounded like over 100 000$ for
           | every single one of them.
           | 
           | Some guy still got a grant to feed mice plastic, didn't he?
        
             | erikpukinskis wrote:
             | Scientists don't have particularly great job security as a
             | group.
        
               | dmbche wrote:
               | The scientists I know are working for the government and
               | univerities, and are pretty well set. What are you
               | alluding to?
        
           | amelius wrote:
           | Some do, but they work in advertising.
        
             | Jeff_Brown wrote:
             | Genetics is hot right now, and probably will be for
             | decades.
        
         | ChatGTP wrote:
         | Have to agree with you. We screwed up the environment, then
         | experiment on innocent creatures to prove we've screwed it up.
         | 
         | Not to say there isn't good science being done, but I do
         | question the ethics.
        
       | christophilus wrote:
       | First, it's great to read the full paper with no paywall. Kudos.
       | 
       | Second, I agree with the conclusion that more research is needed.
       | I'd love to know what effect these plastics have on brain
       | function.
        
         | kergonath wrote:
         | > First, it's great to read the full paper with no paywall.
         | Kudos.
         | 
         | It's MDPI. The no-paywall thing is part of their predatory
         | scheme. Along with blazing fast reviews with not too many
         | questions asked. Seriously, it's completely unbelievable that
         | any significant article would be thoroughly reviewed in 2
         | weeks, as this article seems to have been.
         | 
         | > Second, I agree with the conclusion that more research is
         | needed.
         | 
         | Indeed.
        
         | api wrote:
         | The most important question is whether they are cleared over
         | time or if they are bioaccumulative like heavy metals. Can the
         | body clear them?
         | 
         | Is there a way to clear them at all? Even with medical
         | assistance? There is chelation therapy that can clear some
         | heavy metals. Anything like that for nanoplastic?
         | 
         | I have no idea so I submit the question to the hive mind.
        
           | bookofjoe wrote:
           | Retired academic neurosurgical anesthesiologist [38 years;
           | https://scholar.google.com/citations?user=5DdrMc8AAAAJ&hl=en]
           | here. My best guess is that once inorganic materials such as
           | nanoparticles enter the cerebral circulation and lodge in
           | brain tissue, they are there permanently.
        
             | BaculumMeumEst wrote:
             | If this were the case wouldn't it be low-hanging fruit to
             | study some cadavers to investigate?
        
               | bookofjoe wrote:
               | Indeed it would, and because of the topical nature of the
               | problem publication in a top journal would likely occur.
        
               | bookofjoe wrote:
               | While we wait:
               | 
               | >Brain damage and behavioural disorders in fish induced
               | by plastic nanoparticles delivered through the food chain
               | 
               | https://www.nature.com/articles/s41598-017-10813-0"
        
               | walleeee wrote:
               | Also hermit crabs
               | https://pubmed.ncbi.nlm.nih.gov/32343937/
        
             | dmbche wrote:
             | What kind of interaction would you guess the particles
             | would have with the brain after passing the barrier? I know
             | heavy metals have stong interactions, but I wonder how bad
             | plastic is, really - not that it would be good of course.
        
               | bookofjoe wrote:
               | I wouldn't even guess as to the nature of interaction of
               | cerebral cortex/hypothalamus/brain stem/etc. with plastic
               | nanoparticles -- but I doubt that it would be a benefit.
               | As Deckard remarked in another context, more likely than
               | not a hazard.
        
               | dmbche wrote:
               | Thanks for replying anyway! :)
        
               | bookofjoe wrote:
               | You're most welcome.
        
               | kortex wrote:
               | Depends a lot on the size, polymer, and even geometry
               | (thread, shard, or just blob). Unlike metals, aliphatic
               | plastics have little electronic interaction. My intuition
               | as a chemist is most will just hang out in the lipid
               | membrane or in vacuoles not really interacting with
               | biology much. But it could also be worse, such as
               | disrupting protein folding, messing with DNA replication,
               | or triggering chronic low-grade inflammatory response. We
               | don't really know at this time which is why we need
               | studies like TFA.
        
       | dukeofdoom wrote:
       | I was cuttug up a hot pepper and washed my hands for a pretty
       | long time. But still when I rubbed my eyes I got burned. Made me
       | realize that I've probably ingested all kinds of things by not
       | washing my hands well enough. And that tiny amounts of things
       | enter our body all the time. Also, It's "making the frogs gay" (
       | Alex Jones )
        
       | PragmaticPulp wrote:
       | The title seems to not quite match the article, unless I'm
       | missing something. The title suggests that microplastics can
       | reach the brain, which be a shocking result given that
       | microplastics are relatively large (up to 5mm). The study only
       | found that nanoplastics of a certain small size were found:
       | 
       | > In our study we performed short term uptake studies in mice
       | with orally administered polystyrene micro-/nanoparticles (9.55
       | um, 1.14 um, 0.293 um). We show that nanometer sized particles--
       | but not bigger particles--reach the brain within only 2 h after
       | gavage.
       | 
       | Still concerning, of course. They didn't really do any
       | quantification of how much this happened, they just administered
       | rather extreme concentrations of deliberately produced
       | nanoplastic formulas and then later found a couple particles in
       | brain sample images.
       | 
       | The images they included (scroll down to Figure 3) are somewhat
       | confusing in that they all have green dots in them, but only some
       | of the dots are labeled nanoplastics. Even the control mouse has
       | a lot of little green dots, but they're not identified as
       | nanoplastics for reasons I don't understand. Someone more
       | familiar with the subject matter would have to comment on how
       | reliable this method is. The number of green dots is strikingly
       | large in even the control mouse, so clearly they're not all
       | nanoplastics.
        
         | bookofjoe wrote:
         | >Micro- and Nanoplastics Breach the Blood-Brain Barrier (BBB):
         | Biomolecular Corona's Role Revealed
        
           | PragmaticPulp wrote:
           | From the first paragraph of the article:
           | 
           | > In our study we performed short term uptake studies in mice
           | with orally administered polystyrene micro-/nanoparticles
           | (9.55 um, 1.14 um, 0.293 um). We show that nanometer sized
           | particles--but not bigger particles--reach the brain within
           | only 2 h after gavage.
        
             | bookofjoe wrote:
             | Ah, now I see your point -- and it is a good one. The title
             | should be something like "Ingested Microplastics May Break
             | Down Into Nanoplastics Which Breach Blood-Brain Barrier"
        
         | SapporoChris wrote:
         | I suspect that microplastics are not reaching the brain. We
         | have autopsies that can specifically look for this. Example:
         | "Researchers found evidence of plastic contamination in tissue
         | samples taken from the lungs, liver, spleen and kidneys of
         | donated human cadavers."
         | https://www.upi.com/Health_News/2020/08/17/Autopsies-show-mi...
         | 
         | I'm not downplaying the problem at all. If microplastics are in
         | major organs that is a serious problem that warrants additional
         | research or even outright bans. However, if microplastics are
         | getting to the brain I think there'd be conclusive evidence by
         | now.
        
         | peteradio wrote:
         | I suppose what they are saying is smaller parts of the
         | microplastics were apparently breaking off and entering the
         | brain as nano-sized, none of the samples fed were nano-sized.
        
           | PragmaticPulp wrote:
           | The article says they administered sub-micrometer particles,
           | which they refer to as nanoplastics.
        
             | peteradio wrote:
             | Ahh I see, reading a bit more, I think the idea is that the
             | gut is filtering out the larger particles but simulation
             | indicates the BBB could pass micro-plastics.
             | 
             | > These findings together with the computer model underline
             | that MNP PS particles can cross the gastrointestinal
             | barrier and the BBB within a short time, but only 0.293 um
             | sized particles were able to be taken up from the
             | gastrointestinal tract and to penetrate the BBB. This
             | suggests that the size of the particles may be a critical
             | factor in their ability to penetrate the BBB [42].
        
       | EGreg wrote:
       | And we ingest them now, they are in our water [1], and they can't
       | be flushed out [2] -- right?
       | 
       | But these corporations put out metric tons of it externalizing
       | the cost to everything and everyone. While the individual is told
       | they can't have a plastic bag or straw, and that we can recycle
       | our way out of it (which is a scam -- it was shipped to China,
       | not recycled). Thanks corporatism! Government is carrying water
       | for corporations while individuals are distracted into thinking
       | they can clean up the mess with personal action [3]
       | 
       | 1. https://extension.psu.edu/microplastics-in-our-waters-an-
       | unq...
       | 
       | 2.
       | https://www.theguardian.com/environment/2022/mar/24/micropla...
       | 
       | 3. https://magarshak.com/blog/?p=362
        
         | bandersnitch wrote:
         | Worse yet, the personal action campaign turned a lot of people
         | into rabid animals with 'recycling' everything, including much
         | of which is just landfilled. And if you call into question the
         | whole recycling industry, which has been mostly proven to be a
         | scam of the plastics industry, they'll just get angry and say
         | something like "well you just have to trust them at some
         | point".
         | 
         | Now, metal recycling is definitely a thing. Recycling alu or
         | iron is definitely a valid thing. It costs a lot of energy to
         | convert iron ore or bauxite into the associated pure metals.
         | 
         | Countrywide laws that could change how recycling and products
         | work: require cradle-to-grave product laws, and then make the
         | source responsible for disposal. (That would turn the current
         | externality into an internality. And their scale would help
         | solve it.)
        
           | EGreg wrote:
           | Or at least use pigovian taxes to remove the printed money
           | from the economy. These would be great for forcing companies
           | to start researching and using biodegradeable products right
           | quick.
           | 
           | https://en.wikipedia.org/wiki/Pigouvian_tax
        
             | Jeff_Brown wrote:
             | Pigouvian taxes are great, but what connection do you see
             | between them and the printing of money?
        
               | EGreg wrote:
               | If you don't redistribute the money directly to the
               | people, that tax burden can fall disproportionately on
               | the working class, and you get stuff like this:
               | 
               | https://www.nytimes.com/2019/04/15/business/yellow-vests-
               | mov...
               | 
               | Furthermore, if you redistribute a UBI to the people, it
               | makes the tax _popular_. This is massively important in a
               | society that 's tax-averse, and helps gather support for
               | actually solving collective action problems.
        
         | ajdude wrote:
         | > and they can't be flushed out [2] -- right?
         | 
         | This works for other forever chemicals, it may work for micro
         | plastics:
         | 
         | > Regular Blood Donations Can Reduce Toxic Forever Chemicals in
         | the Bloodstream: Study
         | 
         | > https://theswaddle.com/regular-blood-donations-can-reduce-
         | to...
        
           | tomjakubowski wrote:
           | bloodletting is back baby!
        
           | tmountain wrote:
           | Also significantly reduces risk of heart attacks. Donating
           | blood is good for you and it saves lives.
        
             | yazaddaruvala wrote:
             | If only they would take my blood!
             | 
             | In Seattle I've tried to donate blood multiple times over
             | the last decade.
             | 
             | Every time, "because I've been to India in the last 5
             | years" they are unable to take my blood. Something about
             | the risk of malaria. At worst, given a shortage, why not
             | take my blood and analyze it? maybe even clean it (like
             | with a dialysis machine)?
             | 
             | Talk about a dumb rule. Anyways... is there some other way
             | to get this advantage? Are there blood letting doctors?
        
               | manquer wrote:
               | You could donate in India perhaps ?
               | 
               | Also afaik it is 3 months[1] for malarial region (like
               | India) it was updated from one year after FDA guidance
               | changed in 2020
               | 
               | [1] For former residents of malarial region you must have
               | resided outside for three years first, here is link to
               | the full guidance from FDA
               | 
               | https://www.fda.gov/regulatory-information/search-fda-
               | guidan...
        
         | PragmaticPulp wrote:
         | Your second citation simply says that someone made a
         | breakthrough discovery that the particles could be identified
         | in some subjects. It doesn't conclude that they "can't be
         | flushed out"
         | 
         | Your third citation is a weird ranty blog about everything from
         | anarcho-capitalism anti-vaccine rants that is more angry than
         | informative, but it's somewhat beside the point: We _are_
         | making laws to reduce microplastics deliberately introduced to
         | products. Asking the entire world to stop using plastics
         | immediately isn't a real option. Individual action _does_ have
         | a significant effect, as the highest numbers of microplastic
         | /nanoplastic particles are found directly inside of plastic
         | containers like plastic water bottles. Several orders of
         | magnitude higher than your government-provided tap water.
        
           | EGreg wrote:
           | The vast majority of microplastics aren't deliveberaly
           | introduced into products, but come from breakdown of
           | "everyday" plastics. When you wash your polyester shirts, for
           | instance. Or when your plastic containers are "recycled".
           | 
           | Your characterization of having the entire world stop using
           | plastics "immediately" is a strawman. We had decades. The
           | amount of plastic has only grown, while R&D into non-
           | biodegradable alternatives doesn't get mych funding by
           | comparison. The suggested solution is to have governments
           | fund a UBI with Pigovian taxes. We can't even pass this: http
           | s://csas.earth.columbia.edu/sites/default/files/content/...
           | 
           | We the People _should_ be angry, since we and our children
           | will have to live with the consequences of this dysfunction
           | and inaction, and _increase_ in production and consumption of
           | these things which externalize the cost, thanks to the profit
           | motive. The list of things in that third link goes way beyond
           | plastics. This is how our system works. Ours is an
           | environmentallh irresponsible generstion living on an
           | ecological credit card. The individuals are distracted from
           | banding together to vote in governments that will pass a
           | Pigovian Tax and Dividend on an increasing number of negative
           | externalities. It requires a political movement, and anger is
           | a great motivator and uniting force.
           | 
           | In that third link, I list all the narratives individuals are
           | told, in order to take focus away for governments and
           | corporations, and onto shaming individuals into performing
           | _individual action_ downstream of the actual problem.
        
             | PragmaticPulp wrote:
             | > Your characterization of having the entire world stop
             | using plastics "immediately" is a strawman. We had decades.
             | 
             | You think we can just stop using plastics in a couple
             | decades?
        
               | EGreg wrote:
               | Of course, or at least massively reduce it, if we found
               | alternatives that were good enough! Not "just" stop, but
               | mandate some % of the savings go to R&D when Coca Cola or
               | Snapple switches to Plastic. Tax that stuff!
               | 
               | Look at what we did with CFCs globally when we came
               | together -- that is a massive success:
               | 
               | https://en.m.wikipedia.org/wiki/Montreal_Protocol
               | 
               | We can also help reduce meat consumption gradually with
               | more products like Beyond Meat and Impossible Foods etc.
               | but it is far better and more effective if the government
               | gets involved and taxes factory farms.
               | 
               | As a side note, I know the alternatives have to be good
               | enough before people switch, because I have been building
               | https://qbix.com for OVER a decade, and only now we are
               | ready to present an alternative to the Big Tech
               | monopolies no one can exit because they lack viable
               | alternatives. This problem is everywhere in capitalism.
        
           | yowzadave wrote:
           | > Individual action does have a significant effect, as the
           | highest numbers of microplastic/nanoplastic particles are
           | found directly inside of plastic containers like plastic
           | water bottles
           | 
           | If I limit my personal use of products like these, will this
           | keep microplastics from entering my body? Or is there an
           | effect from the broader environment, regardless of my
           | personal initiatives?
           | 
           | Also, will there be enough products that eliminate
           | microplastics that it won't be a huge cost/effort burden to
           | go without?
        
             | PragmaticPulp wrote:
             | Plastic from water bottles contains about two orders of
             | magnitude more micro plastics than regular tap water. So
             | yes, personal action can have an effect and the size of
             | that effect is about 100x.
             | 
             | It's not possible to keep micro plastics out of your body
             | 100%, but like everything it's a question of how much. Even
             | your tap water contains compounds like cyanide in trace
             | amounts that we can measure, but that just says more about
             | our ability to measure Tony quantities of compounds. You
             | have to look at the relative significance of different
             | amounts.
        
               | kgc wrote:
               | Very interesting. Is there an authoritative source for
               | the 100x measurement? Would like to show friends.
        
       | cubefox wrote:
       | According to this source
       | 
       | https://www.horiba.com/int/scientific/resources/science-in-a...
       | 
       | the main source of microplastics is synthetic textiles. There is
       | a serious argument to be made to ban synthetic textiles in areas
       | where they can be reasonably replaced with cotton.
       | 
       | The other main sources are "city dust" and car tires. I suspect
       | those types of microplastics are much harder to reduce.
        
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